+C Two-component system KO
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Two-Component System - Pseudomonas sp. VLB120
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C PVLB_25195 PAS/PAC sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C PVLB_25190 transcriptional regulator K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C PVLB_05890 integral membrane sensor signal transduction histidine kinase K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C PVLB_05885 two component transcriptional regulator K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C PVLB_24330 integral membrane sensor signal transduction histidine kinase K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C PVLB_24335 ompR; osmolarity response regulator K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C PVLB_05850 integral membrane sensor signal transduction K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C PVLB_05845 two component transcriptional regulator K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C PVLB_17675 two component transcriptional regulator K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C PVLB_00090 heavy metal sensor signal transduction histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PVLB_00215 heavy metal sensor signal transduction histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PVLB_21110 heavy metal sensor signal transduction histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PVLB_08000 heavy metal sensor signal transduction histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PVLB_00300 DNA-binding heavy metal response regulator, puta K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PVLB_00085 two component heavy metal response transcriptional regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PVLB_00210 DNA-binding response regulator CzrR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PVLB_21105 two component heavy metal response transcriptional regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PVLB_08005 two component heavy metal response transcriptional regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C PVLB_13800 integral membrane sensor signal transduction histidine kinase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PVLB_16475 integral membrane sensor signal transduction histidine kinase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PVLB_13805 two component transcriptional regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
C PVLB_16480 two component transcriptional regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C PVLB_16145 osmosensitive K+ channel signal transduction histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C PVLB_16140 transcriptional regulator of kdp operon K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C PVLB_05125 integral membrane sensor signal transduction histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C PVLB_05120 two component transcriptional regulator K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
C PVLB_05970 integral membrane sensor signal transduction histidine kinase K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PVLB_05965 two component transcriptional regulator K19610 pfeR; two-component system, OmpR family, response regulator PfeR
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C PVLB_12770 integral membrane sensor signal transduction histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PVLB_18570 integral membrane sensor signal transduction K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PVLB_11930 integral membrane sensor signal transduction histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PVLB_10435 two component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_14865 two component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_12775 two component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_24215 protein GltR K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_18575 two component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_14685 winged helix family two component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_20105 two component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_11925 Two component transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
C PVLB_08435 two component winged helix family transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C PVLB_12415 putative PAS/PAC sensor protein K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C PVLB_07440 Multi-sensor hybrid histidine kinase K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C PVLB_07450 histidine kinase K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C PVLB_07435 two component LuxR family transcriptional regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C PVLB_05960 multi-sensor hybrid histidine kinase K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C PVLB_15465 two component LuxR family transcriptional regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C PVLB_07715 PAS/PAC sensor hybrid histidine kinase K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PVLB_13645 Hpt sensor hybrid histidine kinase K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PVLB_05445 two component LuxR family transcriptional regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
C PVLB_07720 two component LuxR family transcriptional regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
C PVLB_13640 two component LuxR family transcriptional regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
C PVLB_22155 two component LuxR family transcriptional regulator K27077 pprB; two-component system, NarL family, response regulator PprB
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C PVLB_01155 LytTR family two component transcriptional regulator K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C PVLB_01925 signal transduction histidine kinase, nitrogen specific, NtrB K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C PVLB_01920 nitrogen metabolism transcriptional regulator NtrC K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C PVLB_03605 Fis family transcriptional regulator K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C PVLB_05030 integral membrane sensor signal transduction histidine kinase K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PVLB_24245 histidine kinase K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PVLB_05025 Fis family transcriptional regulator K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C PVLB_24250 two component sigma54 specific Fis family transcriptional regulator K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
C PVLB_00760 multi-sensor signal transduction histidine kinase K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]
C PVLB_00765 two component sigma-54 specific Fis family transcriptional regulator K11384 algB; two-component system, NtrC family, response regulator AlgB
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C PVLB_17090 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PVLB_17100 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PVLB_15210 CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PVLB_17085 chemotaxis-specific protein-glutamate methyltransferase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PVLB_14510 signal transduction histidine kinase with CheB and CheR activity K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
C PVLB_07860 response regulator receiver modulated CheW protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C PVLB_20985 CheW-like chemotaxis signal transduction protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
C PVLB_17405 response regulator receiver modulated CheW protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C PVLB_02240 sensor histidine kinase/response regulator ChpA K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C PVLB_02220 response regulator receiver protein K02657 pilG; twitching motility two-component system response regulator PilG
C PVLB_02225 response regulator receiver protein K02658 pilH; twitching motility two-component system response regulator PilH
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C PVLB_19695 CheA signal transduction histidine kinase K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C PVLB_19685 response regulator/GGDEF domain-containing protein K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C PVLB_19690 chemotaxis-specific methylesterase K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
C PVLB_08480 GAF sensor signal transduction histidine kinase K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
C PVLB_17220 PAS/PAC sensor signal transduction histidine kinase K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C PVLB_17215 Fis family two component sigma-54 specific transcriptional regulator K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
C PVLB_05330 integral membrane sensor signal transduction histidine kinase K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
C PVLB_05325 Fis family two component sigma-54 specific transcriptional regulator K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C PVLB_20490 integral membrane sensor signal transduction histidine kinase K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C PVLB_20485 two component Fis family transcriptional regulator K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C PVLB_06990 histidine kinase K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C PVLB_16215 integral membrane sensor hybrid histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PVLB_17170 Hpt protein K20976 hptB; histidine phosphotransfer protein HptB
C PVLB_17175 response regulator receiver protein K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
C PVLB_07680 nitrate-binding protein NasS K22067 nasS; two-component system, oxyanion-binding sensor
C PVLB_07675 response regulator receiver/ANTAR domain-containing protein K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C PVLB_03205 integral membrane sensor signal transduction histidine kinase K20971 ladS; two-component system, sensor histidine kinase LadS
C PVLB_03090 integral membrane sensor hybrid histidine kinase K20972 retS; two-component system, sensor histidine kinase RetS
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023