+E	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Messenger RNA Biogenesis - Loa loa (eye worm)</h2>
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A<b>Eukaryotic type</b>
B  mRNA processing factors
C    5' end processing
D      Capping factors
E        LOAG_11740 hypothetical protein	K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56] 
E        LOAG_00613 CMGC/CDK/CDK7 protein kinase	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        LOAG_08398 hypothetical protein	K14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57] 
E        LOAG_09900 hypothetical protein	K14590 CMTR2; cap2 methyltransferase [EC:2.1.1.296] 
E        LOAG_01534 hypothetical protein	K18708 FAM103A1; RNMT-activating mini protein 
D      Cap binding complex
E        LOAG_06484 hypothetical protein	K12882 NCBP1; nuclear cap-binding protein subunit 1 
E        LOAG_16677 MIF4G domain-containing protein	K12882 NCBP1; nuclear cap-binding protein subunit 1 
E        LOAG_03270 nuclear cap binding protein subunit 2	K12883 NCBP2; nuclear cap-binding protein subunit 2 
C    3' end processing
D      Pre-mRNA cleavage factor Im (CFIm)
E        LOAG_04228 cleavage and polyadenylation specificity factor subunit 5	K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5 
E        LOAG_04064 pre-mRNA cleavage factor	K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5 
E        LOAG_05751 hypothetical protein	K14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7 
D      Pre-mRNA cleavage factor IIm (CFIIm)
E        LOAG_18127 Clp1	K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78] 
E        LOAG_06367 hypothetical protein	K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11 
D      Cleavage and polyadenylation specificity factor (CPSF) complex
E        LOAG_18015 CPSF A subunit region family protein	K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1 
E        LOAG_08645 cleavage and polyadenylation specificity factor subunit 2	K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2 
E        LOAG_16428 cleavage and polyadenylation specific factor 3	K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] 
E        LOAG_16507 hypothetical protein	K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4 
E        LOAG_16730 pre-mRNA 3'-end-processing factor FIP1	K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1 
E        LOAG_01769 hypothetical protein	K15542 PFS2; polyadenylation factor subunit 2 
E        LOAG_17168 WD repeat protein 82	K14962 WDR82; COMPASS component SWD2 
E        LOAG_06374 serine/threonine-protein phosphatase PP1-alpha	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_04097 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_04919 serine/threonine protein phosphatase PP1 isozyme 1	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_03806 serine/threonine protein phosphatase PP1-alpha catalytic subunit	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_05000 serine/threonine protein phosphatase PP1-alpha catalytic subunit	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_01623 serine/threonine protein phosphatase PP1-gamma catalytic subunit	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_09990 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_04539 serine/threonine protein phosphatase PP1 isozyme 1	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_12700 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_12712 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_11717 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_15242 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_08884 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_16971 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_00253 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_18581 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_17002 serine/threonine-protein phosphatase	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_16619 hypothetical protein	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_17380 serine/threonine-protein phosphatase PP1-beta	K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] 
E        LOAG_08298 hypothetical protein	K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16] 
D      Cleavage stimulation factor (CSTF) complex
E        LOAG_03033 cleavage stimulation factor	K14406 CSTF1; cleavage stimulation factor subunit 1 
E        LOAG_12614 cleavage stimulation factor	K14407 CSTF2; cleavage stimulation factor subunit 2 
E        LOAG_05677 hypothetical protein	K14408 CSTF3; cleavage stimulation factor subunit 3 
E        LOAG_00841 symplekin	K06100 SYMPK; symplekin 
D      U7-dependent histone pre-mRNA processing factors
E        LOAG_01578 hypothetical protein	K11086 SNRPB; small nuclear ribonucleoprotein B and B' 
E        LOAG_05334 small nuclear ribonucleoprotein Sm D3	K11088 SNRPD3; small nuclear ribonucleoprotein D3 
E        LOAG_06135 small nuclear ribonucleoprotein E	K11097 SNRPE; small nuclear ribonucleoprotein E 
E        LOAG_07730 small nuclear ribonucleoprotein F	K11098 SNRPF; small nuclear ribonucleoprotein F 
E        LOAG_05564 small nuclear ribonucleoprotein G	K11099 SNRPG; small nuclear ribonucleoprotein G 
E        LOAG_02501 Sm protein	K25591 LSM10; U7 snRNA-associated Sm-like protein LSm10 
E        LOAG_11947 Sm protein	K25592 LSM11; U7 snRNA-associated Sm-like protein LSm11 
E        LOAG_08645 cleavage and polyadenylation specificity factor subunit 2	K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2 
E        LOAG_16428 cleavage and polyadenylation specific factor 3	K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-] 
E        LOAG_12614 cleavage stimulation factor	K14407 CSTF2; cleavage stimulation factor subunit 2 
E        LOAG_00841 symplekin	K06100 SYMPK; symplekin 
E        LOAG_10843 hypothetical protein	K18710 SLBP; histone RNA hairpin-binding protein 
D      DRB sensitivity inducing factor (DSIF) complex
E        LOAG_04253 transcription elongation factor SPT4	K15171 SUPT4H1; transcription elongation factor SPT4 
E        LOAG_17357 micro-fibrillar-associated protein 1 containing protein	K15172 SUPT5H; transcription elongation factor SPT5 
D      N6-methyltransferase complex
E        LOAG_03516 MT-A70 family protein	K24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72] 
E        LOAG_01952 hypothetical protein	K11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346] 
E        LOAG_05030 hypothetical protein	K22824 WTAP; pre-mRNA-splicing regulator WTAP 
E        LOAG_17591 hypothetical protein	K22910 VIRMA; protein virilizer 
E        LOAG_02347 hypothetical protein	K13190 RBM15; RNA-binding protein 15 
D      Poly(A) addition factors
E        LOAG_00977 hypothetical protein	K14376 PAP; poly(A) polymerase [EC:2.7.7.19] 
E        LOAG_02448 PAP/25A associated domain-containing protein	K14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19] 
E        LOAG_16408 hypothetical protein	K14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19] 
D      Negative regulators of mRNA 3' end processing
E        LOAG_02741 hypothetical protein	K10683 BARD1; BRCA1-associated RING domain protein 1 
E        LOAG_02616 cutaneous T-cell lymphoma tumor antigen se70-2	K13192 RBM26; RNA-binding protein 26 
E        LOAG_01833 TAR-binding protein	K23600 TARDBP; TAR DNA-binding protein 43 
E        LOAG_05785 RNA recognition domain-containing protein domain-containing protein	K23600 TARDBP; TAR DNA-binding protein 43 
E        LOAG_16935 hypothetical protein	K23600 TARDBP; TAR DNA-binding protein 43 
C    Other processing factors
D      LOAG_08415 KIN protein	K13102 KIN; DNA/RNA-binding protein KIN17 
D      LOAG_04766 hypothetical protein	K23038 ZC3H14; zinc finger CCCH domain-containing protein 14 
D      LOAG_04252 hypothetical protein	K27103 SRRT; serrate RNA effector molecule 
B  mRNA surveillance and transport factors
C    Transport factors
D      EJC complex
E        LOAG_16958 hypothetical protein	K12876 RBM8A; RNA-binding protein 8A 
E        LOAG_08619 mago nashi protein	K12877 MAGOH; protein mago nashi 
E        LOAG_06665 RNA binding protein	K12881 THOC4; THO complex subunit 4 
E        LOAG_03885 RNA and export factor binding protein 2	K12881 THOC4; THO complex subunit 4 
E        LOAG_18422 spliceosome RNA helicase BAT1	K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7] 
E        LOAG_07474 eukaryotic initiation factor 4A-III	K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] 
E        LOAG_08899 hypothetical protein	K14323 CASC3; protein CASC3 
E        LOAG_05794 hypothetical protein	K14324 SAP18; histone deacetylase complex subunit SAP18 
E        LOAG_05613 hypothetical protein	K13114 PNN; pinin 
E        LOAG_02896 hypothetical protein	K12875 ACIN1; apoptotic chromatin condensation inducer in the nucleus 
E        LOAG_17528 hypothetical protein	K14325 RNPS1; RNA-binding protein with serine-rich domain 1 
E        LOAG_00129 PWI domain-containing protein	K13171 SRRM1; serine/arginine repetitive matrix protein 1 
D      TREX complex
E        LOAG_00915 hypothetical protein	K12878 THOC1; THO complex subunit 1 
E        LOAG_17756 tho complex subunit protein 2	K12879 THOC2; THO complex subunit 2 
E        LOAG_06034 hypothetical protein	K12880 THOC3; THO complex subunit 3 
E        LOAG_06665 RNA binding protein	K12881 THOC4; THO complex subunit 4 
E        LOAG_03885 RNA and export factor binding protein 2	K12881 THOC4; THO complex subunit 4 
E        LOAG_16461 fms interacting protein	K13174 THOC5; THO complex subunit 5 
E        LOAG_12846 hypothetical protein	K13175 THOC6; THO complex subunit 6 
E        LOAG_10082 hypothetical protein	K13176 THOC7; THO complex subunit 7 
D      TREX-2 complex
E        LOAG_03216 hypothetical protein	K23801 PCID2; nuclear mRNA export protein PCID2/THP1 
E        LOAG_06045 hypothetical protein	K10881 SHFM1; 26 proteasome complex subunit DSS1 
E        LOAG_10406 hypothetical protein	K11368 ENY2; enhancer of yellow 2 transcription factor 
E        LOAG_06026 hypothetical protein	K24317 MCM3AP; germinal-center associated nuclear protein [EC:2.3.1.48] 
D      Nuclear pore complex
E        LOAG_18641 viral A-type inclusion protein repeat containing protein	K09291 TPR; nucleoprotein TPR 
E        LOAG_06150 nucleoporin-17	K14298 RAE1; mRNA export factor 
E        LOAG_17130 WD-40 repeat protein, variant	K14004 SEC13; protein transport protein SEC13 
E        LOAG_13383 hypothetical protein	K14304 NUP85; nuclear pore complex protein Nup85 
E        LOAG_01143 hypothetical protein	K14305 NUP43; nuclear pore complex protein Nup43 
E        LOAG_04583 hypothetical protein	K14295 NUP50; nuclear pore complex protein Nup50 
E        LOAG_04523 hypothetical protein	K14308 NUP54; nuclear pore complex protein Nup54 
E        LOAG_18160 nuclear pore protein	K14306 NUP62; nuclear pore complex protein Nup62 
E        LOAG_17733 hypothetical protein	K14318 NUP88; nuclear pore complex protein Nup88 
E        LOAG_18149 nucleoporin interacting component family protein	K14309 NUP93; nuclear pore complex protein Nup93 
E        LOAG_04654 hypothetical protein	K14297 NUP98; nuclear pore complex protein Nup98-Nup96 
E        LOAG_02422 hypothetical protein	K14301 NUP107; nuclear pore complex protein Nup107 
E        LOAG_02039 hypothetical protein	K14300 NUP133; nuclear pore complex protein Nup133 
E        LOAG_04071 hypothetical protein	K14296 NUP153; nuclear pore complex protein Nup153 
E        LOAG_00466 hypothetical protein	K14312 NUP155; nuclear pore complex protein Nup155 
E        LOAG_06232 hypothetical protein	K14303 NUP160; nuclear pore complex protein Nup160 
E        LOAG_10395 hypothetical protein	K14313 NUP35; nuclear pore complex protein Nup53 
E        LOAG_16991 hypothetical protein	K14310 NUP205; nuclear pore complex protein Nup205 
E        LOAG_16990 hypothetical protein	K14310 NUP205; nuclear pore complex protein Nup205 
E        LOAG_17647 nuclear pore complex protein 12	K14314 NUP210; nuclear pore complex protein Nup210 
E        LOAG_00114 hypothetical protein	K14317 NUP214; nuclear pore complex protein Nup214 
E        LOAG_05514 hypothetical protein	K14307 NUPL1; nucleoporin p58/p45 
E        LOAG_05335 hypothetical protein	K14315 NDC1; nucleoporin NDC1 
E        LOAG_03475 hypothetical protein	K14299 SEH1; nucleoporin SEH1 
E        LOAG_08284 hypothetical protein	K14320 AAAS; aladin 
E        LOAG_09100 hypothetical protein	K14284 NXF; nuclear RNA export factor 
E        LOAG_04847 hypothetical protein, variant 2	K14285 NXT1_2; NTF2-related export protein 1/2 
D      Ran-mediated transport factors
E        LOAG_08002 GTP-binding nuclear protein RAN/TC4	K07936 RAN; GTP-binding nuclear protein Ran 
E        LOAG_02507 leucine Rich Repeat family protein	K18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A/C/D 
E        LOAG_11702 RNA-binding protein	K13208 ELAVL2_3_4; ELAV like protein 2/3/4 
E        LOAG_12054 UBX domain-containing protein	K18726 FAF2; FAS-associated factor 2 
E        LOAG_16940 transitional endoplasmic reticulum ATPase 1	K13525 VCP; transitional endoplasmic reticulum ATPase 
E        LOAG_03828 hypothetical protein	K21806 VCPKMT; protein N-lysine methyltransferase METTL21D [EC:2.1.1.-] 
E        LOAG_18230 importin-beta domain-containing protein	K14290 XPO1; exportin-1 
E        LOAG_17636 exportin-7	K18460 XPO7; exportin-7 
E        LOAG_18036 leucine Rich Repeat family protein	K14319 RANGAP1; Ran GTPase-activating protein 1 
E        LOAG_17724 Zn-finger in Ran binding protein	K14651 TAF15; transcription initiation factor TFIID subunit 15 
D      eIF4F and regulatory proteins
E        LOAG_06877 eukaryotic translation initiation factor 4E-1	K03259 EIF4E; translation initiation factor 4E 
E        LOAG_04336 eukaryotic translation initiation factor 4E type 3	K03259 EIF4E; translation initiation factor 4E 
E        LOAG_00067 translation initiation factor 4E	K03259 EIF4E; translation initiation factor 4E 
E        LOAG_02152 eukaryotic initiation factor 4A	K03257 EIF4A; translation initiation factor 4A 
E        LOAG_17098 eIF4G	K03260 EIF4G; translation initiation factor 4G 
E        LOAG_05351 RNA binding protein	K03258 EIF4B; translation initiation factor 4B 
E        LOAG_05917 hypothetical protein	K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter 
E        LOAG_16439 endonuclease/Exonuclease/phosphatase	K18729 ANGEL; protein angel 
E        LOAG_17045 fragile X mental retardation 1	K15516 FMR; fragile X mental retardation protein 
E        LOAG_03824 hypothetical protein	K05749 CYFIP; cytoplasmic FMR1 interacting protein 
E        LOAG_07772 cytoplasmic polyadenylation element binding protein 3	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_00997 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_16936 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_17395 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_09017 hypothetical protein	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        LOAG_04577 ATP-dependent RNA helicase An3	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        LOAG_18828 GYF domain-containing protein	K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein 
E        LOAG_01058 hypothetical protein	K13126 PABPC; polyadenylate-binding protein 
E        LOAG_17969 hypothetical protein	K14322 PAIP1; polyadenylate-binding protein-interacting protein 1 
E        LOAG_18173 hypothetical protein	K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6] 
E        LOAG_17129 hypothetical protein	K07575 MCTS; malignant T-cell-amplified sequence 
E        LOAG_18572 hypothetical protein	K24272 DENR; density-regulated protein 
D      APOBEC1-ACF complex
D      Other transport factors
E        LOAG_15159 within the bgcn intron protein	K14294 WIBG; partner of Y14 and mago 
E        LOAG_08119 heterogeneous ribonuclear particle protein	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        LOAG_02912 RNA recognition domain-containing protein domain-containing protein	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        LOAG_17145 hypothetical protein	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        LOAG_16471 musashi	K14411 MSI; RNA-binding protein Musashi 
E        LOAG_02431 hypothetical protein	K14416 HBS1; elongation factor 1 alpha-like protein 
E        LOAG_10235 translation factor pelota	K06965 PELO; protein pelota 
E        LOAG_03634 pabpn1-prov protein	K14396 PABPN1; polyadenylate-binding protein 2 
E        LOAG_06510 hypothetical protein	K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7] 
E        LOAG_16549 Xab2 protein	K12867 SYF1; pre-mRNA-splicing factor SYF1 
E        LOAG_06284 hypothetical protein	K18732 SARNP; SAP domain-containing ribonucleoprotein 
E        LOAG_18680 CBR-RAN-3 protein	K11493 RCC1; regulator of chromosome condensation 
E        LOAG_11047 PurA ssDNA and RNA-binding protein	K21772 PURA; transcriptional activator protein Pur-alpha 
E        LOAG_08408 GANP family protein	K23802 LENG8; SAC3 family protein LENG8/THP3 
C    Surveillance factors
D      Surveillance complex
E        LOAG_09139 eukaryotic peptide chain release factor subunit 1	K03265 ETF1; peptide chain release factor subunit 1 
E        LOAG_04858 elongation factor Tu domain-containing protein	K03267 ERF3; peptide chain release factor subunit 3 
E        LOAG_03249 nonsense mRNA reducing factor 1 NORF1	K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3] 
E        LOAG_02196 hypothetical protein	K14327 UPF2; regulator of nonsense transcripts 2 
E        LOAG_05102 hypothetical protein	K14328 UPF3; regulator of nonsense transcripts 3 
D      Protein phosphatase 2A
E        LOAG_08810 serine/threonine-protein phosphatase PP2A	K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16] 
E        LOAG_03638 serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16] 
E        LOAG_00611 phosphatase PP2A regulatory subunit	K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A 
E        LOAG_09069 serine/threonine protein phosphatase 2A	K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B 
E        LOAG_10206 hypothetical protein	K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B'' 
E        LOAG_02242 EF hand family protein	K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B'' 
E        LOAG_16650 EF hand family protein	K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B'' 
E        LOAG_03069 hypothetical protein	K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B' 
E        LOAG_07224 phosphatase 2A regulatory subunit B' delta isoform	K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B' 
D      Other surveillance factors
E        LOAG_16705 hypothetical protein	K08873 SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1] 
E        LOAG_00974 hypothetical protein	K11124 SMG6; protein SMG6 [EC:3.1.-.-] 
E        LOAG_04731 hypothetical protein	K18734 SMG8; protein SMG8 
E        LOAG_05922 hypothetical protein	K18735 SMG9; protein SMG9 
E        LOAG_18828 GYF domain-containing protein	K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein 
E        LOAG_03422 hypothetical protein	K19539 SECISBP2; selenocysteine insertion sequence-binding protein 2 
E        LOAG_08399 ATP-dependent helicase	K20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6] 
E        LOAG_04209 GTP-binding protein AGP-1	K24887 GTPBP1; GTP-binding protein 1 
C    Factors involved in mRNA localization
D      Cargo complex
E        LOAG_17082 pumilio domain-containing protein 12	K14844 PUF6; pumilio homology domain family member 6 
E        LOAG_17456 hypothetical protein	K10357 MYO5; myosin V 
E        LOAG_10536 bicaudal-D	K18739 BICD; protein bicaudal D 
E        LOAG_05240 3'-5' exonuclease	K18740 EXD1; exonuclease 3'-5' domain-containing protein 1 
D      Factors that have mRNA localization signals
E        LOAG_17053 actin-1	K05692 ACTB_G1; actin beta/gamma 1 
E        LOAG_11282 actin-2	K05692 ACTB_G1; actin beta/gamma 1 
E        LOAG_03141 hypothetical protein	K18741 NANOS1; protein nanos 1 
D      Trans-acting binding proteins
E        LOAG_16645 KH domain-containing protein	K13210 FUBP; far upstream element-binding protein 
E        LOAG_08753 elongation factor 1-alpha	K03231 EEF1A; elongation factor 1-alpha 
E        LOAG_06320 elongation factor 1-alpha	K03231 EEF1A; elongation factor 1-alpha 
E        LOAG_06167 hypothetical protein	K03233 EEF1G; elongation factor 1-gamma 
E        LOAG_16985 double-stranded RNA binding domain-containing protein family protein	K17597 STAU; double-stranded RNA-binding protein Staufen 
E        LOAG_18834 polypyrimidine tract-binding protein 1	K13218 PTBP1; polypyrimidine tract-binding protein 1 
E        LOAG_00763 RNA recognition domain-containing protein containing protein	K03102 SQD; squid 
E        LOAG_07772 cytoplasmic polyadenylation element binding protein 3	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_00997 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_16936 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_17395 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
D      Other mRNA localization factors
E        LOAG_17045 fragile X mental retardation 1	K15516 FMR; fragile X mental retardation protein 
E        LOAG_03824 hypothetical protein	K05749 CYFIP; cytoplasmic FMR1 interacting protein 
E        LOAG_18700 hypothetical protein	K21444 PCBP3_4; poly(rC)-binding protein 3/4 
E        LOAG_08235 hypothetical protein	K09276 YBX1; Y-box-binding protein 1 
E        LOAG_17966 pseudouridine synthase	K09276 YBX1; Y-box-binding protein 1 
C    mRNA cycle factors
D      Common to processing body (P body) and stress granule
E        LOAG_09226 hypothetical protein	K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-] 
E        LOAG_00451 hypothetical protein	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        LOAG_09464 hypothetical protein	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        LOAG_03191 piwi domain-containing protein	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        LOAG_17088 piwi domain-containing protein	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        LOAG_00201 piwi domain-containing protein	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        LOAG_07436 argonaute 2	K11593 ELF2C; eukaryotic translation initiation factor 2C 
E        LOAG_06877 eukaryotic translation initiation factor 4E-1	K03259 EIF4E; translation initiation factor 4E 
E        LOAG_04336 eukaryotic translation initiation factor 4E type 3	K03259 EIF4E; translation initiation factor 4E 
E        LOAG_00067 translation initiation factor 4E	K03259 EIF4E; translation initiation factor 4E 
E        LOAG_03249 nonsense mRNA reducing factor 1 NORF1	K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3] 
E        LOAG_09017 hypothetical protein	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        LOAG_04577 ATP-dependent RNA helicase An3	K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7] 
E        LOAG_02698 ATP-dependent RNA helicase cgh-1	K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] 
E        LOAG_07155 cytokinesis	K18749 LSM14; protein LSM14 
E        LOAG_08235 hypothetical protein	K09276 YBX1; Y-box-binding protein 1 
E        LOAG_17966 pseudouridine synthase	K09276 YBX1; Y-box-binding protein 1 
E        LOAG_08174 LIM domain-containing protein	K16682 AJUBA; LIM domain-containing protein 
E        LOAG_16994 importin-beta domain-containing protein	K18752 TNPO1; transportin-1 
E        LOAG_16705 hypothetical protein	K08873 SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1] 
E        LOAG_00974 hypothetical protein	K11124 SMG6; protein SMG6 [EC:3.1.-.-] 
E        LOAG_04694 hypothetical protein	K15308 TTP; tristetraprolin 
E        LOAG_06554 hypothetical protein	K18753 ZFP36L; butyrate response factor 
E        LOAG_03119 tristetraproline	K18753 ZFP36L; butyrate response factor 
E        LOAG_17084 hypothetical protein	K18753 ZFP36L; butyrate response factor 
E        LOAG_06033 cold-shock DNA-binding domain-containing protein	K18754 LIN28; protein lin-28 
E        LOAG_18001 hypothetical protein	K04533 HD; huntingtin 
E        LOAG_02957 hypothetical protein	K18756 BICC1; protein bicaudal C 
E        LOAG_17056 hypothetical protein	K18756 BICC1; protein bicaudal C 
E        LOAG_08119 heterogeneous ribonuclear particle protein	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        LOAG_02912 RNA recognition domain-containing protein domain-containing protein	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        LOAG_17145 hypothetical protein	K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3 
E        LOAG_18601 AGC/PKA protein kinase	K04345 PKA; protein kinase A [EC:2.7.11.11] 
E        LOAG_00811 hypothetical protein	K18757 LARP1; la-related protein 1 
D      P-body specific factors
E        LOAG_18465 mRNA-decapping enzyme 2	K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62] 
E        LOAG_07386 hypothetical protein	K12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-] 
E        LOAG_08792 U6 snRNA-associated Sm-family protein LSm	K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1 
E        LOAG_10075 U6 snRNA-associated Sm-like protein LSm2	K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2 
E        LOAG_17508 hypothetical protein	K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3 
E        LOAG_09541 hypothetical protein	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        LOAG_03146 hypothetical protein	K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5 
E        LOAG_05763 U6 snRNA-associated Sm-like protein LSm6	K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 
E        LOAG_01816 hypothetical protein	K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 
E        LOAG_00762 U6 snRNA-associated Sm-like protein LSm8	K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8 
E        LOAG_00420 kinesin light chain protein 2	K10407 KLC; kinesin light chain 
E        LOAG_17456 hypothetical protein	K10357 MYO5; myosin V 
E        LOAG_17301 tubulin alpha chain	K07374 TUBA; tubulin alpha 
E        LOAG_03501 tubulin alpha chain	K07374 TUBA; tubulin alpha 
E        LOAG_10553 hypothetical protein	K07374 TUBA; tubulin alpha 
E        LOAG_12328 tubulin alpha chain	K07374 TUBA; tubulin alpha 
E        LOAG_18966 tubulin alpha chain	K07374 TUBA; tubulin alpha 
E        LOAG_18993 tubulin alpha-2 chain	K07374 TUBA; tubulin alpha 
E        LOAG_02725 tubulin alpha chain	K07374 TUBA; tubulin alpha 
E        LOAG_07772 cytoplasmic polyadenylation element binding protein 3	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_00997 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_16936 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_17395 hypothetical protein	K02602 CPEB; cytoplasmic polyadenylation element-binding protein 
E        LOAG_16430 hypothetical protein	K18412 TNRC6; trinucleotide repeat-containing gene 6 protein 
E        LOAG_17788 CCR4-Not complex component	K12604 CNOT1; CCR4-NOT transcription complex subunit 1 
E        LOAG_09579 NOT2/NOT3/NOT5 family protein	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        LOAG_16933 CCR4-NOT transcription complex subunit 2	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        LOAG_18631 Not1 domain-containing protein	K12580 CNOT3; CCR4-NOT transcription complex subunit 3 
E        LOAG_18762 Cnot4-prov protein	K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27] 
E        LOAG_02052 CCR4-NOT transcription complex subunit 6 family protein	K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
E        LOAG_04270 CCR4-NOT transcription complex subunit 7	K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
E        LOAG_07994 hypothetical protein	K18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-] 
E        LOAG_00636 hypothetical protein	K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] 
E        LOAG_00323 PAB-dependent Poly(A) specific ribonuclease subunit	K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 
E        LOAG_09500 hypothetical protein	K14443 TOB; protein Tob/BTG 
E        LOAG_08799 hypothetical protein	K14443 TOB; protein Tob/BTG 
E        LOAG_05917 hypothetical protein	K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter 
E        LOAG_06065 hypothetical protein	K12617 PATL1; DNA topoisomerase 2-associated protein PAT1 
E        LOAG_02196 hypothetical protein	K14327 UPF2; regulator of nonsense transcripts 2 
E        LOAG_05102 hypothetical protein	K14328 UPF3; regulator of nonsense transcripts 3 
E        LOAG_16673 B-box zinc finger family protein	K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27] 
E        LOAG_07941 RING finger protein nhl-1	K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27] 
E        LOAG_03448 DNA-directed RNA polymerase II subunit RPB7	K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7 
D      Stress granule specific factors
E        LOAG_09365 hypothetical protein	K13201 TIA1; nucleolysin TIA-1/TIAR 
E        LOAG_07126 hypothetical protein	K13201 TIA1; nucleolysin TIA-1/TIAR 
E        LOAG_01058 hypothetical protein	K13126 PABPC; polyadenylate-binding protein 
E        LOAG_16985 double-stranded RNA binding domain-containing protein family protein	K17597 STAU; double-stranded RNA-binding protein Staufen 
E        LOAG_17045 fragile X mental retardation 1	K15516 FMR; fragile X mental retardation protein 
E        LOAG_06067 hypothetical protein	K24983 G3BP2; Ras GTPase-activating protein-binding protein 2 
E        LOAG_04420 hypothetical protein	K15026 EIF2A; translation initiation factor 2A 
E        LOAG_04419 hypothetical protein	K15026 EIF2A; translation initiation factor 2A 
E        LOAG_06233 Eif3s9 protein	K03253 EIF3B; translation initiation factor 3 subunit B 
E        LOAG_02152 eukaryotic initiation factor 4A	K03257 EIF4A; translation initiation factor 4A 
E        LOAG_07474 eukaryotic initiation factor 4A-III	K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7] 
E        LOAG_05351 RNA binding protein	K03258 EIF4B; translation initiation factor 4B 
E        LOAG_17098 eIF4G	K03260 EIF4G; translation initiation factor 4G 
E        LOAG_01357 AGC/RSK/RSK protein kinase	K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1] 
E        LOAG_04975 guanine nucleotide-binding protein subunit beta-2-like 1	K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein 
E        LOAG_09100 hypothetical protein	K14284 NXF; nuclear RNA export factor 
E        LOAG_06869 hypothetical protein	K18404 TDRD3; tudor domain-containing protein 3 
E        LOAG_17857 La domain-containing protein	K18763 LARP4; la-related protein 4 
B  mRNA degradation factors
C    5'-3' decay
D      Decapping complex
E        LOAG_07386 hypothetical protein	K12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-] 
E        LOAG_18465 mRNA-decapping enzyme 2	K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62] 
E        LOAG_02698 ATP-dependent RNA helicase cgh-1	K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7] 
E        LOAG_06065 hypothetical protein	K12617 PATL1; DNA topoisomerase 2-associated protein PAT1 
D      Lsm complex
E        LOAG_08792 U6 snRNA-associated Sm-family protein LSm	K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1 
E        LOAG_10075 U6 snRNA-associated Sm-like protein LSm2	K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2 
E        LOAG_17508 hypothetical protein	K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3 
E        LOAG_09541 hypothetical protein	K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4 
E        LOAG_03146 hypothetical protein	K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5 
E        LOAG_05763 U6 snRNA-associated Sm-like protein LSm6	K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6 
E        LOAG_01816 hypothetical protein	K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7 
E        LOAG_00762 U6 snRNA-associated Sm-like protein LSm8	K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8 
D      5' exonucleases
E        LOAG_09226 hypothetical protein	K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-] 
D      Other 5'-3' decay factors
E        LOAG_09879 hypothetical protein	K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59] 
C    3'-5' decay
D      Core exosome factors
E        LOAG_02001 hypothetical protein	K07573 CSL4; exosome complex component CSL4 
E        LOAG_00357 Rrp4-PA	K03679 RRP4; exosome complex component RRP4 
E        LOAG_17979 hypothetical protein	K03681 RRP40; exosome complex component RRP40 
E        LOAG_00358 EXOSome component family member	K11600 RRP41; exosome complex component RRP41 
E        LOAG_03684 hypothetical protein	K12590 RRP46; exosome complex component RRP46 
E        LOAG_05308 hypothetical protein	K12587 MTR3; exosome complex component MTR3 
E        LOAG_02842 3' exoribonuclease	K12589 RRP42; exosome complex component RRP42 
E        LOAG_12866 hypothetical protein	K12586 RRP43; exosome complex component RRP43 
E        LOAG_07104 hypothetical protein	K03678 RRP45; exosome complex component RRP45 
D      Exosome cofactors
E        LOAG_00677 3'-5' exonuclease	K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-] 
E        LOAG_10180 nuclear DNA-binding protein C1D	K12592 C1D; exosome complex protein LRP1 
E        LOAG_01694 hypothetical protein	K12593 MPHOSPH6; M-phase phosphoprotein 6, animal type 
E        LOAG_17243 DEAD/DEAH box helicase	K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7] 
D      TRAMP complex
E        LOAG_05671 PAP/25A associated domain-containing protein	K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19] 
E        LOAG_06429 hypothetical protein	K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6] 
D      Ski complex
E        LOAG_18173 hypothetical protein	K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6] 
E        LOAG_01377 hypothetical protein	K12602 WDR61; WD repeat-containing protein 61 
D      Ccr4-NOT complex
E        LOAG_02052 CCR4-NOT transcription complex subunit 6 family protein	K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4] 
E        LOAG_17788 CCR4-Not complex component	K12604 CNOT1; CCR4-NOT transcription complex subunit 1 
E        LOAG_09579 NOT2/NOT3/NOT5 family protein	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        LOAG_16933 CCR4-NOT transcription complex subunit 2	K12605 CNOT2; CCR4-NOT transcription complex subunit 2 
E        LOAG_18631 Not1 domain-containing protein	K12580 CNOT3; CCR4-NOT transcription complex subunit 3 
E        LOAG_18762 Cnot4-prov protein	K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27] 
E        LOAG_04270 CCR4-NOT transcription complex subunit 7	K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8 
E        LOAG_17796 cell differentiation protein RCD1	K12606 RCD1; CCR4-NOT transcription complex subunit 9 
D      Pan complex
E        LOAG_00636 hypothetical protein	K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4] 
E        LOAG_00323 PAB-dependent Poly(A) specific ribonuclease subunit	K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3 
D      Other 3'-5' decay factors
E        LOAG_09500 hypothetical protein	K14443 TOB; protein Tob/BTG 
E        LOAG_08799 hypothetical protein	K14443 TOB; protein Tob/BTG 
E        LOAG_11888 exonuclease	K18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-] 
E        LOAG_09879 hypothetical protein	K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59] 
E        LOAG_07537 endonuclease/Exonuclease/phosphatase	K19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-] 
E        LOAG_16865 hypothetical protein	K26109 NRDE2; nuclear exosome regulator NRDE2 
C    Other degradation factors
D      RNases
E        LOAG_01779 hypothetical protein	K18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-] 
E        LOAG_00620 hypothetical protein	K18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-] 
#
A<b>Prokaryotic type</b>
B  Bacterial mRNA degradation factors
C    RNA degradosome components
D      Ribonucreases
E        LOAG_02335 RNase3 domain-containing protein	K03685 rnc; ribonuclease III [EC:3.1.26.3] 
E        LOAG_01772 smfn protein	K13288 orn; oligoribonuclease [EC:3.1.-.-] 
D      Helicases
D      Other RNA degradosome components
E        LOAG_00912 enolase	K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] 
E        LOAG_14155 enolase	K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] 
E        LOAG_18896 3' exoribonuclease family	K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] 
E        LOAG_00771 6-phosphofructokinase	K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] 
E        LOAG_06199 6-phosphofructokinase	K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] 
E        LOAG_00014 6-phosphofructokinase	K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] 
C    Other RNA degradation factors
D      Chaperones
E        LOAG_16336 chaperone DnaK	K04043 dnaK; molecular chaperone DnaK 
E        LOAG_17523 chaperonin Hsp-60	K04077 groEL; chaperonin GroEL [EC:5.6.1.7] 
D      Others
D      Bacterial Small RNA Regulators
B  Archeal mRNA degradation factors
C    Exosome components
D      Core exosome
E        LOAG_00357 Rrp4-PA	K03679 RRP4; exosome complex component RRP4 
E        LOAG_02001 hypothetical protein	K07573 CSL4; exosome complex component CSL4 
D      Cofactors
E        LOAG_00358 EXOSome component family member	K11600 RRP41; exosome complex component RRP41 
E        LOAG_02842 3' exoribonuclease	K12589 RRP42; exosome complex component RRP42 
D      Others
!
#<hr>
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#Last updated: April 25, 2024