+E Messenger RNA Biogenesis KO
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Messenger RNA Biogenesis - Plasmodium falciparum 3D7
%
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AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E PF3D7_1356900 protein kinase 5 K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]
E PF3D7_1014400 MO15-related protein kinase K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E PF3D7_1414600 mRNA-capping enzyme subunit alpha K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
D Cap binding complex
E PF3D7_0415500 nuclear cap-binding protein subunit 2, putative K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
E PF3D7_0109200 cleavage and polyadenylation specificity factor subunit 5, putative K14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5
D Pre-mRNA cleavage factor IIm (CFIIm)
E PF3D7_0821600 polyribonucleotide 5'-hydroxyl-kinase Clp1, putative K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
D Cleavage and polyadenylation specificity factor (CPSF) complex
E PF3D7_1438500 cleavage and polyadenylation specificity factor subunit 3, putative K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E PF3D7_1243800 uncharacterized protein K14962 WDR82; COMPASS component SWD2
E PF3D7_1414400 serine/threonine protein phosphatase PP1 K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E PF3D7_0620500 cleavage stimulation factor subunit 1, putative K14406 CSTF1; cleavage stimulation factor subunit 1
D U7-dependent histone pre-mRNA processing factors
E PF3D7_1414800 small nuclear ribonucleoprotein-associated protein B, putative K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E PF3D7_0909800 small nuclear ribonucleoprotein Sm D3, putative K11088 SNRPD3; small nuclear ribonucleoprotein D3
E PF3D7_1350200 small nuclear ribonucleoprotein E, putative K11097 SNRPE; small nuclear ribonucleoprotein E
E PF3D7_1126900 small nuclear ribonucleoprotein F, putative K11098 SNRPF; small nuclear ribonucleoprotein F
E PF3D7_0822300 small nuclear ribonucleoprotein G, putative K11099 SNRPG; small nuclear ribonucleoprotein G
E PF3D7_1438500 cleavage and polyadenylation specificity factor subunit 3, putative K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E PF3D7_0519000 histone RNA hairpin-binding protein, putative K18710 SLBP; histone RNA hairpin-binding protein
D DRB sensitivity inducing factor (DSIF) complex
E PF3D7_1030000 transcription elongation factor SPT4, putative K15171 SUPT4H1; transcription elongation factor SPT4
E PF3D7_0610900 transcription elongation factor SPT5, putative K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
E PF3D7_0729500 mRNA (N6-adenosine)-methyltransferase, putative K05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]
E PF3D7_1235500 mRNA methyltransferase, putative K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit
E PF3D7_1230800 pre-mRNA-splicing regulator, putative K22824 WTAP; pre-mRNA-splicing regulator WTAP
D Poly(A) addition factors
E PF3D7_0625600 poly(A) polymerase PAP, putative K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
D Negative regulators of mRNA 3' end processing
C Other processing factors
D PF3D7_1467500 DNA/RNA-binding protein KIN17, putative K13102 KIN; DNA/RNA-binding protein KIN17
D PF3D7_0623100 nuclear polyadenylated RNA-binding protein NAB2, putative K23038 ZC3H14; zinc finger CCCH domain-containing protein 14
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E PF3D7_1406000 RNA-binding protein 8A, putative K12876 RBM8A; RNA-binding protein 8A
E PF3D7_0725200 mago nashi protein homologue, putative K12877 MAGOH; protein mago nashi
E PF3D7_0615700 RNA and export factor binding protein, putative K12881 THOC4; THO complex subunit 4
E PF3D7_0209800 ATP-dependent RNA helicase UAP56 K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7]
E PF3D7_0422700 eukaryotic initiation factor 4A-III, putative K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
D TREX complex
E PF3D7_0615700 RNA and export factor binding protein, putative K12881 THOC4; THO complex subunit 4
D TREX-2 complex
E PF3D7_0721800 conserved Plasmodium protein, unknown function K10881 SHFM1; 26 proteasome complex subunit DSS1
E PF3D7_1027700.1 centrin-3 K16466 CETN3; centrin-3
D Nuclear pore complex
E PF3D7_1230700 protein transport protein SEC13 K14004 SEC13; protein transport protein SEC13
E PF3D7_1027700.1 centrin-3 K16466 CETN3; centrin-3
D Ran-mediated transport factors
E PF3D7_1117700 GTP-binding nuclear protein RAN/TC4 K07936 RAN; GTP-binding nuclear protein Ran
E PF3D7_1427900 leucine-rich repeat protein K18647 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B
E PF3D7_0934700 UBX domain-containing protein, putative K18726 FAF2; FAS-associated factor 2
E PF3D7_0619400 cell division cycle protein 48 homologue, putative K13525 VCP; transitional endoplasmic reticulum ATPase
E PF3D7_0302900 exportin-1, putative K14290 XPO1; exportin-1
E PF3D7_0910100 exportin-7, putative K18460 XPO7; exportin-7
D eIF4F and regulatory proteins
E PF3D7_0315100 eukaryotic translation initiation factor 4E K03259 EIF4E; translation initiation factor 4E
E PF3D7_1468700 eukaryotic initiation factor 4A K03257 EIF4A; translation initiation factor 4A
E PF3D7_0810600 ATP-dependent RNA helicase DBP1, putative K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PF3D7_1031500 DEAD/DEAH box helicase, putative K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PF3D7_1224300 polyadenylate-binding protein 1, putative K13126 PABPC; polyadenylate-binding protein
E PF3D7_0529500 cell cycle regulator protein, putative K07575 MCTS; malignant T-cell-amplified sequence
E PF3D7_0813600 translation initiation factor SUI1, putative K24272 DENR; density-regulated protein
D APOBEC1-ACF complex
D Other transport factors
E PF3D7_1209000 mago-binding protein, putative K14294 WIBG; partner of Y14 and mago
E PF3D7_0414500 RNA-binding protein, putative K14411 MSI; RNA-binding protein Musashi
E PF3D7_0722100 protein pelota homolog, putative K06965 PELO; protein pelota
E PF3D7_0923900 polyadenylate-binding protein 2, putative K14396 PABPN1; polyadenylate-binding protein 2
E PF3D7_1459000 ATP-dependent RNA helicase DBP5 K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E PF3D7_1235900 pre-mRNA-splicing factor SYF1, putative K12867 SYF1; pre-mRNA-splicing factor SYF1
E PF3D7_0912500 SAP domain-containing protein, putative K18732 SARNP; SAP domain-containing ribonucleoprotein
E PF3D7_0711500 regulator of chromosome condensation, putative K11493 RCC1; regulator of chromosome condensation
C Surveillance factors
D Surveillance complex
E PF3D7_0212300 peptide chain release factor subunit 1, putative K03265 ETF1; peptide chain release factor subunit 1
E PF3D7_1123400 translation elongation factor EF-1, subunit alpha, putative K03267 ERF3; peptide chain release factor subunit 3
E PF3D7_1005500 regulator of nonsense transcripts 1, putative K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E PF3D7_0925800 armadillo repeat protein, putative K14327 UPF2; regulator of nonsense transcripts 2
D Protein phosphatase 2A
E PF3D7_0925400 protein phosphatase-beta K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E PF3D7_1356400 phosphatase 2A regulatory subunit-related protein, putative K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
D Other surveillance factors
E PF3D7_0309700 SECIS-binding protein 2, putative K19539 SECISBP2; selenocysteine insertion sequence-binding protein 2
C Factors involved in mRNA localization
D Cargo complex
E PF3D7_0621300 mRNA-binding protein PUF3 K14844 PUF6; pumilio homology domain family member 6
E PF3D7_0204800 3'-5' exonuclease, putative K18740 EXD1; exonuclease 3'-5' domain-containing protein 1
D Factors that have mRNA localization signals
D Trans-acting binding proteins
E PF3D7_1357000 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha
E PF3D7_1357100 elongation factor 1-alpha K03231 EEF1A; elongation factor 1-alpha
E PF3D7_1338300 elongation factor 1-gamma, putative K03233 EEF1G; elongation factor 1-gamma
D Other mRNA localization factors
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E PF3D7_1106300 exonuclease, putative K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E PF3D7_0315100 eukaryotic translation initiation factor 4E K03259 EIF4E; translation initiation factor 4E
E PF3D7_1005500 regulator of nonsense transcripts 1, putative K14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E PF3D7_0810600 ATP-dependent RNA helicase DBP1, putative K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PF3D7_1031500 DEAD/DEAH box helicase, putative K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PF3D7_0320800 ATP-dependent RNA helicase DDX6 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E PF3D7_1474900 trailer hitch homolog, putative K18749 LSM14; protein LSM14
E PF3D7_0627700 transportin K18752 TNPO1; transportin-1
E PF3D7_0934800 cAMP-dependent protein kinase catalytic subunit K04345 PKA; protein kinase A [EC:2.7.11.11]
D P-body specific factors
E PF3D7_1308900 mRNA-decapping enzyme 2, putative K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E PF3D7_1124400 U6 snRNA-associated Sm-like protein LSm1, putative K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E PF3D7_0520300 U6 snRNA-associated Sm-like protein LSm2, putative K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E PF3D7_0819900 U6 snRNA-associated Sm-like protein LSm3, putative K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E PF3D7_1107000 U6 snRNA-associated Sm-like protein LSm4, putative K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E PF3D7_1443300 U6 snRNA-associated Sm-like protein LSm5, putative K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E PF3D7_1325000 U6 snRNA-associated Sm-like protein LSm6, putative K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E PF3D7_1209200 U6 snRNA-associated Sm-like protein LSm7, putative K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E PF3D7_0829300 U6 snRNA-associated Sm-like protein LSm8, putative K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
E PF3D7_0422300 alpha tubulin 2 K07374 TUBA; tubulin alpha
E PF3D7_0903700 alpha tubulin 1 K07374 TUBA; tubulin alpha
E PF3D7_1103800 CCR4-NOT transcription complex subunit 1, putative K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E PF3D7_1128600 CCR4-NOT transcription complex subunit 2, putative K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E PF3D7_0519500 CCR4 domain-containing protein 1, putative K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E PF3D7_0811300 CCR4-associated factor 1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E PF3D7_0925800 armadillo repeat protein, putative K14327 UPF2; regulator of nonsense transcripts 2
E PF3D7_1027400 DNA-directed RNA polymerase II subunit RPB7, putative K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
D Stress granule specific factors
E PF3D7_1224300 polyadenylate-binding protein 1, putative K13126 PABPC; polyadenylate-binding protein
E PF3D7_1438000 eukaryotic translation initiation factor eIF2A, putative K15026 EIF2A; translation initiation factor 2A
E PF3D7_0517700 eukaryotic translation initiation factor 3 subunit B, putative K03253 EIF3B; translation initiation factor 3 subunit B
E PF3D7_1468700 eukaryotic initiation factor 4A K03257 EIF4A; translation initiation factor 4A
E PF3D7_0422700 eukaryotic initiation factor 4A-III, putative K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E PF3D7_0826700 receptor for activated c kinase K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E PF3D7_1308900 mRNA-decapping enzyme 2, putative K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E PF3D7_0320800 ATP-dependent RNA helicase DDX6 K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
D Lsm complex
E PF3D7_1124400 U6 snRNA-associated Sm-like protein LSm1, putative K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E PF3D7_0520300 U6 snRNA-associated Sm-like protein LSm2, putative K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E PF3D7_0819900 U6 snRNA-associated Sm-like protein LSm3, putative K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E PF3D7_1107000 U6 snRNA-associated Sm-like protein LSm4, putative K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E PF3D7_1443300 U6 snRNA-associated Sm-like protein LSm5, putative K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E PF3D7_1325000 U6 snRNA-associated Sm-like protein LSm6, putative K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E PF3D7_1209200 U6 snRNA-associated Sm-like protein LSm7, putative K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E PF3D7_0829300 U6 snRNA-associated Sm-like protein LSm8, putative K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
D 5' exonucleases
E PF3D7_1106300 exonuclease, putative K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E PF3D7_0909400 exoribonuclease, putative K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D Other 5'-3' decay factors
C 3'-5' decay
D Core exosome factors
E PF3D7_0720000 exosome complex component CSL4, putative K07573 CSL4; exosome complex component CSL4
E PF3D7_0410400 exosome complex component RRP4 K03679 RRP4; exosome complex component RRP4
E PF3D7_1307000 exosome complex component RRP40, putative K03681 RRP40; exosome complex component RRP40
E PF3D7_1427800 exosome complex component RRP41 K11600 RRP41; exosome complex component RRP41
E PF3D7_1340100 exosome complex component RRP42, putative K12589 RRP42; exosome complex component RRP42
E PF3D7_1364500 exosome complex component RRP45, putative K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E PF3D7_1359300 exosome complex exonuclease RRP44 K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
E PF3D7_1445500 conserved Plasmodium protein, unknown function K12592 C1D; exosome complex protein LRP1
E PF3D7_0903400 ATP-dependent RNA helicase DDX60, putative K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]
D TRAMP complex
E PF3D7_1332400 nucleotidyltransferase, putative K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E PF3D7_0602100 ATP-dependent RNA helicase, putative K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
D Ski complex
D Ccr4-NOT complex
E PF3D7_0519500 CCR4 domain-containing protein 1, putative K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E PF3D7_1103800 CCR4-NOT transcription complex subunit 1, putative K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E PF3D7_1128600 CCR4-NOT transcription complex subunit 2, putative K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E PF3D7_0811300 CCR4-associated factor 1 K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E PF3D7_0507600 protein CAF40, putative K12606 RCD1; CCR4-NOT transcription complex subunit 9
E PF3D7_1434000 CCR4-associated factor 16, putative K12608 CAF16; CCR4-NOT complex subunit CAF16
D Pan complex
D Other 3'-5' decay factors
E PF3D7_1443500 poly(A)-specific ribonuclease PARN, putative K01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]
E PF3D7_0821300 ATP-dependent RNA helicase DHX36, putative K14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]
C Other degradation factors
D RNases
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AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
D Helicases
D Other RNA degradosome components
E PF3D7_1015900 enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
C Other RNA degradation factors
D Chaperones
E PF3D7_1134000 heat shock protein 70 K04043 dnaK; molecular chaperone DnaK
E PF3D7_1015600 heat shock protein 60 K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
E PF3D7_1232100 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E PF3D7_0410400 exosome complex component RRP4 K03679 RRP4; exosome complex component RRP4
E PF3D7_0720000 exosome complex component CSL4, putative K07573 CSL4; exosome complex component CSL4
D Cofactors
E PF3D7_1427800 exosome complex component RRP41 K11600 RRP41; exosome complex component RRP41
E PF3D7_1340100 exosome complex component RRP42, putative K12589 RRP42; exosome complex component RRP42
D Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024