+C Peptidases and inhibitors KO
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Peptidases and Inhibitors - Streptomyces avermitilis
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AAspartic peptidases
B Family A1: pepsin family
B Family A2: retropepsin family
B Family A5: thermopsin family
B Family A8: signal peptidase II family
C SAVERM_6132 lspA; putative signal peptidase II K03101 lspA; signal peptidase II [EC:3.4.23.36]
B Family A22: presenilin family
B Family A24: type IV prepilin peptidase family
C SAVERM_4824 pilD; putative leader peptidase (prepilin peptidase) / N-methyltransferase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
B Family A25: gpr protease family
B Family A26: omptin family
B Family A28
B Family A31: HybD endopeptidase family
C SAVERM_7372 hupD; putative [NiFe] hydrogenase-specific C-terminal protease K03605 hyaD; hydrogenase maturation protease [EC:3.4.23.-]
B Family A36
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ACysteine peptidases
B Family C1: papain family
B Family C2: calpain family
B Family C3: picornain family
B Family C4: NIa protease family
B Family C5
B Family C9
B Family C10: streptopain family
B Family C11: clostripain family
B Family C12: ubiquitin C-terminal hydrolase family
B Family C13: legumain family
B Family C14: caspase family
B Family C15: pyroglutamyl peptidase I family
B Family C16
B Family C19: ubiquitin-specific protease family
B Family C25: gingipain family
B Family C26: gamma-glutamyl hydrolase family
C SAVERM_3479 guaA; putative GMP synthase K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
C SAVERM_6723 putative secreted protein K07010 K07010; putative glutamine amidotransferase
B Family C27
B Family C30
B Family C37
B Family C39
B Family C40
C SAVERM_6062 putative NLP/P60-family secreted protein (PgpA peptidase) K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C SAVERM_3464 putative NLP/P60-family secreted protein (PgpA peptidase) K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C SAVERM_2957 putative NLP/P60-family secreted protein (PgpA peptidase) K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
C SAVERM_6063 putative NLP/P60-family secreted protein (PgpA peptidase) K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
B Family C44
C SAVERM_4135 purF; putative phosphoribosylpyrophosphate amidotransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C SAVERM_6189 gltB; putative glutamate synthase(NADPH) large subunit K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
C SAVERM_4963 glmS1; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C SAVERM_5265 glmS2; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
C SAVERM_5689 mcjC2; putative asparagine synthase K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
C SAVERM_259 mcjC1; putative asparagine synthase K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
C SAVERM_2197 hypothetical protein K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
B Family C45
B Family C46: hedgehog family
B Family C47: staphopain family
B Family C48: Ulp1 endopeptidase family
B Family C50: separase family
B Family C54: Aut2 peptidase family
B Family C55: YopJ protease family
B Family C56: PfpI endopeptidase family
C SAVERM_7231 pfpI2; putative intracellular protease/amidase K05520 yhbO; deglycase [EC:3.5.1.124]
C SAVERM_1876 pfpI1; putative intracellular protease/amidase K05520 yhbO; deglycase [EC:3.5.1.124]
B Family C57: vaccinia virus I7 peptidase family
B Family C58
B Family C59
B Family C60
C SAVERM_4336 hypothetical protein K07284 srtA; sortase A [EC:3.4.22.70]
C SAVERM_4333 putative secreted protein K07284 srtA; sortase A [EC:3.4.22.70]
B Family C63
B Family C64
B Family C65
B Family C67
B Family C69
B Family C70
B Family C75
B Family C76
B Family C78
B Family C79
B Family C82
B Family C83
B Family C85
B Family C86
B Family C88
B Family C89
B Family C97
B Family C98
B Family C110
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AGlutamic peptidases
B Family G1
B Family G4
B Family G5: prenyl protease 2 family
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AMetallo peptidases
B Family M1
C SAVERM_6212 pepN3; putative aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
C SAVERM_5395 pepN2; putative aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2]
C SAVERM_5411 pepG; putative aminopeptidase G K01256 pepN; aminopeptidase N [EC:3.4.11.2]
B Family M2
B Family M3
B Family M4: thermolysin family
B Family M5: mycolysin family
B Family M6: immune inhibitor A family
C SAVERM_5155 putative protease, secreted K09607 ina; immune inhibitor A [EC:3.4.24.-]
B Family M7: snapalysin family
C SAVERM_4407 putative snapalysin (secreted metalloprotease) K01416 snpA; snapalysin [EC:3.4.24.77]
C SAVERM_2939 putative snapalysin (secreted metalloprotease) K01416 snpA; snapalysin [EC:3.4.24.77]
B Family M8: leishmanolysin family
B Family M9
B Family M10
B Family M12: astacin/adamalysin family
B Family M13: neprilysin family
B Family M14: carboxypeptidase A family
C SAVERM_3266 putative carboxypeptidase T (secreted zinc-binding carboxypeptidase) K05996 cpt; carboxypeptidase T [EC:3.4.17.18]
B Family M15: zinc D-Ala-D-Ala carboxypeptidase family
C SAVERM_1809 putative dipeptidase K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]
B Family M16: pitrilysin family
B Family M17: leucyl aminopeptidase family
C SAVERM_6025 pepA; putative leucyl aminopeptidase (cytosol aminopeptidase) K01255 CARP; leucyl aminopeptidase [EC:3.4.11.1]
B Family M18
B Family M19: membrane dipeptidase family
C SAVERM_5023 putative dipeptidase K01273 DPEP; membrane dipeptidase [EC:3.4.13.19]
B Family M20
C SAVERM_3125 dapE; putative succinyl-diaminopimelate desuccinylase K01439 dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]
C SAVERM_1471 putative peptidase K23980 tpdA; cysteinylglycine-S-conjugate dipeptidase [EC:3.4.13.23]
B Family M23
B Family M24
C SAVERM_4948 map3; putative methionyl aminopeptidase, secreted K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C SAVERM_5931 map4; putative methionyl aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C SAVERM_1956 map1; putative methionyl aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C SAVERM_1974 map2; putative methionyl aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
C SAVERM_4230 pepP; putative Xaa-Pro aminopeptidase aminopeptidase P) K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
B Family M26
B Family M27
B Family M28: aminopeptidase Y family
C SAVERM_4872 lap; putative leucyl aminopeptidase, secreted (aminopeptidase S) K19702 E3.4.11.24; aminopeptidase S [EC:3.4.11.24]
B Family M29: aminopeptidase T family
B Family M32: carboxypeptidase Taq family
B Family M34: anthrax lethal factor family
B Family M35: deuterolysin family
B Family M36: fungalysin family
B Family M38: beta-aspartyl dipeptidase family
B Family M41: FtsH endopeptidase family
C SAVERM_4666 ftsH; putative cell division protein FtsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
B Family M42: glutamyl aminopeptidase family
B Family M43: cytophagalysin family
B Family M44
B Family M48: Ste24 endopeptidase family
C SAVERM_6003 htpX2; putative heat shock protein, protease K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
C SAVERM_4891 htpX1; putative heat shock protein, protease K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
B Family M49: dipeptidyl-peptidase III family
B Family M50: S2P protease family
C SAVERM_1106 putative subfamily M50B peptidases K16922 yydH; putative peptide zinc metalloprotease protein
B Family M54
B Family M55: DppA aminopeptidase family
C SAVERM_1111 dppA1; putative D-aminopeptidase (family M55 peptidases) K16203 dppA1; D-amino peptidase [EC:3.4.11.-]
C SAVERM_1900 dppA2; putative D-aminopeptidase K16203 dppA1; D-amino peptidase [EC:3.4.11.-]
B Family M56
C SAVERM_1500 putative integral membrane protein K02172 blaR1; bla regulator protein blaR1
B Family M67
B Family M72
B Family M73
B Family M74
B Family M80
B Family M82
C SAVERM_4116 putative membrane protein K24131 prsW; protease PrsW [EC:3.4.-.-]
B Family M85
B Family M88
B Family M90
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AAsparagine peptide lyases
B Family N1
B Family N8
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AMixed peptidases
B Family P1: DmpA aminopeptidase family
B Family P2
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ASerine peptidases
B Family S1: chymotrypsin family
C SAVERM_3115 pepD1; putative serine protease K08372 pepD; putative serine protease PepD [EC:3.4.21.-]
C SAVERM_4223 pepD3; putative serine protease, secreted K08372 pepD; putative serine protease PepD [EC:3.4.21.-]
C SAVERM_4045 putative Htra2 peptidase K08372 pepD; putative serine protease PepD [EC:3.4.21.-]
C SAVERM_6552 sprA; putative serine protease precursor K18545 sprB; streptogrisin B [EC:3.4.21.81]
C SAVERM_1000 sprC; putative streptogrisin C (secreted serine protease) K18546 sprC; streptogrisin C [EC:3.4.21.-]
C SAVERM_6553 sprD1; putative streptogrisin D (secreted serine protease) K18547 sprD; streptogrisin D [EC:3.4.21.-]
C SAVERM_7497 sprD2; putative streptogrisin D (secreted serine protease) K18547 sprD; streptogrisin D [EC:3.4.21.-]
B Family S3: togavirin family
B Family S6
B Family S7: flavivirin family
B Family S8: subtilisin family
C SAVERM_2540 putative mycosin-1 (secreted serine protease) K14743 mycP; membrane-anchored mycosin MYCP [EC:3.4.21.-]
B Family S9: prolyl oligopeptidase family
C SAVERM_3144 putative peptidase K01278 DPP4; dipeptidyl-peptidase 4 [EC:3.4.14.5]
B Family S10
B Family S11: D-Ala-D-Ala carboxypeptidase A family
C SAVERM_1311 dacA; putative D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C SAVERM_3413 dacB; putative D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C SAVERM_5913 dacF; putative D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C SAVERM_4379 dacD; putative D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
C SAVERM_3781 dacC; putative D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
B Family S12: D-Ala-D-Ala carboxypeptidase B family
B Family S13: D-Ala-D-Ala peptidase C family
C SAVERM_4662 dacE; putative D-alanyl-D-alanine carboxypeptidase K07259 dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]
B Family S14: ClpP endopeptidase family
C SAVERM_1146 clpP4; putative ATP-dependent Clp protease proteolytic subunit 1 K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C SAVERM_1147 clpP5; putative ATP-dependent Clp protease proteolytic subunit 2 K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C SAVERM_7101 clpP3; putative ATP-dependent Clp protease proteolytic subunit 2 K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C SAVERM_5447 clpP1; putative ATP-dependent Clp protease proteolytic subunit 1 K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
C SAVERM_5448 clpP2; putative ATP-dependent Clp protease proteolytic subunit 2 K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
B Family S15
B Family S16: lon protease family
C SAVERM_2966 lonA; putative lon class III heat-shock ATP-dependent protease K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
C SAVERM_3057 putative secreted protein K07177 K07177; Lon-like protease
C SAVERM_5142 sdrC; putative secreted protein K07177 K07177; Lon-like protease
B Family S21: assemblin family
B Family S24: LexA family
C SAVERM_2463 lexA; putative SOS regulatory protein LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
B Family S26: signal peptidase I family
C SAVERM_2636 lepB1; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C SAVERM_2637 lepB2; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C SAVERM_2638 lepB3; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
C SAVERM_2639 lepB4; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
B Family S28
B Family S31
B Family S32
B Family S33
C SAVERM_875 pip; putative proline iminopeptidase K01259 pip; proline iminopeptidase [EC:3.4.11.5]
C SAVERM_141 ephA1; putative epoxide hydrolase K27108 ephA_B; epoxide hydrolase A/B [EC:3.3.2.-]
C SAVERM_2105 ephB; putative epoxide hydrolase K27108 ephA_B; epoxide hydrolase A/B [EC:3.3.2.-]
C SAVERM_3810 ephA2; putative epoxide hydrolase K27108 ephA_B; epoxide hydrolase A/B [EC:3.3.2.-]
B Family S41: C-terminal processing peptidase family
C SAVERM_5106 putative carboxy-terminal processing protease precursor, secreted K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
C SAVERM_5574 pepD4; putative tricorn core peptidase K08676 tri; tricorn protease [EC:3.4.21.-]
C SAVERM_3620 pepD2; putative tricorn core peptidase K08676 tri; tricorn protease [EC:3.4.21.-]
B Family S45
C SAVERM_3675 pacB1; putative penicillin acylase, secreted K01434 pac; penicillin G amidase [EC:3.5.1.11]
C SAVERM_4171 pacB2; putative penicillin acylase K01434 pac; penicillin G amidase [EC:3.5.1.11]
B Family S49: protease IV family
B Family S50
B Family S51
B Family S53
B Family S54: Rhomboid family
C SAVERM_2227 hypothetical protein K07059 K07059; rhomboid family protein
C SAVERM_6059 putative integral membrane protein K07059 K07059; rhomboid family protein
B Family S55: SpoIVB peptidase family
B Family S62
B Family S66
C SAVERM_1897 putative LD-carboxypeptidase (murein tetrapeptidase) K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
B Family S77: phage prohead processing peptidase family
B Family S78
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AThreonine peptidases
B Family T1: proteasome family
C SAVERM_6682 prcA; putative 20S proteasome alpha-subunit K03432 psmA; proteasome alpha subunit [EC:3.4.25.1]
C SAVERM_6681 prcB1; putative 20S proteasome beta-subunit K03433 psmB; proteasome beta subunit [EC:3.4.25.1]
C SAVERM_2812 prcB2; putative 20S proteasome beta-subunit K03433 psmB; proteasome beta subunit [EC:3.4.25.1]
B Family T2
B Family T3: gamma-glutamyltransferase family
C SAVERM_1938 ggt1; putative gamma-glutamyltranspeptidase K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
C SAVERM_1957 ggt2; putative gamma-glutamyltranspeptidase, secreted K00681 ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]
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APeptidases of unknown catalytic type
B Family U32
B Family U62
C SAVERM_6461 tldD; putative modulator of DNA gyrase K03568 tldD; TldD protein
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APeptidase inhibitors
B Family I1: Kazal family
B Family I2: Kunitz - BPTI family
B Family I4: serpin family
B Family I11: ecotin family
B Family I17: WAP-type family
B Family I25: cystatin family
B Family I27: calpastatin family
B Family I32: IAP family
B Family I34: IA3 family
B Family I35: timp family
B Family I39: alpha2M family
B Family I47: latexin family
B Family I49: proSAAS family
B Family I51: IC family
B Family I57: staphostatin B family
B Family I63
B Family I80
B Family I87
B Family I93
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 13, 2023
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Classification taken and modified from MEROPS