+F Repair protein KO
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DNA Repair and Recombination Proteins - Physeter catodon (sperm whale)
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 102974189 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 102991764 ALKBH2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 102977330 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 102980840 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 102993141 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 102985561 CCNO; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 102989557 TDG; G/T mismatch-specific thymine DNA glycosylase isoform X2 K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 102995368 MPG; DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 102984087 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 102981566 MUTYH; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 102992016 MBD4; methyl-CpG-binding domain protein 4 isoform X1 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 102975402 OGG1; N-glycosylase/DNA lyase isoform X6 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 102975094 NEIL1; endonuclease 8-like 1 isoform X2 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 102983062 NEIL2; endonuclease 8-like 2 isoform X1 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 102988885 NEIL3; endonuclease 8-like 3 isoform X1 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 102986112 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 102982322 APEX1; DNA-(apurinic or apyrimidinic site) endonuclease K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 102982378 APEX2; DNA-(apurinic or apyrimidinic site) endonuclease 2 isoform X1 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 102982946 POLD1; DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 112061949 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
F 102975526 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 102977443 POLD3; DNA polymerase delta subunit 3 isoform X3 K03504 POLD3; DNA polymerase delta subunit 3
F 102978355 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
E DNA polymerase epsilon complex
F 102986727 POLE; DNA polymerase epsilon catalytic subunit A isoform X4 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 102975920 POLE2; DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 102976987 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 102989305 DNA polymerase epsilon subunit 4-like K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
F 102983674 POLE4; DNA polymerase epsilon subunit 4 isoform X3 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 102992318 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 102980166 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 102988491 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 102990379 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 102976221 POLB; DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 102983345 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 102996639 XRCC1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 102987285 LIG3; DNA ligase 3 isoform X2 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 102983054 TDP1; tyrosyl-DNA phosphodiesterase 1 isoform X1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 102980098 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 112064821 LOW QUALITY PROTEIN: aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 102985521 APLF; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 102990641 PNKP; bifunctional polynucleotide phosphatase/kinase isoform X4 K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 102983656 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 102975367 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 102996986 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 102981106 PARP2; poly [ADP-ribose] polymerase 2 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 102986056 PARP3; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 102979284 XPC; DNA repair protein complementing XP-C cells K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 102973242 RAD23A; UV excision repair protein RAD23 homolog A isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 102991804 RAD23B; UV excision repair protein RAD23 homolog B isoform X1 K10839 RAD23; UV excision repair protein RAD23
F 102990221 CETN2; centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 102989901 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 112064697 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 129391324 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 102974257 CUL4B; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 102976544 CUL4A; cullin-4A isoform X2 K10609 CUL4; cullin 4
F 102983594 LOW QUALITY PROTEIN: cullin-4B-like K10609 CUL4; cullin 4
F 102994780 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 102974256 DDB2; DNA damage-binding protein 2 isoform X1 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 102989947 POLR2A; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 102994341 DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 102991298 POLR2C; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 102984853 POLR2D; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 102992399 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 102985826 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 102977449 POLR2G; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 102977584 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 102994843 POLR2I; DNA-directed RNA polymerase II subunit RPB9 isoform X1 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 112065025 DNA-directed RNA polymerases I, II, and III subunit RPABC5-like K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 112066994 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 102982194 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 102990421 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
F 112065026 DNA-directed RNA polymerases I, II, and III subunit RPABC4-like K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 102989901 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 112064697 E3 ubiquitin-protein ligase RBX1-like K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 129391324 RBX1; E3 ubiquitin-protein ligase RBX1 isoform X1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 102974257 CUL4B; cullin-4B isoform X1 K10609 CUL4; cullin 4
F 102976544 CUL4A; cullin-4A isoform X2 K10609 CUL4; cullin 4
F 102983594 LOW QUALITY PROTEIN: cullin-4B-like K10609 CUL4; cullin 4
F 102994780 DDB1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 102974901 ERCC8; DNA excision repair protein ERCC-8 isoform X1 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 102996757 ERCC6; LOW QUALITY PROTEIN: DNA excision repair protein ERCC-6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 102975964 UVSSA; UV-stimulated scaffold protein A isoform X2 K23720 UVSSA; UV-stimulated scaffold protein A
F 102977993 ELOF1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 102985673 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 102996240 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X3 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 102975419 GTF2H1; general transcription factor IIH subunit 1 isoform X2 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 102986844 general transcription factor IIH subunit 2 isoform X2 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 102985970 GTF2H3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 102981001 GTF2H4; general transcription factor IIH subunit 4 isoform X1 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 102984352 GTF2H5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 102981310 CDK7; cyclin-dependent kinase 7 isoform X1 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 102991216 CCNH; cyclin-H isoform X1 K06634 CCNH; cyclin H
E 102980588 MNAT1; CDK-activating kinase assembly factor MAT1 isoform X2 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 102976284 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 102973407 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 102987455 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 102973892 RPA3; replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
E 102996166 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Other NER factors
E 102993413 XPA; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 102981160 ERCC1; DNA excision repair protein ERCC-1 isoform X1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 102984855 ERCC4; DNA repair endonuclease XPF isoform X2 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 102979297 ERCC5; DNA excision repair protein ERCC-5 isoform X1 K10846 ERCC5; DNA excision repair protein ERCC-5
E 102990379 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 102981007 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1 K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 102983252 CUL3; cullin-3 K03869 CUL3; cullin 3
E 102977916 CUL5; cullin-5 K10612 CUL5; cullin 5
E 102993527 ELOC; elongin-C isoform X1 K03872 ELOC; elongin-C
E 102976552 ELOB; elongin-B K03873 ELOB; elongin-B
E 102978607 elongin-B-like K03873 ELOB; elongin-B
E 102982649 ELOA; elongin-A isoform X2 K15076 ELOA; elongin-A
E 102985895 LOW QUALITY PROTEIN: elongin-A-like K15076 ELOA; elongin-A
E 102988429 LOW QUALITY PROTEIN: elongin-A-like K15076 ELOA; elongin-A
E 102991103 UBAP2L; ubiquitin-associated protein 2-like isoform X25 K26545 UBAP2; ubiquitin-associated protein 2
E 102992402 UBAP2; ubiquitin-associated protein 2 isoform X2 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 102987486 MSH2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 102978499 MSH3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 102994456 MSH6; DNA mismatch repair protein Msh6 isoform X1 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 102982163 PMS1; PMS1 protein homolog 1 isoform X1 K10864 PMS1; DNA mismatch repair protein PMS1
E 102987940 MLH1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 102974596 PMS2; mismatch repair endonuclease PMS2 isoform X2 K10858 PMS2; DNA mismatch repair protein PMS2
E 102980204 MLH3; DNA mismatch repair protein Mlh3 isoform X1 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 102982946 POLD1; DNA polymerase delta catalytic subunit isoform X1 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 112061949 DNA polymerase delta subunit 2-like K02328 POLD2; DNA polymerase delta subunit 2
E 102975526 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 102977443 POLD3; DNA polymerase delta subunit 3 isoform X3 K03504 POLD3; DNA polymerase delta subunit 3
E 102978355 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
D RPA (replication factor A)
E 102976284 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 102973407 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 102987455 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 102973892 RPA3; replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
E 102996166 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D RFC (replication factor C)
E 102983114 RFC1; replication factor C subunit 1 isoform X1 K10754 RFC1; replication factor C subunit 1
E 102980871 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 102987713 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 114485382 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
E 102989998 RFC3; replication factor C subunit 3 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
E 102980467 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 102992318 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 102980166 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
E 102975827 EXO1; exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 102983656 HMGB1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 102990379 LIG1; DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 102996132 WDR76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 102983647 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 102983917 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 102981964 NBN; nibrin isoform X1 K10867 NBN; nibrin
D BRCA1-core complex
E 102986597 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 102978596 BARD1; BRCA1-associated RING domain protein 1 isoform X1 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 102986597 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 102986870 ABRAXAS1; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 102981266 UIMC1; BRCA1-A complex subunit RAP80 isoform X3 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 102984501 BABAM1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 102994105 BABAM2; BRISC and BRCA1-A complex member 2 isoform X1 K12173 BRE; BRCA1-A complex subunit BRE
E 102982818 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 102986597 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 102982599 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 102975886 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 102986597 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 102973293 RBBP8; DNA endonuclease RBBP8 isoform X1 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 102982500 LOW QUALITY PROTEIN: DNA endonuclease RBBP8-like K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 102983647 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 102983917 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 102981964 NBN; nibrin isoform X1 K10867 NBN; nibrin
D BRCA complex
E 102986597 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 102995983 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 102975423 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
E 102989193 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 102978529 LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 102989193 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 102978529 LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 102976760 RAD51B; DNA repair protein RAD51 homolog 2 K10869 RAD51L1; RAD51-like protein 1
E 102991234 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 102982111 RAD51D; DNA repair protein RAD51 homolog 4 isoform X1 K10871 RAD51L3; RAD51-like protein 3
E 102985077 XRCC2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 102983632 XRCC3; DNA repair protein XRCC3 isoform X1 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 102990844 RAD52; DNA repair protein RAD52 homolog isoform X1 K10873 RAD52; DNA repair and recombination protein RAD52
E 102992462 LOW QUALITY PROTEIN: RAD52 motif-containing protein 1-like K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 102978381 RAD54L; DNA repair and recombination protein RAD54-like isoform X1 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 102987619 RAD54L2; helicase ARIP4 isoform X1 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 102980291 RAD54B; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 102987301 RECQL; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 102988164 WRN; bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 102995998 BLM; recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 102996250 RECQL4; ATP-dependent DNA helicase Q4 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 102995998 BLM; recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 102975497 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 102983748 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 102995036 RMI1; recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 112064813 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 102976284 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
E 102973407 RPA2; replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
E 102987455 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
E 102973892 RPA3; replication protein A 14 kDa subunit isoform X1 K10740 RPA3; replication factor A3
E 102996166 RPA4; replication protein A 30 kDa subunit K10741 RPA4; replication factor A4
D Protein phosphatase 4
E 102985887 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit isoform X1 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 102991749 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X2 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 102980992 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform X3 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 102992817 PPP4R3A; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 102995325 serine/threonine-protein phosphatase 4 regulatory subunit 3B-like K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 102974983 serine/threonine-protein phosphatase 4 regulatory subunit 3B isoform X3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 102996435 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 102975834 AP5B1; AP-5 complex subunit beta-1 isoform X1 K19022 AP5B1; AP-5 complex subunit beta-1
E 102979349 AP5M1; AP-5 complex subunit mu-1 isoform X1 K19023 AP5M1; AP-5 complex subunit mu-1
E 102991578 AP5Z1; AP-5 complex subunit zeta-1 isoform X3 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 102981239 SMC5; structural maintenance of chromosomes protein 5 isoform X1 K22803 SMC5; structural maintenance of chromosomes protein 5
E 102973266 SMC6; structural maintenance of chromosomes protein 6 isoform X1 K22804 SMC6; structural maintenance of chromosomes protein 6
E 102994156 LRATD1; protein LRATD1 K22805 FAM84A; protein FAM84A
E 102979559 NSMCE1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 102995809 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 102983439 NSMCE3; non-structural maintenance of chromosomes element 3 homolog K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 102989366 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 114484923 non-structural maintenance of chromosomes element 4 homolog A-like K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 102984356 EID3; EP300-interacting inhibitor of differentiation 3 K22826 EID3; EP300-interacting inhibitor of differentiation 3
E 102977143 SLF1; SMC5-SMC6 complex localization factor protein 1 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 102995319 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 102993466 EME1; crossover junction endonuclease EME1 isoform X1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 102982365 EME2; LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 102976562 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 102977256 MUS81; crossover junction endonuclease MUS81 isoform X3 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 102980508 SEM1; 26S proteasome complex subunit SEM1 isoform X2 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 102989044 SWI5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 102978388 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 102991822 swi5-dependent recombination DNA repair protein 1 homolog K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 102984384 SLX1A; structure-specific endonuclease subunit SLX1 isoform X2 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 102991859 SLX4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 102973908 GEN1; flap endonuclease GEN homolog 1 isoform X2 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 102987807 SPG11; spatacsin isoform X1 K19026 SPG11; spatacsin
E 102977403 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X10 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 112066354 RAD51AP1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 102973770 MORF4L1; mortality factor 4-like protein 1 isoform X1 K11339 MORF4L1; mortality factor 4-like protein 1
E 102974229 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X3 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 102988376 FIGNL1; fidgetin-like protein 1 isoform X2 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 102996303 DNA repair-scaffolding protein isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 114485259 uncharacterized protein LOC114485259 isoform X1 K22806 SPIDR; DNA repair-scaffolding protein
E 102978132 LRATD2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 102990911 BRAT1; BRCA1-associated ATM activator 1 isoform X1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 102976130 CFAP410; cilia- and flagella-associated protein 410 isoform X1 K23456 CFAP410; cilla- and flagella-associated protein
E 102974306 HDGFL2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 112065977 ZSWIM7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 102986925 SWSAP1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 102985027 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X11 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 102983535 HSF2BP; heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 102981138 MMS22L; protein MMS22-like isoform X1 K26125 MMS22L; protein MMS22-like
E 102994685 TONSL; tonsoku-like protein isoform X1 K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 102990945 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 102990285 PARPBP; PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 102977758 XRCC6; X-ray repair cross-complementing protein 6 isoform X3 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 102984827 XRCC5; X-ray repair cross-complementing protein 5 isoform X3 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 102996579 PRKDC; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 102983647 MRE11; double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
E 102983917 RAD50; DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 102975530 LIG4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 102985568 XRCC4; DNA repair protein XRCC4 isoform X1 K10886 XRCC4; DNA-repair protein XRCC4
E 102989694 non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 102975367 POLL; DNA polymerase lambda isoform X1 K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 102976298 POLM; LOW QUALITY PROTEIN: DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 102994470 DNTT; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 102976221 POLB; DNA polymerase beta isoform X1 K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 102983345 DNA polymerase beta-like K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 102980098 APTX; aprataxin isoform X1 K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 112064821 LOW QUALITY PROTEIN: aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 102985521 APLF; aprataxin and PNK-like factor isoform X1 K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 102987761 DCLRE1C; protein artemis isoform X4 K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 102974332 TDP2; tyrosyl-DNA phosphodiesterase 2 isoform X1 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 102990901 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 102991302 PWWP3A; PWWP domain-containing DNA repair factor 3A K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 102996513 PWWP3B; PWWP domain-containing DNA repair factor 3B K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 112065487 PAXX; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 112066357 LOW QUALITY PROTEIN: cell cycle regulator of non-homologous end joining-like K26155 CYREN; cell cycle regulator of non-homologous end joining
E 102981770 cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 102979152 JMJD8; jmjC domain-containing protein 8 isoform X1 K25792 JMJD8; jumonji domain-containing protein 8
E 102990245 SHLD1; shieldin complex subunit 1 isoform X1 K26128 SHLD1; shieldin complex subunit 1
E 102990375 SHLD2; shieldin complex subunit 2 isoform X1 K26129 SHLD2; shieldin complex subunit 2
E 102975410 SHLD3; shieldin complex subunit 3 K26130 SHLD3; shieldin complex subunit 3
C FA (Fanconi anemia) pathway
D FA core complex
E 102992281 FANCA; Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 102990782 FANCB; Fanconi anemia group B protein isoform X1 K10889 FANCB; fanconi anemia group B protein
E 102995115 FANCC; Fanconi anemia group C protein isoform X5 K10890 FANCC; fanconi anemia group C protein
E 102988622 FANCE; Fanconi anemia group E protein isoform X1 K10892 FANCE; fanconi anemia group E protein
E 102990619 FANCF; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 102983549 FANCG; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 102989361 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1 K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 102977098 FANCM; Fanconi anemia group M protein isoform X1 K10896 FANCM; fanconi anemia group M protein
E 102975398 FAAP24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 102994782 FAAP100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 102975703 HES1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 102973389 CENPS; centromere protein S K11511 APITD1; centromere protein S
E 102979860 CENPX; centromere protein X isoform X2 K15360 STRA13; centromere protein X
E 102985809 UBE2T; ubiquitin-conjugating enzyme E2 T isoform X2 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 102995998 BLM; recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 102975497 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 102983748 TOP3B; DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 102995036 RMI1; recQ-mediated genome instability protein 1 isoform X1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 112064813 RMI2; recQ-mediated genome instability protein 2 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 102974424 FANCD2; Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 102979988 FANCI; Fanconi anemia group I protein isoform X5 K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 102986597 BRCA1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 102995983 BRCA2; breast cancer type 2 susceptibility protein isoform X1 K08775 BRCA2; breast cancer 2 susceptibility protein
E 102982599 BRIP1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 102975423 PALB2; partner and localizer of BRCA2 isoform X1 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 102982127 FAN1; fanconi-associated nuclease 1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 102989193 RAD51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 102978529 LOW QUALITY PROTEIN: DNA repair protein RAD51 homolog 1-like K04482 RAD51; DNA repair protein RAD51
E 102991234 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1 K10870 RAD51L2; RAD51-like protein 2
E 102994749 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
E 102992319 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 102978562 USP1; ubiquitin carboxyl-terminal hydrolase 1 isoform X1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 102984090 LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 1-like K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 102983664 WDR48; WD repeat-containing protein 48 isoform X2 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 102984506 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit isoform X1 K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 102984163 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X1 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 102981014 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 102993401 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 102984725 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 102974729 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1 K15503 ANKRD44; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
E 102980271 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X4 K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 102980640 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X3 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 102975508 RNF168; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 102985330 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF168-like K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 102980221 RNF169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 102994646 HERC2; E3 ubiquitin-protein ligase HERC2 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 102985373 WRAP53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
E 102983597 TPRN; taperin isoform X1 K24164 TPRN; taperin
E 102982888 ZCWPW1; zinc finger CW-type PWWP domain protein 1 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 102987632 WDR70; WD repeat-containing protein 70 isoform X1 K24752 WDR70; WD repeat-containing protein 70
E 102996132 WDR76; WD repeat-containing protein 76 isoform X1 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 102979962 POLH; DNA polymerase eta isoform X1 K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 102996327 POLI; DNA polymerase iota isoform X5 K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 102976634 POLK; DNA polymerase kappa isoform X1 K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 102977385 REV1; DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 102975351 REV3L; DNA polymerase zeta catalytic subunit isoform X2 K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 102980284 POLN; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 102974917 UBE2A; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 102982410 UBE2B; ubiquitin-conjugating enzyme E2 B isoform X1 K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 102992348 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X1 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 102975970 HLTF; helicase-like transcription factor isoform X1 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 102992008 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 variant 1-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 102984548 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 102976417 ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 102976341 ubiquitin-conjugating enzyme E2 variant 2-like K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 102990237 UBE2N; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 102973700 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 102981073 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
D 102985799 ubiquitin-conjugating enzyme E2 N-like K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 102992318 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 102980166 proliferating cell nuclear antigen-like K04802 PCNA; proliferating cell nuclear antigen
D 102990285 PARPBP; PCNA-interacting partner isoform X1 K27412 PARPBP; PCNA-interacting partner
D 102986451 SPRTN; DNA-dependent metalloprotease SPRTN isoform X1 K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 102979443 GCNA; germ cell nuclear acidic protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 102977158 RAD9A; cell cycle checkpoint control protein RAD9A isoform X4 K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 102983220 RAD9B; LOW QUALITY PROTEIN: cell cycle checkpoint control protein RAD9B K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 102987844 RAD1; cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 102983640 RAD17; cell cycle checkpoint protein RAD17 isoform X2 K06662 HRAD17; cell cycle checkpoint protein
D 102980871 RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 102987713 RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 114485382 replication factor C subunit 2-like K10755 RFC2_4; replication factor C subunit 2/4
D 102989998 RFC3; replication factor C subunit 3 isoform X2 K10756 RFC3_5; replication factor C subunit 3/5
D 102980467 RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 102987844 RAD1; cell cycle checkpoint protein RAD1 isoform X1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 102983447 protein timeless homolog isoform X1 K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 102992472 TIPIN; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 102989416 CLSPN; claspin K25773 CLSPN; claspin
C Triple T complex
D 102994749 TELO2; telomere length regulation protein TEL2 homolog isoform X1 K11137 TELO2; telomere length regulation protein
D 102985253 TTI1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 102982173 TTI2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 102978768 BAG6; large proline-rich protein BAG6 isoform X1 K23390 BAG6; large proline-rich protein BAG6
D 102982543 UBL4A; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 112063841 LOW QUALITY PROTEIN: ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 102980149 LOW QUALITY PROTEIN: ubiquitin-like protein 4B K23388 UBL4; ubiquitin-like protein 4
D 102989581 GET4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 102979131 ATR; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 102980193 ATRIP; ATR-interacting protein isoform X1 K10905 ATRIP; ATR interacting protein
D 102975752 ATM; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 102985658 TP53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 102989266 CHEK1; serine/threonine-protein kinase Chk1 isoform X1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 102986126 CHEK2; serine/threonine-protein kinase Chk2 isoform X1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 102992519 CDC25A; M-phase inducer phosphatase 1 isoform X1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 102979525 CDC25B; M-phase inducer phosphatase 2 isoform X1 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 102978115 CDC25C; M-phase inducer phosphatase 3 isoform X1 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 102984255 YWHAB; LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 102977339 YWHAQ; LOW QUALITY PROTEIN: 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 102993808 LOW QUALITY PROTEIN: 14-3-3 protein zeta/delta-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 102984179 14-3-3 protein beta/alpha-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 112067524 LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha-like K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 102995638 YWHAH; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 102986425 YWHAG; 14-3-3 protein gamma isoform X1 K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 102982286 YWHAE; 14-3-3 protein epsilon isoform X1 K06630 YWHAE; 14-3-3 protein epsilon
D 114488017 neuron navigator 2-like K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 102981541 WEE2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 102982250 WEE1; wee1-like protein kinase isoform X1 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 102992286 PER1; period circadian protein homolog 1 isoform X1 K21944 PER1; period circadian protein 1
D 102989201 PER2; period circadian protein homolog 2 isoform X1 K02633 PER2; period circadian protein 2
D 102985412 PER3; period circadian protein homolog 3 isoform X2 K21945 PER3; period circadian protein 3
D 102977791 MDC1; mediator of DNA damage checkpoint protein 1 isoform X3 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 102980437 PLS3; plastin-3 K17336 PLS3; plastin-3
D 102994199 AEN; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 102990542 PLK3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 102993819 PLK5; LOW QUALITY PROTEIN: inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 102981544 NEK1; serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 102976069 NEK4; serine/threonine-protein kinase Nek4 isoform X4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 102974446 NEK10; serine/threonine-protein kinase Nek10 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 102986232 NEK11; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 102996763 DONSON; protein downstream neighbor of Son K22422 DONSON; protein downstream neighbor of Son
D 102983722 KANK2; KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 102983158 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 102974404 KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 102979037 KANK4; KN motif and ankyrin repeat domain-containing protein 4 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 102985318 KLLN; LOW QUALITY PROTEIN: killin K23389 KLLN; killin
D 102980445 SLFN11; schlafen family member 11 K24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]
D 102975629 CHMP4C; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 102976814 VPS4A; vacuolar protein sorting-associated protein 4A isoform X2 K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 102986996 VPS4B; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 102991398 ZFYVE19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 102985813 SDE2; splicing regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 102995261 POLQ; DNA polymerase theta isoform X1 K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 102985494 MYBBP1A; LOW QUALITY PROTEIN: myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 102975216 PRIMPOL; DNA-directed primase/polymerase protein isoform X1 K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 102980491 TREX1; three-prime repair exonuclease 1 K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]
D 102990114 TREX2; LOW QUALITY PROTEIN: three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 102997011 DCLRE1A; DNA cross-link repair 1A protein isoform X1 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 102989173 DCLRE1B; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 102980409 EXO5; exonuclease V K17815 EXO5; exonuclease V [EC:3.1.-.-]
D 102981459 ENDOV; endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 102995566 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X2 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 102989021 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 102985748 HELQ; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 102980867 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 102981938 PRPF19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 102991279 CDC5L; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 102995112 BCAS2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 102979996 PLRG1; pleiotropic regulator 1 isoform X1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 102979740 nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 112065412 LOW QUALITY PROTEIN: nucleotide triphosphate diphosphatase NUDT15-like K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 102988018 NUDT1; oxidized purine nucleoside triphosphate hydrolase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 102992845 NUDT18; 8-oxo-dGDP phosphatase NUDT18 isoform X1 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 102992102 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 102976077 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 102989062 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 102995944 RRM1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 102991905 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 102975539 RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 102974189 MGMT; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 102993141 UNG; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 102984087 SMUG1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 102995368 MPG; DNA-3-methyladenine glycosylase isoform X1 K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 102981566 MUTYH; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 102986112 NTHL1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 102981829 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 102981829 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1 K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 102979740 nucleotide triphosphate diphosphatase NUDT15 isoform X1 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 112065412 LOW QUALITY PROTEIN: nucleotide triphosphate diphosphatase NUDT15-like K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 102992102 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 102976077 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 102989062 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024