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Transfer RNA Biogenesis - Methanosarcina thermophila CHTI-55
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
D MSTHC_2146 Ribonuclease P protein component 1 K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D MSTHC_0408 Ribonuclease P protein component 2 K03537 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
D MSTHC_0407 Ribonuclease P protein component 3 K03539 RPP1; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
D MSTHC_1281 Ribonuclease P protein component 4 K03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D MSTHC_0745 Ribonuclease Z K00784 rnz; ribonuclease Z [EC:3.1.26.11]
C CCA adding factors
B tRNA spricing factors
C tRNA splicing endonuclease complex
C tRNA splicing ligase complex
D MSTHC_1260 RNA-2',3'-PO4:RNA-5'-OH ligase K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D MSTHC_1259 Archease K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
D MSTHC_2298 Translation elongation factor 1 alpha subunit K03231 EEF1A; elongation factor 1-alpha
C tRNA import factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D MSTHC_1185 Glutamyl-tRNA synthetase / Glutamyl-tRNA(Gln) synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D MSTHC_0963 Prolyl-tRNA synthetase, archaeal/eukaryal type K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D MSTHC_2518 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D MSTHC_0729 Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MSTHC_1802 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D MSTHC_1435 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D MSTHC_1917 Lysyl-tRNA synthetase (class II) K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
C Other AARSs
D MSTHC_1323 Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D MSTHC_1396 Glycyl-tRNA synthetase K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]
D MSTHC_0367 Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D MSTHC_0658 Seryl-tRNA synthetase, archaeal K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D MSTHC_1911 Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D MSTHC_0756 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D MSTHC_1943 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D MSTHC_1334 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D MSTHC_2453 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D MSTHC_2000 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MSTHC_1333 Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D MSTHC_0037 D-tyrosyl-tRNA(Tyr) deacylase K09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D MSTHC_0691 Ser-tRNA(Ala) deacylase K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
C AARS associated factors
D MSTHC_1995 purine nucleoside phosphoramidase K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
C Methylthiotransferase
D MSTHC_2195 (dimethylallyl)adenosine tRNA methylthiotransferase K15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 [EC:2.8.4.5]
C Methyltransferases
D MSTHC_0097 tRNA N2,N2-dimethyl(Guanine26-N2)-methyltransferase K00555 TRMT1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D MSTHC_2487 tRNA (guanine(37)-N1)-methyltransferase Trm5a K15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D MSTHC_1157 tRNA (Guanine37-N1) -methyltransferase K15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D MSTHC_1122 S-adenosyl-L-methionine-binding protein K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D MSTHC_1437 Fe-S OXIDOREDUCTASE Wyeosine biosynthesis K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D MSTHC_0281 tRNA methylase Trm12p Wyeosine biosynthesis K07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]
C Psudouridine synthases
D MSTHC_1297 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D MSTHC_0593 tRNA pseudouridine 13 synthase K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D MSTHC_0103 tRNA pseudouridine 55 synthase Archaea K07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]
C Thiolation factors
D MSTHC_0382 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MSTHC_1992 Homocysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MSTHC_0588 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
C Elongator complex
D MSTHC_2010 histone acetyltransferase, ELP3 family K07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]
C Elongator related proteins
C Other tRNA modification factors
D MSTHC_1653 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
B tRNA degradation factors
C TRAMP complex
C Rapid tRNA decay (RTD) pathway factors
C Other tRNA degradation factors
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AProkaryotic type
B 5'processing factors
C Ribonucrease P
D MSTHC_1963 hypothetical protein K09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D MSTHC_0745 Ribonuclease Z K00784 rnz; ribonuclease Z [EC:3.1.26.11]
C CCA adding factors
D MSTHC_2243 tRNA nucleotidyltransferase, archaeal type K07558 K07558; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72]
B tRNA spricing factors
C tRNA splicing endonucleases
D MSTHC_0829 tRNA-intron endonuclease K01170 endA; tRNA-intron endonuclease, archaea type [EC:4.6.1.16]
C tRNA splicing ligases
D MSTHC_1260 RNA-2',3'-PO4:RNA-5'-OH ligase K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
D MSTHC_1054 2'-5' RNA ligase K01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]
D MSTHC_1480 RNA:NAD 2'-phosphotransferase K07559 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-]
B tRNA transport factors
C tRNA export factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D MSTHC_0729 Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MSTHC_1215 Lysyl-tRNA synthetase (class I) K04566 lysK; lysyl-tRNA synthetase, class I [EC:6.1.1.6]
D MSTHC_0963 Prolyl-tRNA synthetase, archaeal/eukaryal type K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D MSTHC_2000 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MSTHC_1333 Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D MSTHC_0367 Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D MSTHC_2518 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D MSTHC_1917 Lysyl-tRNA synthetase (class II) K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D MSTHC_1323 Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D MSTHC_0756 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D MSTHC_1802 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D MSTHC_0658 Seryl-tRNA synthetase, archaeal K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D MSTHC_1911 Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D MSTHC_1185 Glutamyl-tRNA synthetase / Glutamyl-tRNA(Gln) synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D MSTHC_1435 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D MSTHC_1334 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D MSTHC_2453 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D MSTHC_1943 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D MSTHC_2504 Aspartyl-tRNA synthetase / Aspartyl-tRNA(Asn) synthetase K09759 aspC; nondiscriminating aspartyl-tRNA synthetase [EC:6.1.1.23]
D MSTHC_1349 Pyrrolysyl-tRNA synthetase K11627 pylS; pyrrolysyl-tRNA synthetase [EC:6.1.1.26]
D MSTHC_1401 O-phosphoseryl-tRNA(Cys) synthetase K07587 sepRS; O-phosphoseryl-tRNA synthetase [EC:6.1.1.27]
D MSTHC_2472 O-phosphoseryl-tRNA:Cysteinyl-tRNA synthase K06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]
D MSTHC_1892 O-phosphoseryl-tRNA:Cysteinyl-tRNA synthase K06868 sepcysS; Sep-tRNA:Cys-tRNA synthetase [EC:2.5.1.73]
C Trans-editing factors
D MSTHC_0037 D-tyrosyl-tRNA(Tyr) deacylase K09716 dtdA; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D MSTHC_0691 Ser-tRNA(Ala) deacylase K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
D MSTHC_1440 tRNA dihydrouridine synthase B K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]
C Methylthiotransferases
C Methyltransferases
D MSTHC_0983 SAM-dependent methyltransferase K15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]
D MSTHC_1122 S-adenosyl-L-methionine-binding protein K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D MSTHC_0102 protein of unknown function DUF358 K16317 trmY; tRNA (pseudouridine54-N1)-methyltransferase [EC:2.1.1.257]
D MSTHC_1296 tRNA-(G10-N2) methyltransferase K07446 trm-G10; tRNA (guanine10-N2)-dimethyltransferase [EC:2.1.1.213]
D MSTHC_0573 tRNA cytosine methylase Pos56 K07254 atrm56; tRNA (cytidine56-2'-O)-methyltransferase [EC:2.1.1.206]
C Psudouridine synthases
D MSTHC_1297 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D MSTHC_0593 tRNA pseudouridine 13 synthase K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D MSTHC_1994 hypothetical protein K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D MSTHC_0382 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MSTHC_1992 Homocysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MSTHC_0588 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
D MSTHC_0868 YgjD/Kae1/Qri7 family, required for N6-threonylcarbamoyl adenosine t(6)A37 modification in tRNA K15904 kae1-bud32; bifunctional N6-L-threonylcarbamoyladenine synthase / protein kinase Bud32 [EC:2.3.1.234 2.7.11.1]
D MSTHC_2193 KEOPS complex Cgi121-like subunit K09119 cgi121; KEOPS complex subunit Cgi121
D MSTHC_0433 hypothetical protein K09741 pcc1; KEOPS complex subunit Pcc1
C Other tRNA modification factors
D MSTHC_0985 Queuosine Biosynthesis QueC ATPase K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D MSTHC_0988 Queuosine biosynthesis QueD, PTPS-I K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D MSTHC_0987 Queuosine Biosynthesis QueE Radical SAM K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D MSTHC_1559 archaeosine tRNA-ribosyltransferase type 1 K18779 tgtA; 7-cyano-7-deazaguanine tRNA-ribosyltransferase [EC:2.4.2.48]
D MSTHC_2365 tRNA S(4)U 4-thiouridine synthase (former ThiI) K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D MSTHC_2224 OB-fold nucleic acid binding domain protein K06932 tiaS; tRNA(Ile2)-agmatinylcytidine synthase [EC:6.3.4.22]
D MSTHC_1653 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
B tRNA degradation factors
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024