+D Protein KO
#
Membrane Trafficking - Saccharomyces cerevisiae (budding yeast)
%
!
AExocytosis
B Calcium ion-dependent exocytosis
C Synaptotagmins
C Septins
D YLR314C CDC3; septin CDC3 K16944 SEPT7; septin 7
C DOC-2 proteins
C Acrosomal exocytosis proteins
D YDR466W PKH3; protein kinase PKH3 K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
D YDR490C PKH1; serine/threonine protein kinase PKH1 K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
D YOL100W PKH2; serine/threonine protein kinase PKH2 K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
C Phospholipases
D YPL268W PLC1; phosphatidylinositol phospholipase C K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
D YKR031C SPO14; phospholipase D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
C Kinases and associated proteins
D YDR208W MSS4; 1-phosphatidylinositol-4-phosphate 5-kinase K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D YHL007C STE20; mitogen-activated protein kinase kinase kinase kinase STE20 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
D YKL067W YNK1; nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D YDR122W KIN1; serine/threonine protein kinase KIN1 K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
D YLR096W KIN2; serine/threonine protein kinase KIN2 K19852 KIN1_2; serine/threonine protein kinase KIN1/2 [EC:2.7.11.1]
C Others
D YDR373W FRQ1; frequenin K19932 NCS1; neuronal calcium sensor
B Small GTPases and associated proteins
C Rab GTPases
D YFL005W SEC4; Rab family GTPase SEC4 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
D YBR109C CMD1; calmodulin K02183 CALM; calmodulin
D YNL272C SEC2; guanine nucleotide exchange factor SEC2 K19940 SEC2; Rab guanine nucleotide exchange factor SEC2
D YDR164C SEC1; Sec1p K15292 STXBP1; syntaxin-binding protein 1
D YBL106C SRO77; putative Rab GTPase-binding protein SRO77 K08518 STXBP5; syntaxin-binding protein 5
D YPR032W SRO7; Rab GTPase-binding protein SRO7 K08518 STXBP5; syntaxin-binding protein 5
D YPR017C DSS4; guanine nucleotide exchange factor DSS4 K19952 RABIF; guanine nucleotide exchange factor
D YNL293W MSB3; Rab GTPase-activating protein MSB3 K19953 GRTP1; TBC1 domain family member 6
D YOL112W MSB4; Rab GTPase-activating protein MSB4 K19953 GRTP1; TBC1 domain family member 6
D YGR100W MDR1; GTPase-activating protein MDR1 K19951 TBC1D8_9; TBC1 domain family member 8/9
D YDR244W PEX5; Pex5p K13342 PEX5; peroxin-5
D YOR370C MRS6; GTPase-activating protein MRS6 K23460 CHM; Rab proteins geranylgeranyltransferase component A
D YJL031C BET4; Rab geranylgeranyltransferase BET4 K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D YPR176C BET2; Rab geranylgeranyltransferase BET2 K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D YJR033C RAV1; Rav1p K24155 DMXL; rabconnectin-3a
C Rho GTPases
D YLR229C CDC42; Rho family GTPase CDC42 K04393 CDC42; cell division control protein 42
C Other small GTPases and associated proteins
B Tethering complex
C Exocyst complex
D YER008C SEC3; GTP-Rho binding exocyst subunit SEC3 K19983 EXOC1; exocyst complex component 1
D YDR166C SEC5; exocyst subunit SEC5 K17637 EXOC2; exocyst complex component 2
D YIL068C SEC6; SNARE-binding exocyst subunit SEC6 K06110 EXOC3; exocyst complex component 3
D YPR055W SEC8; exocyst subunit SEC8 K06111 EXOC4; exocyst complex component 4
D YLR166C SEC10; exocyst subunit SEC10 K19984 EXOC5; exocyst complex component 5
D YGL233W SEC15; Rab GTPase-binding exocyst subunit SEC15 K19985 EXOC6; exocyst complex component 6
D YJL085W EXO70; GTP-Rho binding exocyst subunit EXO70 K07195 EXOC7; exocyst complex component 7
D YBR102C EXO84; exocyst subunit EXO84 K19986 EXOC8; exocyst complex component 8
C Exocyst complex assembly proteins
D YDR363W-A SEM1; proteasome regulatory particle lid subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
D YIL138C TPM2; tropomyosin TPM2 K17945 TPM1_2; tropomyosin, fungi type
D YNL079C TPM1; tropomyosin TPM1 K17945 TPM1_2; tropomyosin, fungi type
B Others
C Exomer complex
D YLR330W CHS5; Chs5p K19877 CHS5; chitin biosynthesis protein CHS5
D YKR027W BCH2; Bch2p K19880 CHS6; Chs5-Arf1p-binding protein CHS6/BCH2
D YJL099W CHS6; Chs6p K19880 CHS6; Chs5-Arf1p-binding protein CHS6/BCH2
D YMR237W BCH1; exomer complex subunit K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
D YOR299W BUD7; exomer complex subunit K19881 BUD7; Chs5-Arf1p-binding protein BUD7/BCH1
C Others
D YNR049C MSO1; Mso1p K19992 MSO1; protein MSO1
D YDR323C PEP7; phosphatidylinositol-3-phosphate binding protein K12481 RBSN; rabenosyn-5
D YJL145W SFH5; Sfh5p K19996 SFH5; phosphatidylinositol transfer protein SFH5
#
ASNARE
B Syntaxin (Qa)
C Stx-PM
D YMR183C SSO2; syntaxin K08486 STX1B_2_3; syntaxin 1B/2/3
D YPL232W SSO1; syntaxin K08486 STX1B_2_3; syntaxin 1B/2/3
C Stx-Endo
D YOR106W VAM3; SNAP receptor VAM3 K21155 VAM3; syntaxin VAM3
C Stx-TGN / EE
D YOL018C TLG2; Tlg2p K08489 STX16; syntaxin 16
C Stx-cisGolgi
D YLR026C SED5; t-SNARE syntaxin K08490 STX5; syntaxin 5
C Stx-sER
C Stx-rER
D YOR075W UFE1; Ufe1p K08492 STX18; syntaxin 18
B SNAP-25[N] (Qb)
C Vti1
D YMR197C VTI1; v-SNARE protein VTI1 K08493 VTI1; vesicle transport through interaction with t-SNAREs 1
C NPSN
C Gos1 (Gos28)
D YHL031C GOS1; Gos1p K08495 GOSR1; golgi SNAP receptor complex member 1
C Bos1 / Membrin
D YLR078C BOS1; Bos1p K08496 GOSR2; golgi SNAP receptor complex member 2
C Sec20
D YDR498C SEC20; Sec20p K08497 SEC20; protein transport protein SEC20
B SNAP-25[C] (Qc)
C STX6
D YDR468C TLG1; Tlg1p K08499 TLG1; member of the syntaxin family of t-SNAREs
C STX8
D YAL014C SYN8; syntaxin K08501 STX8; syntaxin 8
D YGL212W VAM7; Vam7p K08502 VAM7; regulator of vacuolar morphogenesis
C STX10
C Bet1
D YIL004C BET1; Bet1p K08504 BET1; blocked early in transport 1
C Sft1
D YKL006C-A SFT1; Sft1p K08505 SFT1; protein transport protein SFT1
C Syp7
C Use1
D YGL098W USE1; SNAP receptor USE1 K08507 USE1; unconventional SNARE in the endoplasmic reticulum protein 1
B SNAP-25 (Qb,c)
C SNAP-23
C SNAP-25
D YGR009C SEC9; Sec9p K19950 SEC9; protein transport protein SEC9
C SNAP-29
C SNAP-47
B VAMP, Ykt6, Sec22 (R)
C VAMP
D YAL030W SNC1; SNAP receptor SNC1 K08513 VAMP4; vesicle-associated membrane protein 4
D YOR327C SNC2; SNAP receptor SNC2 K08513 VAMP4; vesicle-associated membrane protein 4
D YLR093C NYV1; Nyv1p K08564 NYV1; vacuolar v-SNARE NYV1
C Ykt6
D YKL196C YKT6; palmitoyltransferase YKT6 K08516 YKT6; synaptobrevin homolog YKT6
C Sec22
D YLR268W SEC22; SNAP receptor SEC22 K08517 SEC22; vesicle transport protein SEC22
C Tomosyn
D YBL106C SRO77; putative Rab GTPase-binding protein SRO77 K08518 STXBP5; syntaxin-binding protein 5
D YPR032W SRO7; Rab GTPase-binding protein SRO7 K08518 STXBP5; syntaxin-binding protein 5
C Putative SNAREs
B SNARE associated proteins
C Syntaxin-binding proteins
D YDR164C SEC1; Sec1p K15292 STXBP1; syntaxin-binding protein 1
D YDR189W SLY1; syntaxin-binding protein K19998 SCFD1; sec1 family domain-containing protein 1
C Palmitoyltransferases
D YNL326C PFA3; palmitoyltransferase PFA3 K20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]
D YDR126W SWF1; palmitoyltransferase SWF1 K20003 ZDHHC4; palmitoyltransferase ZDHHC4 [EC:2.3.1.225]
D YDR264C AKR1; palmitoyltransferase AKR1 K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
D YOR034C AKR2; putative palmitoyltransferase AKR2 K20032 ZDHHC13_17; palmitoyltransferase ZDHHC13/17 [EC:2.3.1.225]
C Others
D YBR080C SEC18; AAA family ATPase SEC18 K06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]
D YBL050W SEC17; Sec17p K15296 NAPA; alpha-soluble NSF attachment protein
D YJL036W SNX4; Snx4p K17919 SNX4; sorting nexin-4
D YDL113C ATG20; Atg20p K21996 SNX41_42; sorting nexin-41/42
D YDR425W SNX41; Snx41p K21996 SNX41_42; sorting nexin-41/42
D YDR372C VPS74; Vps74p K15620 GOLPH3; golgi phosphoprotein 3
D YDL126C CDC48; AAA family ATPase CDC48 K13525 VCP; transitional endoplasmic reticulum ATPase
D YBL058W SHP1; protein phosphatase regulator SHP1 K14012 NSFL1C; UBX domain-containing protein 1
D YOR359W VTS1; Vts1p K27407 VTS1; RNA-binding protein VTS1
#
AEndocytosis
B Clathrin-mediated endocytosis
C Clathrin
D YGL206C CHC1; clathrin heavy chain K04646 CLTC; clathrin heavy chain
C Dynamin
D YLL001W DNM1; dynamin-related GTPase DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
C AP-2 complex
D YBL037W APL3; Apl3p K11824 AP2A; AP-2 complex subunit alpha
D YJR005W APL1; Apl1p K11825 AP2B1; AP-2 complex subunit beta-1
D YOL062C APM4; Apm4p K11826 AP2M1; AP-2 complex subunit mu-1
D YJR058C APS2; Aps2p K11827 AP2S1; AP-2 complex subunit sigma-1
C Other core components
D YCR030C SYP1; Syp1p K20042 FCHO; F-BAR domain only protein
D YLR206W ENT2; epsin K12471 EPN; epsin
D YDL161W ENT1; epsin K12471 EPN; epsin
D YJR125C ENT3; Ent3p K12471 EPN; epsin
D YDR153C ENT5; Ent5p K12471 EPN; epsin
D YBL047C EDE1; Ede1p K12472 EPS15; epidermal growth factor receptor substrate 15
D YHR161C Yap1801p K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D YGR241C Yap1802p K20044 PICALM; phosphatidylinositol-binding clathrin assembly protein
D YDR388W RVS167; amphiphysin K12562 AMPH; amphiphysin
D YBL007C SLA1; cytoskeletal protein-binding protein SLA1 K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D YIR006C PAN1; Pan1p K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D YNL084C END3; End3p K20048 END3; actin cytoskeleton-regulatory complex protein END3
D YLL024C SSA2; Hsp70 family chaperone SSA2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YAL005C SSA1; Hsp70 family ATPase SSA1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YER103W SSA4; Hsp70 family chaperone SSA4 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YBL075C SSA3; Hsp70 family ATPase SSA3 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YNL209W SSB2; Hsp70 family ATPase SSB2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YDL229W SSB1; Hsp70 family ATPase SSB1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
C Low-density lipoprotein receptor (LDLR) family proteins
C LDLR adaptor proteins
D YDR208W MSS4; 1-phosphatidylinositol-4-phosphate 5-kinase K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
C GPCR adaptor proteins
D YOR322C LDB19; Ldb19p K20059 LDB19; arrestin-related trafficking adapter 1
D YBL101C ECM21; Ecm21p K20060 ECM21; arrestin-related trafficking adapter 2/8
D YPR030W CSR2; Csr2p K20060 ECM21; arrestin-related trafficking adapter 2/8
D YJL084C ALY2; Aly2p K20061 ALY1_2; arrestin-related trafficking adapter 3/6
D YKR021W ALY1; Aly1p K20061 ALY1_2; arrestin-related trafficking adapter 3/6
D YFR022W ROG3; Rog3p K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D YGR068C ART5; Art5p K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D YOR018W ROD1; Rod1p K20062 ART4_5_7; arrestin-related trafficking adapter 4/5/7
D YGL045W RIM8; Rim8p K20063 RIM8; arrestin-related trafficking adapter 9
C Receptor tyrosine kinase (RTK) adaptor proteins
C Inositol 5-phosphatases
D YIL002C INP51; phosphoinositide 5-phosphatase INP51 K20279 SYNJ; synaptojanin [EC:3.1.3.36]
D YNL106C INP52; phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52 K20279 SYNJ; synaptojanin [EC:3.1.3.36]
D YOR109W INP53; phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 K20279 SYNJ; synaptojanin [EC:3.1.3.36]
C Kinases
D YIL095W PRK1; serine/threonine protein kinase PRK1 K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D YNL020C ARK1; serine/threonine protein kinase ARK1 K08853 AAK; AP2-associated kinase [EC:2.7.11.1]
D YGL083W SCY1; Scy1p K17541 SCYL2; SCY1-like protein 2
C Ubiquitin E3 ligases
D YER125W RSP5; NEDD4 family E3 ubiquitin-protein ligase K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C Others
D YNL243W SLA2; Sla2p K20040 HIP1R; huntingtin-interacting protein 1-related protein
D YAL058W CNE1; calnexin K08054 CANX; calnexin
B Lipid raft mediated endocytosis
C Caveolin-mediated endocytosis
D YLL001W DNM1; dynamin-related GTPase DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
D YBL105C PKC1; protein kinase C K02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]
C Flotillin-dependent endocytosis
C GRAF1-dependent endocytosis
D YLR229C CDC42; Rho family GTPase CDC42 K04393 CDC42; cell division control protein 42
D YDL192W ARF1; Arf family GTPase ARF1 K07937 ARF1_2; ADP-ribosylation factor 1/2
D YDL137W ARF2; Arf family GTPase ARF2 K07937 ARF1_2; ADP-ribosylation factor 1/2
C Arf6-dependent endocytosis
D YOR094W ARF3; Arf family GTPase ARF3 K07941 ARF6; ADP-ribosylation factor 6
C RhoA-dependent endocytosis
D YPR165W RHO1; Rho family GTPase RHO1 K04513 RHOA; Ras homolog gene family, member A
D YLL001W DNM1; dynamin-related GTPase DNM1 K17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]
B Phagocytosis
C Fc receptors
C Integrins (complement receptors)
C Opsonins
C Toll-like receptors
C C-lectin receptors
C Scavenger receptors
C Coronins
C Others
D YKL129C MYO3; myosin 3 K10356 MYO1; myosin I
D YMR109W MYO5; myosin 5 K10356 MYO1; myosin I
B Macropinocytosis
C Ras GTPases
D YNL098C RAS2; Ras family GTPase RAS2 K07827 KRAS; GTPase KRas
D YOR101W RAS1; Ras family GTPase RAS1 K07827 KRAS; GTPase KRas
D YLR229C CDC42; Rho family GTPase CDC42 K04393 CDC42; cell division control protein 42
C Kinases
D YLR240W VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D YFR019W FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D YHL007C STE20; mitogen-activated protein kinase kinase kinase kinase STE20 K04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]
C Phospholipase C
D YPL268W PLC1; phosphatidylinositol phospholipase C K05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]
C Sorting nexins
D YOR069W VPS5; sorting nexin 1 K17917 SNX1_2; sorting nexin-1/2
C Others
B Bin/Amphiphysin/Rvs (BAR) family proteins
C N-BAR proteins
D YDR388W RVS167; amphiphysin K12562 AMPH; amphiphysin
D YCR009C RVS161; amphiphysin-like protein RVS161 K20120 BIN3; bridging integrator 3
C F-BAR proteins
D YHR114W BZZ1; Bzz1p K20121 FNBP1; formin-binding protein 1
D YCR030C SYP1; Syp1p K20042 FCHO; F-BAR domain only protein
D YBR260C RGD1; GTPase-activating protein RGD1 K20643 RGD1; Rho GTPase-activating protein RGD1
C I-BAR proteins
B Rab GTPases and associated proteins
C Rab GTPases
D YKR014C YPT52; Rab family GTPase YPT52 K07889 RAB5C; Ras-related protein Rab-5C
D YOR089C VPS21; Rab family GTPase VPS21 K07889 RAB5C; Ras-related protein Rab-5C
C Rab associated proteins
D YML097C VPS9; guanine nucleotide exchange factor VPS9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D YDR323C PEP7; phosphatidylinositol-3-phosphate binding protein K12481 RBSN; rabenosyn-5
D YLR240W VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D YBR097W VPS15; ubiquitin-binding serine/threonine protein kinase VPS15 K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D YGL095C VPS45; Vps45p K12479 VPS45; vacuolar protein sorting-associated protein 45
B Arf GTPases and associated proteins
C Arf GTPases
D YDL192W ARF1; Arf family GTPase ARF1 K07937 ARF1_2; ADP-ribosylation factor 1/2
D YDL137W ARF2; Arf family GTPase ARF2 K07937 ARF1_2; ADP-ribosylation factor 1/2
D YOR094W ARF3; Arf family GTPase ARF3 K07941 ARF6; ADP-ribosylation factor 6
C Arf associated proteins
D YIL044C AGE2; GTPase-activating protein AGE2 K12486 SMAP; stromal membrane-associated protein
D YGL181W GTS1; Gts1p K12486 SMAP; stromal membrane-associated protein
B Others
C Fucosyltransferase
C EFR3-PI4KIII alpha complex and associated proteins
D YLR305C STT4; 1-phosphatidylinositol 4-kinase STT4 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D YMR212C EFR3; Efr3p K21842 EFR3; protein EFR3
D YGR198W YPP1; Ypp1p K21845 YPP1; cargo-transport protein YPP1
C Insulin-like growth factor-binding proteins
C Others
#
AEndosome - Lysosome transport
B Rab GTPases and associated proteins
C Rab GTPases
D YKR014C YPT52; Rab family GTPase YPT52 K07889 RAB5C; Ras-related protein Rab-5C
D YOR089C VPS21; Rab family GTPase VPS21 K07889 RAB5C; Ras-related protein Rab-5C
D YML001W YPT7; Rab family GTPase YPT7 K07897 RAB7A; Ras-related protein Rab-7A
C Retromer subcomplex
D YJL154C VPS35; retromer subunit VPS35 K18468 VPS35; vacuolar protein sorting-associated protein 35
D YHR012W VPS29; retromer subunit VPS29 K18467 VPS29; vacuolar protein sorting-associated protein 29
D YJL053W PEP8; retromer subunit PEP8 K18466 VPS26A_B; vacuolar protein sorting-associated protein 26A/B
C FTS/Hook/FHIP (FHF) complex
C Rab associated proteins
D YLR240W VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D YOL038W PRE6; proteasome core particle subunit alpha 4 K02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
D YJL044C GYP6; GTPase-activating protein GYP6 K18469 TBC1D5; TBC1 domain family member 5
D YDL234C GYP7; GTPase-activating protein GYP7 K20168 TBC1D15; TBC1 domain family member 15
D YOR370C MRS6; GTPase-activating protein MRS6 K23460 CHM; Rab proteins geranylgeranyltransferase component A
D YJL031C BET4; Rab geranylgeranyltransferase BET4 K14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
D YPR176C BET2; Rab geranylgeranyltransferase BET2 K05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
D YDR372C VPS74; Vps74p K15620 GOLPH3; golgi phosphoprotein 3
B Arf GTPases and associated proteins
C Arf GTPases
C BLOC-one-related complex (BORC)
C N-acetyl transferase complex C (NatC)
D YPR051W MAK3; peptide alpha-N-acetyltransferase MAK3 K00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]
D YEL053C MAK10; Mak10p K20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit
D YCR020C-A MAK31; Mak31p K20824 NAA38; N-alpha-acetyltransferase 38, NatC auxiliary subunit
C Other Arf associated proteins
B Endosomal sorting complexes required for transport (ESCRT)
C ESCRT-0 complex
D YNR006W VPS27; ESCRT-0 subunit protein VPS27 K12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate
D YHL002W HSE1; ESCRT-0 subunit protein HSE1 K04705 STAM; signal transducing adaptor molecule
C ESCRT-I complex
D YCL008C STP22; ubiquitin-binding ESCRT-I subunit protein STP22 K12183 TSG101; ESCRT-I complex subunit TSG101
D YPL065W VPS28; ESCRT-I subunit protein VPS28 K12184 VPS28; ESCRT-I complex subunit VPS28
D YGR206W MVB12; ubiquitin-binding ESCRT-I subunit protein MVB12 K12187 MVB12; ESCRT-I complex subunit MVB12
C ESCRT-II complex
D YPL002C SNF8; ESCRT-II subunit protein SNF8 K12188 SNF8; ESCRT-II complex subunit VPS22
D YJR102C VPS25; ESCRT-II subunit protein VPS25 K12189 VPS25; ESCRT-II complex subunit VPS25
D YLR417W VPS36; ESCRT-II subunit protein VPS36 K12190 VPS36; ESCRT-II complex subunit VPS36
C ESCRT-III complex
D YKR035W-A DID2; Did2p K12197 CHMP1; charged multivesicular body protein 1
D YKL002W DID4; ESCRT-III subunit protein DID4 K12191 CHMP2A; charged multivesicular body protein 2A
D YKL041W VPS24; ESCRT-III subunit protein VPS24 K12193 VPS24; charged multivesicular body protein 3
D YLR025W SNF7; ESCRT-III subunit protein SNF7 K12194 CHMP4A_B; charged multivesicular body protein 4A/B
D YDR486C VPS60; Vps60p K12198 CHMP5; charged multivesicular body protein 5
D YMR077C VPS20; ESCRT-III subunit protein VPS20 K12195 CHMP6; charged multivesicular body protein 6
D YJL049W CHM7; Chm7p K15053 CHMP7; charged multivesicular body protein 7
D YPR173C VPS4; AAA family ATPase VPS4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
C ESCRT associated proteins
D YLR181C VTA1; Vta1p K12199 VTA1; vacuolar protein sorting-associated protein VTA1
D YOR275C RIM20; Rim20p K12200 PDCD6IP; programmed cell death 6-interacting protein
B Tethering complex
C CORVET complex
D YDR495C VPS3; CORVET complex subunit VPS3 K20177 VPS3; vacuolar protein sorting-associated protein 3
D YAL002W VPS8; CORVET complex membrane-binding subunit VPS8 K20178 VPS8; vacuolar protein sorting-associated protein 8
D YMR231W PEP5; tethering complex subunit PEP5 K20179 VPS11; vacuolar protein sorting-associated protein 11
D YPL045W VPS16; tethering complex subunit VPS16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D YLR148W PEP3; tethering complex subunit PEP3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D YLR396C VPS33; tethering complex ATP-binding subunit VPS33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
C Hops complex
D YMR231W PEP5; tethering complex subunit PEP5 K20179 VPS11; vacuolar protein sorting-associated protein 11
D YPL045W VPS16; tethering complex subunit VPS16 K20180 VPS16; vacuolar protein sorting-associated protein 16
D YLR148W PEP3; tethering complex subunit PEP3 K20181 VPS18; vacuolar protein sorting-associated protein 18
D YLR396C VPS33; tethering complex ATP-binding subunit VPS33 K20182 VPS33A; vacuolar protein sorting-associated protein 33A
D YDL077C VAM6; Vam6p K20183 VPS39; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
D YDR080W VPS41; Vps41p K20184 VPS41; vacuolar protein sorting-associated protein 41
B Acidification regulators
C Rabconnectin-3 complex
D YJR033C RAV1; Rav1p K24155 DMXL; rabconnectin-3a
C RAVE complex
D YJR033C RAV1; Rav1p K24155 DMXL; rabconnectin-3a
D YDR202C RAV2; Rav2p K25485 RAV2; regulator of V-ATPase in vacuolar membrane protein 2
D YDR328C SKP1; SCF ubiquitin ligase subunit SKP1 K03094 SKP1; S-phase kinase-associated protein 1
B Others
C AP-3 complex
D YPL195W APL5; Apl5p K12396 AP3D; AP-3 complex subunit delta
D YGR261C APL6; Apl6p K12397 AP3B; AP-3 complex subunit beta
D YBR288C APM3; Apm3p K12398 AP3M; AP-3 complex subunit mu
D YJL024C APS3; Aps3p K12399 AP3S; AP-3 complex subunit sigma
C BLOC-1 complex
C BLOC-1 complex (yeast)
D YKL061W BLI1; Bli1p K22238 BLI1; biogenesis of lysosome-related organelles complex 1 subunit BLI1
D YLR408C BLS1; Bls1p K22239 BLS1; biogenesis of lysosome-related organelles complex 1 subunit BLS1
D YDR357C CNL1; Cnl1p K22240 CNL1; biogenesis of lysosome-related organelles complex 1 subunit CNL1
D YNL086W SNN1; Snn1p K22241 SNN1; biogenesis of lysosome-related organelles complex 1 subunit SNN1
D YEL005C VAB2; Vab2p K22242 VAB2; biogenesis of lysosome-related organelles complex 1 subunit VAB2
D YGL079W KXD1; Kxd1p K22243 KXD1; biogenesis of lysosome-related organelles complex 1 subunit KXD1
C BLOC-2 complex
C BLOC-3 complex
C Ferlins
C Others
D YGL124C MON1; Mon1p K20195 MON1; vacuolar fusion protein MON1
D YBR131W CCZ1; Ccz1p K21156 CCZ1; vacuolar fusion protein CCZ1, fungi type
D YDR069C DOA4; ubiquitin-specific protease DOA4 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D YER144C UBP5; putative ubiquitin-specific protease UBP5 K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D YKR001C VPS1; dynamin-like GTPase VPS1 K23481 VPS1; vacuolar protein sorting-associated protein 1
D YCR032W BPH1; Bph1p K24781 BPH1; beige protein homolog 1
#
AProtein recycling
B Rab GTPases and associated proteins
C Rab GTPases
D YGL210W YPT32; Rab family GTPase YPT32 K07905 RAB11B; Ras-related protein Rab-11B
D YER031C YPT31; Rab family GTPase YPT31 K07905 RAB11B; Ras-related protein Rab-11B
C Rab4 associated proteins
D YDR323C PEP7; phosphatidylinositol-3-phosphate binding protein K12481 RBSN; rabenosyn-5
D YJL036W SNX4; Snx4p K17919 SNX4; sorting nexin-4
C Rab11 associated proteins
D YMR102C LAF1; Laf1p K20241 WDR44; WD repeat-containing protein 44
D YLR208W SEC13; GTPase-activating protein SEC13 K14004 SEC13; protein transport protein SEC13
D YGL233W SEC15; Rab GTPase-binding exocyst subunit SEC15 K19985 EXOC6; exocyst complex component 6
D YPL249C GYP5; GTPase-activating protein GYP5 K20242 EVI5; ecotropic viral integration site 5 protein
D YDR372C VPS74; Vps74p K15620 GOLPH3; golgi phosphoprotein 3
C Other Rab GTPase associated proteins
D YML097C VPS9; guanine nucleotide exchange factor VPS9 K20131 RABGEF1; Rab5 GDP/GTP exchange factor
D YER095W RAD51; recombinase RAD51 K04482 RAD51; DNA repair protein RAD51
B Others
C Glutamate receptor-interacting proteins (GRIPs)
C GRIP associated proteins
C EARP complex
D YDR484W VPS52; Vps52p K20298 VPS52; vacuolar protein sorting-associated protein 52
D YJL029C VPS53; Vps53p K20299 VPS53; vacuolar protein sorting-associated protein 53
C WASH complex
D YKL007W CAP1; Cap1p K10364 CAPZA; F-actin-capping protein subunit alpha
D YIL034C CAP2; F-actin-capping protein subunit beta K10365 CAPZB; F-actin-capping protein subunit beta
C Retriever complex
D YHR012W VPS29; retromer subunit VPS29 K18467 VPS29; vacuolar protein sorting-associated protein 29
C Others
#
AEndosome - Golgi transport
B Rab GTPases and associated proteins
C Rab GTPases
D YLR262C YPT6; Rab family GTPase YPT6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D YDR372C VPS74; Vps74p K15620 GOLPH3; golgi phosphoprotein 3
D YGR100W MDR1; GTPase-activating protein MDR1 K19951 TBC1D8_9; TBC1 domain family member 8/9
D YJR134C SGM1; Sgm1p K20286 TMF1; TATA element modulatory factor
D YPL174C NIP100; Nip100p K04648 DCTN1; dynactin 1
D YLL040C VPS13; membrane morphogenesis protein VPS13 K19525 VPS13A_C; vacuolar protein sorting-associated protein 13A/C
B Arf GTPases and associated proteins
C Arf GTPases
D YDL192W ARF1; Arf family GTPase ARF1 K07937 ARF1_2; ADP-ribosylation factor 1/2
D YDL137W ARF2; Arf family GTPase ARF2 K07937 ARF1_2; ADP-ribosylation factor 1/2
D YBR164C ARL1; Arf family GTPase ARL1 K07942 ARL1; ADP-ribosylation factor-like protein 1
D YPL051W ARL3; Arf family GTPase ARL3 K07952 ARFRP1; ADP-ribosylation factor related protein 1
C Arf GTPase associated proteins
D YDL226C GCS1; GTPase-activating protein GCS1 K12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1
D YER122C GLO3; ADP-ribosylation factor GTPase-activating protein K12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2/3
D YIL044C AGE2; GTPase-activating protein AGE2 K12486 SMAP; stromal membrane-associated protein
D YGL181W GTS1; Gts1p K12486 SMAP; stromal membrane-associated protein
D YDR524C AGE1; GTPase-activating protein AGE1 K12488 ASAP; Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein
D YDR170C SEC7; Arf family guanine nucleotide exchange factor SEC7 K18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein
D YEL022W GEA2; Arf family guanine nucleotide exchange factor GEA2 K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
D YJR031C GEA1; Arf family guanine nucleotide exchange factor GEA1 K18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
B Tethering complex
C Conserved oligomeric Golgi (COG) complex
D YER157W COG3; Golgi transport complex subunit COG3 K20290 COG3; conserved oligomeric Golgi complex subunit 3
D YPR105C COG4; Golgi transport complex subunit COG4 K20291 COG4; conserved oligomeric Golgi complex subunit 4
D YNL041C COG6; Golgi transport complex subunit COG6 K20293 COG6; conserved oligomeric Golgi complex subunit 6
D YML071C COG8; Golgi transport complex subunit COG8 K20295 COG8; conserved oligomeric Golgi complex subunit 8
C GARP complex
D YKR020W VPS51; Vps51p K20297 VPS51; vacuolar protein sorting-associated protein 51
D YDR484W VPS52; Vps52p K20298 VPS52; vacuolar protein sorting-associated protein 52
D YJL029C VPS53; Vps53p K20299 VPS53; vacuolar protein sorting-associated protein 53
D YDR027C VPS54; Vps54p K17600 VPS54; vacuolar protein sorting-associated protein 54
C TRAPP complex II
D YML077W BET5; TRAPP subunit BET5 K20300 TRAPPC1; trafficking protein particle complex subunit 1
D YBR254C TRS20; TRAPP subunit TRS20 K20301 TRAPPC2; trafficking protein particle complex subunit 2
D YKR068C BET3; TRAPP complex core subunit BET3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D YDR246W TRS23; TRAPP subunit TRS23 K20303 TRAPPC4; trafficking protein particle complex subunit 4
D YDR472W TRS31; TRAPP subunit TRS31 K20280 TRAPPC5; trafficking protein particle complex subunit 5
D YOR115C TRS33; Trs33p K20304 TRAPPC6; trafficking protein particle complex subunit 6
D YDR108W TRS85; Trs85p K20305 TRAPPC8; trafficking protein particle complex subunit 8
D YDR407C TRS120; Trs120p K20306 TRAPPC9; trafficking protein particle complex subunit 9
D YMR218C TRS130; transport protein particle complex II subunit TRS130 K20307 TRAPPC10; trafficking protein particle complex subunit 10
D YGR166W TRS65; Trs65p K20311 TRS65; trafficking protein particle complex II-specific subunit 65
D YEL048C TCA17; Tca17p K20312 TCA17; TRAPP-associated protein TCA17
B Others
C AP-1 complex
D YPR029C APL4; Apl4p K12391 AP1G1; AP-1 complex subunit gamma-1
D YKL135C APL2; Apl2p K12392 AP1B1; AP-1 complex subunit beta-1
D YPL259C APM1; Apm1p K12393 AP1M; AP-1 complex subunit mu
D YLR170C APS1; Aps1p K12394 AP1S1_2; AP-1 complex subunit sigma 1/2
C AP-3 complex
D YPL195W APL5; Apl5p K12396 AP3D; AP-3 complex subunit delta
D YGR261C APL6; Apl6p K12397 AP3B; AP-3 complex subunit beta
D YBR288C APM3; Apm3p K12398 AP3M; AP-3 complex subunit mu
D YJL024C APS3; Aps3p K12399 AP3S; AP-3 complex subunit sigma
C AP-4 complex
C GGA
D YHR108W GGA2; phosphatidylinositol 4-phosphate-binding protein K12404 GGA; ADP-ribosylation factor-binding protein GGA
D YDR358W GGA1; ubiquitin-binding protein K12404 GGA; ADP-ribosylation factor-binding protein GGA
C Aftiphilin/p200/gamma-synergin complex
D YJL207C LAA1; Laa1p K24814 HEATR5; HEAT repeat-containing protein 5
C Others
D YKR031C SPO14; phospholipase D K01115 PLD1_2; phospholipase D1/2 [EC:3.1.4.4]
D YLR305C STT4; 1-phosphatidylinositol 4-kinase STT4 K00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]
D YDR208W MSS4; 1-phosphatidylinositol-4-phosphate 5-kinase K00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]
D YFR019W FAB1; 1-phosphatidylinositol-3-phosphate 5-kinase K00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]
D YJL004C SYS1; Sys1p K20318 SYS1; protein SYS1
D YBR187W GDT1; putative ribosome biosynthesis protein GDT1 K23541 TMEM165; Ca2+/H+ antiporter, TMEM165/GDT1 family
D YKL119C VPH2; Vph2p K23542 TMEM199; TMEM199 family protein
D YHR060W VMA22; Vma22p K23543 CCDC115; coiled-coil domain-containing protein 115
D YDR105C TMS1; Tms1p K23544 SERINC1; serine incorporator 1
D YOR357C SNX3; Snx3p K17918 SNX3_12; sorting nexin-3/12
D YMR004W MVP1; Mvp1p K17922 SNX8; sorting nexin-8
D YNL297C MON2; Mon2p K26678 MON2; protein MON2
D YDR141C DOP1; Dop1p K26680 DOP1; protein dopey
D YDR100W TVP15; Tvp15p K26750 TVP15; golgi apparatus membrane protein TVP15
D YMR071C TVP18; Tvp18p K26751 TVP18; golgi apparatus membrane protein TVP18
D YDR084C TVP23; Tvp23p K26752 TVP23; golgi apparatus membrane protein TVP23
D YKR088C TVP38; Tvp38p K26753 TVP38; golgi apparatus membrane protein TVP38
D YKR001C VPS1; dynamin-like GTPase VPS1 K23481 VPS1; vacuolar protein sorting-associated protein 1
#
AEndoplasmic reticulum (ER) - Golgi transport
B Forward pathways
C Coat protein complex II (COP-II)
D YPL218W SAR1; Arf family GTPase SAR1 K07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]
D YLR208W SEC13; GTPase-activating protein SEC13 K14004 SEC13; protein transport protein SEC13
D YDL195W SEC31; Sec31p K14005 SEC31; protein transport protein SEC31
D YPR181C SEC23; GTPase-activating protein SEC23 K14006 SEC23; protein transport protein SEC23
D YIL109C SEC24; COPII subunit SEC24 K14007 SEC24; protein transport protein SEC24
D YHR098C SFB3; Sfb3p K14007 SEC24; protein transport protein SEC24
D YNL049C SFB2; COPII subunit SFB2 K14007 SEC24; protein transport protein SEC24
D YCR067C SED4; GTPase-activating protein SED4 K14003 PREB; prolactin regulatory element-binding protein
D YNR026C SEC12; Sar family guanine nucleotide exchange factor SEC12 K14003 PREB; prolactin regulatory element-binding protein
D YPL085W SEC16; Sec16p K20353 SEC16; COPII coat assembly protein SEC16
C TRAPP complex I
D YML077W BET5; TRAPP subunit BET5 K20300 TRAPPC1; trafficking protein particle complex subunit 1
D YBR254C TRS20; TRAPP subunit TRS20 K20301 TRAPPC2; trafficking protein particle complex subunit 2
D YKR068C BET3; TRAPP complex core subunit BET3 K20302 TRAPPC3; trafficking protein particle complex subunit 3
D YDR246W TRS23; TRAPP subunit TRS23 K20303 TRAPPC4; trafficking protein particle complex subunit 4
D YDR472W TRS31; TRAPP subunit TRS31 K20280 TRAPPC5; trafficking protein particle complex subunit 5
D YOR115C TRS33; Trs33p K20304 TRAPPC6; trafficking protein particle complex subunit 6
C p24 family proteins
D YAR002C-A ERP1; Erp1p K20346 TMED4_9_11; p24 family protein alpha
D YHR110W ERP5; Erp5p K20346 TMED4_9_11; p24 family protein alpha
D YGL002W ERP6; Erp6p K20346 TMED4_9_11; p24 family protein alpha
D YGL200C EMP24; Emp24p K20347 TMED2; p24 family protein beta-1
D YAL007C ERP2; Erp2p K14825 TMED5; p24 family protein gamma-2
D YOR016C ERP4; Erp4p K14825 TMED5; p24 family protein gamma-2
D YML012W ERV25; Erv25p K20352 TMED10; p24 family protein delta-1
C PDI family proteins
D YCL043C PDI1; protein disulfide isomerase PDI1 K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D YDR518W EUG1; protein disulfide isomerase EUG1 K09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]
D YOR288C MPD1; protein disulfide isomerase MPD1 K09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]
C Rab GTPases
D YFL038C YPT1; Rab family GTPase YPT1 K07874 RAB1A; Ras-related protein Rab-1A
C Rab associated proteins
D YNL044W YIP3; Yip3p K20359 RABAC1; PRA1 family protein 1
D YFL027C GYP8; GTPase-activating protein GYP8 K20372 TBC1D20; TBC1 domain family member 20
D YOR070C GYP1; GTPase-activating protein GYP1 K20360 TBC1D22; TBC1 domain family member 2
D YNL263C YIF1; protein transporter YIF1 K20362 YIF1; protein transport protein YIF1
D YER074W-A YOS1; Yos1p K22939 IER3IP1; immediate early response 3-interacting protein 1
D YDL058W USO1; Uso1p K20361 USO1; intracellular protein transport protein USO1
C ER-Golgi intermediate compartment (ERGIC) proteins
D YLR080W EMP46; Emp46p K10080 LMAN1; lectin, mannose-binding 1
D YFL048C EMP47; Emp47p K10080 LMAN1; lectin, mannose-binding 1
D YLR057W MNL2; putative mannosidase MNL2 K01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]
D YJR131W MNS1; mannosyl-oligosaccharide 1,2-alpha-mannosidase K23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]
D YML067C ERV41; Erv41p K20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2
D YAL042W ERV46; Erv46p K20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3
D YBR210W ERV15; Erv15p K20368 CNIH; protein cornichon
D YGL054C ERV14; cornichon family protein K20368 CNIH; protein cornichon
D YGR284C ERV29; Erv29p K20369 ERV29; ER-derived vesicles protein
D YJL034W KAR2; Hsp70 family ATPase KAR2 K09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
B Retrieval pathways
C Coat protein complex I (COP-I)
D YDL145C COP1; coatomer subunit alpha K05236 COPA; coatomer subunit alpha
D YDR238C SEC26; coatomer subunit beta K17301 COPB1; coatomer subunit beta
D YGL137W SEC27; coatomer subunit beta' K17302 COPB2; coatomer subunit beta'
D YNL287W SEC21; coatomer subunit gamma K17267 COPG; coatomer subunit gamma
D YFR051C RET2; coatomer subunit delta K20471 COPD; coatomer subunit delta
D YIL076W SEC28; coatomer subunit epsilon K17268 COPE; coatomer subunit epsilon
D YPL010W RET3; coatomer subunit zeta K20472 COPZ; coatomer subunit zeta
C NRZ (DSL1) complex
D YGL145W TIP20; Tip20p K20474 RINT1; RAD50-interacting protein 1
D YNL258C DSL1; Dsl1p K11578 ZW10; protein transport protein DSL1/ZW10
D YLR440C SEC39; Sec39p K20475 SEC39; protein transport protein SEC39
C Golgi to ER traffic proteins (GET)
D YGL020C GET1; GET complex subunit GET1 K22384 GET1; tail-anchored protein insertion receptor
D YER083C GET2; GET complex subunit GET2 K22386 GET2; GET complex subunit GET2
D YDL100C GET3; guanine nucleotide exchange factor GET3 K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D YOR164C GET4; Get4p K23387 GET4; golgi to ER traffic protein 4
D YOL111C MDY2; Mdy2p K23388 UBL4; ubiquitin-like protein 4
C Rab GTPases
D YLR262C YPT6; Rab family GTPase YPT6 K07893 RAB6A; Ras-related protein Rab-6A
C Rab associated proteins
D YLR039C RIC1; Ric1p K20476 RIC1; RAB6A-GEF complex partner protein 1
D YDR137W RGP1; Rgp1p K20477 RGP1; RAB6A-GEF complex partner protein 2
D YBL040C ERD2; Erd2p K10949 KDELR; ER lumen protein retaining receptor
D YDR323C PEP7; phosphatidylinositol-3-phosphate binding protein K12481 RBSN; rabenosyn-5
D YOR070C GYP1; GTPase-activating protein GYP1 K20360 TBC1D22; TBC1 domain family member 2
B Others
C Oxysterol-binding proteins
D YAR042W SWH1; oxysterol-binding protein related protein SWH1 K20456 OSBP; oxysterol-binding protein 1
D YDL019C OSH2; oxysterol-binding protein related protein OSH2 K20456 OSBP; oxysterol-binding protein 1
D YHR073W OSH3; oxysterol-binding protein related protein OSH3 K20463 OSBPL3_6_7; oxysterol-binding protein-related protein 3/6/7
D YKR003W OSH6; oxysterol-binding protein OSH6 K22285 OSBPL8; oxysterol-binding protein-related protein 8
D YHR001W OSH7; oxysterol-binding protein related protein OSH7 K22285 OSBPL8; oxysterol-binding protein-related protein 8
D YPL145C KES1; oxysterol-binding protein KES1 K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
D YOR237W HES1; oxysterol-binding protein related protein HES1 K20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9/10/11
C FXYD proteins
C YIPF proteins
D YGL161C YIP5; Yip5p K22940 YIPF1_2; protein YIPF1/2
D YGR172C YIP1; transporter YIP1 K20363 YIPF5_7; protein YIPF5/7
D YGL198W YIP4; Yip4p K22943 YIPF6; protein YIPF6
C ER membrane protein complex
D YCL045C EMC1; Emc1p K23562 EMC1; ER membrane protein complex subunit 1
D YJR088C EMC2; Emc2p K23563 EMC2; ER membrane protein complex subunit 2
D YKL207W EMC3; Emc3p K23564 EMC3; ER membrane protein complex subunit 3
D YGL231C EMC4; chaperone EMC4 K23565 EMC4; ER membrane protein complex subunit 4
D YIL027C EMC5; Emc5p K23566 MMGT1; membrane magnesium transporter 1
D YLL014W EMC6; Emc6p K23567 EMC6; ER membrane protein complex subunit 6
C SEC61 complex
D YLR378C SEC61; translocon subunit SEC61 K10956 SEC61A; protein transport protein SEC61 subunit alpha
D YBR283C SSH1; Ssh1p K10956 SEC61A; protein transport protein SEC61 subunit alpha
D YER087C-B SBH1; Arf family guanine nucleotide exchange factor SBH1 K09481 SEC61B; protein transport protein SEC61 subunit beta
D YER019C-A SBH2; Arf family guanine nucleotide exchange factor SBH2 K09481 SEC61B; protein transport protein SEC61 subunit beta
D YDR086C SSS1; translocon subunit SSS1 K07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins
C TRAP complex
C Multi-pass translocon (MPT) complex
D YNR021W uncharacterized protein K24962 CCDC47; PAT complex subunit CCDC47
C Post-GPI attachment to proteins factors (PGAP)
D YFL025C BST1; Bst1p K05294 PGAP1; GPI inositol-deacylase [EC:3.-.-.-]
D YCR044C PER1; Per1p K23553 PGAP3; post-GPI attachment to proteins factor 3
D YDR182W CDC1; putative lipid phosphatase CDC1 K23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]
C Others
D YDR189W SLY1; syntaxin-binding protein K19998 SCFD1; sec1 family domain-containing protein 1
D YLR064W PER33; Per33p K20724 TMEM33; transmembrane protein 33
D YLL023C POM33; nucleoporin POM33 K20724 TMEM33; transmembrane protein 33
D YLR242C ARV1; sterol homeostasis protein ARV1 K21848 ARV1; lipid intermediate transporter
D YFR042W KEG1; Keg1p K21849 KEG1; beta-1,6-glucan synthesis-associated protein KEG1
D YPR159W KRE6; beta-glucan synthesis-associated protein KRE6 K21850 KRE6; beta-glucan synthesis-associated protein KRE6
D YGR143W SKN1; beta-glucan synthesis-associated protein SKN1 K21850 KRE6; beta-glucan synthesis-associated protein KRE6
D YDR372C VPS74; Vps74p K15620 GOLPH3; golgi phosphoprotein 3
D YNL156C NSG2; Nsg2p K26681 INSIG; insulin-induced protein
D YHR133C NSG1; Nsg1p K26681 INSIG; insulin-induced protein
D YMR292W GOT1; Got1p K26683 GOLT1; vesicle transport protein GOT1
D YOR165W SEY1; dynamin-like GTPase SEY1 K22698 SEY1; protein SEY1 [EC:3.6.5.-]
#
AAutophagy
B Autophagosome formation proteins
C ULK complex
D YPR185W ATG13; serine/threonine protein kinase regulatory subunit ATG13 K08331 ATG13; autophagy-related protein 13
C Atg1 complex
D YGL180W ATG1; serine/threonine protein kinase ATG1 K08269 ULK2; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
D YPR185W ATG13; serine/threonine protein kinase regulatory subunit ATG13 K08331 ATG13; autophagy-related protein 13
D YLR423C ATG17; protein kinase regulatory subunit ATG17 K08329 ATG17; autophagy-related protein 17
D YPL166W ATG29; Atg29p K21143 ATG29; autophagy-related protein 29
D YDR022C ATG31; Atg31p K21144 ATG31; autophagy-related protein 31
C PI3K complex
D YLR240W VPS34; phosphatidylinositol 3-kinase VPS34 K00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]
D YBR097W VPS15; ubiquitin-binding serine/threonine protein kinase VPS15 K08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
D YBR128C ATG14; Atg14p K08335 ATG14; autophagy-related protein 14
D YPL120W VPS30; beclin 1 K08334 BECN; beclin
D YLR211C ATG38; Atg38p K21145 ATG38; autophagy-related protein 38
C ATG9 transmembrane protein
D YDL149W ATG9; autophagy protein ATG9 K17907 ATG9; autophagy-related protein 9
C Atg18-Atg2 complex
D YFR021W ATG18; phosphoinositide binding protein ATG18 K17908 WIPI1_2; autophagy-related protein 18
D YPL100W ATG21; Atg21p K17908 WIPI1_2; autophagy-related protein 18
D YNL242W ATG2; Atg2p K17906 ATG2; autophagy-related protein 2
C Atg12 conjugation proteins
D YBR217W ATG12; Atg12p K08336 ATG12; ubiquitin-like protein ATG12
D YHR171W ATG7; Atg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D YLL042C ATG10; E2-like conjugating enzyme K08338 ATG10; ubiquitin-like-conjugating enzyme ATG10
D YPL149W ATG5; Atg5p K08339 ATG5; autophagy-related protein 5
D YMR159C ATG16; Atg16p K08340 ATG16; autophagy-related protein 16
C Atg8 conjugation proteins
D YBL078C ATG8; ubiquitin-like protein ATG8 K08341 GABARAP; GABA(A) receptor-associated protein
D YNL223W ATG4; cysteine protease ATG4 K08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]
D YHR171W ATG7; Atg7p K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
D YNR007C ATG3; Atg3p K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
B Cytoplasm to vacuolar targeting (CVT) pathway
C Selective cargos
D YKL103C APE1; metalloaminopeptidase APE1 K01268 LAP4; aminopeptidase I [EC:3.4.11.22]
D YGL156W AMS1; alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D YHR113W APE4; aspartyl aminopeptidase K01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]
C Cargo receptors
D YOL082W ATG19; Atg19p K21997 ATG19_34; autophagy-related protein 19/34
D YOL083W ATG34; Atg34p K21997 ATG19_34; autophagy-related protein 19/34
C Scaffold protein
D YPR049C ATG11; autophagy protein ATG11 K08330 ATG11; autophagy-related protein 11
C Other Cvt associated proteins
D YDL113C ATG20; Atg20p K21996 SNX41_42; sorting nexin-41/42
D YDR425W SNX41; Snx41p K21996 SNX41_42; sorting nexin-41/42
D YJL036W SNX4; Snx4p K17919 SNX4; sorting nexin-4
D YCR068W ATG15; triglyceride lipase ATG15 K17900 ATG15; lipase ATG15 [EC:3.1.1.3]
D YLR431C ATG23; Atg23p K17909 ATG23; autophagy-related protein 23
D YJL178C ATG27; Atg27p K21141 ATG27; autophagy-related protein 27
D YEL013W VAC8; protein anchor VAC8 K08332 VAC8; vacuolar protein 8
B Mitophagy
C Cargo receptors
D YIL146C ATG32; mitophagy protein ATG32 K17984 ATG32; autophagy-related protein 32
C Scaffold proteins
D YPR049C ATG11; autophagy protein ATG11 K08330 ATG11; autophagy-related protein 11
C PINK1-Parkin associated proteins
D YBR179C FZO1; mitofusin K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C Other mitophagy associated proteins
D YGL253W HXK2; hexokinase 2 K00844 HK; hexokinase [EC:2.7.1.1]
D YFR053C HXK1; hexokinase 1 K00844 HK; hexokinase [EC:2.7.1.1]
D YCL040W GLK1; glucokinase K00844 HK; hexokinase [EC:2.7.1.1]
D YDR516C EMI2; putative glucokinase K00844 HK; hexokinase [EC:2.7.1.1]
D YLR446W NGK1; hexokinase K00844 HK; hexokinase [EC:2.7.1.1]
D YDL130W-A STF1; ATPase-binding protein K22255 ATPIF1; ATPase inhibitor, mitochondrial
D YDL181W INH1; ATPase inhibitor K22255 ATPIF1; ATPase inhibitor, mitochondrial
D YNL070W TOM7; Tom7p K17771 TOM7; mitochondrial import receptor subunit TOM7
D YLR356W ATG33; Atg33p K19717 ATG33; autophagy-related protein 33
B Pexophagy
C Selective cargos
D YDR329C PEX3; Pex3p K13336 PEX3; peroxin-3
D YGL153W PEX14; Pex14p K13343 PEX14; peroxin-14
C Cargo receptors
D YJL185C ATG36; Atg36p K22258 ATG36; autophagy-related protein 36
C Other pexophagy associated proteins
D YKL197C PEX1; AAA family ATPase peroxin 1 K13338 PEX1; peroxin-1
D YNL329C PEX6; AAA family ATPase peroxin 6 K13339 PEX6; peroxin-6
D YOL044W PEX15; Pex15p K22260 PEX15; peroxin-15
B Aggrephagy
C Cargo receptors
C Scaffold proteins
C Other aggrephagy associated proteins
D YDL126C CDC48; AAA family ATPase CDC48 K13525 VCP; transitional endoplasmic reticulum ATPase
D YNL021W HDA1; histone deacetylase HDA1 K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
B Xenophagy
C Cargo receptors
C Other xenophagy associated proteins
B Chaperone mediated autophagy (CMA)
C Selective cargos
D YLR027C AAT2; aspartate transaminase AAT2 K14454 GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
D YGR192C TDH3; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D YJL052W TDH1; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D YJR009C TDH2; glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D YDL021W GPM2; phosphoglycerate mutase family protein GPM2 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D YKL152C GPM1; phosphoglycerate mutase GPM1 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D YOL056W GPM3; phosphoglycerate mutase family protein GPM3 K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D YAL038W CDC19; pyruvate kinase CDC19 K00873 PK; pyruvate kinase [EC:2.7.1.40]
D YOR347C PYK2; pyruvate kinase PYK2 K00873 PK; pyruvate kinase [EC:2.7.1.40]
D YMR276W DSK2; ubiquitin domain-containing protein DSK2 K04523 UBQLN; ubiquilin
C Cargo receptors
C Chaperones
D YLL024C SSA2; Hsp70 family chaperone SSA2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YAL005C SSA1; Hsp70 family ATPase SSA1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YER103W SSA4; Hsp70 family chaperone SSA4 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YBL075C SSA3; Hsp70 family ATPase SSA3 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YNL209W SSB2; Hsp70 family ATPase SSB2 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YDL229W SSB1; Hsp70 family ATPase SSB1 K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
D YPL240C HSP82; Hsp90 family chaperone HSP82 K04079 HSP90A; molecular chaperone HtpG
D YMR186W HSC82; Hsp90 family chaperone HSC82 K04079 HSP90A; molecular chaperone HtpG
C Co-chaperones
C Other CMA associated proteins
D YPR080W TEF1; translation elongation factor EF-1 alpha K03231 EEF1A; elongation factor 1-alpha
D YBR118W TEF2; translation elongation factor EF-1 alpha K03231 EEF1A; elongation factor 1-alpha
D YMR297W PRC1; carboxypeptidase C PRC1 K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
D YBR139W ATG42; carboxypeptidase C K13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
B Other autophagy associated proteins
C RNautophagy/DNautophagy
C Micronucleophagy
D YHR195W NVJ1; Nvj1p K22264 NVJ1; nucleus-vacuole junction protein 1
D YEL013W VAC8; protein anchor VAC8 K08332 VAC8; vacuolar protein 8
C Midbophagy
C Glycophagy
C TRIM-directed selective autophagy
C ER-mitochondria tethering complex
D YBR179C FZO1; mitofusin K06030 MFN2; mitofusin 2 [EC:3.6.5.-]
C mTORC1 complex
D YJR066W TOR1; phosphatidylinositol kinase-related protein kinase TOR1 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D YKL203C TOR2; phosphatidylinositol kinase-related protein kinase TOR2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D YNL006W LST8; TOR complex subunit LST8 K08266 MLST8; target of rapamycin complex subunit LST8
D YHR186C KOG1; ubiquitin-binding TORC1 subunit KOG1 K07204 RAPTOR; regulatory associated protein of mTOR
D YPL180W TCO89; Tco89p K25579 TCO89; target of rapamycin complex 1 subunit TCO89
C mTORC2 complex
D YJR066W TOR1; phosphatidylinositol kinase-related protein kinase TOR1 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D YKL203C TOR2; phosphatidylinositol kinase-related protein kinase TOR2 K07203 MTOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
D YNL006W LST8; TOR complex subunit LST8 K08266 MLST8; target of rapamycin complex subunit LST8
D YOL078W AVO1; Avo1p K20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1/AVO1
D YER093C TSC11; TORC2 complex subunit TSC11 K08267 RICTOR; rapamycin-insensitive companion of mTOR
D YMR068W AVO2; Avo2p K25576 AVO2; target of rapamycin complex 2 subunit AVO2
D YBR270C BIT2; Bit2p K25577 BIT61_2; target of rapamycin complex 2 subunit BIT61/BIT2
D YJL058C BIT61; Bit61p K25577 BIT61_2; target of rapamycin complex 2 subunit BIT61/BIT2
C SEACIT/GATOR1 complex
D YJR138W IML1; GTPase-activating protein IML1 K20404 DEPDC5; SEA/GATOR complex protein SEA1/DEPDC5
D YEL062W NPR2; nitrogen permease regulating protein NPR2 K20405 NPRL2; nitrogen permease regulator 2
D YHL023C NPR3; Npr3p K20406 NPRL3; nitrogen permease regulator 3
C SEACAT/GATOR2 complex
D YOL138C RTC1; Rtc1p K20408 WDR24; SEA/GATOR complex protein SEA2/WDR24
D YDR128W MTC5; Mtc5p K20409 WDR59; SEA/GATOR complex protein SEA3/WDR59
D YBL104C SEA4; Sea4p K20407 MIOS; SEA/GATOR complex protein SEA4/MIOS
D YGL100W SEH1; Seh1p K14299 SEH1; nucleoporin SEH1
D YLR208W SEC13; GTPase-activating protein SEC13 K14004 SEC13; protein transport protein SEC13
C KICSTOR complex
C Rab GTPases
D YFL038C YPT1; Rab family GTPase YPT1 K07874 RAB1A; Ras-related protein Rab-1A
D YFL005W SEC4; Rab family GTPase SEC4 K07901 RAB8A; Ras-related protein Rab-8A
C Rab associated proteins
C Others
D YDL134C PPH21; phosphoprotein phosphatase 2A catalytic subunit PPH21 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D YDL188C PPH22; phosphoprotein phosphatase 2A catalytic subunit PPH22 K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
D YMR028W TAP42; Tap42p K17606 IGBP1; immunoglobulin-binding protein 1
D YCL038C ATG22; Atg22p K06902 UMF1; MFS transporter, UMF1 family
D YNL101W AVT4; Avt4p K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D YKL146W AVT3; Avt3p K14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)
D YGR223C HSV2; Hsv2p K22991 WDR45; WD repeat-containing protein 45
D YGR105W VMA21; Vma21p K23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21
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AOthers
B NADPH oxidases (Nox) and associated proteins
C NADPH oxidases
C Nox associated proteins
B Actin-binding proteins
C Myosins
D YKL129C MYO3; myosin 3 K10356 MYO1; myosin I
D YMR109W MYO5; myosin 5 K10356 MYO1; myosin I
D YOR326W MYO2; myosin 2 K10357 MYO5; myosin V
D YAL029C MYO4; myosin 4 K10357 MYO5; myosin V
C Arp2/3 complex
D YBR234C ARC40; Arc40p K05757 ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
D YNR035C ARC35; Arc35p K05758 ARPC2; actin related protein 2/3 complex, subunit 2
D YLR370C ARC18; Arc18p K05756 ARPC3; actin related protein 2/3 complex, subunit 3
D YKL013C ARC19; Arc19p K05755 ARPC4; actin related protein 2/3 complex, subunit 4
D YIL062C ARC15; Arc15p K05754 ARPC5; actin related protein 2/3 complex, subunit 5
D YDL029W ARP2; actin-related protein 2 K17260 ACTR2; actin-related protein 2
D YJR065C ARP3; actin-related protein 3 K18584 ACTR3; actin-related protein 3
C Nucleation-promoting factors (NPFs)
D YOR181W LAS17; actin-binding protein LAS17 K23612 WASL; neural Wiskott-Aldrich syndrome protein
D YCR088W ABP1; Abp1p K20520 DBNL; drebrin-like protein
D YIR006C PAN1; Pan1p K20047 PAN1; actin cytoskeleton-regulatory complex protein PAN1
D YDR388W RVS167; amphiphysin K12562 AMPH; amphiphysin
D YBL007C SLA1; cytoskeletal protein-binding protein SLA1 K20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1
D YJL020C BBC1; Bbc1p K20521 BBC1; myosin tail region-interacting protein MTI1
D YGR136W LSB1; Lsb1p K20522 LSB1_2; LAS seventeen-binding protein 1/2
D YPR154W PIN3; Pin3p K20522 LSB1_2; LAS seventeen-binding protein 1/2
D YFR024C-A LSB3; Lsb3p K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D YHR016C YSC84; Ysc84p K20523 SH3YL1; SH3 domain-containing YSC84-like protein 1
D YCL034W LSB5; Lsb5p K20524 LSB5; LAS seventeen-binding protein 5
D YJL100W LSB6; 1-phosphatidylinositol 4-kinase LSB6 K13711 PI4K2; phosphatidylinositol 4-kinase type 2 [EC:2.7.1.67]
C Others
D YOR122C PFY1; profilin K05759 PFN; profilin
D YLL050C COF1; cofilin K05765 CFL; cofilin
D YNL138W SRV2; adenylate cyclase-binding protein K17261 CAP1_2; adenylyl cyclase-associated protein
D YKL079W SMY1; Smy1p K10396 KIF5; kinesin family member 5
D YOR367W SCP1; Scp1p K20526 TAGLN; transgelin
B Mucins
C Membrane bound mucins
C Secretory mucins
B Rab GTPases of specific organelles
C Melanosome
C Auto phagosome
C Lipid droplets
C Mitochondrion
B Rho GTPase associated proteins
C Rho GTPase-activating proteins
D YBR260C RGD1; GTPase-activating protein RGD1 K20643 RGD1; Rho GTPase-activating protein RGD1
C Rho guanine nucleotide exchange factors (GEFs)
D YLR422W DCK1; Dck1p K05727 DOCK3; dedicator of cytokinesis protein 3
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 10, 2024