+D	Messenger RNA Biogenesis	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Prokaryotic Defense System - Cupriavidus metallidurans</h2>
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A<b>CRISPR-Cas system</b>
B  Universal Cas proteins
B  Type I CRISPR-Cas system
C    Type I signiture cas proteins
C    Subtype I-A factors
C    Subtype I-B factors
C    Subtype I-C factors
C    Subtype I-D factors
C    Subtype I-E factors
C    Subtype I-F factors
C    Subtype I-U factors
B  Type II CRISPR-Cas system
C    Type II signiture cas proteins
C    Subtype II-A factors
C    Subtype II-B factors
B  Type III CRISPR-Cas system
C    Type III signiture cas proteins
C    Subtype III-A factors
C    Subtype III-B factors
C    Subtype III-U factors
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A<b>Restriction and modification system (R-M system)</b>
B  Type I R-M system
B  Type II R-M system
C    Restriction endonucleases
D      Rmet_6120 copL; type II site-specific deoxyribonuclease (type II restriction enzyme) involved in resistance to copper (Cu(I)/Cu(II))	K01155 E3.1.21.4; type II restriction enzyme [EC:3.1.21.4] 
C    DNA methyltransferases
D      Rmet_5483 dam; DNA adenine methylase	K06223 dam; DNA adenine methylase [EC:2.1.1.72] 
D      Rmet_2466 DNA methylase N-4/N-6	K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] 
B  Type III R-M system
B  Type IV R-M system
C    Rmet_6329 HNH endonuclease typeIV restriction enzyme	K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 
C    Rmet_2668 conserved hypothetical protein	K07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-] 
C    Rmet_2667 hypothetical protein	K19147 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC 
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A<b>Toxin-antitoxin system (TA system)</b>
B  Type I TA system
C    Hok-Sok
C    SymE-SymR
C    Ldr-Rdl
C    TisB-IstR
C    Ibs-Sib
C    ShoB-OhsC
C    RalR-RalA
B  Type II TA system
C    MazF-MazE
C    ChpB-ChpS
C    YhaV-PrlF
C    RelE/StbE-RelB/StbD
C    YafQ-dinJ
C    YoeB-YefM
D      Rmet_1659 toxin of the YoeB-YefM toxin-antitoxin system (fragment)	K19158 yoeB; toxin YoeB [EC:3.1.-.-] 
D      Rmet_6160 stbD; Antitoxin of toxin-antitoxin stability system	K19159 yefM; antitoxin YefM 
C    HipA-HipB
D      Rmet_4901 putative regulator containing a HipA-like domain	K07154 hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] 
D      Rmet_5270 putative transcriptional regulator (XRE family)	K15773 hipB; HTH-type transcriptional regulator / antitoxin HipB 
C    HicA-HicB
C    YafO-YafN
C    Hha-TomB
C    PspC-PspB
C    CcdB-CcdA
C    ParE-ParD
D      Rmet_6341 stbE; toxin of a toxin/antitoxin system, parE-like; Plasmid stabilization system protein (IncP-1beta multiresistance plasmid pB8)Addiction module toxin, RelE/StbE	K19092 parE1_3_4; toxin ParE1/3/4 
C    Doc-Phd
C    HigB-HigA
D      Rmet_4763 plasmid maintenance system killer	K07334 higB-1; toxin HigB-1 
D      Rmet_4764 plasmid maintenance system antidote protein	K21498 higA-1; antitoxin HigA-1 
D      Rmet_1294 putative plasmid maintenance system antidote protein, XRE family Putative HTH-type transcriptional regulator ybaQ (belongs to CMGI-2)	K21498 higA-1; antitoxin HigA-1 
C    MqsR-MqsA
C    VapC-VapB
C    PezT-PezA
C    YobL-YobK
C    YokI-YokJ
C    YqcG-YqcF
C    YxiD-YxxD
C    FitB-FitA
D      Rmet_4008 putative PilT-like protein	K07062 fitB; toxin FitB [EC:3.1.-.-] 
C    BC_0920-BC_0921
C    Type II TA system related factors
D      Rmet_3123 ftsZ; GTP-binding tubulin-like cell division protein	K03531 ftsZ; cell division protein FtsZ 
D      Rmet_0051 mreB; cell shape determining protein, MreB/MreI family	K03569 mreB; rod shape-determining protein MreB and related proteins 
D      Rmet_2519 parC; DNA topoisomerase IV, subunit A	K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] 
D      Rmet_2521 parE; DNA topoisomerase IV, subunit B	K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] 
D      Rmet_2140 gltX; glutamyl-tRNA synthetase	K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17] 
B  Type III TA system
C    AbiQ system
B  Type IV TA system
C    YeeV-YeeU
C    CptA-CptB
D      Rmet_2482 conserved hypothetical protein	K09159 cptB; antitoxin CptB 
B  Type V TA system
C    GhoT-GhoS
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A<b>DNA phosphothiolation system</b>
B  Sulfur modification proteins
C    Rmet_1025 iscS; cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
C    Rmet_5230 iscS2; cysteine desulfurase	K04487 iscS; cysteine desulfurase [EC:2.8.1.7] 
C    Rmet_6216 phosphoadenosine phosphosulfate reductase	K19170 dndC; DNA sulfur modification protein DndC 
C    Rmet_6014 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase	K19170 dndC; DNA sulfur modification protein DndC 
B  DNA phosphorothioation-dependent restriction proteins
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#Last updated: November 7, 2023