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Transfer RNA Biogenesis - Plasmodium falciparum HB3
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
D PFHG_02584 hypothetical protein K01164 POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
D PFHG_00632 conserved hypothetical protein K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D PFHG_04654 hypothetical protein K03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
D PFHG_01790 conserved hypothetical protein K14530 RPP40; ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D PFHG_03964 conserved hypothetical protein K00784 rnz; ribonuclease Z [EC:3.1.26.11]
C CCA adding factors
D PFHG_01953 hypothetical protein similar to tRNA nucleotidyltransferase, mitochondrial precursor K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonuclease complex
C tRNA splicing ligase complex
D PFHG_01759 hypothetical protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D PFHG_03440 hypothetical protein similar to ATP-dependent helicase ddx1 K13177 DDX1; ATP-dependent RNA helicase DDX1 [EC:5.6.2.7]
D PFHG_00481 conserved hypothetical protein K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
D PFHG_04048 GTP-binding nuclear protein ran/tc4 K07936 RAN; GTP-binding nuclear protein Ran
D PFHG_04092 hypothetical protein K14288 XPOT; exportin-T
D PFHG_02381 hypothetical protein K14290 XPO1; exportin-1
D PFHG_05553 hypothetical protein similar to elongation factor-1 alpha 2 K03231 EEF1A; elongation factor 1-alpha
D PFHG_04125 elongation factor 1 alpha K03231 EEF1A; elongation factor 1-alpha
D PFHG_04124 elongation factor 1 alpha K03231 EEF1A; elongation factor 1-alpha
D PFHG_02742 hypothetical protein K08876 SCYL1; SCY1-like protein 1
C tRNA import factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D PFHG_03012 glutamate-tRNA ligase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D PFHG_04126 hypothetical protein K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D PFHG_01382 conserved hypothetical protein K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D PFHG_02803 hypothetical protein similar to ATP binding / proline-tRNA ligase/ tRNA ligase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D PFHG_02839 isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D PFHG_01130 hypothetical protein similar to leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D PFHG_02762 hypothetical protein K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D PFHG_01338 hypothetical protein similar to methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D PFHG_01560 hypothetical protein similar to methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D PFHG_02828 glutaminyl-tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D PFHG_04399 conserved hypothetical protein K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D PFHG_03021 lysine-tRNA ligase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D PFHG_03319 hypothetical protein similar to lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D PFHG_04801 aspartyl-tRNA synthetase K22503 DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12]
D PFHG_00206 conserved hypothetical protein K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
C Other AARSs
D PFHG_04153 conserved hypothetical protein K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D PFHG_00933 hypothetical protein similar to asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D PFHG_04884 asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D PFHG_03139 hypothetical protein similar to glycyl-tRNA synthetase K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]
D PFHG_03507 threonyl-tRNA synthetase, mitochondrial precursor K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D PFHG_03188 hypothetical protein similar to seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D PFHG_04098 conserved hypothetical protein K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D PFHG_02601 hypothetical protein similar to cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D PFHG_02034 conserved hypothetical protein K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D PFHG_03219 valyl-tRNA synthetase, mitochondrial precursor K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D PFHG_02225 conserved hypothetical protein K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D PFHG_01730 conserved hypothetical protein K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D PFHG_00378 conserved hypothetical protein K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D PFHG_01029 conserved hypothetical protein K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D PFHG_01204 hypothetical protein similar to phenylalanine-tRNA ligase K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D PFHG_01742 hypothetical protein similar to phenylalanyl-tRNA synthetase subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D PFHG_02626 hypothetical protein K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D PFHG_04046 hypothetical protein similar to tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D PFHG_02937 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D PFHG_04466 conserved hypothetical protein K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D PFHG_05062 hypothetical protein similar to hydrolase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
C AARS associated factors
B tRNA modification factors
C Deaminases
D PFHG_03014 conserved hypothetical protein K15441 TAD2; tRNA-specific adenosine deaminase 2 [EC:3.5.4.-]
D PFHG_04430 conserved hypothetical protein K15442 TAD3; tRNA-specific adenosine deaminase 3
C Dihydorouridine synthases
D PFHG_03486 conserved hypothetical protein K05545 DUS4; tRNA-dihydrouridine synthase 4 [EC:1.3.1.90]
C Methylthiotransferase
C Methyltransferases
D PFHG_03900 hypothetical protein similar to N2,N2-dimethylguanosine tRNA methyltransferase K00555 TRMT1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D PFHG_00485 conserved hypothetical protein K15333 TRM3; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34]
D PFHG_01420 hypothetical protein K15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D PFHG_04090 conserved hypothetical protein K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D PFHG_00138 hypothetical protein similar to cell division protein K14864 FTSJ1; tRNA (cytidine32/guanosine34-2'-O)-methyltransferase [EC:2.1.1.205]
D PFHG_01892 hypothetical protein similar to methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D PFHG_01939 conserved hypothetical protein K15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D PFHG_02131 conserved hypothetical protein K15430 TRM11; tRNA (guanine10-N2)-methyltransferase [EC:2.1.1.214]
D PFHG_00460 hypothetical protein K15448 TRM112; multifunctional methyltransferase subunit TRM112
D PFHG_03746 conserved hypothetical protein K17053 ABP140; tRNAThr (cytosine32-N3)-methyltransferase [EC:2.1.1.268]
D PFHG_02982 conserved hypothetical protein K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D PFHG_00306 conserved hypothetical protein K15451 PPM2; tRNA wybutosine-synthesizing protein 4 [EC:2.1.1.290 2.3.1.231]
C Psudouridine synthases
D PFHG_03933 conserved hypothetical protein K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D PFHG_00139 conserved hypothetical protein K01855 PUS3; tRNA pseudouridine38/39 synthase [EC:5.4.99.45]
D PFHG_01474 conserved hypothetical protein K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D PFHG_01339 conserved hypothetical protein K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D PFHG_05474 hypothetical protein K21027 TRMU; tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]
D PFHG_01493 conserved hypothetical protein K21027 TRMU; tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]
D PFHG_00545 hypothetical protein K14168 CTU1; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]
D PFHG_04832 conserved hypothetical protein K14169 CTU2; cytoplasmic tRNA 2-thiolation protein 2
D PFHG_02181 hypothetical protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D PFHG_02989 conserved hypothetical protein K12161 URM1; ubiquitin related modifier 1
D PFHG_03548 hypothetical protein similar to molybdopterin biosynthesis protein MoeB K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C KEOPS/EKC complex
D PFHG_02571 hypothetical protein K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D PFHG_01297 glycoprotease pgp2 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D PFHG_00178 conserved hypothetical protein K15901 TPRKB; EKC/KEOPS complex subunit TPRKB/CGI121
C Elongator complex
C Elongator related proteins
D PFHG_05066 hypothetical protein K15455 DPH3; diphthamide biosynthesis protein 3
C Other tRNA modification factors
D PFHG_05119 conserved hypothetical protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D PFHG_03660 conserved hypothetical protein K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D PFHG_02157 tRNA uridine 5-carboxymethylaminomethyl modification enzyme gidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D PFHG_03185 conserved hypothetical protein K00777 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit [EC:2.4.2.64]
D PFHG_00252 hypothetical protein similar to queuine tRNA-ribosyltransferase K15407 QTRT2; queuine tRNA-ribosyltransferase accessory subunit
D PFHG_00157 hypothetical protein similar to selenophosphate synthetase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D PFHG_01261 conserved hypothetical protein K10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]
B tRNA degradation factors
C TRAMP complex
D PFHG_02834 conserved hypothetical protein K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D PFHG_05334 hypothetical protein similar to ATP dependent RNA helicase K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
C Rapid tRNA decay (RTD) pathway factors
D PFHG_01765 conserved hypothetical protein K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
D PFHG_00146 conserved hypothetical protein K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
C Other tRNA degradation factors
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AProkaryotic type
B 5'processing factors
C Ribonucrease P
B 3'processing and CCA adding factors
C 3'processing factors
D PFHG_03964 conserved hypothetical protein K00784 rnz; ribonuclease Z [EC:3.1.26.11]
C CCA adding factors
D PFHG_01953 hypothetical protein similar to tRNA nucleotidyltransferase, mitochondrial precursor K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonucleases
C tRNA splicing ligases
D PFHG_01759 hypothetical protein K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D PFHG_01130 hypothetical protein similar to leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D PFHG_02762 hypothetical protein K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D PFHG_01382 conserved hypothetical protein K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D PFHG_02803 hypothetical protein similar to ATP binding / proline-tRNA ligase/ tRNA ligase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D PFHG_02626 hypothetical protein K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D PFHG_04046 hypothetical protein similar to tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D PFHG_02937 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D PFHG_04466 conserved hypothetical protein K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D PFHG_03507 threonyl-tRNA synthetase, mitochondrial precursor K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D PFHG_02839 isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D PFHG_03021 lysine-tRNA ligase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D PFHG_03319 hypothetical protein similar to lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D PFHG_04153 conserved hypothetical protein K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D PFHG_02034 conserved hypothetical protein K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D PFHG_03219 valyl-tRNA synthetase, mitochondrial precursor K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D PFHG_01338 hypothetical protein similar to methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D PFHG_01560 hypothetical protein similar to methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D PFHG_03188 hypothetical protein similar to seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D PFHG_04098 conserved hypothetical protein K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D PFHG_00206 conserved hypothetical protein K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D PFHG_02601 hypothetical protein similar to cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D PFHG_03012 glutamate-tRNA ligase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D PFHG_04126 hypothetical protein K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D PFHG_02828 glutaminyl-tRNA synthetase K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D PFHG_04399 conserved hypothetical protein K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D PFHG_00378 conserved hypothetical protein K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D PFHG_01029 conserved hypothetical protein K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D PFHG_01204 hypothetical protein similar to phenylalanine-tRNA ligase K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D PFHG_01742 hypothetical protein similar to phenylalanyl-tRNA synthetase subunit K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D PFHG_02225 conserved hypothetical protein K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D PFHG_01730 conserved hypothetical protein K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D PFHG_00933 hypothetical protein similar to asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D PFHG_04884 asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
C Trans-editing factors
D PFHG_05062 hypothetical protein similar to hydrolase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
D PFHG_01465 conserved hypothetical protein K05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]
C Methylthiotransferases
C Methyltransferases
D PFHG_01892 hypothetical protein similar to methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
C Psudouridine synthases
D PFHG_03933 conserved hypothetical protein K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D PFHG_01474 conserved hypothetical protein K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D PFHG_01339 conserved hypothetical protein K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D PFHG_02181 hypothetical protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
D PFHG_02571 hypothetical protein K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D PFHG_01297 glycoprotease pgp2 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
C Other tRNA modification factors
D PFHG_02157 tRNA uridine 5-carboxymethylaminomethyl modification enzyme gidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D PFHG_03660 conserved hypothetical protein K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D PFHG_00157 hypothetical protein similar to selenophosphate synthetase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D PFHG_02140 hypothetical protein similar to queuine tRNA-ribosyltransferase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D PFHG_05119 conserved hypothetical protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
B tRNA degradation factors
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024