+E Replication protein KO
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DNA Replication Proteins - Protobothrops mucrosquamatus (Taiwan habu)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 107283069 ORC1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 107291760 ORC2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 107284741 ORC3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 107294302 ORC4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 107297208 origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 107300736 origin recognition complex subunit 5-like K02607 ORC5; origin recognition complex subunit 5
D 107290114 ORC6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 107283479 CDT1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 107303083 CDC6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 107302449 MCM2; DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 107285564 MCM3; DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 107289323 MCM4; DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 107302638 MCM5; DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 107284389 MCM6; DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 107296115 MCM7; DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 107296600 CCNA2; cyclin-A2 K06627 CCNA; cyclin-A
D 107287659 CCNA1; cyclin-A1 K06627 CCNA; cyclin-A
D 107292735 CCNE1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 107289143 CCNE2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 107287774 CDK2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 107294837 CDC7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 107283304 DBF4; protein DBF4 homolog A K06629 DBF4; protein DBF4
C GINS complex
D 107284148 GINS1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 107288242 GINS2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 107284183 GINS3; DNA replication complex GINS protein PSF3 isoform X1 K10734 GINS3; GINS complex subunit 3
D 107289255 GINS4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 107293886 TOPBP1; DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 107297502 RECQL4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 107293411 CDC45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 107297361 MCM8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 107299757 MCM9; DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 107297426 MCM10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 107295698 FAM111A; protein FAM111A K24274 FAM111A; protein FAM111A
D 107298015 CINP; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 107296685 MTBP; mdm2-binding protein K26116 MTBP; Mdm2-binding protein
D 107286854 TICRR; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 107294370 POLA2; DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 107293736 PRIM1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 107288327 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 107285443 POLE; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 107298233 POLE2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 107302552 POLE3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 107299622 POLE4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 107282401 POLD1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 107286229 POLD2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 107287041 POLD3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D 107296657 POLD4; DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 107286848 POLG; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 107284858 POLG2; DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 107296194 RPA1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 107288015 RPA2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 107283682 RPA3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 107302798 RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 107293330 RFC4; LOW QUALITY PROTEIN: replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 107302352 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 107292839 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 107286810 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 107294088 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 107287849 LOW QUALITY PROTEIN: ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 107286878 RNASEH2A; ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 107293402 RNASEH2B; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 107297110 RNASEH2C; ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
D 107301591 ribonuclease H2 subunit C-like K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 107283633 PCNA; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 107288094 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 107287983 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 114923124 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 107300651 exonuclease 1-like K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 107300817 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 107284393 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 107285325 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
D 107284200 DNMT1; DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 107295539 DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 107289595 GMNN; geminin isoform X1 K10749 GMNN; geminin
D 107283786 MCIDAS; multicilin K26119 MCIDAS; multicilin
D 107300638 CCNB1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 107303272 CCNB3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 107297330 CDK1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 107303296 POT1; protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 107288540 TERF1; telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 107283497 TERF2; telomeric repeat-binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 114922912 TINF2; TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
D TERB1-TERB2-MAJIN complex
E 107288904 TERB1; LOW QUALITY PROTEIN: telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 107294061 TERB2; telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
D CST complex (animals)
E 107284102 CTC1; CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 107284688 STN1; CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 107290783 TEN1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 107296967 telomerase-binding protein EST1A-like K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 107296198 SMG6; telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 107296400 SMG5; protein SMG5 isoform X1 K11125 SMG5; protein SMG5
D 107292114 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 107298570 GAR1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 107294706 NHP2; H/ACA ribonucleoprotein complex subunit 2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 107292695 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 107292707 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 107295399 DKC1; H/ACA ribonucleoprotein complex subunit DKC1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 107292114 TERT; telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 107296127 SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 107293810 SNRPD1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 107291971 SNRPD2; small nuclear ribonucleoprotein Sm D2 isoform X1 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 107289812 SNRPD3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 107302986 SNRPE; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 107284560 SNRPF; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 107283260 SNRPG; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 107293330 RFC4; LOW QUALITY PROTEIN: replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 107302352 RFC2; replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 107292839 RFC5; replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 107286810 RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 107297670 MRE11; double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 107290655 RAD50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 107285753 NBN; nibrin K10867 NBN; nibrin
C Other termination factors
D 107284835 ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 107285620 WRN; Werner syndrome ATP-dependent helicase K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 107283943 BLM; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 107287153 PRKDC; LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 107293802 ERCC4; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 107291208 PARP1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 107295708 PARP2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 107291041 PARP3; protein mono-ADP-ribosyltransferase PARP3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 107288235 PARP4; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 107293532 TNKS2; poly [ADP-ribose] polymerase tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 107285629 TNKS; poly [ADP-ribose] polymerase tankyrase-1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 107285568 PINX1; PIN2/TERF1-interacting telomerase inhibitor 1 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 107292217 TELO2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 107286883 TRIR; telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 107299610 telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 107283410 PIF1; ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 107284141 PURA; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 107285619 PURG; purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 107299941 WRAP53; telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 107291212 SDE2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 107295466 RTF2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 107293932 LOW QUALITY PROTEIN: DNA topoisomerase I, mitochondrial-like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 107287258 TOP1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 107283762 TOP2B; DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 107298572 DNA topoisomerase 2-beta K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 107303085 TOP2A; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 107293415 TOP3B; LOW QUALITY PROTEIN: DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 107289151 TOP3A; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 107290168 SSBP1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 107294088 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 107287849 LOW QUALITY PROTEIN: ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 107294088 RNASEH1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 107287849 LOW QUALITY PROTEIN: ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 107288094 DNA2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 107287983 FEN1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 114923124 flap endonuclease 1-like K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 107285325 LIG1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022