+E Replication protein KO
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DNA Replication Proteins - Lingula anatina
%
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 106181039 origin recognition complex subunit 1 isoform X1 K02603 ORC1; origin recognition complex subunit 1
D 106160026 origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 106155498 origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 106160311 origin recognition complex subunit 3-like K02605 ORC3; origin recognition complex subunit 3
D 106150592 origin recognition complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 106172577 origin recognition complex subunit 4-like K02606 ORC4; origin recognition complex subunit 4
D 106174786 origin recognition complex subunit 5-like K02607 ORC5; origin recognition complex subunit 5
D 106161876 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 106162792 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 106173133 origin recognition complex subunit 6-like K02608 ORC6; origin recognition complex subunit 6
D 106177747 DNA replication factor Cdt1-like isoform X2 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 106155022 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 106181688 DNA replication licensing factor mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 112041974 DNA replication licensing factor mcm2-like K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 106160876 zygotic DNA replication licensing factor mcm3-like K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 106173359 zygotic DNA replication licensing factor mcm3-like K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 106156400 DNA replication licensing factor mcm4-A K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 106179387 DNA replication licensing factor mcm4-A-like isoform X1 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 106181517 DNA replication licensing factor mcm5-A-like isoform X1 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 106161749 DNA replication licensing factor mcm5-A isoform X1 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 106161045 zygotic DNA replication licensing factor mcm6-B-like K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 106179053 zygotic DNA replication licensing factor mcm6-B K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 106161413 DNA replication licensing factor mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 106168850 G2/mitotic-specific cyclin-A-like K06627 CCNA; cyclin-A
D 106168918 G2/mitotic-specific cyclin-A K06627 CCNA; cyclin-A
D 106177995 G1/S-specific cyclin-E-like isoform X1 K06626 CCNE; G1/S-specific cyclin-E1
D 106175729 G1/S-specific cyclin-E K06626 CCNE; G1/S-specific cyclin-E1
D 106173442 cyclin-dependent kinase 2-like K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 106178516 cell division cycle 7-related protein kinase-like K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 106161919 cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 106162033 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 106167595 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 106157162 DNA replication complex GINS protein PSF2 isoform X1 K10733 GINS2; GINS complex subunit 2
D 106150876 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 106180368 DNA replication complex GINS protein PSF3-like K10734 GINS3; GINS complex subunit 3
D 106159755 DNA replication complex GINS protein SLD5-like K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 106180974 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 106157815 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 106153856 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 106177222 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 106176569 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 106154345 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 106154639 DNA helicase B-like isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 106153203 DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 106169626 cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 106167763 uncharacterized protein LOC106167763 K26116 MTBP; Mdm2-binding protein
D 106164974 uncharacterized protein LOC106164974 K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 106165166 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 106180200 DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 106155693 LOW QUALITY PROTEIN: DNA primase small subunit-like K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 106181510 DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
D 106162054 DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 112041832 DNA primase large subunit-like K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 106165766 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 106166515 DNA polymerase epsilon catalytic subunit A-like K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 106157009 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 106180764 DNA polymerase epsilon subunit 3-like K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 106181069 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 106179781 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 106172309 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
D 106173742 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 106177559 DNA polymerase delta subunit 3-like K03504 POLD3; DNA polymerase delta subunit 3
D 106158575 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D 106164929 DNA polymerase delta subunit 4-like K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 106162337 DNA polymerase subunit gamma-1 isoform X1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 106162019 DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 106163603 DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 106179989 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 106163744 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 106158405 replication protein A 32 kDa subunit-A-like K10739 RFA2; replication factor A2
D 106165443 uncharacterized protein LOC106165443 K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 106174155 replication factor C subunit 1-like K10754 RFC1; replication factor C subunit 1
D 106169835 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 106159143 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 106177191 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 106170217 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 106180511 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 106165611 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 106173655 ribonuclease H2 subunit A-like K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 106177477 ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 106172728 ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 112042378 ribonuclease H2 subunit B-like K10744 RNASEH2B; ribonuclease H2 subunit B
D 106164216 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 106164074 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 106173736 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 106150783 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 106170223 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 106159685 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 106161808 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 106173594 DNA annealing helicase and endonuclease ZRANB3-like isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 106176891 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 106174397 ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 106166632 DNA (cytosine-5)-methyltransferase PliMCI K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 106171650 geminin-like K10749 GMNN; geminin
D 106181597 G2/mitotic-specific cyclin-B-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 106167570 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 106167119 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 106152763 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
D 106161157 cyclin-dependent kinase 1 isoform X1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 106158238 protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 106161917 protection of telomeres protein 1-like K11109 POT1; protection of telomeres protein 1
E 106180648 telomeric repeat-binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 106165832 telomeric repeat-binding factor 2-interacting protein 1 isoform X1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 106180327 telomeric repeat-binding factor 2-interacting protein 1-like K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
D TERB1-TERB2-MAJIN complex
E 106171461 uncharacterized protein LOC106171461 isoform X1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 106151954 uncharacterized protein LOC106151954 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
D CST complex (animals)
E 106164747 CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 106176218 CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 106181157 CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 106153649 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 106158056 protein SMG5 K11125 SMG5; protein SMG5
D 106151756 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 106171286 telomerase protein component 1 isoform X1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 106176877 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 106171329 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 106179172 H/ACA ribonucleoprotein complex subunit 4 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 106151756 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 106150886 small nuclear ribonucleoprotein-associated protein B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 106152682 small nuclear ribonucleoprotein-associated protein B'-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 106170959 small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 106164370 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 106176784 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 106153202 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 106162546 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 106162565 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 106175496 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 106168885 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 106159143 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 106177191 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 106170217 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 106180511 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 106156071 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 106168900 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 106179244 nibrin K10867 NBN; nibrin
C Other termination factors
D 106167267 serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 106151755 Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 106179093 Bloom syndrome protein homolog K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 106174393 DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 106169576 DNA-dependent protein kinase catalytic subunit-like K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 106169308 DNA repair endonuclease XPF-like K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 106165632 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 106174408 poly [ADP-ribose] polymerase 1-like K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 106162781 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 106154131 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106150907 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 3-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106166644 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106168254 poly [ADP-ribose] polymerase 2-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106165688 poly [ADP-ribose] polymerase 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 106159753 tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 106169027 PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 112041843 regulator of telomere elongation helicase 1-like K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 106182081 regulator of telomere elongation helicase 1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 106154094 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 106167985 telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 106158530 telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 106152069 telomere-associated protein RIF1-like K11138 RIF1; telomere-associated protein RIF1
D 106179667 telomere-associated protein RIF1-like K11138 RIF1; telomere-associated protein RIF1
D 106167512 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 106158543 transcriptional activator protein Pur-beta isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 106181347 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 106151005 replication stress response regulator SDE2-like K25059 SDE2; replication stress response regulator SDE2
D 106160785 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 106153151 DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 106174550 LOW QUALITY PROTEIN: DNA topoisomerase 2-alpha-like K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 106176570 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 106178006 DNA topoisomerase 3-alpha-like K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 106165611 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 106165611 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 106150783 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 106170223 DNA replication ATP-dependent helicase/nuclease DNA2-like K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 106159685 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 106176891 DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022