+E Replication protein KO
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DNA Replication Proteins - Oryctolagus cuniculus (rabbit)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 100348910 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 100349658 origin recognition complex subunit 2 isoform X2 K02604 ORC2; origin recognition complex subunit 2
D 100338660 origin recognition complex subunit 3 isoform X5 K02605 ORC3; origin recognition complex subunit 3
D 100358091 origin recognition complex subunit 4 isoform X3 K02606 ORC4; origin recognition complex subunit 4
D 100342116 origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 100348944 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 100357421 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 100337896 DNA replication licensing factor MCM2 isoform X1 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 100339825 DNA replication licensing factor MCM3 isoform X1 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 100349822 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 100345230 DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 100343390 DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 100343855 DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 100358389 cyclin-A1 isoform X1 K06627 CCNA; cyclin-A
D 100134866 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 100352785 cyclin-A2-like K06627 CCNA; cyclin-A
D 100134864 G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 100134867 G1/S-specific cyclin-E2 isoform X3 K06626 CCNE; G1/S-specific cyclin-E1
D 100134865 cyclin-dependent kinase 2 isoform X2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 127487420 cyclin-dependent kinase 2 isoform X1 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 100343407 cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 100339152 protein DBF4 homolog A isoform X1 K06629 DBF4; protein DBF4
D 100353300 protein DBF4 homolog B isoform X1 K06629 DBF4; protein DBF4
C GINS complex
D 100339603 DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 100338732 DNA replication complex GINS protein PSF3 isoform X1 K10734 GINS3; GINS complex subunit 3
D 100357432 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 100349197 DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 100351717 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 127482835 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 100337967 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 100340330 DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 100343921 protein MCM10 homolog isoform X2 K10736 MCM10; minichromosome maintenance protein 10
D 100338890 DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 100345567 serine protease FAM111A isoform X2 K24274 FAM111A; protein FAM111A
D 100356238 cyclin-dependent kinase 2-interacting protein isoform X1 K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 100354267 mdm2-binding protein isoform X2 K26116 MTBP; Mdm2-binding protein
D 103352503 treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 100354472 DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 100355173 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 100338944 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 100347242 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 100338950 DNA polymerase epsilon catalytic subunit A isoform X1 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 100345613 DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 100355895 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 100358589 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 100358263 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 100357626 DNA polymerase delta subunit 3 isoform X2 K03504 POLD3; DNA polymerase delta subunit 3
D 100356010 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 100347697 DNA polymerase subunit gamma-1 isoform X1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 100351035 DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 100341460 replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 100347550 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
D 100358262 replication protein A 14 kDa subunit isoform X2 K10740 RPA3; replication factor A3
D 103351965 LOW QUALITY PROTEIN: replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
C RFC (replication factor C)
D 100352565 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 100343517 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100342140 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100339186 replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 100345366 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 100345458 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 127485446 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 127488467 ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 103346676 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 100339381 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100342227 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 100352966 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 100338764 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 100350819 DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100340979 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 100350844 ATPase family AAA domain-containing protein 5 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 103345712 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100344715 DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 100349823 DNA (cytosine-5)-methyltransferase 3B isoform X2 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 100351332 geminin K10749 GMNN; geminin
D 100347062 multicilin K26119 MCIDAS; multicilin
D 100338989 G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 100357416 G2/mitotic-specific cyclin-B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 100356406 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 100352863 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 100343999 protection of telomeres protein 1-like K11109 POT1; protection of telomeres protein 1
E 100346791 protection of telomeres protein 1 isoform X2 K11109 POT1; protection of telomeres protein 1
E 100338571 LOW QUALITY PROTEIN: telomeric repeat-binding factor 1-like K11110 TERF1; telomeric repeat-binding factor 1
E 100339301 telomeric repeat-binding factor 1 isoform X1 K11110 TERF1; telomeric repeat-binding factor 1
E 100341683 telomeric repeat-binding factor 2 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 127489133 telomeric repeat-binding factor 2-like isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
E 100349690 TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 100344057 telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 100346875 adrenocortical dysplasia protein homolog isoform X1 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 100342788 telomere repeats-binding bouquet formation protein 1 isoform X6 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 100356133 telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 103346153 membrane-anchored junction protein K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 100354465 CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 100344851 STN1; CST complex subunit STN1 isoform X1 K23312 STN1; CST complex subunit STN1
E 100338195 CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
E 127489547 CST complex subunit TEN1-like K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 100355820 telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 100341361 nonsense-mediated mRNA decay factor SMG5 K11125 SMG5; protein SMG5
D 100351437 telomerase protein component 1 isoform X1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 100358023 H/ACA ribonucleoprotein complex subunit 1 isoform X2 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 100337799 H/ACA ribonucleoprotein complex subunit 2 isoform X2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100351483 H/ACA ribonucleoprotein complex subunit 2-like K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100344594 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 108178276 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 100340288 H/ACA ribonucleoprotein complex subunit DKC1 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E 100341600 small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 100355799 small nuclear ribonucleoprotein-associated protein B-like K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 100343057 small nuclear ribonucleoprotein Sm D1 isoform X1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 100349685 small nuclear ribonucleoprotein Sm D1-like K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 100347459 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 100357789 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 100352696 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 100348389 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 100352744 small nuclear ribonucleoprotein G isoform X3 K11099 SNRPG; small nuclear ribonucleoprotein G
E 100341791 small nuclear ribonucleoprotein G-like K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 100343517 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100342140 replication factor C subunit 4 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 100339186 replication factor C subunit 3 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 100345366 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 100356946 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 100328725 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 100352398 nibrin isoform X1 K10867 NBN; nibrin
C Other termination factors
D 100349299 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 100341925 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN isoform X4 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 100345123 recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 100125348 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 100350642 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 100347336 poly [ADP-ribose] polymerase 1 isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 100351185 poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100346107 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100344824 protein mono-ADP-ribosyltransferase PARP3 isoform X2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100351292 poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100340857 poly [ADP-ribose] polymerase tankyrase-2 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100347040 PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 103347365 regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 100356602 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 100351561 TRIR; telomerase RNA component interacting RNase isoform X1 K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 100342194 telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 100351596 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100345406 transcriptional activator protein Pur-alpha isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 100342855 purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 100358935 purine-rich element-binding protein gamma isoform X1 K21800 PURG; purine-rich element-binding protein gamma
D 100343593 telomerase Cajal body protein 1 isoform X2 K23314 WRAP53; telomerase Cajal body protein 1
D 100346302 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 100345377 RTF2; replication termination factor 2 isoform X1 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 100349705 DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 100351427 DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100357676 DNA topoisomerase 2-alpha isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100345272 DNA topoisomerase 3-beta-1 isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 100008866 SSBP1; single-stranded DNA-binding protein, mitochondrial precursor K03111 ssb; single-strand DNA-binding protein
D 100342744 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
D 100357130 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
D 127490310 single-stranded DNA-binding protein, mitochondrial-like K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 100345458 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 127485446 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 100345458 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 127485446 ribonuclease H1-like isoform X1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 100342227 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 100352966 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100340979 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022