+F Repair protein KO
#
DNA Repair and Recombination Proteins - Mus musculus (house mouse)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 17314 Mgmt; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 231642 Alkbh2; alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 69113 Alkbh3; alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 77987 Ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 22256 Ung; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 218630 Ccno; cyclin O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 21665 Tdg; thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 545124 Tdg-ps; thymine DNA glycosylase, pseudogene K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 268395 Mpg; N-methylpurine-DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 71726 Smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 70603 Mutyh; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 17193 Mbd4; methyl-CpG binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 18294 Ogg1; 8-oxoguanine DNA-glycosylase 1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 72774 Neil1; nei endonuclease VIII-like 1 (E. coli) K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 382913 Neil2; nei like 2 (E. coli) K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 234258 Neil3; nei like 3 (E. coli) K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 18207 Nthl1; nth (endonuclease III)-like 1 (E.coli) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 11792 Apex1; apurinic/apyrimidinic endonuclease 1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 77622 Apex2; apurinic/apyrimidinic endonuclease 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 18971 Pold1; polymerase (DNA directed), delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 18972 Pold2; polymerase (DNA directed), delta 2, regulatory subunit K02328 POLD2; DNA polymerase delta subunit 2
F 67967 Pold3; polymerase (DNA-directed), delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
F 69745 Pold4; polymerase (DNA-directed), delta 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 18973 Pole; polymerase (DNA directed), epsilon K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 18974 Pole2; polymerase (DNA directed), epsilon 2 (p59 subunit) K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 59001 Pole3; polymerase (DNA directed), epsilon 3 (p17 subunit) K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 66979 Pole4; polymerase (DNA-directed), epsilon 4 (p12 subunit) K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 18538 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 14156 Fen1; flap structure specific endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 16881 Lig1; ligase I, DNA, ATP-dependent K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 18970 Polb; polymerase (DNA directed), beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 22594 Xrcc1; X-ray repair complementing defective repair in Chinese hamster cells 1 K10803 XRCC1; DNA-repair protein XRCC1
E 16882 Lig3; ligase III, DNA, ATP-dependent K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 104884 Tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 66408 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 72103 Aplf; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 59047 Pnkp; polynucleotide kinase 3'- phosphatase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 15289 Hmgb1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 102641752 Gm38574; predicted gene, 38574 K10802 HMGB1; high mobility group protein B1
E 385454 Gm5396; predicted pseudogene 5396 K10802 HMGB1; high mobility group protein B1
E 56626 Poll; polymerase (DNA directed), lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 11545 Parp1; poly (ADP-ribose) polymerase family, member 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 11546 Parp2; poly (ADP-ribose) polymerase family, member 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 235587 Parp3; poly (ADP-ribose) polymerase family, member 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 328417 Parp4; poly (ADP-ribose) polymerase family, member 4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 22591 Xpc; xeroderma pigmentosum, complementation group C K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 19359 Rad23b; RAD23 homolog B, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 19358 Rad23a; RAD23 homolog A, nucleotide excision repair protein K10839 RAD23; UV excision repair protein RAD23
F 26370 Cetn2; centrin 2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 56438 Rbx1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 72584 Cul4b; cullin 4B K10609 CUL4; cullin 4
F 99375 Cul4a; cullin 4A K10609 CUL4; cullin 4
F 13194 Ddb1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 107986 Ddb2; damage specific DNA binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 20020 Polr2a; polymerase (RNA) II (DNA directed) polypeptide A K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 231329 Polr2b; polymerase (RNA) II (DNA directed) polypeptide B K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 20021 Polr2c; polymerase (RNA) II (DNA directed) polypeptide C K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 69241 Polr2d; polymerase (RNA) II (DNA directed) polypeptide D K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 66420 Polr2e; polymerase (RNA) II (DNA directed) polypeptide E K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 69833 Polr2f; polymerase (RNA) II (DNA directed) polypeptide F K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 67710 Polr2g; polymerase (RNA) II (DNA directed) polypeptide G K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 245841 Polr2h; polymerase (RNA) II (DNA directed) polypeptide H K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 69920 Polr2i; polymerase (RNA) II (DNA directed) polypeptide I K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 66491 Polr2l; polymerase (RNA) II (DNA directed) polypeptide L K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 20022 Polr2j; polymerase (RNA) II (DNA directed) polypeptide J K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 17749 Polr2k; polymerase (RNA) II (DNA directed) polypeptide K K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 56438 Rbx1; ring-box 1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 72584 Cul4b; cullin 4B K10609 CUL4; cullin 4
F 99375 Cul4a; cullin 4A K10609 CUL4; cullin 4
F 13194 Ddb1; damage specific DNA binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 71991 Ercc8; excision repaiross-complementing rodent repair deficiency, complementation group 8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 319955 Ercc6; excision repair cross-complementing rodent repair deficiency, complementation group 6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 71101 Uvssa; UV stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 66126 Elof1; ELF1 homolog, elongation factor 1 K25829 ELOF1; transcription elongation factor 1
F 102640717 Gm36718; predicted gene, 36718 K25829 ELOF1; transcription elongation factor 1
F 102640601 Gm36627; predicted gene, 36627 K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 13872 Ercc3; excision repair cross-complementing rodent repair deficiency, complementation group 3 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 13871 Ercc2; excision repair cross-complementing rodent repair deficiency, complementation group 2 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 14884 Gtf2h1; general transcription factor II H, polypeptide 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 23894 Gtf2h2; general transcription factor II H, polypeptide 2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 209357 Gtf2h3; general transcription factor IIH, polypeptide 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 14885 Gtf2h4; general transcription factor II H, polypeptide 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 66467 Gtf2h5; general transcription factor IIH, polypeptide 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 12572 Cdk7; cyclin dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 66671 Ccnh; cyclin H K06634 CCNH; cyclin H
E 17420 Mnat1; menage a trois 1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 68275 Rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 19891 Rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 68240 Rpa3; replication protein A3 K10740 RPA3; replication factor A3
E 108167613 Gm6195; predicted pseudogene 6195 K10740 RPA3; replication factor A3
D Other NER factors
E 22590 Xpa; xeroderma pigmentosum, complementation group A K10847 XPA; DNA-repair protein complementing XP-A cells
E 13870 Ercc1; excision repair cross-complementing rodent repair deficiency, complementation group 1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 50505 Ercc4; excision repair cross-complementing rodent repair deficiency, complementation group 4 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 22592 Ercc5; excision repair cross-complementing rodent repair deficiency, complementation group 5 K10846 ERCC5; DNA excision repair protein ERCC-5
E 16881 Lig1; ligase I, DNA, ATP-dependent K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 72199 Mms19; MMS19 cytosolic iron-sulfur assembly component K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 26554 Cul3; cullin 3 K03869 CUL3; cullin 3
E 75717 Cul5; cullin 5 K10612 CUL5; cullin 5
E 67923 Eloc; elongin C K03872 ELOC; elongin-C
E 102631956 Gm30155; predicted gene, 30155 K03872 ELOC; elongin-C
E 102637110 Gm34005; predicted gene, 34005 K03872 ELOC; elongin-C
E 67673 Elob; elongin B K03873 ELOB; elongin-B
E 27224 Eloa; elongin A K15076 ELOA; elongin-A
E 74383 Ubap2l; ubiquitin-associated protein 2-like K26545 UBAP2; ubiquitin-associated protein 2
E 68926 Ubap2; ubiquitin-associated protein 2 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 17685 Msh2; mutS homolog 2 K08735 MSH2; DNA mismatch repair protein MSH2
E 17686 Msh3; mutS homolog 3 K08736 MSH3; DNA mismatch repair protein MSH3
E 17688 Msh6; mutS homolog 6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 227099 Pms1; PMS1 homolog 1, mismatch repair system component K10864 PMS1; DNA mismatch repair protein PMS1
E 17350 Mlh1; mutL homolog 1 K08734 MLH1; DNA mismatch repair protein MLH1
E 18861 Pms2; PMS1 homolog2, mismatch repair system component K10858 PMS2; DNA mismatch repair protein PMS2
E 217716 Mlh3; mutL homolog 3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 18971 Pold1; polymerase (DNA directed), delta 1, catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 18972 Pold2; polymerase (DNA directed), delta 2, regulatory subunit K02328 POLD2; DNA polymerase delta subunit 2
E 67967 Pold3; polymerase (DNA-directed), delta 3, accessory subunit K03504 POLD3; DNA polymerase delta subunit 3
E 69745 Pold4; polymerase (DNA-directed), delta 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 68275 Rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 19891 Rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 68240 Rpa3; replication protein A3 K10740 RPA3; replication factor A3
E 108167613 Gm6195; predicted pseudogene 6195 K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 19687 Rfc1; replication factor C (activator 1) 1 K10754 RFC1; replication factor C subunit 1
E 106344 Rfc4; replication factor C (activator 1) 4 K10755 RFC2_4; replication factor C subunit 2/4
E 19718 Rfc2; replication factor C (activator 1) 2 K10755 RFC2_4; replication factor C subunit 2/4
E 72151 Rfc5; replication factor C (activator 1) 5 K10756 RFC3_5; replication factor C subunit 3/5
E 69263 Rfc3; replication factor C (activator 1) 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 18538 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 26909 Exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 15289 Hmgb1; high mobility group box 1 K10802 HMGB1; high mobility group protein B1
E 102641752 Gm38574; predicted gene, 38574 K10802 HMGB1; high mobility group protein B1
E 385454 Gm5396; predicted pseudogene 5396 K10802 HMGB1; high mobility group protein B1
E 16881 Lig1; ligase I, DNA, ATP-dependent K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 241627 Wdr76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 17535 Mre11a; MRE11A homolog A, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 19360 Rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 27354 Nbn; nibrin K10867 NBN; nibrin
D BRCA1-core complex
E 12189 Brca1; breast cancer 1, early onset K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 12021 Bard1; BRCA1 associated RING domain 1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 12189 Brca1; breast cancer 1, early onset K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 70681 Abraxas1; BRCA1 A complex subunit K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 20184 Uimc1; ubiquitin interaction motif containing 1 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 68251 Babam1; BRISC and BRCA1 A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 107976 Babam2; BRISC and BRCA1 A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 210766 Brcc3; BRCA1/BRCA2-containing complex, subunit 3 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
E 368203 Brcc3dc; BRCA1/BRCA2-containing complex, subunit 3, domain containing K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 12189 Brca1; breast cancer 1, early onset K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 237911 Brip1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 235559 Topbp1; topoisomerase (DNA) II binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 12189 Brca1; breast cancer 1, early onset K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 225182 Rbbp8; retinoblastoma binding protein 8, endonuclease K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 17535 Mre11a; MRE11A homolog A, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 19360 Rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 27354 Nbn; nibrin K10867 NBN; nibrin
D BRCA complex
E 12189 Brca1; breast cancer 1, early onset K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 12190 Brca2; breast cancer 2, early onset K08775 BRCA2; breast cancer 2 susceptibility protein
E 233826 Palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 19361 Rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 19361 Rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 19363 Rad51b; RAD51 paralog B K10869 RAD51L1; RAD51-like protein 1
E 114714 Rad51c; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 19364 Rad51d; RAD51 paralog D K10871 RAD51L3; RAD51-like protein 3
E 57434 Xrcc2; X-ray repair complementing defective repair in Chinese hamster cells 2 K10879 XRCC2; DNA-repair protein XRCC2
E 74335 Xrcc3; X-ray repair complementing defective repair in Chinese hamster cells 3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 19365 Rad52; RAD52 homolog, DNA repair protein K10873 RAD52; DNA repair and recombination protein RAD52
E 66599 Rdm1; RAD52 motif 1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 19366 Rad54l; RAD54 like (S. cerevisiae) K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 81000 Rad54l2; RAD54 like 2 (S. cerevisiae) K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 623474 Rad54b; RAD54 homolog B (S. cerevisiae) K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 19691 Recql; RecQ protein-like K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 22427 Wrn; Werner syndrome RecQ like helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 12144 Blm; Bloom syndrome, RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 79456 Recql4; RecQ protein-like 4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 170472 Recql5; RecQ protein-like 5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 12144 Blm; Bloom syndrome, RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 21976 Top3b; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 21975 Top3a; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 74386 Rmi1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 223970 Rmi2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 68275 Rpa1; replication protein A1 K07466 RFA1; replication factor A1
E 19891 Rpa2; replication protein A2 K10739 RFA2; replication factor A2
E 68240 Rpa3; replication protein A3 K10740 RPA3; replication factor A3
E 108167613 Gm6195; predicted pseudogene 6195 K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 56420 Ppp4c; protein phosphatase 4, catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 70351 Ppp4r1; protein phosphatase 4, regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 232314 Ppp4r2; protein phosphatase 4, regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 104570 Ppp4r3b; protein phosphatase 4 regulatory subunit 3B K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 245509 Ppp4r3c2; protein phosphatase 4 regulatory subunit 3C2 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 245511 Ppp4r3c1; protein phosphatase 4 regulatory subunit 3C1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 68734 Ppp4r3a; protein phosphatase 4 regulatory subunit 3A K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 74521 Ppp4r4; protein phosphatase 4, regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 381201 Ap5b1; adaptor-related protein complex 5, beta 1 subunit K19022 AP5B1; AP-5 complex subunit beta-1
E 74385 Ap5m1; adaptor-related protein complex 5, mu 1 subunit K19023 AP5M1; AP-5 complex subunit mu-1
E 69596 Ap5s1; adaptor-related protein 5 complex, sigma 1 subunit K19024 AP5S1; AP-5 complex subunit sigma-1
E 231855 Ap5z1; adaptor-related protein complex 5, zeta 1 subunit K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 226026 Smc5; structural maintenance of chromosomes 5 K22803 SMC5; structural maintenance of chromosomes protein 5
E 67241 Smc6; structural maintenance of chromosomes 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 105005 Lratd1; LRAT domain containing 1 K22805 FAM84A; protein FAM84A
E 67711 Nsmce1; NSE1 homolog, SMC5-SMC6 complex component K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 68501 Nsmce2; NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 66647 Nsmce3; NSE3 homolog, SMC5-SMC6 complex component K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 75555 Nscme3l; NSE3 homolog, SMC5-SMC6 complex component like K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 67872 Nsmce4a; NSE4 homolog A, SMC5-SMC6 complex component K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 66341 Eid3; EP300 interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 105377 Slf1; SMC5-SMC6 complex localization factor 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 226151 Slf2; SMC5-SMC6 complex localization factor 2 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 268465 Eme1; essential meiotic structure-specific endonuclease 1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 193838 Eme2; essential meiotic structure-specific endonuclease subunit 2 K10883 EME2; crossover junction endonuclease EME2
E 97827 Exd2; exonuclease 3'-5' domain containing 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 71711 Mus81; MUS81 structure-specific endonuclease subunit K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 20422 Sem1; SEM1, 26S proteasome complex subunit K10881 SHFM1; 26 proteasome complex subunit DSS1
E 72931 Swi5; SWI5 recombination repair homolog (yeast) K10991 SWI5; DNA repair protein Swi5/Sae3
E 67788 Sfr1; SWI5 dependent recombination repair 1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 75764 Slx1b; SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 52864 Slx4; SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 209334 Gen1; GEN1, Holliday junction 5' flap endonuclease K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 214585 Spg11; SPG11, spatacsin vesicle trafficking associated K19026 SPG11; spatacsin
E 211978 Zfyve26; zinc finger, FYVE domain containing 26 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 19362 Rad51ap1; RAD51 associated protein 1 K20778 RAD51AP1; RAD51-associated protein 1
E 627352 Morf4l1b; mortality factor 4 like 1B K11339 MORF4L1; mortality factor 4-like protein 1
E 21761 Morf4l1; mortality factor 4 like 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 56045 Samhd1; SAM domain and HD domain, 1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 60530 Fignl1; fidgetin-like 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 224008 Spidr; scaffolding protein involved in DNA repair K22806 SPIDR; DNA repair-scaffolding protein
E 399603 Lratd2; LRAT domain containing 1 K22810 FAM84B; protein FAM84B
E 231841 Brat1; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 67884 Cfap410; cilia and flagella associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 15193 Hdgfl2; HDGF like 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 69747 Zswim7; zinc finger SWIM-type containing 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 66962 Swsap1; SWIM type zinc finger 7 associated protein 1 K25771 SWSAP1; ATPase SWSAP1
E 233545 Emsy; EMSY, BRCA2-interacting transcriptional repressor K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 74377 Hsf2bp; heat shock transcription factor 2 binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 212377 Mms22l; MMS22-like, DNA repair protein K26125 MMS22L; protein MMS22-like
E 72749 Tonsl; tonsoku-like, DNA repair protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 665775 Bod1l; biorientation of chromosomes in cell division 1-like K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 75317 Parpbp; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 14375 Xrcc6; X-ray repair complementing defective repair in Chinese hamster cells 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 22596 Xrcc5; X-ray repair complementing defective repair in Chinese hamster cells 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 19090 Prkdc; protein kinase, DNA activated, catalytic polypeptide K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 17535 Mre11a; MRE11A homolog A, double strand break repair nuclease K10865 MRE11; double-strand break repair protein MRE11
E 19360 Rad50; RAD50 double strand break repair protein K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 319583 Lig4; ligase IV, DNA, ATP-dependent K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 108138 Xrcc4; X-ray repair complementing defective repair in Chinese hamster cells 4 K10886 XRCC4; DNA-repair protein XRCC4
E 75570 Nhej1; non-homologous end joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 56626 Poll; polymerase (DNA directed), lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 54125 Polm; polymerase (DNA directed), mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 21673 Dntt; deoxynucleotidyltransferase, terminal K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 18970 Polb; polymerase (DNA directed), beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 66408 Aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 72103 Aplf; aprataxin and PNKP like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 227525 Dclre1c; DNA cross-link repair 1C K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 56196 Tdp2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 74355 Smchd1; SMC hinge domain containing 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 245631 Pwwp3b; PWWP domain containing 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 434797 Pwwp4c; PWWP domain containing 4C K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 546325 Pwwp4d; PWWP domain containing 4D K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 574404 Pwwp4a; PWWP domain containing 4A K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 574405 Pwwp4b; PWWP domain containing 4B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 68114 Pwwp3a; PWWP domain containing 3A, DNA repair factor K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 227622 Paxx; non-homologous end joining factor K25772 PAXX; protein PAXX
E 78412 Cyren; cell cycle regulator of NHEJ K26155 CYREN; cell cycle regulator of non-homologous end joining
E 72106 Jmjd8; jumonji domain containing 8 K25792 JMJD8; jumonji domain-containing protein 8
E 73747 Shld1; shieldin complex subunit 1 K26128 SHLD1; shieldin complex subunit 1
E 75698 Shld2; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
E 113002583 Shld3; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 14087 Fanca; Fanconi anemia, complementation group A K10888 FANCA; fanconi anemia group A protein
E 237211 Fancb; Fanconi anemia, complementation group B K10889 FANCB; fanconi anemia group B protein
E 14088 Fancc; Fanconi anemia, complementation group C K10890 FANCC; fanconi anemia group C protein
E 72775 Fance; Fanconi anemia, complementation group E K10892 FANCE; fanconi anemia group E protein
E 100040608 Fancf; Fanconi anemia, complementation group F K10893 FANCF; fanconi anemia group F protein
E 60534 Fancg; Fanconi anemia, complementation group G K10894 FANCG; fanconi anemia group G protein
E 67030 Fancl; Fanconi anemia, complementation group L K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 104806 Fancm; Fanconi anemia, complementation group M K10896 FANCM; fanconi anemia group M protein
E 101831 Faap24; Fanconi anemia core complex associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 71885 Faap100; Fanconi anemia core complex associated protein 100 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 15205 Hes1; hes family bHLH transcription factor 1 K06054 HES1; hairy and enhancer of split 1
E 69928 Cenps; centromere protein S K11511 APITD1; centromere protein S
E 20892 Cenpx; centromere protein X K15360 STRA13; centromere protein X
E 67196 Ube2t; ubiquitin-conjugating enzyme E2T K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 12144 Blm; Bloom syndrome, RecQ like helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 21976 Top3b; topoisomerase (DNA) III beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 21975 Top3a; topoisomerase (DNA) III alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 74386 Rmi1; RecQ mediated genome instability 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 223970 Rmi2; RecQ mediated genome instability 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 211651 Fancd2; Fanconi anemia, complementation group D2 K10891 FANCD2; fanconi anemia group D2 protein
E 208836 Fanci; Fanconi anemia, complementation group I K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 12189 Brca1; breast cancer 1, early onset K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 12190 Brca2; breast cancer 2, early onset K08775 BRCA2; breast cancer 2 susceptibility protein
E 237911 Brip1; BRCA1 interacting protein C-terminal helicase 1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 233826 Palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 330554 Fan1; FANCD2/FANCI-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 19361 Rad51; RAD51 recombinase K04482 RAD51; DNA repair protein RAD51
E 114714 Rad51c; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 71718 Telo2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
E 230484 Usp1; ubiquitin specific peptidase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 67561 Wdr48; WD repeat domain 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 67857 Ppp6c; protein phosphatase 6, catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 243819 Ppp6r1; protein phosphatase 6, regulatory subunit 1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 71474 Ppp6r2; protein phosphatase 6, regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 52036 Ppp6r3; protein phosphatase 6, regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 105522 Ankrd28; ankyrin repeat domain 28 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 329154 Ankrd44; ankyrin repeat domain 44 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 237615 Ankrd52; ankyrin repeat domain 52 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 58230 Rnf8; ring finger protein 8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 70238 Rnf168; ring finger protein 168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 108937 Rnf169; ring finger protein 169 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 15204 Herc2; HECT and RLD domain containing E3 ubiquitin protein ligase 2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 216853 Wrap53; WD repeat containing, antisense to Trp53 K23314 WRAP53; telomerase Cajal body protein 1
E 97031 Tprn; taperin K24164 TPRN; taperin
E 381678 Zcwpw1; zinc finger, CW type with PWWP domain 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 545085 Wdr70; WD repeat domain 70 K24752 WDR70; WD repeat-containing protein 70
E 241627 Wdr76; WD repeat domain 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 80905 Polh; polymerase (DNA directed), eta (RAD 30 related) K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 26447 Poli; polymerase (DNA directed), iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 27015 Polk; polymerase (DNA directed), kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 56210 Rev1; REV1, DNA directed polymerase K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 19714 Rev3l; REV3 like, DNA directed polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 272158 Poln; DNA polymerase N K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 22209 Ube2a; ubiquitin-conjugating enzyme E2A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 22210 Ube2b; ubiquitin-conjugating enzyme E2B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 58186 Rad18; RAD18 E3 ubiquitin protein ligase K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 20585 Hltf; helicase-like transcription factor K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 66589 Ube2v1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 70620 Ube2v2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 93765 Ube2n; ubiquitin-conjugating enzyme E2N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 100041224 Gm3213; predicted gene 3213 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 18538 Pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 75317 Parpbp; PARP1 binding protein K27412 PARPBP; PCNA-interacting partner
D 244666 Sprtn; SprT-like N-terminal domain K24051 SPRTN; SprT-like domain-contaning protein Spartan
B Check point factors
C Rad9-Hus1-Rad1 complex
D 19367 Rad9a; RAD9 checkpoint clamp component A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 231724 Rad9b; RAD9 checkpoint clamp component B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 15574 Hus1; HUS1 checkpoint clamp component K10903 HUS1; HUS1 checkpoint protein
D 210554 Hus1b; HUS1 checkpoint clamp component B K10996 HUS1B; checkpoint protein HUS1B
D 19355 Rad1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 19356 Rad17; RAD17 checkpoint clamp loader component K06662 HRAD17; cell cycle checkpoint protein
D 106344 Rfc4; replication factor C (activator 1) 4 K10755 RFC2_4; replication factor C subunit 2/4
D 19718 Rfc2; replication factor C (activator 1) 2 K10755 RFC2_4; replication factor C subunit 2/4
D 72151 Rfc5; replication factor C (activator 1) 5 K10756 RFC3_5; replication factor C subunit 3/5
D 69263 Rfc3; replication factor C (activator 1) 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 19355 Rad1; RAD1 checkpoint DNA exonuclease K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 21853 Timeless; timeless circadian clock 1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 66131 Tipin; timeless interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 269582 Clspn; claspin K25773 CLSPN; claspin
C Triple T complex
D 71718 Telo2; telomere maintenance 2 K11137 TELO2; telomere length regulation protein
D 75425 Tti1; TELO2 interacting protein 1 K20403 TTI1; TELO2-interacting protein 1
D 234138 Tti2; TELO2 interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 224727 Bag6; BCL2-associated athanogene 6 K23390 BAG6; large proline-rich protein BAG6
D 100169864 Gm44504; predicted readthrough transcript (NMD candidate), 44504 K23388 UBL4; ubiquitin-like protein 4
D 67591 Ubl4b; ubiquitin-like 4B K23388 UBL4; ubiquitin-like protein 4
D 27643 Ubl4a; ubiquitin-like 4A K23388 UBL4; ubiquitin-like protein 4
D 67604 Get4; golgi to ER traffic protein 4 K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 245000 Atr; ataxia telangiectasia and Rad3 related K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 235610 Atrip; ATR interacting protein K10905 ATRIP; ATR interacting protein
D 11920 Atm; ataxia telangiectasia mutated K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 22059 Trp53; transformation related protein 53 K04451 TP53; tumor protein p53
D 12649 Chek1; checkpoint kinase 1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 50883 Chek2; checkpoint kinase 2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 12530 Cdc25a; cell division cycle 25A K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 12531 Cdc25b; cell division cycle 25B K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 12532 Cdc25c; cell division cycle 25C K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 22631 Ywhaz; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 54401 Ywhab; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 22630 Ywhaq; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 100039786 Gm2423; predicted gene 2423 K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 22629 Ywhah; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 22628 Ywhag; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 22627 Ywhae; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide K06630 YWHAE; 14-3-3 protein epsilon
D 78286 Nav2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 22390 Wee1; WEE 1 homolog 1 (S. pombe) K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 381759 Wee2; WEE1 homolog 2 (S. pombe) K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 18626 Per1; period circadian clock 1 K21944 PER1; period circadian protein 1
D 18627 Per2; period circadian clock 2 K02633 PER2; period circadian protein 2
D 18628 Per3; period circadian clock 3 K21945 PER3; period circadian protein 3
D 240087 Mdc1; mediator of DNA damage checkpoint 1 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 102866 Pls3; plastin 3 (T-isoform) K17336 PLS3; plastin-3
D 68048 Aen; apoptosis enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 12795 Plk3; polo like kinase 3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 216166 Plk5; polo like kinase 5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 18004 Nek1; NIMA (never in mitosis gene a)-related expressed kinase 1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 330721 Nek5; NIMA (never in mitosis gene a)-related expressed kinase 5 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 23955 Nek4; NIMA (never in mitosis gene a)-related expressed kinase 4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 674895 Nek10; NIMA (never in mitosis gene a)- related kinase 10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 208583 Nek11; NIMA (never in mitosis gene a)-related expressed kinase 11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 60364 Donson; downstream neighbor of SON K22422 DONSON; protein downstream neighbor of Son
D 107351 Kank1; KN motif and ankyrin repeat domains 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 235041 Kank2; KN motif and ankyrin repeat domains 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 242553 Kank4; KN motif and ankyrin repeat domains 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 80880 Kank3; KN motif and ankyrin repeat domains 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 66371 Chmp4c; charged multivesicular body protein 4C K24782 CHMP4C; charged multivesicular body protein 4C
D 20479 Vps4b; vacuolar protein sorting 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 116733 Vps4a; vacuolar protein sorting 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 72008 Zfyve19; zinc finger, FYVE domain containing 19 K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 208768 Sde2; SDE2 telomere maintenance homolog (S. pombe) K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 77782 Polq; polymerase (DNA directed), theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 18432 Mybbp1a; MYB binding protein (P160) 1a K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 408022 Primpol; primase and polymerase (DNA-directed) K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 22040 Trex1; three prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 24102 Trex2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 55947 Dclre1a; DNA cross-link repair 1A K15340 DCLRE1A; DNA cross-link repair 1A protein
D 140917 Dclre1b; DNA cross-link repair 1B K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 73172 Exo5; exonuclease 5 K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 338371 Endov; endonuclease V K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 226409 Zranb3; zinc finger, RAN-binding domain containing 3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 234396 Ankle1; ankyrin repeat and LEM domain containing 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 191578 Helq; helicase, POLQ-like K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 76251 Ercc6l2; excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 28000 Prpf19; pre-mRNA processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 71702 Cdc5l; cell division cycle 5-like K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 668205 Cdc5lrt7; cell division cycle 5 like, retrotransposed 7 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 668216 Cdc5lrt10; cell division cycle 5 like, retrotransposed 10 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 668198 Cdc5lrt5; cell division cycle 5 like, retrotransposed 5 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 668203 Cdc5lrt6; cell division cycle 5 like, retrotransposed 6 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 668213 Cdc5lrt9; cell division cycle 5 like, retrotransposed 9 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 668209 Cdc5lrt8; cell division cycle 5 like, retrotransposed 8 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 102635357 Cdc5lrt1; cell division cycle 5 like, retrotransposed 1 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 102635473 Cdc5lrt4; cell division cycle 5 like, retrotransposed 4 K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 68183 Bcas2; BCAS2 pre-mRNA processing factor K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 53317 Plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 214254 Nudt15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 17766 Nudt1; nudix hydrolase 1 K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 213484 Nudt18; nudix hydrolase 18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 110074 Dut; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 20133 Rrm1; ribonucleotide reductase M1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 382985 Rrm2b; ribonucleotide reductase M2 B (TP53 inducible) K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 20135 Rrm2; ribonucleotide reductase M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 17314 Mgmt; O-6-methylguanine-DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 22256 Ung; uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 71726 Smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 268395 Mpg; N-methylpurine-DNA glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 70603 Mutyh; mutY DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 18207 Nthl1; nth (endonuclease III)-like 1 (E.coli) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 381760 Ssbp1; single-stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 381760 Ssbp1; single-stranded DNA binding protein 1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 214254 Nudt15; nudix hydrolase 15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 110074 Dut; deoxyuridine triphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024