+D GENES KO
#
KEGG Orthology (KO) - Streptococcus pyogenes MGAS10750 (serotype M4)
%
!
A09100 Metabolism
B
B 09101 Carbohydrate metabolism
C 00010 Glycolysis / Gluconeogenesis [PATH:spi00010]
D MGAS10750_Spy1365 glcK; Glucokinase K25026 glk; glucokinase [EC:2.7.1.2]
D MGAS10750_Spy0179 pgi; Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D MGAS10750_Spy1663 fba; Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D MGAS10750_Spy0528 tpi; Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D MGAS10750_Spy0228 plr; Glyceraldehyde 3-phosphate dehydrogenase K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D MGAS10750_Spy1657 pgk; Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D MGAS10750_Spy1272 gpmA; Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D MGAS10750_Spy0639 eno; Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D MGAS10750_Spy1138 pyk; Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D MGAS10750_Spy0903 acoA; Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
D MGAS10750_Spy0904 acoB; Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
D MGAS10750_Spy0905 acoC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy1022 ldh; L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D MGAS10750_Spy0041 Alcohol dehydrogenase / Acetaldehyde dehydrogenase (acetylating) K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D MGAS10750_Spy0042 adhA; Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D MGAS10750_Spy1087 pgmA; Phosphoglucomutase / Phosphomannomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D MGAS10750_Spy1221 gapN; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]
D MGAS10750_Spy0498 bglA; 6-phospho-beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D MGAS10750_Spy1178 bglA2; Beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D MGAS10750_Spy1422 Beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
C 00020 Citrate cycle (TCA cycle) [PATH:spi00020]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy0903 acoA; Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
D MGAS10750_Spy0904 acoB; Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
D MGAS10750_Spy0905 acoC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
C 00030 Pentose phosphate pathway [PATH:spi00030]
D MGAS10750_Spy0179 pgi; Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D MGAS10750_Spy0219 rpe; Ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
D MGAS10750_Spy1485 tkt; Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D MGAS10750_Spy1755 Transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2]
D MGAS10750_Spy1487 Transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2]
D MGAS10750_Spy0787 rpiA; Ribose 5-phosphate isomerase K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]
D MGAS10750_Spy1643 deoC; Deoxyribose-phosphate aldolase K01619 deoC; deoxyribose-phosphate aldolase [EC:4.1.2.4]
D MGAS10750_Spy0788 deoB; Phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7]
D MGAS10750_Spy1087 pgmA; Phosphoglucomutase / Phosphomannomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D MGAS10750_Spy0996 Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D MGAS10750_Spy0018 prsA2; Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D MGAS10750_Spy0546 kgdA; 4-Hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxyphosphogluconate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]
D MGAS10750_Spy1221 gapN; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]
D MGAS10750_Spy0545 2-dehydro-3-deoxygluconokinase K00874 kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]
D MGAS10750_Spy1663 fba; Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C 00040 Pentose and glucuronate interconversions [PATH:spi00040]
D MGAS10750_Spy0469 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D MGAS10750_Spy0188 hasC; UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D MGAS10750_Spy0157 3-keto-L-gulonate-6-phosphate decarboxylase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]
D MGAS10750_Spy0158 L-xylulose 5-phosphate 3-epimerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22]
D MGAS10750_Spy0159 araD; L-ribulose-5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]
D MGAS10750_Spy0219 rpe; Ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
C 00051 Fructose and mannose metabolism [PATH:spi00051]
D MGAS10750_Spy1598 scrK; Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4]
D MGAS10750_Spy1597 pmi; Mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D MGAS10750_Spy0752 fruB; 1-phosphofructokinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56]
D MGAS10750_Spy1663 fba; Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D MGAS10750_Spy0528 tpi; Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D MGAS10750_Spy0753 fruA; PTS system, fructose-specific IIABC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D MGAS10750_Spy0931 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D MGAS10750_Spy1538 manL; PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D MGAS10750_Spy1539 manM; PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy0933 ptsC; PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy1540 manN; PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component
D MGAS10750_Spy0934 ptsD; PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component
C 00052 Galactose metabolism [PATH:spi00052]
D MGAS10750_Spy0188 hasC; UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D MGAS10750_Spy1087 pgmA; Phosphoglucomutase / Phosphomannomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D MGAS10750_Spy1365 glcK; Glucokinase K25026 glk; glucokinase [EC:2.7.1.2]
D MGAS10750_Spy1413 lacZ; Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23]
D MGAS10750_Spy1733 lacC2; Tagatose-6-phosphate kinase K00917 lacC; tagatose 6-phosphate kinase [EC:2.7.1.144]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D MGAS10750_Spy1508 lacD1; Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]
D MGAS10750_Spy1732 lacD2; Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]
D MGAS10750_Spy1734 lacB2; Galactose-6-phosphate isomerase lacB subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26]
D MGAS10750_Spy1735 lacA2; Galactose-6-phosphate isomerase lacA subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26]
D MGAS10750_Spy1510 lacB1; Galactose-6-phosphate isomerase lacB subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26]
D MGAS10750_Spy1511 lacA1; Galactose-6-phosphate isomerase lacA subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26]
D MGAS10750_Spy1729 lacG; 6-phospho-beta-galactosidase K01220 E3.2.1.85; 6-phospho-beta-galactosidase [EC:3.2.1.85]
D MGAS10750_Spy1731 lacF; PTS system, lactose-specific IIA component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D MGAS10750_Spy1730 lacE; PTS system, lactose-specific IIBC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D MGAS10750_Spy1602 scrB; Sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26]
D MGAS10750_Spy0540 agaV; PTS system, N-acetylgalactosamine-specific IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
D MGAS10750_Spy0539 PTS system, N-acetylgalactosamine-specific IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component
D MGAS10750_Spy0538 agaD; PTS system, N-acetylgalactosamine-specific IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component
D MGAS10750_Spy0628 agaS; Galactosamine-6-phosphate deaminase (isomerizing) K02082 agaS; D-galactosamine 6-phosphate deaminase/isomerase [EC:3.5.99.-]
C 00053 Ascorbate and aldarate metabolism [PATH:spi00053]
D MGAS10750_Spy0469 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D MGAS10750_Spy0156 PTS system, 3-keto-L-gulonate specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D MGAS10750_Spy1758 Transcription antiterminator, BglG family / PTS system, mannitol (Cryptic)-specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D MGAS10750_Spy0155 PTS system, 3-keto-L-gulonate specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D MGAS10750_Spy1757 PTS system, IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D MGAS10750_Spy0154 PTS system, 3-keto-L-gulonate specific IIC component K03475 ulaA; ascorbate PTS system EIIC component
D MGAS10750_Spy1756 Putative transport protein sgaT K03475 ulaA; ascorbate PTS system EIIC component
D MGAS10750_Spy0162 Metal-dependent hydrolase K03476 ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-]
D MGAS10750_Spy0157 3-keto-L-gulonate-6-phosphate decarboxylase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85]
D MGAS10750_Spy0158 L-xylulose 5-phosphate 3-epimerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22]
D MGAS10750_Spy0159 araD; L-ribulose-5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4]
C 00500 Starch and sucrose metabolism [PATH:spi00500]
D MGAS10750_Spy1601 scrA; PTS system, sucrose-specific IIABC component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211]
D MGAS10750_Spy1602 scrB; Sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26]
D MGAS10750_Spy0188 hasC; UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D MGAS10750_Spy1840 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1174 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1839 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1175 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1172 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D MGAS10750_Spy1838 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D MGAS10750_Spy0498 bglA; 6-phospho-beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D MGAS10750_Spy1178 bglA2; Beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D MGAS10750_Spy1422 Beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86]
D MGAS10750_Spy1147 glgP; Maltodextrin phosphorylase K00688 PYG; glycogen phosphorylase [EC:2.4.1.1]
D MGAS10750_Spy1159 amyB; Neopullulanase / Cyclomaltodextrinase / Maltogenic alpha-amylase K01208 cd; cyclomaltodextrinase / maltogenic alpha-amylase / neopullulanase [EC:3.2.1.54 3.2.1.133 3.2.1.135]
D MGAS10750_Spy1148 malM; 4-alpha-glucanotransferase K00705 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]
D MGAS10750_Spy1784 PTS system, glucose-specific IIABC component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208]
D MGAS10750_Spy1783 Endonuclease/Exonuclease/phosphatase family protein K06896 mapP; maltose 6'-phosphate phosphatase [EC:3.1.3.90]
D MGAS10750_Spy1158 amyA; Cyclodextrin glucanotransferase K00701 cgt; cyclomaltodextrin glucanotransferase [EC:2.4.1.19]
D MGAS10750_Spy1876 PTS system, trehalose-specific IIBC component / PTS system, trehalose-specific IIA component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201]
D MGAS10750_Spy1875 dexS; Trehalose-6-phosphate hydrolase K01226 treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93]
D MGAS10750_Spy1087 pgmA; Phosphoglucomutase / Phosphomannomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D MGAS10750_Spy1365 glcK; Glucokinase K25026 glk; glucokinase [EC:2.7.1.2]
D MGAS10750_Spy0179 pgi; Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D MGAS10750_Spy1598 scrK; Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4]
C 00520 Amino sugar and nucleotide sugar metabolism [PATH:spi00520]
D MGAS10750_Spy1500 nagA; N-acetylglucosamine-6-phosphate deacetylase K01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]
D MGAS10750_Spy1246 nagB; Glucosamine-6-phosphate isomerase K02564 nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6]
D MGAS10750_Spy1598 scrK; Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4]
D MGAS10750_Spy1136 glmS; Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D MGAS10750_Spy0915 femD; Phosphoglucosamine mutase K03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10]
D MGAS10750_Spy0364 gcaD; Glucosamine-1-phosphate acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
D MGAS10750_Spy0668 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D MGAS10750_Spy1206 murZ; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D MGAS10750_Spy0976 murB; UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D MGAS10750_Spy0206 N-acetylmannosamine-6-phosphate 2-epimerase K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]
D MGAS10750_Spy0212 nanH; N-acetylneuraminate lyase K01639 E4.1.3.3; N-acetylneuraminate lyase [EC:4.1.3.3]
D MGAS10750_Spy1365 glcK; Glucokinase K25026 glk; glucokinase [EC:2.7.1.2]
D MGAS10750_Spy1087 pgmA; Phosphoglucomutase / Phosphomannomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D MGAS10750_Spy0188 hasC; UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D MGAS10750_Spy0469 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D MGAS10750_Spy0931 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D MGAS10750_Spy1538 manL; PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D MGAS10750_Spy1539 manM; PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy0933 ptsC; PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy1540 manN; PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component
D MGAS10750_Spy0934 ptsD; PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component
D MGAS10750_Spy0179 pgi; Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D MGAS10750_Spy1597 pmi; Mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
C 00620 Pyruvate metabolism [PATH:spi00620]
D MGAS10750_Spy0903 acoA; Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
D MGAS10750_Spy0904 acoB; Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
D MGAS10750_Spy0905 acoC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy1628 pfl; Formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54]
D MGAS10750_Spy0041 Alcohol dehydrogenase / Acetaldehyde dehydrogenase (acetylating) K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D MGAS10750_Spy0042 adhA; Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D MGAS10750_Spy0101 ackA; Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
D MGAS10750_Spy1001 pta; Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D MGAS10750_Spy1138 pyk; Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D MGAS10750_Spy1543 accD; Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D MGAS10750_Spy1547 accB; Biotin carboxyl carrier protein of acetyl-CoA carboxylase K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D MGAS10750_Spy1545 accC; Biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D MGAS10750_Spy1544 accA; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D MGAS10750_Spy0291 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7]
D MGAS10750_Spy1022 ldh; L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D MGAS10750_Spy1039 ddh; D-2-hydroxyacid dehydrogenase K03778 ldhA; D-lactate dehydrogenase [EC:1.1.1.28]
D MGAS10750_Spy0434 gloA; Lactoylglutathione lyase K01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5]
D MGAS10750_Spy0552 Hydroxyacylglutathione hydrolase K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6]
D MGAS10750_Spy0984 NAD-dependent malic enzyme K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]
D MGAS10750_Spy1043 oadA2; Na+ transporting oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2]
D MGAS10750_Spy1059 oadA1; Na+ transporting oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2]
D MGAS10750_Spy1046 Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1052 oadB; Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1044 hypothetical membrane associated protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma
D MGAS10750_Spy0524 ppc; Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
C 00630 Glyoxylate and dicarboxylate metabolism [PATH:spi00630]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1654 glnA; Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D MGAS10750_Spy1016 glyA; serinehydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy1675 Glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165]
D MGAS10750_Spy0546 kgdA; 4-Hydroxy-2-oxoglutarate aldolase / 2-dehydro-3-deoxyphosphogluconate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]
C 00640 Propanoate metabolism [PATH:spi00640]
D MGAS10750_Spy0101 ackA; Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
D MGAS10750_Spy1001 pta; Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy1628 pfl; Formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54]
D MGAS10750_Spy1543 accD; Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D MGAS10750_Spy1547 accB; Biotin carboxyl carrier protein of acetyl-CoA carboxylase K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D MGAS10750_Spy1545 accC; Biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D MGAS10750_Spy1544 accA; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D MGAS10750_Spy1022 ldh; L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D MGAS10750_Spy1835 gldA; Glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6]
C 00650 Butanoate metabolism [PATH:spi00650]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1454 atoD1; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0125 atoD2; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy1455 atoA; Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0126 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0041 Alcohol dehydrogenase / Acetaldehyde dehydrogenase (acetylating) K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D MGAS10750_Spy1046 Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1052 oadB; Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1045 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
D MGAS10750_Spy1051 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
D MGAS10750_Spy0938 gabD; Succinate-semialdehyde dehydrogenase (NADP+) K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
D MGAS10750_Spy1628 pfl; Formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54]
D MGAS10750_Spy0779 mvaS1; Hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
D MGAS10750_Spy1456 D-beta-hydroxybutyrate dehydrogenase K00019 BDH1; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30]
D MGAS10750_Spy0985 Zn-dependent alcohol dehydrogenase K18369 adh2; alcohol dehydrogenase [EC:1.1.1.-]
D MGAS10750_Spy0553 (R,R)-butanediol dehydrogenase / Acetoin dehydrogenase K03366 butA; meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304]
C 00660 C5-Branched dibasic acid metabolism
C 00562 Inositol phosphate metabolism [PATH:spi00562]
D MGAS10750_Spy1107 Myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D MGAS10750_Spy1108 Myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D MGAS10750_Spy0362 NAD-dependent oxidoreductase K22230 iolU; scyllo-inositol 2-dehydrogenase (NADP+) [EC:1.1.1.-]
D MGAS10750_Spy0528 tpi; Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
B
B 09102 Energy metabolism
C 00190 Oxidative phosphorylation [PATH:spi00190]
D MGAS10750_Spy0663 atpA; ATP synthase alpha chain K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D MGAS10750_Spy0665 atpD; ATP synthase beta chain K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D MGAS10750_Spy0664 atpG; ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D MGAS10750_Spy0662 atpH; ATP synthase delta chain K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D MGAS10750_Spy0666 atpC; ATP synthase epsilon chain K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D MGAS10750_Spy0660 atpB; ATP synthase A chain K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D MGAS10750_Spy0661 atpF; ATP synthase B chain K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D MGAS10750_Spy0659 atpE; ATP synthase C chain K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D MGAS10750_Spy0136 ntpA; V-type sodium ATP synthase subunit A K02117 ATPVA; V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1]
D MGAS10750_Spy0137 ntpB; V-type sodium ATP synthase subunit B K02118 ATPVB; V/A-type H+/Na+-transporting ATPase subunit B
D MGAS10750_Spy0134 ntpC; V-type sodium ATP synthase subunit C K02119 ATPVC; V/A-type H+/Na+-transporting ATPase subunit C
D MGAS10750_Spy0138 ntpD; V-type sodium ATP synthase subunit D K02120 ATPVD; V/A-type H+/Na+-transporting ATPase subunit D
D MGAS10750_Spy0133 ntpE; V-type sodium ATP synthase subunit E K02121 ATPVE; V/A-type H+/Na+-transporting ATPase subunit E
D MGAS10750_Spy0135 ntpF; V-type sodium ATP synthase subunit F K02122 ATPVF; V/A-type H+/Na+-transporting ATPase subunit F
D MGAS10750_Spy0130 hypothetical protein K02107 ATPVG; V/A-type H+/Na+-transporting ATPase subunit G/H
D MGAS10750_Spy0131 ntpI; V-type sodium ATP synthase subunit I K02123 ATPVI; V/A-type H+/Na+-transporting ATPase subunit I
D MGAS10750_Spy0132 ntpK; V-type sodium ATP synthase subunit K K02124 ATPVK; V/A-type H+/Na+-transporting ATPase subunit K
D MGAS10750_Spy0313 ppaC; Inorganic pyrophosphatase K15986 ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]
C 00195 Photosynthesis
C 00196 Photosynthesis - antenna proteins
C 00710 Carbon fixation in photosynthetic organisms
C 00720 Carbon fixation pathways in prokaryotes
C 00680 Methane metabolism [PATH:spi00680]
D MGAS10750_Spy1016 glyA; serinehydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D MGAS10750_Spy0639 eno; Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D MGAS10750_Spy0524 ppc; Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
D MGAS10750_Spy1663 fba; Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D MGAS10750_Spy0101 ackA; Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
D MGAS10750_Spy1001 pta; Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D MGAS10750_Spy1272 gpmA; Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D MGAS10750_Spy0463 hypothetical protein K12234 cofE; coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34]
C 00910 Nitrogen metabolism [PATH:spi00910]
D MGAS10750_Spy1654 glnA; Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D MGAS10750_Spy1377 arcC; Carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2]
D MGAS10750_Spy0196 Carbonic anhydrase K01673 cynT; carbonic anhydrase [EC:4.2.1.1]
C 00920 Sulfur metabolism [PATH:spi00920]
D MGAS10750_Spy0630 Phosphoesterase, DHH family protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
D MGAS10750_Spy1752 cysE; serineacetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]
D MGAS10750_Spy1438 cysM; Cysteine synthase K01738 cysK; cysteine synthase [EC:2.5.1.47]
B
B 09103 Lipid metabolism
C 00061 Fatty acid biosynthesis [PATH:spi00061]
D MGAS10750_Spy1543 accD; Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D MGAS10750_Spy1547 accB; Biotin carboxyl carrier protein of acetyl-CoA carboxylase K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein
D MGAS10750_Spy1545 accC; Biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D MGAS10750_Spy1544 accA; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]
D MGAS10750_Spy1553 acpP; acyl-carrier protein K02078 acpP; acyl carrier protein
D MGAS10750_Spy0021 acpP2; acyl-carrier protein K02078 acpP; acyl carrier protein
D MGAS10750_Spy1550 fabD; Malonyl-CoA-(acyl-carrier-protein) transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D MGAS10750_Spy1554 fabH; 3-oxoacyl-(acyl-carrier-protein) synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D MGAS10750_Spy1548 fabF; 3-oxoacyl-(acyl-carrier-protein) synthase K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D MGAS10750_Spy1549 3-oxoacyl-reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D MGAS10750_Spy0361 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D MGAS10750_Spy1546 fabZ; (3R)-hydroxyacyl-dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D MGAS10750_Spy1551 fabK; Enoyl-reductase (NADH) K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
D MGAS10750_Spy1552 Enoyl-reductase (NADH) K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
D MGAS10750_Spy1556 phaB; Enoyl-CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14]
D MGAS10750_Spy0453 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C 00062 Fatty acid elongation
C 00071 Fatty acid degradation [PATH:spi00071]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0453 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D MGAS10750_Spy0041 Alcohol dehydrogenase / Acetaldehyde dehydrogenase (acetylating) K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D MGAS10750_Spy0042 adhA; Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
C 00073 Cutin, suberine and wax biosynthesis
C 00100 Steroid biosynthesis
C 00120 Primary bile acid biosynthesis
C 00121 Secondary bile acid biosynthesis
C 00140 Steroid hormone biosynthesis
C 00561 Glycerolipid metabolism [PATH:spi00561]
D MGAS10750_Spy1675 Glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165]
D MGAS10750_Spy0447 Dihydroxyacetone kinase K05878 dhaK; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]
D MGAS10750_Spy0448 Dihydroxyacetone kinase K05879 dhaL; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]
D MGAS10750_Spy0449 Dihydroxyacetone kinase phosphotransfer protein K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121]
D MGAS10750_Spy1835 gldA; Glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6]
D MGAS10750_Spy1492 glpK; Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30]
D MGAS10750_Spy0020 plsX; Fatty acid/phospholipid synthesis protein plsX K03621 plsX; phosphate acyltransferase [EC:2.3.1.274]
D MGAS10750_Spy0802 hypothetical membrane spanning protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D MGAS10750_Spy1257 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
D MGAS10750_Spy0656 Diacylglycerol kinase family protein K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107]
D MGAS10750_Spy0439 1,2-diacylglycerol 3-glucosyltransferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]
D MGAS10750_Spy0438 Glycosyltransferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208]
D MGAS10750_Spy0709 Sulfatase family protein K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20]
C 00564 Glycerophospholipid metabolism [PATH:spi00564]
D MGAS10750_Spy0189 gpsA; Glycerol-3-phosphate dehydrogenase (NAD(P)+) K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
D MGAS10750_Spy1491 glpO; Alpha-glycerophosphate oxidase K00105 E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21]
D MGAS10750_Spy0802 hypothetical membrane spanning protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D MGAS10750_Spy1257 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
D MGAS10750_Spy0656 Diacylglycerol kinase family protein K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107]
D MGAS10750_Spy0737 hypothetical protein / Glycerophosphodiester phosphodiesterase K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]
D MGAS10750_Spy1769 cdsA; Phosphatidate cytidylyltransferase K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41]
D MGAS10750_Spy1963 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase K00995 pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]
D MGAS10750_Spy1619 Phosphatidylglycerophosphatase B K01096 pgpB; phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27]
D MGAS10750_Spy1075 Cardiolipin synthetase K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]
C 00565 Ether lipid metabolism
C 00600 Sphingolipid metabolism
D MGAS10750_Spy1413 lacZ; Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23]
C 00590 Arachidonic acid metabolism
C 00591 Linoleic acid metabolism
C 00592 alpha-Linolenic acid metabolism
C 01040 Biosynthesis of unsaturated fatty acids
B
B 09104 Nucleotide metabolism
C 00230 Purine metabolism [PATH:spi00230]
D MGAS10750_Spy0365 ADP-ribose pyrophosphatase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-]
D MGAS10750_Spy0788 deoB; Phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7]
D MGAS10750_Spy1087 pgmA; Phosphoglucomutase / Phosphomannomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D MGAS10750_Spy0996 Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D MGAS10750_Spy0018 prsA2; Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D MGAS10750_Spy0024 purF; Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D MGAS10750_Spy0030 purD; Phosphoribosylamine--glycine ligase K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13]
D MGAS10750_Spy0026 purN; Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
D MGAS10750_Spy0023 Phosphoribosylformylglycinamidine synthase K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]
D MGAS10750_Spy0025 purM; Phosphoribosylformylglycinamidine cyclo-ligase K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]
D MGAS10750_Spy0032 purK; Phosphoribosylaminoimidazole carboxylase NCAIR mutase subunit K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]
D MGAS10750_Spy0031 purE; Phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]
D MGAS10750_Spy0022 Phosphoribosylamidoimidazole-succinocarboxamide synthase K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]
D MGAS10750_Spy0035 purB; Adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D MGAS10750_Spy0027 Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D MGAS10750_Spy0822 apt; Adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]
D MGAS10750_Spy0770 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
D MGAS10750_Spy0790 punA; Purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
D MGAS10750_Spy0791 deoD2; Purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]
D MGAS10750_Spy0012 Hypoxanthine-guanine phosphoribosyltransferase K00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]
D MGAS10750_Spy1970 guaB; Inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D MGAS10750_Spy0298 Xanthosine triphosphate pyrophosphatase K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]
D MGAS10750_Spy1007 xpt; Xanthine phosphoribosyltransferase K03816 xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]
D MGAS10750_Spy1068 guaA; GMP synthase (glutamine-hydrolyzing) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D MGAS10750_Spy1006 guaC; GMP reductase K00364 guaC; GMP reductase [EC:1.7.1.7]
D MGAS10750_Spy1450 gmk; Guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8]
D MGAS10750_Spy0351 nrdE1; Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MGAS10750_Spy1226 nrdE2; Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MGAS10750_Spy1228 nrdF2; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MGAS10750_Spy0349 nrdF1; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MGAS10750_Spy1885 nrdD; Anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6]
D MGAS10750_Spy1780 relA; GTP pyrophosphokinase / Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D MGAS10750_Spy0998 GTP pyrophosphokinase-like protein K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5]
D MGAS10750_Spy0771 GTP pyrophosphokinase K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5]
D MGAS10750_Spy0141 purA; Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D MGAS10750_Spy0069 adk; Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D MGAS10750_Spy1377 arcC; Carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2]
C 00240 Pyrimidine metabolism [PATH:spi00240]
D MGAS10750_Spy0733 carB; Carbamoyl-phosphate synthase large chain K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D MGAS10750_Spy0731 carA; Carbamoyl-phosphate synthase small chain K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D MGAS10750_Spy0730 pyrB; Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D MGAS10750_Spy0801 pyrC; Dihydroorotase K01465 URA4; dihydroorotase [EC:3.5.2.3]
D MGAS10750_Spy1273 pyrD; Dihydroorotate dehydrogenase K00226 pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1]
D MGAS10750_Spy0796 pyrE; Orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]
D MGAS10750_Spy0795 pyrF; Orotidine 5'-phosphate decarboxylase K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]
D MGAS10750_Spy0378 pyrH; Uridylate kinase K09903 pyrH; uridylate kinase [EC:2.7.4.22]
D MGAS10750_Spy1665 pyrG; CTP synthase K01937 pyrG; CTP synthase [EC:6.3.4.2]
D MGAS10750_Spy0705 cmk; Cytidylate kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25]
D MGAS10750_Spy1216 udk; Uridine kinase K00876 udk; uridine kinase [EC:2.7.1.48]
D MGAS10750_Spy0770 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
D MGAS10750_Spy1645 udp; Uridine phosphorylase K00757 udp; uridine phosphorylase [EC:2.4.2.3]
D MGAS10750_Spy0323 upp; Uracil phosphoribosyltransferase K00761 upp; uracil phosphoribosyltransferase [EC:2.4.2.9]
D MGAS10750_Spy0728 pyrR; Uracil phosphoribosyltransferase / Pyrimidine operon regulatory protein pyrR K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
D MGAS10750_Spy1706 Cytidine deaminase K01489 cdd; cytidine deaminase [EC:3.5.4.5]
D MGAS10750_Spy1092 cdd; Cytidine deaminase K01489 cdd; cytidine deaminase [EC:3.5.4.5]
D MGAS10750_Spy1885 nrdD; Anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6]
D MGAS10750_Spy0351 nrdE1; Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MGAS10750_Spy1226 nrdE2; Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MGAS10750_Spy1228 nrdF2; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MGAS10750_Spy0349 nrdF1; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MGAS10750_Spy1607 comEB; ComE operon protein 2 K01493 comEB; dCMP deaminase [EC:3.5.4.12]
D MGAS10750_Spy0326 tmk; Thymidylate kinase K00943 tmk; dTMP kinase [EC:2.7.4.9]
D MGAS10750_Spy0194 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D MGAS10750_Spy1011 tdk2; Thymidine kinase K00857 tdk; thymidine kinase [EC:2.7.1.21]
D MGAS10750_Spy0780 thyA; Thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45]
D MGAS10750_Spy1002 Short chain dehydrogenase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-]
B
B 09105 Amino acid metabolism
C 00250 Alanine, aspartate and glutamate metabolism [PATH:spi00250]
D MGAS10750_Spy1576 asnB; L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1]
D MGAS10750_Spy1376 asnA; Aspartate--ammonia ligase K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1]
D MGAS10750_Spy0555 aspC; Aspartate aminotransferase K22457 E2.6.1.14; asparagine---oxo-acid transaminase [EC:2.6.1.14]
D MGAS10750_Spy1573 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D MGAS10750_Spy0141 purA; Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D MGAS10750_Spy0035 purB; Adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D MGAS10750_Spy0730 pyrB; Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D MGAS10750_Spy0938 gabD; Succinate-semialdehyde dehydrogenase (NADP+) K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
D MGAS10750_Spy1654 glnA; Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D MGAS10750_Spy0733 carB; Carbamoyl-phosphate synthase large chain K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D MGAS10750_Spy0731 carA; Carbamoyl-phosphate synthase small chain K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D MGAS10750_Spy1136 glmS; Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D MGAS10750_Spy0024 purF; Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C 00260 Glycine, serine and threonine metabolism [PATH:spi00260]
D MGAS10750_Spy1016 glyA; serinehydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D MGAS10750_Spy1675 Glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165]
D MGAS10750_Spy1272 gpmA; Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D MGAS10750_Spy1002 Short chain dehydrogenase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy1957 sdhB; L-serinedehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
D MGAS10750_Spy1958 sdhA; L-serinedehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
C 00270 Cysteine and methionine metabolism [PATH:spi00270]
D MGAS10750_Spy1752 cysE; serineacetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]
D MGAS10750_Spy1438 cysM; Cysteine synthase K01738 cysK; cysteine synthase [EC:2.5.1.47]
D MGAS10750_Spy0152 metB; Cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
D MGAS10750_Spy0465 metK1; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D MGAS10750_Spy1207 metK2; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D MGAS10750_Spy0367 pfs; 5'-methylthioadenosine nucleosidase / S-adenosylhomocysteine nucleosidase K01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9]
D MGAS10750_Spy1213 GAF domain-containing protein K08968 msrC; L-methionine (R)-S-oxide reductase [EC:1.8.4.14]
D MGAS10750_Spy1697 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy0948 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy1458 luxS; Autoinducer-2 production protein luxS K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]
D MGAS10750_Spy0805 bcaT; Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D MGAS10750_Spy1022 ldh; L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D MGAS10750_Spy1957 sdhB; L-serinedehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
D MGAS10750_Spy1958 sdhA; L-serinedehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17]
C 00280 Valine, leucine and isoleucine degradation [PATH:spi00280]
D MGAS10750_Spy0805 bcaT; Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0779 mvaS1; Hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
C 00290 Valine, leucine and isoleucine biosynthesis [PATH:spi00290]
D MGAS10750_Spy0805 bcaT; Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D MGAS10750_Spy1573 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
C 00300 Lysine biosynthesis
D MGAS10750_Spy1265 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
C 00310 Lysine degradation [PATH:spi00310]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0938 gabD; Succinate-semialdehyde dehydrogenase (NADP+) K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
D MGAS10750_Spy1454 atoD1; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0125 atoD2; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy1455 atoA; Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0126 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
C 00220 Arginine biosynthesis [PATH:spi00220]
D MGAS10750_Spy1380 arcB; Ornithine carbamoyltransferase K00611 OTC; ornithine carbamoyltransferase [EC:2.1.3.3]
D MGAS10750_Spy1382 arcA; Arginine deiminase K01478 arcA; arginine deiminase [EC:3.5.3.6]
D MGAS10750_Spy1654 glnA; Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D MGAS10750_Spy1377 arcC; Carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2]
D MGAS10750_Spy1573 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
C 00330 Arginine and proline metabolism [PATH:spi00330]
D MGAS10750_Spy0797 amiC; Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy1788 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy0103 proC; Pyrroline-5-carboxylate reductase K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]
D MGAS10750_Spy1481 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11]
D MGAS10750_Spy1480 proA; Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
C 00340 Histidine metabolism [PATH:spi00340]
D MGAS10750_Spy1869 hutH; Histidine ammonia-lyase K01745 hutH; histidine ammonia-lyase [EC:4.3.1.3]
D MGAS10750_Spy1863 hutU; Urocanate hydratase K01712 hutU; urocanate hydratase [EC:4.2.1.49]
D MGAS10750_Spy1862 hutI; Imidazolonepropionase K01468 hutI; imidazolonepropionase [EC:3.5.2.7]
D MGAS10750_Spy1870 hutG; Formiminoglutamase K01479 hutG; formiminoglutamase [EC:3.5.3.8]
D MGAS10750_Spy1864 glutamate formiminotransferase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2]
C 00350 Tyrosine metabolism [PATH:spi00350]
D MGAS10750_Spy0041 Alcohol dehydrogenase / Acetaldehyde dehydrogenase (acetylating) K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
D MGAS10750_Spy0042 adhA; Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D MGAS10750_Spy0938 gabD; Succinate-semialdehyde dehydrogenase (NADP+) K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
C 00360 Phenylalanine metabolism
D MGAS10750_Spy0797 amiC; Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy1788 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
C 00380 Tryptophan metabolism [PATH:spi00380]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0797 amiC; Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy1788 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:spi00400]
D MGAS10750_Spy1406 3-deoxy-7-phosphoheptulonate synthase K03856 AROA2; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D MGAS10750_Spy1407 aroB; 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4]
D MGAS10750_Spy0711 aroD; 3-dehydroquinate dehydratase K03785 aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10]
D MGAS10750_Spy0461 aroE2; Shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25]
D MGAS10750_Spy1199 aroK; Shikimate kinase K00891 aroK; shikimate kinase [EC:2.7.1.71]
D MGAS10750_Spy1200 3-phosphoshikimate 1-carboxyvinyltransferase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]
D MGAS10750_Spy0712 aroF; Chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5]
D MGAS10750_Spy1790 trpG; Anthranilate synthase component II / Para-aminobenzoate synthase glutamine amidotransferase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
D MGAS10750_Spy0632 Chorismate mutase K04516 AROA1; chorismate mutase [EC:5.4.99.5]
B
B 09106 Metabolism of other amino acids
C 00410 beta-Alanine metabolism
C 00430 Taurine and hypotaurine metabolism [PATH:spi00430]
D MGAS10750_Spy1001 pta; Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8]
D MGAS10750_Spy0101 ackA; Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1]
C 00440 Phosphonate and phosphinate metabolism
C 00450 Selenocompound metabolism [PATH:spi00450]
D MGAS10750_Spy0152 metB; Cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
D MGAS10750_Spy0241 nifS3; Cysteine desulfurase / Selenocysteine lyase K11717 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]
D MGAS10750_Spy1469 Thioredoxin reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]
D MGAS10750_Spy0347 metS; Methionyl-tRNA synthetase / Protein secretion chaperonin CsaA K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
C 00460 Cyanoamino acid metabolism [PATH:spi00460]
D MGAS10750_Spy1576 asnB; L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1]
D MGAS10750_Spy1376 asnA; Aspartate--ammonia ligase K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1]
D MGAS10750_Spy1016 glyA; serinehydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
C 00470 D-Amino acid metabolism [PATH:spi00470]
D MGAS10750_Spy1591 acpS; Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D MGAS10750_Spy1266 ddlA; D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D MGAS10750_Spy1166 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D MGAS10750_Spy1164 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D MGAS10750_Spy0297 glr; Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D MGAS10750_Spy1361 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
C 00480 Glutathione metabolism [PATH:spi00480]
D MGAS10750_Spy1098 pepN; Lysyl aminopeptidase / alanine aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2]
D MGAS10750_Spy0813 Glutathione S-transferase K00799 GST; glutathione S-transferase [EC:2.5.1.18]
D MGAS10750_Spy0715 gor; Glutathione reductase K00383 GSR; glutathione reductase (NADPH) [EC:1.8.1.7]
D MGAS10750_Spy0522 Glutathione peroxidase K00432 gpx; glutathione peroxidase [EC:1.11.1.9]
B
B 09107 Glycan biosynthesis and metabolism
C 00510 N-Glycan biosynthesis
C 00513 Various types of N-glycan biosynthesis
C 00512 Mucin type O-glycan biosynthesis
C 00515 Mannose type O-glycan biosynthesis
C 00514 Other types of O-glycan biosynthesis
C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
C 00533 Glycosaminoglycan biosynthesis - keratan sulfate
C 00531 Glycosaminoglycan degradation
C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series
C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series
C 00604 Glycosphingolipid biosynthesis - ganglio series
C 00511 Other glycan degradation [PATH:spi00511]
D MGAS10750_Spy1413 lacZ; Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23]
D MGAS10750_Spy1426 Alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
C 00540 Lipopolysaccharide biosynthesis
C 00542 O-Antigen repeat unit biosynthesis [PATH:spi00542]
D MGAS10750_Spy0237 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
C 00541 O-Antigen nucleotide sugar biosynthesis [PATH:spi00541]
D MGAS10750_Spy0188 hasC; UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D MGAS10750_Spy0469 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D MGAS10750_Spy0828 cpsFO; Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D MGAS10750_Spy0830 cpsFQ; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D MGAS10750_Spy0829 cpsFP; dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D MGAS10750_Spy0689 rmlD; dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
D MGAS10750_Spy1597 pmi; Mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8]
D MGAS10750_Spy0364 gcaD; Glucosamine-1-phosphate acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
C 00550 Peptidoglycan biosynthesis [PATH:spi00550]
D MGAS10750_Spy0668 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D MGAS10750_Spy1206 murZ; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D MGAS10750_Spy0976 murB; UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D MGAS10750_Spy0285 murC; UDP-N-acetylmuramate--alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D MGAS10750_Spy1361 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D MGAS10750_Spy1266 ddlA; D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D MGAS10750_Spy1265 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D MGAS10750_Spy0388 dgk; Diacylglycerol kinase K00887 dgkA; undecaprenol kinase [EC:2.7.1.66]
D MGAS10750_Spy1770 uppS; Undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D MGAS10750_Spy0235 bacA; Bacitracin resistance protein K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D MGAS10750_Spy0308 Membrane-associated phospholipid phosphatase K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]
D MGAS10750_Spy1475 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D MGAS10750_Spy1360 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D MGAS10750_Spy1464 pbp1A; Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy1847 pbp2A; Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy0968 dacA1; D-alanyl-D-alanine serine-type carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D MGAS10750_Spy0245 dacA2; D-alanyl-D-alanine serine-type carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D MGAS10750_Spy1562 D-alanyl-D-alanine metallocarboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D MGAS10750_Spy0321 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--lysine ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7]
D MGAS10750_Spy0912 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase K23393 murT; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13]
D MGAS10750_Spy0911 CobB/CobQ-like glutamine amidotransferase domain K07009 gatD; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13]
D MGAS10750_Spy1069 UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10]
D MGAS10750_Spy0530 murM; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10]
D MGAS10750_Spy0529 Factor essential for expression of methicillin resistance K12554 murN; alanine adding enzyme [EC:2.3.2.-]
D MGAS10750_Spy0089 pbp1b; Multimodular transpeptidase-transglycosylase PBP 1B K03693 pbp1b; penicillin-binding protein 1B
D MGAS10750_Spy1476 Division specific D,D-transpeptidase / Cell division protein ftsI K12556 pbp2X; penicillin-binding protein 2X
C 00552 Teichoic acid biosynthesis [PATH:spi00552]
D MGAS10750_Spy0235 bacA; Bacitracin resistance protein K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D MGAS10750_Spy0308 Membrane-associated phospholipid phosphatase K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]
D MGAS10750_Spy0237 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
D MGAS10750_Spy1166 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D MGAS10750_Spy1164 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D MGAS10750_Spy1165 Protein dltB K03739 dltB; membrane protein involved in D-alanine export
D MGAS10750_Spy1163 dltD; Protein dltD precursor K03740 dltD; D-alanine transfer protein
D MGAS10750_Spy1533 lytR; Transcriptional regulator, LytR family K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-]
D MGAS10750_Spy1198 Transcriptional regulator, LytR family K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-]
D MGAS10750_Spy0709 Sulfatase family protein K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20]
D MGAS10750_Spy0439 1,2-diacylglycerol 3-glucosyltransferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]
C 00571 Lipoarabinomannan (LAM) biosynthesis
C 00572 Arabinogalactan biosynthesis - Mycobacterium
C 00543 Exopolysaccharide biosynthesis [PATH:spi00543]
D MGAS10750_Spy0237 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
D MGAS10750_Spy1752 cysE; serineacetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30]
B
B 09108 Metabolism of cofactors and vitamins
C 00730 Thiamine metabolism [PATH:spi00730]
D MGAS10750_Spy0995 nifS2; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy0718 nifS1; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy0719 thiI; Thiamine biosynthesis protein thiI K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D MGAS10750_Spy0218 GTPase K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
D MGAS10750_Spy0220 Thiamin pyrophosphokinase K00949 thiN; thiamine pyrophosphokinase [EC:2.7.6.2]
D MGAS10750_Spy0069 adk; Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
C 00740 Riboflavin metabolism [PATH:spi00740]
D MGAS10750_Spy1537 Hydrolase K21064 ycsE; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104]
D MGAS10750_Spy1111 mreA; Riboflavin kinase / FMN adenylyltransferase K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]
D MGAS10750_Spy0986 Class B acid phosphatase K03788 aphA; acid phosphatase (class B) [EC:3.1.3.2]
D MGAS10750_Spy0365 ADP-ribose pyrophosphatase K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-]
C 00750 Vitamin B6 metabolism [PATH:spi00750]
D MGAS10750_Spy1072 Pyridoxine kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35]
D MGAS10750_Spy1671 thiD; Phosphomethylpyrimidine kinase / Hydroxymethylpyrimidine kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35]
C 00760 Nicotinate and nicotinamide metabolism [PATH:spi00760]
D MGAS10750_Spy1186 nadC; Nicotinate-nucleotide pyrophosphorylase (carboxylating) K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]
D MGAS10750_Spy1467 nadE; Nicotinate phosphoribosyltransferase K00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21]
D MGAS10750_Spy0790 punA; Purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
D MGAS10750_Spy0791 deoD2; Purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]
D MGAS10750_Spy0770 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5]
D MGAS10750_Spy0257 nadD; Nicotinate-nucleotide adenylyltransferase K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]
D MGAS10750_Spy1466 NH(3)-dependent NAD(+) synthetase K01916 nadE; NAD+ synthase [EC:6.3.1.5]
D MGAS10750_Spy0145 nga; NAD glycohydrolase K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5]
D MGAS10750_Spy0999 ATP-NAD kinase K00858 ppnK; NAD+ kinase [EC:2.7.1.23]
D MGAS10750_Spy0938 gabD; Succinate-semialdehyde dehydrogenase (NADP+) K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
C 00770 Pantothenate and CoA biosynthesis [PATH:spi00770]
D MGAS10750_Spy0750 apbA; Ketopantoate reductase PanE/ApbA family protein K00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169]
D MGAS10750_Spy1094 coaA; Pantothenate kinase K00867 coaA; type I pantothenate kinase [EC:2.7.1.33]
D MGAS10750_Spy1084 dpfB; Phosphopantothenate--cysteine ligase K21977 coaB; phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5]
D MGAS10750_Spy1085 dfp; Phosphopantothenoylcysteine decarboxylase K01598 PPCDC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36]
D MGAS10750_Spy1374 Phosphopantetheine adenylyltransferase K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]
D MGAS10750_Spy0422 Dephospho-CoA kinase K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24]
D MGAS10750_Spy1592 alr; holo-synthase K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]
D MGAS10750_Spy0805 bcaT; Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
C 00780 Biotin metabolism [PATH:spi00780]
D MGAS10750_Spy1548 fabF; 3-oxoacyl-(acyl-carrier-protein) synthase K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D MGAS10750_Spy1549 3-oxoacyl-reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D MGAS10750_Spy0361 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D MGAS10750_Spy1546 fabZ; (3R)-hydroxyacyl-dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D MGAS10750_Spy1209 birA; Biotin operon repressor / Biotin--(acetyl-CoA-carboxylase) synthetase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
C 00785 Lipoic acid metabolism [PATH:spi00785]
D MGAS10750_Spy0910 lplB; Lipoate-protein ligase A K03800 lplA; lipoate---protein ligase [EC:6.3.1.20]
D MGAS10750_Spy1077 lplA; Lipoate-protein ligase A K03800 lplA; lipoate---protein ligase [EC:6.3.1.20]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy0903 acoA; Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
D MGAS10750_Spy0904 acoB; Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1]
D MGAS10750_Spy0905 acoC; Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12]
C 00790 Folate biosynthesis [PATH:spi00790]
D MGAS10750_Spy0972 folE; GTP cyclohydrolase I K01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16]
D MGAS10750_Spy0974 folQ; Dihydroneopterin aldolase K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81]
D MGAS10750_Spy0975 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
D MGAS10750_Spy0973 folP; Dihydropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15]
D MGAS10750_Spy0781 dyr; Dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]
D MGAS10750_Spy0716 folC2; Folylpolyglutamate synthase / Dihydrofolate synthase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
D MGAS10750_Spy0971 folC1; Folylpolyglutamate synthase / Dihydrofolate synthase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
D MGAS10750_Spy1789 Para-aminobenzoate synthetase component I / 4-amino-4-deoxychorismate lyase K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38]
C 00670 One carbon pool by folate [PATH:spi00670]
D MGAS10750_Spy0781 dyr; Dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3]
D MGAS10750_Spy1076 fhs1; Formate--tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3]
D MGAS10750_Spy1866 fhs2; Formate--tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3]
D MGAS10750_Spy1341 folD; Methylenetetrahydrofolate dehydrogenase (NADP+) / Methenyltetrahydrofolate cyclohydrolase K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
D MGAS10750_Spy1865 formiminotetrahydrofolate cyclodeaminase K01500 fchA; methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9]
D MGAS10750_Spy1016 glyA; serinehydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D MGAS10750_Spy0026 purN; Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]
D MGAS10750_Spy0027 Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D MGAS10750_Spy1864 glutamate formiminotransferase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2]
D MGAS10750_Spy1447 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
D MGAS10750_Spy0780 thyA; Thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45]
C 00830 Retinol metabolism
C 00860 Porphyrin metabolism
C 00130 Ubiquinone and other terpenoid-quinone biosynthesis
B
B 09109 Metabolism of terpenoids and polyketides
C 00900 Terpenoid backbone biosynthesis [PATH:spi00900]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0779 mvaS1; Hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]
D MGAS10750_Spy0778 3-hydroxy-3-methylglutaryl-coenzyme A reductase / 3-hydroxy-3-methylglutaryl-coenzyme A reductase K00054 mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]
D MGAS10750_Spy0774 mvaK1; Mevalonate kinase K00869 MVK; mevalonate kinase [EC:2.7.1.36]
D MGAS10750_Spy0776 mvaK2; Phosphomevalonate kinase K00938 E2.7.4.2; phosphomevalonate kinase [EC:2.7.4.2]
D MGAS10750_Spy0775 mvaD; Diphosphomevalonate decarboxylase K01597 MVD; diphosphomevalonate decarboxylase [EC:4.1.1.33]
D MGAS10750_Spy0777 Isopentenyl-diphosphate delta-isomerase K01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]
D MGAS10750_Spy1338 fps; Dimethylallyltransferase / Geranyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]
D MGAS10750_Spy1770 uppS; Undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
C 00902 Monoterpenoid biosynthesis
C 00909 Sesquiterpenoid and triterpenoid biosynthesis
C 00904 Diterpenoid biosynthesis
C 00906 Carotenoid biosynthesis
C 00905 Brassinosteroid biosynthesis
C 00981 Insect hormone biosynthesis
C 00908 Zeatin biosynthesis
C 00903 Limonene degradation
C 00907 Pinene, camphor and geraniol degradation
C 01052 Type I polyketide structures
C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides
C 01051 Biosynthesis of ansamycins
D MGAS10750_Spy1485 tkt; Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
C 01059 Biosynthesis of enediyne antibiotics
C 01056 Biosynthesis of type II polyketide backbone
C 01057 Biosynthesis of type II polyketide products
C 00253 Tetracycline biosynthesis
C 00523 Polyketide sugar unit biosynthesis [PATH:spi00523]
D MGAS10750_Spy0828 cpsFO; Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D MGAS10750_Spy0830 cpsFQ; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D MGAS10750_Spy0829 cpsFP; dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D MGAS10750_Spy0689 rmlD; dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
C 01054 Nonribosomal peptide structures
C 01053 Biosynthesis of siderophore group nonribosomal peptides
C 01055 Biosynthesis of vancomycin group antibiotics
D MGAS10750_Spy0830 cpsFQ; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
B
B 09110 Biosynthesis of other secondary metabolites
C 00940 Phenylpropanoid biosynthesis
C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
C 00941 Flavonoid biosynthesis
C 00944 Flavone and flavonol biosynthesis
C 00942 Anthocyanin biosynthesis
C 00943 Isoflavonoid biosynthesis
C 00946 Degradation of flavonoids
C 00901 Indole alkaloid biosynthesis
C 00403 Indole diterpene alkaloid biosynthesis
C 00950 Isoquinoline alkaloid biosynthesis
C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis
C 00996 Biosynthesis of various alkaloids
C 00232 Caffeine metabolism
C 00965 Betalain biosynthesis
C 00966 Glucosinolate biosynthesis
C 00402 Benzoxazinoid biosynthesis
C 00311 Penicillin and cephalosporin biosynthesis
C 00332 Carbapenem biosynthesis [PATH:spi00332]
D MGAS10750_Spy1481 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11]
D MGAS10750_Spy1480 proA; Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
C 00261 Monobactam biosynthesis
C 00331 Clavulanic acid biosynthesis
C 00521 Streptomycin biosynthesis [PATH:spi00521]
D MGAS10750_Spy1365 glcK; Glucokinase K25026 glk; glucokinase [EC:2.7.1.2]
D MGAS10750_Spy1087 pgmA; Phosphoglucomutase / Phosphomannomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2]
D MGAS10750_Spy1107 Myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D MGAS10750_Spy1108 Myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D MGAS10750_Spy0828 cpsFO; Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D MGAS10750_Spy0830 cpsFQ; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D MGAS10750_Spy0829 cpsFP; dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D MGAS10750_Spy0689 rmlD; dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
C 00524 Neomycin, kanamycin and gentamicin biosynthesis
D MGAS10750_Spy1365 glcK; Glucokinase K25026 glk; glucokinase [EC:2.7.1.2]
C 00525 Acarbose and validamycin biosynthesis [PATH:spi00525]
D MGAS10750_Spy0828 cpsFO; Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D MGAS10750_Spy0830 cpsFQ; dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
C 00401 Novobiocin biosynthesis
C 00404 Staurosporine biosynthesis
C 00405 Phenazine biosynthesis
D MGAS10750_Spy1790 trpG; Anthranilate synthase component II / Para-aminobenzoate synthase glutamine amidotransferase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
C 00333 Prodigiosin biosynthesis
D MGAS10750_Spy1550 fabD; Malonyl-CoA-(acyl-carrier-protein) transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D MGAS10750_Spy1549 3-oxoacyl-reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D MGAS10750_Spy0361 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
C 00254 Aflatoxin biosynthesis
C 00998 Biosynthesis of various antibiotics
D MGAS10750_Spy1553 acpP; acyl-carrier protein K02078 acpP; acyl carrier protein
D MGAS10750_Spy0021 acpP2; acyl-carrier protein K02078 acpP; acyl carrier protein
C 00999 Biosynthesis of various plant secondary metabolites [PATH:spi00999]
D MGAS10750_Spy0465 metK1; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D MGAS10750_Spy1207 metK2; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D MGAS10750_Spy0461 aroE2; Shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25]
C 00997 Biosynthesis of various other secondary metabolites
B
B 09111 Xenobiotics biodegradation and metabolism
C 00362 Benzoate degradation [PATH:spi00362]
D MGAS10750_Spy1879 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
D MGAS10750_Spy1010 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6]
D MGAS10750_Spy1046 Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1052 oadB; Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1045 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
D MGAS10750_Spy1051 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
C 00627 Aminobenzoate degradation [PATH:spi00627]
D MGAS10750_Spy0797 amiC; Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy1788 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy0291 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7]
D MGAS10750_Spy1454 atoD1; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0125 atoD2; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy1455 atoA; Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0126 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
C 00364 Fluorobenzoate degradation
C 00625 Chloroalkane and chloroalkene degradation [PATH:spi00625]
D MGAS10750_Spy0042 adhA; Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D MGAS10750_Spy0041 Alcohol dehydrogenase / Acetaldehyde dehydrogenase (acetylating) K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
C 00361 Chlorocyclohexane and chlorobenzene degradation
D MGAS10750_Spy1879 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
C 00623 Toluene degradation
C 00622 Xylene degradation [PATH:spi00622]
D MGAS10750_Spy1879 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
D MGAS10750_Spy1010 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6]
C 00633 Nitrotoluene degradation
C 00642 Ethylbenzene degradation
C 00643 Styrene degradation [PATH:spi00643]
D MGAS10750_Spy0797 amiC; Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy1788 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4]
D MGAS10750_Spy1879 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2]
C 00791 Atrazine degradation
C 00930 Caprolactam degradation
C 00363 Bisphenol degradation
C 00621 Dioxin degradation
D MGAS10750_Spy1010 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6]
C 00626 Naphthalene degradation [PATH:spi00626]
D MGAS10750_Spy0042 adhA; Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D MGAS10750_Spy0041 Alcohol dehydrogenase / Acetaldehyde dehydrogenase (acetylating) K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
C 00624 Polycyclic aromatic hydrocarbon degradation
C 00365 Furfural degradation
C 00984 Steroid degradation
C 00980 Metabolism of xenobiotics by cytochrome P450
C 00982 Drug metabolism - cytochrome P450
C 00983 Drug metabolism - other enzymes
B
B 09112 Not included in regular maps
C 09113 Global maps only
#
A09120 Genetic Information Processing
B
B 09121 Transcription
C 03020 RNA polymerase [PATH:spi03020]
D MGAS10750_Spy0090 rpoB; DNA-directed RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D MGAS10750_Spy0091 rpoC; DNA-directed RNA polymerase beta' chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D MGAS10750_Spy0074 rpoA; DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D MGAS10750_Spy1449 DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D MGAS10750_Spy1666 rpoE; DNA-directed RNA polymerase delta chain K03048 rpoE; DNA-directed RNA polymerase subunit delta
C 03022 Basal transcription factors
C 03040 Spliceosome
B
B 09122 Translation
C 03010 Ribosome [PATH:spi03010]
D MGAS10750_Spy0809 SSU ribosomal protein S1P K02945 RP-S1; small subunit ribosomal protein S1
D MGAS10750_Spy1872 rpsB; SSU ribosomal protein S2P K02967 RP-S2; small subunit ribosomal protein S2
D MGAS10750_Spy0053 rpsC; SSU ribosomal protein S3P K02982 RP-S3; small subunit ribosomal protein S3
D MGAS10750_Spy1949 rpsD; SSU ribosomal protein S4P K02986 RP-S4; small subunit ribosomal protein S4
D MGAS10750_Spy0065 rpsE; SSU ribosomal protein S5P K02988 RP-S5; small subunit ribosomal protein S5
D MGAS10750_Spy1614 rpsF; SSU ribosomal protein S6P K02990 RP-S6; small subunit ribosomal protein S6
D MGAS10750_Spy0226 rpsG; SSU ribosomal protein S7P K02992 RP-S7; small subunit ribosomal protein S7
D MGAS10750_Spy0062 rpsH; SSU ribosomal protein S8P K02994 RP-S8; small subunit ribosomal protein S8
D MGAS10750_Spy1740 rpsI; SSU ribosomal protein S9P K02996 RP-S9; small subunit ribosomal protein S9
D MGAS10750_Spy0044 rpsJ; SSU ribosomal protein S10P K02946 RP-S10; small subunit ribosomal protein S10
D MGAS10750_Spy0073 rpsK; SSU ribosomal protein S11P K02948 RP-S11; small subunit ribosomal protein S11
D MGAS10750_Spy0225 rpsL; SSU ribosomal protein S12P K02950 RP-S12; small subunit ribosomal protein S12
D MGAS10750_Spy0072 rpsM; SSU ribosomal protein S13P K02952 RP-S13; small subunit ribosomal protein S13
D MGAS10750_Spy1648 rpsN2; SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14
D MGAS10750_Spy0061 rpsN; SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14
D MGAS10750_Spy1760 SSU ribosomal protein S15P K02956 RP-S15; small subunit ribosomal protein S15
D MGAS10750_Spy0738 rpsP; SSU ribosomal protein S16P K02959 RP-S16; small subunit ribosomal protein S16
D MGAS10750_Spy0056 rpsQ; SSU ribosomal protein S17P K02961 RP-S17; small subunit ribosomal protein S17
D MGAS10750_Spy1612 rpsR; SSU ribosomal protein S18P K02963 RP-S18; small subunit ribosomal protein S18
D MGAS10750_Spy0051 rpsS; SSU ribosomal protein S19P K02965 RP-S19; small subunit ribosomal protein S19
D MGAS10750_Spy1095 rpsT; SSU ribosomal protein S20P K02968 RP-S20; small subunit ribosomal protein S20
D MGAS10750_Spy0682 SSU ribosomal protein S21P K02970 RP-S21; small subunit ribosomal protein S21
D MGAS10750_Spy0377 rplA; LSU ribosomal protein L1P K02863 RP-L1; large subunit ribosomal protein L1
D MGAS10750_Spy0050 rplB; LSU ribosomal protein L2P K02886 RP-L2; large subunit ribosomal protein L2
D MGAS10750_Spy0045 rplC; LSU ribosomal protein L3P K02906 RP-L3; large subunit ribosomal protein L3
D MGAS10750_Spy0048 rplD; LSU ribosomal protein L1E (L4P) K02926 RP-L4; large subunit ribosomal protein L4
D MGAS10750_Spy0047 LSU ribosomal protein L1E (L4P) K02926 RP-L4; large subunit ribosomal protein L4
D MGAS10750_Spy0060 rplE; LSU ribosomal protein L5P K02931 RP-L5; large subunit ribosomal protein L5
D MGAS10750_Spy0063 rplF; LSU ribosomal protein L6P K02933 RP-L6; large subunit ribosomal protein L6
D MGAS10750_Spy0944 rplL; LSU ribosomal protein L12P (L7/L12) K02935 RP-L7; large subunit ribosomal protein L7/L12
D MGAS10750_Spy1952 rplI; LSU ribosomal protein L9P K02939 RP-L9; large subunit ribosomal protein L9
D MGAS10750_Spy0943 rplJ; LSU ribosomal protein L10P K02864 RP-L10; large subunit ribosomal protein L10
D MGAS10750_Spy0376 rplK; LSU ribosomal protein L11P K02867 RP-L11; large subunit ribosomal protein L11
D MGAS10750_Spy1741 rplM; LSU ribosomal protein L13P K02871 RP-L13; large subunit ribosomal protein L13
D MGAS10750_Spy0057 rplN; LSU ribosomal protein L14P K02874 RP-L14; large subunit ribosomal protein L14
D MGAS10750_Spy0058 LSU ribosomal protein L14P K02874 RP-L14; large subunit ribosomal protein L14
D MGAS10750_Spy0067 rplO; LSU ribosomal protein L15P K02876 RP-L15; large subunit ribosomal protein L15
D MGAS10750_Spy0054 rplP; LSU ribosomal protein L16P K02878 RP-L16; large subunit ribosomal protein L16
D MGAS10750_Spy0075 rplQ; LSU ribosomal protein L17P K02879 RP-L17; large subunit ribosomal protein L17
D MGAS10750_Spy0064 rplR; LSU ribosomal protein L18P K02881 RP-L18; large subunit ribosomal protein L18
D MGAS10750_Spy0634 rplS; LSU ribosomal protein L19P K02884 RP-L19; large subunit ribosomal protein L19
D MGAS10750_Spy0708 rplT; LSU ribosomal protein L20P K02887 RP-L20; large subunit ribosomal protein L20
D MGAS10750_Spy0722 rplU; LSU ribosomal protein L21P K02888 RP-L21; large subunit ribosomal protein L21
D MGAS10750_Spy0052 rplV; LSU ribosomal protein L22P K02890 RP-L22; large subunit ribosomal protein L22
D MGAS10750_Spy0049 rplW; LSU ribosomal protein L23P K02892 RP-L23; large subunit ribosomal protein L23
D MGAS10750_Spy0059 rplX; LSU ribosomal protein L24P K02895 RP-L24; large subunit ribosomal protein L24
D MGAS10750_Spy0724 rpmA; LSU ribosomal protein L27P K02899 RP-L27; large subunit ribosomal protein L27
D MGAS10750_Spy1662 rpmB; LSU ribosomal protein L28P K02902 RP-L28; large subunit ribosomal protein L28
D MGAS10750_Spy0055 rpmC; LSU ribosomal protein L29P K02904 RP-L29; large subunit ribosomal protein L29
D MGAS10750_Spy0066 rpmD; LSU ribosomal protein L30P K02907 RP-L30; large subunit ribosomal protein L30
D MGAS10750_Spy0629 rpmE; LSU ribosomal protein L31P K02909 RP-L31; large subunit ribosomal protein L31
D MGAS10750_Spy1932 rpmF; LSU ribosomal protein L32P K02911 RP-L32; large subunit ribosomal protein L32
D MGAS10750_Spy1846 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33
D MGAS10750_Spy1933 rpmG; LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33
D MGAS10750_Spy0425 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33
D MGAS10750_Spy0205 rpmH; LSU ribosomal protein L34P K02914 RP-L34; large subunit ribosomal protein L34
D MGAS10750_Spy0707 rpl36; LSU ribosomal protein L35P K02916 RP-L35; large subunit ribosomal protein L35
D MGAS10750_Spy0071 rpmJ; LSU ribosomal protein L36P K02919 RP-L36; large subunit ribosomal protein L36
D MGAS10750SpyR2237 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2272 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2257 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2292 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2300 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2225 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2226 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2273 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2238 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2258 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2298 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2290 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2227 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2274 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2239 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2259 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2289 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2297 5S RNA K01985 5SrRNA; 5S ribosomal RNA
C 00970 Aminoacyl-tRNA biosynthesis [PATH:spi00970]
D MGAS10750SpyR2291 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D MGAS10750SpyR2299 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D MGAS10750SpyR2237 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2272 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2257 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2280 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2305 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2277 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2235 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2247 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2276 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2295 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2303 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D MGAS10750SpyR2275 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D MGAS10750SpyR2296 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D MGAS10750SpyR2229 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D MGAS10750SpyR2287 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D MGAS10750SpyR2241 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D MGAS10750SpyR2302 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D MGAS10750SpyR2279 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D MGAS10750SpyR2270 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D MGAS10750SpyR2282 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D MGAS10750SpyR2304 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D MGAS10750SpyR2263 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D MGAS10750SpyR2254 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2261 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2233 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2245 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2269 tRNA-His K14226 tRNA-His; tRNA His
D MGAS10750SpyR2255 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D MGAS10750SpyR2283 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D MGAS10750SpyR2262 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D MGAS10750SpyR2234 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2246 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2271 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2231 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2243 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2285 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2294 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2230 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2286 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2242 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2301 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2249 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2250 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2252 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2265 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2253 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D MGAS10750SpyR2266 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D MGAS10750SpyR2236 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D MGAS10750SpyR2248 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D MGAS10750SpyR2251 pseudogene K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2264 pseudogene K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2293 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2256 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2281 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2232 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2284 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2244 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2268 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D MGAS10750SpyR2267 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D MGAS10750SpyR2278 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D MGAS10750SpyR2288 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750SpyR2260 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750SpyR2240 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750SpyR2228 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750_Spy0198 gltX; Glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
D MGAS10750_Spy1567 gatA; Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
D MGAS10750_Spy1566 gatB; Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
D MGAS10750_Spy1568 gatC; Glutamyl-tRNA(Gln) amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
D MGAS10750_Spy1239 alaS; Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D MGAS10750_Spy1930 aspS; Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D MGAS10750_Spy0482 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D MGAS10750_Spy0556 asnS; Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D MGAS10750_Spy1496 glyQ; Glycyl-tRNA synthetase alpha chain K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D MGAS10750_Spy1495 glyS; Glycyl-tRNA synthetase beta chain K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D MGAS10750_Spy0440 thrS; Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D MGAS10750_Spy1542 serS; Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D MGAS10750_Spy1749 cysS; Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D MGAS10750_Spy0347 metS; Methionyl-tRNA synthetase / Protein secretion chaperonin CsaA K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D MGAS10750_Spy1447 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
D MGAS10750_Spy1400 valS; Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D MGAS10750_Spy0153 leuS; Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MGAS10750_Spy1350 ileS; Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D MGAS10750_Spy0514 lysS; Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D MGAS10750_Spy1925 argS; Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D MGAS10750_Spy1767 proS; Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D MGAS10750_Spy1931 hisS; Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D MGAS10750_Spy0672 pheS; Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D MGAS10750_Spy0673 pheT; Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D MGAS10750_Spy0088 tyrS; Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MGAS10750_Spy1971 trsA; Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C 03013 Nucleocytoplasmic transport
C 03015 mRNA surveillance pathway
C 03008 Ribosome biogenesis in eukaryotes
B
B 09123 Folding, sorting and degradation
C 03060 Protein export [PATH:spi03060]
D MGAS10750_Spy0068 secY; Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY
D MGAS10750_Spy1845 secE; Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE
D MGAS10750_Spy0426 secG; Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG
D MGAS10750_Spy1771 yajC; Protein translocase subunit YajC K03210 yajC; preprotein translocase subunit YajC
D MGAS10750_Spy0203 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy0290 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy1593 secA; Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D MGAS10750_Spy1064 ffh; signal recognition particle subunit FFH/SRP54 K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D MGAS10750_Spy0494 ftsY; Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor
D MGAS10750_Spy1137 sipC; Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D MGAS10750_Spy1624 spi; Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D MGAS10750_Spy0726 lsp; Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36]
C 04141 Protein processing in endoplasmic reticulum
C 04130 SNARE interactions in vesicular transport
C 04120 Ubiquitin mediated proteolysis
C 04122 Sulfur relay system [PATH:spi04122]
D MGAS10750_Spy0995 nifS2; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy0718 nifS1; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy1956 trmU; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D MGAS10750_Spy0719 thiI; Thiamine biosynthesis protein thiI K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
C 03050 Proteasome
C 03018 RNA degradation [PATH:spi03018]
D MGAS10750_Spy0639 eno; Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D MGAS10750_Spy1754 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D MGAS10750_Spy0427 Exoribonuclease II K12573 rnr; ribonuclease R [EC:3.1.13.1]
D MGAS10750_Spy1261 deaD; ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D MGAS10750_Spy1451 Hydrolase K18682 rny; ribonucrease Y [EC:3.1.-.-]
D MGAS10750_Spy1653 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-]
D MGAS10750_Spy0899 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D MGAS10750_Spy1558 dnaK; Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D MGAS10750_Spy1855 groEL; 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
B
B 09124 Replication and repair
C 03030 DNA replication [PATH:spi03030]
D MGAS10750_Spy1640 dnaQ; DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D MGAS10750_Spy1140 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D MGAS10750_Spy1766 polC; DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D MGAS10750_Spy1211 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D MGAS10750_Spy0327 dnaX; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D MGAS10750_Spy1253 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D MGAS10750_Spy0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D MGAS10750_Spy1951 holB; Replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D MGAS10750_Spy0686 dnaG; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D MGAS10750_Spy1613 ssb2; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy0109 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy1032 Ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D MGAS10750_Spy1623 Ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4]
D MGAS10750_Spy0165 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D MGAS10750_Spy0655 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03410 Base excision repair [PATH:spi03410]
D MGAS10750_Spy0824 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D MGAS10750_Spy0800 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
D MGAS10750_Spy1616 mutY; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D MGAS10750_Spy0421 fpg; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
D MGAS10750_Spy1893 tag; DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
D MGAS10750_Spy0337 exoA; Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D MGAS10750_Spy0165 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D MGAS10750_Spy0821 recJ; Single-stranded-DNA-specific exonuclease recJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D MGAS10750_Spy0655 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03420 Nucleotide excision repair [PATH:spi03420]
D MGAS10750_Spy0006 trcF; Transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D MGAS10750_Spy1609 uvrA; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
D MGAS10750_Spy1168 uvrB; Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
D MGAS10750_Spy0939 uvrC; Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
D MGAS10750_Spy1127 pcrA; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D MGAS10750_Spy0165 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D MGAS10750_Spy0655 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03430 Mismatch repair [PATH:spi03430]
D MGAS10750_Spy1922 mutS; DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS
D MGAS10750_Spy1620 mutS2; DNA mismatch repair protein mutS K07456 mutS2; DNA mismatch repair protein MutS2
D MGAS10750_Spy1896 mutL; DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL
D MGAS10750_Spy1127 pcrA; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D MGAS10750_Spy1340 Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D MGAS10750_Spy1339 xseB; Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D MGAS10750_Spy0821 recJ; Single-stranded-DNA-specific exonuclease recJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D MGAS10750_Spy1613 ssb2; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy0109 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy1140 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D MGAS10750_Spy1766 polC; DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D MGAS10750_Spy0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D MGAS10750_Spy1211 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D MGAS10750_Spy1253 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D MGAS10750_Spy0327 dnaX; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D MGAS10750_Spy1640 dnaQ; DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D MGAS10750_Spy0655 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03440 Homologous recombination [PATH:spi03440]
D MGAS10750_Spy0821 recJ; Single-stranded-DNA-specific exonuclease recJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D MGAS10750_Spy1613 ssb2; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy0109 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy1968 recF; DNA replication and repair protein recF K03629 recF; DNA replication and repair protein RecF
D MGAS10750_Spy0019 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
D MGAS10750_Spy1267 recR; Recombination protein recR K06187 recR; recombination protein RecR
D MGAS10750_Spy1891 recA; RecA protein K03553 recA; recombination protein RecA
D MGAS10750_Spy0165 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D MGAS10750_Spy1894 ruvA; Holliday junction DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
D MGAS10750_Spy0037 ruvB; Holliday junction DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D MGAS10750_Spy1579 recG; ATP-dependent DNA helicase recG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D MGAS10750_Spy1625 recD; Exodeoxyribonuclease V alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
D MGAS10750_Spy1140 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D MGAS10750_Spy1766 polC; DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D MGAS10750_Spy0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D MGAS10750_Spy1211 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D MGAS10750_Spy1253 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D MGAS10750_Spy0327 dnaX; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D MGAS10750_Spy1640 dnaQ; DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D MGAS10750_Spy1448 priA; Primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
C 03450 Non-homologous end-joining
C 03460 Fanconi anemia pathway
B
B 09126 Chromosome
C 03082 ATP-dependent chromatin remodeling
C 03083 Polycomb repressive complex
B
B 09125 Information processing in viruses
C 03230 Viral genome structure
C 03240 Viral replication
C 03250 Viral life cycle - HIV-1 [PATH:spi03250]
D MGAS10750_Spy0373 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
C 03260 Virion - Human immunodeficiency virus
C 03271 Virion - Rotavirus
C 03262 Virion - Coronavirus
C 03261 Virion - Influenza virus
C 03263 Virion - Enterovirus
C 03264 Virion - Flavivirus
C 03265 Virion - Ebolavirus and Lyssavirus
C 03266 Virion - Herpesvirus
C 03268 Virion - Orthopoxvirus
C 03267 Virion - Adenovirus
C 03259 Virion - Bacteriophages T4 and T7
C 03258 Virion - Bacteriophage lambda
#
A09130 Environmental Information Processing
B
B 09131 Membrane transport
C 02010 ABC transporters [PATH:spi02010]
D MGAS10750_Spy0937 Iron(III)-binding protein K02012 afuA; iron(III) transport system substrate-binding protein
D MGAS10750_Spy0980 Spermidine/putrescine-binding protein K11069 potD; spermidine/putrescine transport system substrate-binding protein
D MGAS10750_Spy0979 potC; Spermidine/putrescine transport system permease protein potC K11070 potC; spermidine/putrescine transport system permease protein
D MGAS10750_Spy0978 potB; Spermidine/putrescine transport system permease protein potB K11071 potB; spermidine/putrescine transport system permease protein
D MGAS10750_Spy0977 potA; Spermidine/putrescine transport ATP-binding protein potA K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11]
D MGAS10750_Spy0164 opuABC; Glycine betaine-binding protein / Glycine betaine transport system permease protein K02001 proW; glycine betaine/proline transport system permease protein
D MGAS10750_Spy0163 opuAA; Glycine betaine transport ATP-binding protein K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9]
D MGAS10750_Spy1005 Glycine betaine transport system permease protein / Glycine betaine-binding protein K05845 opuC; osmoprotectant transport system substrate-binding protein
D MGAS10750_Spy1004 proV; Glycine betaine transport ATP-binding protein K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9]
D MGAS10750_Spy1776 msmK; Multiple sugar transport ATP-binding protein msmK K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]
D MGAS10750_Spy1160 malX; Maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein
D MGAS10750_Spy1150 malE; Maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein
D MGAS10750_Spy1151 malF; Maltodextrin transport system permease protein malC K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1156 malC; Maltodextrin transport system permease protein malC K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1152 malG; Maltose transport system permease protein malG K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1155 malD; Maltodextrin transport system permease protein malD K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1417 Sugar-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein
D MGAS10750_Spy1419 Sugar transport system permease protein K17319 lplB; putative aldouronate transport system permease protein
D MGAS10750_Spy1418 Sugar transport system permease protein K17320 lplC; putative aldouronate transport system permease protein
D MGAS10750_Spy0142 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins
D MGAS10750_Spy1091 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins
D MGAS10750_Spy1089 Nucleoside transport system permease protein K23535 nupB; general nucleoside transport system permease protein
D MGAS10750_Spy1088 Nucleoside transport system permease protein K23536 nupC; general nucleoside transport system permease protein
D MGAS10750_Spy1090 Nucleoside transport ATP-binding protein K23537 nupA; general nucleoside transport system ATP-binding protein
D MGAS10750_Spy1105 pstS; Phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein
D MGAS10750_Spy1104 pstC; Phosphate transport system permease protein pstC K02037 pstC; phosphate transport system permease protein
D MGAS10750_Spy1103 pstA; Phosphate transport system permease protein pstA K02038 pstA; phosphate transport system permease protein
D MGAS10750_Spy1101 pstB; Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D MGAS10750_Spy1102 pstB2; Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D MGAS10750_Spy1169 glnH; Glutamine-binding protein / Glutamine transport system permease protein glnP K10036 glnH; glutamine transport system substrate-binding protein
D MGAS10750_Spy1170 glnQ2; Glutamine transport ATP-binding protein glnQ K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1]
D MGAS10750_Spy0798 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
D MGAS10750_Spy0265 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
D MGAS10750_Spy0799 Cystine transport system permease protein K10009 tcyB; L-cystine transport system permease protein
D MGAS10750_Spy1472 Amino acid ABC transporter permease protein K10009 tcyB; L-cystine transport system permease protein
D MGAS10750_Spy1471 Amino acid transport ATP-binding protein K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1]
D MGAS10750_Spy0681 Arginine-binding protein K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein
D MGAS10750_Spy1345 artQ; Arginine transport system permease protein artQ K17077 artQ; arginine/lysine/histidine transport system permease protein
D MGAS10750_Spy1344 artP; Arginine transport ATP-binding protein artP K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1]
D MGAS10750_Spy0231 ABC transporter amino acid-binding protein / Amino acid ABC transporter permease protein K17073 lysX1; putative lysine transport system substrate-binding protein
D MGAS10750_Spy0230 Amino acid transport ATP-binding protein K17076 lysY; putative lysine transport system ATP-binding protein
D MGAS10750_Spy0266 ABC transporter substrate-binding protein K02073 metQ; D-methionine transport system substrate-binding protein
D MGAS10750_Spy0268 ABC transporter permease protein K02072 metI; D-methionine transport system permease protein
D MGAS10750_Spy0267 ABC transporter ATP-binding protein K02071 metN; D-methionine transport system ATP-binding protein
D MGAS10750_Spy0246 oppA; Oligopeptide-binding protein oppA K15580 oppA; oligopeptide transport system substrate-binding protein
D MGAS10750_Spy0247 oppB; Oligopeptide transport system permease protein oppB K15581 oppB; oligopeptide transport system permease protein
D MGAS10750_Spy0248 oppC; Oligopeptide transport system permease protein oppC K15582 oppC; oligopeptide transport system permease protein
D MGAS10750_Spy0249 oppD; Oligopeptide transport ATP-binding protein oppD K15583 oppD; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy0250 oppF; Oligopeptide transport ATP-binding protein oppF K10823 oppF; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy0624 High-affinity zinc uptake system protein znuA precursor / hypothetical exported protein K09815 znuA; zinc transport system substrate-binding protein
D MGAS10750_Spy1805 lmb; Laminin-binding surface protein K09815 znuA; zinc transport system substrate-binding protein
D MGAS10750_Spy0086 adcB; High-affinity zinc uptake system membrane protein znuB K09816 znuB; zinc transport system permease protein
D MGAS10750_Spy0085 adcC; High-affinity zinc uptake system ATP-binding protein znuC K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D MGAS10750_Spy0370 mtsA; Manganese-binding protein K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein
D MGAS10750_Spy0372 mtsC; Manganese transport system membrane protein K11705 mtsC; iron/zinc/manganese/copper transport system permease protein
D MGAS10750_Spy0371 mtsB; Manganese transport system ATP-binding protein K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein
D MGAS10750_Spy0172 BioY protein K03523 bioY; biotin transport system substrate-specific component
D MGAS10750_Spy1960 cbiQ; Hyaluronan ABC exporter permease protein K16785 ecfT; energy-coupling factor transport system permease protein
D MGAS10750_Spy1581 Cobalt transport protein cbiQ K16785 ecfT; energy-coupling factor transport system permease protein
D MGAS10750_Spy1962 cbiO1; Hyaluronan ABC exporter ATP-binding protein K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D MGAS10750_Spy1961 cbiO2; Hyaluronan ABC exporter ATP-binding protein K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D MGAS10750_Spy0960 srtE; Lantibiotic transport permease protein K20491 nisE; lantibiotic transport system permease protein
D MGAS10750_Spy0961 srtG; Lantibiotic transport permease protein K20492 nisG; lantibiotic transport system permease protein
D MGAS10750_Spy0959 srtF; Lantibiotic transport ATP-binding protein K20490 nisF; lantibiotic transport system ATP-binding protein
D MGAS10750_Spy0551 ftsX; Cell division protein ftsX K09811 ftsX; cell division transport system permease protein
D MGAS10750_Spy0550 ftsE; Cell division ATP-binding protein ftsE K09812 ftsE; cell division transport system ATP-binding protein
D MGAS10750_Spy0191 Multidrug resistance ABC transporter ATP-binding and permease protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy0192 Multidrug/protein/lipid ABC transporter family, ATP-binding and permease protein K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy1019 Multidrug resistance ABC transporter ATP-binding and permease protein K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy1020 Multidrug/protein/lipid ABC transporter family, ATP-binding and permease protein K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy0408 Bacteriocin processing peptidase / Bacteriocin export ABC transporter K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D MGAS10750_Spy0395 Bacteriocin processing peptidase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
C 02060 Phosphotransferase system (PTS) [PATH:spi02060]
D MGAS10750_Spy1222 pstI; Phosphoenolpyruvate-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9]
D MGAS10750_Spy1223 ptsH; Phosphocarrier protein HPr K02784 ptsH; phosphocarrier protein HPr
D MGAS10750_Spy1784 PTS system, glucose-specific IIABC component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208]
D MGAS10750_Spy1601 scrA; PTS system, sucrose-specific IIABC component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211]
D MGAS10750_Spy0497 PTS system, beta-glucoside-specific IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-]
D MGAS10750_Spy1876 PTS system, trehalose-specific IIBC component / PTS system, trehalose-specific IIA component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201]
D MGAS10750_Spy1731 lacF; PTS system, lactose-specific IIA component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D MGAS10750_Spy1730 lacE; PTS system, lactose-specific IIBC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D MGAS10750_Spy1840 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1174 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1839 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1175 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1172 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D MGAS10750_Spy1838 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D MGAS10750_Spy0931 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D MGAS10750_Spy1538 manL; PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D MGAS10750_Spy1539 manM; PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy0933 ptsC; PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy1540 manN; PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component
D MGAS10750_Spy0934 ptsD; PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component
D MGAS10750_Spy0932 ptsB; PTS system, mannose/fructose family IIB component K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-]
D MGAS10750_Spy0540 agaV; PTS system, N-acetylgalactosamine-specific IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
D MGAS10750_Spy0539 PTS system, N-acetylgalactosamine-specific IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component
D MGAS10750_Spy0538 agaD; PTS system, N-acetylgalactosamine-specific IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component
D MGAS10750_Spy1514 PTS system, galactose-specific IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204]
D MGAS10750_Spy1513 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204]
D MGAS10750_Spy1512 PTS system, galactose-specific IIC component K20114 gatC; galactose PTS system EIIC component
D MGAS10750_Spy0156 PTS system, 3-keto-L-gulonate specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D MGAS10750_Spy1758 Transcription antiterminator, BglG family / PTS system, mannitol (Cryptic)-specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D MGAS10750_Spy0155 PTS system, 3-keto-L-gulonate specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D MGAS10750_Spy1757 PTS system, IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D MGAS10750_Spy0154 PTS system, 3-keto-L-gulonate specific IIC component K03475 ulaA; ascorbate PTS system EIIC component
D MGAS10750_Spy1756 Putative transport protein sgaT K03475 ulaA; ascorbate PTS system EIIC component
D MGAS10750_Spy0753 fruA; PTS system, fructose-specific IIABC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D MGAS10750_Spy0752 fruB; 1-phosphofructokinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56]
C 03070 Bacterial secretion system [PATH:spi03070]
D MGAS10750_Spy1845 secE; Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE
D MGAS10750_Spy0426 secG; Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG
D MGAS10750_Spy0068 secY; Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY
D MGAS10750_Spy1771 yajC; Protein translocase subunit YajC K03210 yajC; preprotein translocase subunit YajC
D MGAS10750_Spy0203 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy0290 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy1593 secA; Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D MGAS10750_Spy0494 ftsY; Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor
D MGAS10750_Spy1064 ffh; signal recognition particle subunit FFH/SRP54 K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D MGAS10750_Spy1683 TraG/TraD family K03205 virD4; type IV secretion system protein VirD4 [EC:7.4.2.8]
B
B 09132 Signal transduction
C 02020 Two-component system [PATH:spi02020]
D MGAS10750_Spy1105 pstS; Phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein
D MGAS10750_Spy1978 htrA; Endopeptidase degP K04771 degP; serine protease Do [EC:3.4.21.107]
D MGAS10750_Spy0456 vicK; Two-component sensor histidine kinase VicK K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
D MGAS10750_Spy0455 vicR; Two-component response regulator VicR K07668 vicR; two-component system, OmpR family, response regulator VicR
D MGAS10750_Spy0001 dnaA; Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein
D MGAS10750_Spy1166 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D MGAS10750_Spy1165 Protein dltB K03739 dltB; membrane protein involved in D-alanine export
D MGAS10750_Spy1164 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D MGAS10750_Spy1163 dltD; Protein dltD precursor K03740 dltD; D-alanine transfer protein
D MGAS10750_Spy1096 ciaH; Sensor protein ciaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D MGAS10750_Spy1097 ciaR; Transcriptional regulatory protein ciaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR
D MGAS10750_Spy1562 D-alanyl-D-alanine metallocarboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D MGAS10750_Spy0278 covS; Transmembrane histidine kinase CsrS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
D MGAS10750_Spy0277 covR; Response regulator CsrR K18941 arlR; two-component system, OmpR family, response regulator ArlR
D MGAS10750_Spy1815 ihk; two-component system histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3]
D MGAS10750_Spy1816 irr; Two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr
D MGAS10750_Spy0954 srtK; Lantibiotic biosynthesis sensor protein K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3]
D MGAS10750_Spy0953 srtR; Lantibiotic biosynthesis two-component response regulator K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR
D MGAS10750_Spy0955 srtA; Lantibiotic srtA precursor K20482 nisA; lantibiotic bacteriocin
D MGAS10750_Spy0958 serine/threoninedehydratase K20483 nisB; lantibiotic biosynthesis protein
D MGAS10750_Spy0957 Lanthionine synthetase K20484 nisC; lantibiotic biosynthesis protein
D MGAS10750_Spy0956 srtT; Lantibiotic transport permease protein / Lantibiotic transport ATP-binding protein K20485 nisT; ATP-binding cassette, subfamily B, bacterial NisT/SpaT
D MGAS10750_Spy0959 srtF; Lantibiotic transport ATP-binding protein K20490 nisF; lantibiotic transport system ATP-binding protein
D MGAS10750_Spy0960 srtE; Lantibiotic transport permease protein K20491 nisE; lantibiotic transport system permease protein
D MGAS10750_Spy0961 srtG; Lantibiotic transport permease protein K20492 nisG; lantibiotic transport system permease protein
D MGAS10750_Spy1060 citC; (Citrate (pro-3S)-lyase) ligase K01910 citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22]
D MGAS10750_Spy1055 citD; Citrate lyase acyl-carrier protein K01646 citD; citrate lyase subunit gamma (acyl carrier protein)
D MGAS10750_Spy1056 citE; Citrate lyase beta chain / Citryl-CoA lyase subunit K01644 citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]
D MGAS10750_Spy1057 citF; Citrate lyase alpha chain / Citrate CoA-transferase K01643 citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]
D MGAS10750_Spy1058 citX; Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase K05964 citX; holo-ACP synthase [EC:2.7.7.61]
D MGAS10750_Spy1047 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase K05966 citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52]
D MGAS10750_Spy0984 NAD-dependent malic enzyme K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]
D MGAS10750_Spy0983 malP; Malate-sodium symport K11616 maeN; malate:Na+ symporter
D MGAS10750_Spy1427 rocA; Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0404 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0199 fasB; Sensory transduction protein kinase FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0200 fasC; Sensory transduction protein kinase FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0403 Response regulator FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA
D MGAS10750_Spy0201 fasA; Response regulator FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA
D MGAS10750_Spy0253 Competence-specific sigma factor ComX K12296 comX1_2; competence protein ComX
D MGAS10750_Spy1673 comX2; Competence-specific sigma factor ComX K12296 comX1_2; competence protein ComX
D MGAS10750_Spy0010 Beta-lactamase K01467 ampC; beta-lactamase class C [EC:3.5.2.6]
D MGAS10750_Spy1442 yvqE; Two-component sensor protein yvqE K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
D MGAS10750_Spy1441 yvqC; Two-component response regulator yvqC K11618 liaR; two-component system, NarL family, response regulator LiaR
D MGAS10750_Spy1723 Sensory transduction protein kinase K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK
D MGAS10750_Spy1722 salR; Transcriptional regulatory protein degU K14989 salR; two-component system, NarL family, secretion system response regulator SalR
D MGAS10750_Spy1654 glnA; Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D MGAS10750_Spy1454 atoD1; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0125 atoD2; Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy1455 atoA; Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0126 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]
D MGAS10750_Spy0122 atoE; Short-chain fatty acids transporter K02106 atoE; short-chain fatty acids transporter
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1415 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D MGAS10750_Spy1387 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D MGAS10750_Spy0936 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN
D MGAS10750_Spy1414 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN
D MGAS10750_Spy1388 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN
D MGAS10750_Spy0038 Protein tyrosine phosphatase K25307 wzb; low molecular weight protein-tyrosine phosphatase [EC:3.1.3.48]
C 04010 MAPK signaling pathway
C 04013 MAPK signaling pathway - fly
C 04016 MAPK signaling pathway - plant
C 04011 MAPK signaling pathway - yeast
C 04012 ErbB signaling pathway
C 04014 Ras signaling pathway
C 04015 Rap1 signaling pathway
C 04310 Wnt signaling pathway
C 04330 Notch signaling pathway
C 04340 Hedgehog signaling pathway
C 04341 Hedgehog signaling pathway - fly
C 04350 TGF-beta signaling pathway
C 04390 Hippo signaling pathway
C 04391 Hippo signaling pathway - fly
C 04392 Hippo signaling pathway - multiple species
C 04370 VEGF signaling pathway
C 04371 Apelin signaling pathway
C 04630 JAK-STAT signaling pathway
C 04064 NF-kappa B signaling pathway
C 04668 TNF signaling pathway
C 04066 HIF-1 signaling pathway
C 04068 FoxO signaling pathway
C 04020 Calcium signaling pathway
C 04070 Phosphatidylinositol signaling system
C 04072 Phospholipase D signaling pathway
C 04071 Sphingolipid signaling pathway
C 04024 cAMP signaling pathway
C 04022 cGMP-PKG signaling pathway
C 04151 PI3K-Akt signaling pathway
C 04152 AMPK signaling pathway
C 04150 mTOR signaling pathway
C 04075 Plant hormone signal transduction
B
B 09133 Signaling molecules and interaction
C 04080 Neuroactive ligand-receptor interaction
C 04060 Cytokine-cytokine receptor interaction
C 04061 Viral protein interaction with cytokine and cytokine receptor
C 04512 ECM-receptor interaction
C 04514 Cell adhesion molecules
#
A09140 Cellular Processes
B
B 09141 Transport and catabolism
C 04144 Endocytosis
C 04145 Phagosome
C 04142 Lysosome
C 04146 Peroxisome
C 04140 Autophagy - animal
C 04138 Autophagy - yeast
C 04136 Autophagy - other
C 04137 Mitophagy - animal
C 04139 Mitophagy - yeast
C 04148 Efferocytosis
B
B 09143 Cell growth and death
C 04110 Cell cycle
C 04111 Cell cycle - yeast
C 04112 Cell cycle - Caulobacter
C 04113 Meiosis - yeast
C 04114 Oocyte meiosis
C 04210 Apoptosis
C 04214 Apoptosis - fly
C 04215 Apoptosis - multiple species
C 04216 Ferroptosis
C 04217 Necroptosis
C 04115 p53 signaling pathway
C 04218 Cellular senescence
B
B 09144 Cellular community - eukaryotes
C 04510 Focal adhesion
C 04520 Adherens junction
C 04530 Tight junction
C 04540 Gap junction
C 04550 Signaling pathways regulating pluripotency of stem cells
B
B 09145 Cellular community - prokaryotes
C 02024 Quorum sensing [PATH:spi02024]
D MGAS10750_Spy1458 luxS; Autoinducer-2 production protein luxS K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]
D MGAS10750_Spy1790 trpG; Anthranilate synthase component II / Para-aminobenzoate synthase glutamine amidotransferase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
D MGAS10750_Spy0453 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D MGAS10750_Spy1427 rocA; Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0404 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0199 fasB; Sensory transduction protein kinase FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0200 fasC; Sensory transduction protein kinase FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0403 Response regulator FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA
D MGAS10750_Spy0201 fasA; Response regulator FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA
D MGAS10750_Spy0147 slo; Streptolysin O K11031 slo; thiol-activated cytolysin
D MGAS10750_Spy1096 ciaH; Sensor protein ciaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D MGAS10750_Spy1097 ciaR; Transcriptional regulatory protein ciaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR
D MGAS10750_Spy0246 oppA; Oligopeptide-binding protein oppA K15580 oppA; oligopeptide transport system substrate-binding protein
D MGAS10750_Spy0247 oppB; Oligopeptide transport system permease protein oppB K15581 oppB; oligopeptide transport system permease protein
D MGAS10750_Spy0248 oppC; Oligopeptide transport system permease protein oppC K15582 oppC; oligopeptide transport system permease protein
D MGAS10750_Spy0249 oppD; Oligopeptide transport ATP-binding protein oppD K15583 oppD; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy0250 oppF; Oligopeptide transport ATP-binding protein oppF K10823 oppF; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy0036 Transcriptional regulator K20342 comR; HTH-type transcriptional regulator, regulator for ComX
D MGAS10750_Spy0253 Competence-specific sigma factor ComX K12296 comX1_2; competence protein ComX
D MGAS10750_Spy1673 comX2; Competence-specific sigma factor ComX K12296 comX1_2; competence protein ComX
D MGAS10750_Spy0408 Bacteriocin processing peptidase / Bacteriocin export ABC transporter K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D MGAS10750_Spy0395 Bacteriocin processing peptidase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D MGAS10750_Spy0407 Bacteriocin export accessory protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter
D MGAS10750_Spy0406 Bacteriocin export accessory protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter
D MGAS10750_Spy0420 mutR; Transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator
D MGAS10750_Spy0460 Transcriptional regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor
D MGAS10750_Spy1797 dppA; Dipeptide-binding protein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein
D MGAS10750_Spy1798 dppB; Dipeptide transport system permease protein dppB K02033 ABC.PE.P; peptide/nickel transport system permease protein
D MGAS10750_Spy1799 dppC; Dipeptide transport system permease protein dppC K02034 ABC.PE.P1; peptide/nickel transport system permease protein
D MGAS10750_Spy1800 dppD; Dipeptide transport ATP-binding protein dppD K02031 ddpD; peptide/nickel transport system ATP-binding protein
D MGAS10750_Spy1801 dppE; Dipeptide transport ATP-binding protein dppF K02032 ddpF; peptide/nickel transport system ATP-binding protein
D MGAS10750_Spy1831 rgg; Transcriptional regulator K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator
D MGAS10750_Spy1828 speB; Streptopain precursor K01364 speB; streptopain [EC:3.4.22.10]
D MGAS10750_Spy1508 lacD1; Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]
D MGAS10750_Spy1732 lacD2; Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]
D MGAS10750_Spy0203 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy0290 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy1845 secE; Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE
D MGAS10750_Spy0426 secG; Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG
D MGAS10750_Spy0068 secY; Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY
D MGAS10750_Spy1771 yajC; Protein translocase subunit YajC K03210 yajC; preprotein translocase subunit YajC
D MGAS10750_Spy1593 secA; Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D MGAS10750_Spy0494 ftsY; Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor
D MGAS10750_Spy1064 ffh; signal recognition particle subunit FFH/SRP54 K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D MGAS10750_Spy0955 srtA; Lantibiotic srtA precursor K20482 nisA; lantibiotic bacteriocin
D MGAS10750_Spy0958 serine/threoninedehydratase K20483 nisB; lantibiotic biosynthesis protein
D MGAS10750_Spy0957 Lanthionine synthetase K20484 nisC; lantibiotic biosynthesis protein
D MGAS10750_Spy0956 srtT; Lantibiotic transport permease protein / Lantibiotic transport ATP-binding protein K20485 nisT; ATP-binding cassette, subfamily B, bacterial NisT/SpaT
D MGAS10750_Spy0954 srtK; Lantibiotic biosynthesis sensor protein K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3]
D MGAS10750_Spy0953 srtR; Lantibiotic biosynthesis two-component response regulator K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR
D MGAS10750_Spy0959 srtF; Lantibiotic transport ATP-binding protein K20490 nisF; lantibiotic transport system ATP-binding protein
D MGAS10750_Spy0960 srtE; Lantibiotic transport permease protein K20491 nisE; lantibiotic transport system permease protein
D MGAS10750_Spy0961 srtG; Lantibiotic transport permease protein K20492 nisG; lantibiotic transport system permease protein
C 05111 Biofilm formation - Vibrio cholerae
C 02025 Biofilm formation - Pseudomonas aeruginosa
C 02026 Biofilm formation - Escherichia coli
B
B 09142 Cell motility
C 02030 Bacterial chemotaxis
C 02040 Flagellar assembly [PATH:spi02040]
D MGAS10750_Spy0798 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
D MGAS10750_Spy0265 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
D MGAS10750_Spy0687 rpoD; RNA polymerase sigma factor rpoD K03086 rpoD; RNA polymerase primary sigma factor
C 04814 Motor proteins
C 04820 Cytoskeleton in muscle cells
D MGAS10750_Spy0639 eno; Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
C 04810 Regulation of actin cytoskeleton
#
A09150 Organismal Systems
B
B 09151 Immune system
C 04640 Hematopoietic cell lineage
C 04610 Complement and coagulation cascades
C 04611 Platelet activation
C 04613 Neutrophil extracellular trap formation
C 04620 Toll-like receptor signaling pathway
C 04624 Toll and Imd signaling pathway
C 04621 NOD-like receptor signaling pathway
C 04622 RIG-I-like receptor signaling pathway
C 04623 Cytosolic DNA-sensing pathway
C 04625 C-type lectin receptor signaling pathway
C 04650 Natural killer cell mediated cytotoxicity
C 04612 Antigen processing and presentation
C 04660 T cell receptor signaling pathway
C 04658 Th1 and Th2 cell differentiation
C 04659 Th17 cell differentiation
C 04657 IL-17 signaling pathway
C 04662 B cell receptor signaling pathway
C 04664 Fc epsilon RI signaling pathway
C 04666 Fc gamma R-mediated phagocytosis
C 04670 Leukocyte transendothelial migration
C 04672 Intestinal immune network for IgA production
C 04062 Chemokine signaling pathway
B
B 09152 Endocrine system
C 04911 Insulin secretion
C 04910 Insulin signaling pathway
C 04922 Glucagon signaling pathway
C 04923 Regulation of lipolysis in adipocytes
C 04920 Adipocytokine signaling pathway
C 03320 PPAR signaling pathway
C 04929 GnRH secretion
C 04912 GnRH signaling pathway
C 04913 Ovarian steroidogenesis
C 04915 Estrogen signaling pathway
C 04914 Progesterone-mediated oocyte maturation
C 04917 Prolactin signaling pathway
C 04921 Oxytocin signaling pathway
C 04926 Relaxin signaling pathway
C 04935 Growth hormone synthesis, secretion and action
C 04918 Thyroid hormone synthesis
C 04919 Thyroid hormone signaling pathway
C 04928 Parathyroid hormone synthesis, secretion and action
C 04916 Melanogenesis
C 04924 Renin secretion
C 04614 Renin-angiotensin system
C 04925 Aldosterone synthesis and secretion
C 04927 Cortisol synthesis and secretion
B
B 09153 Circulatory system
C 04260 Cardiac muscle contraction
C 04261 Adrenergic signaling in cardiomyocytes
C 04270 Vascular smooth muscle contraction
B
B 09154 Digestive system
C 04970 Salivary secretion
C 04971 Gastric acid secretion
C 04972 Pancreatic secretion
C 04976 Bile secretion
C 04973 Carbohydrate digestion and absorption
C 04974 Protein digestion and absorption
C 04975 Fat digestion and absorption
C 04979 Cholesterol metabolism
C 04977 Vitamin digestion and absorption
C 04980 Cobalamin transport and metabolism
C 04978 Mineral absorption
B
B 09155 Excretory system
C 04962 Vasopressin-regulated water reabsorption
C 04960 Aldosterone-regulated sodium reabsorption
C 04961 Endocrine and other factor-regulated calcium reabsorption
C 04964 Proximal tubule bicarbonate reclamation
C 04966 Collecting duct acid secretion
B
B 09156 Nervous system
C 04724 Glutamatergic synapse
C 04727 GABAergic synapse
C 04725 Cholinergic synapse
C 04728 Dopaminergic synapse
C 04726 Serotonergic synapse
C 04720 Long-term potentiation
C 04730 Long-term depression
C 04723 Retrograde endocannabinoid signaling
C 04721 Synaptic vesicle cycle
C 04722 Neurotrophin signaling pathway
B
B 09157 Sensory system
C 04744 Phototransduction
C 04745 Phototransduction - fly
C 04740 Olfactory transduction
C 04742 Taste transduction
C 04750 Inflammatory mediator regulation of TRP channels
B
B 09158 Development and regeneration
C 04320 Dorso-ventral axis formation
C 04360 Axon guidance
C 04361 Axon regeneration
C 04380 Osteoclast differentiation
B
B 09149 Aging
C 04211 Longevity regulating pathway
C 04212 Longevity regulating pathway - worm
C 04213 Longevity regulating pathway - multiple species
B
B 09159 Environmental adaptation
C 04710 Circadian rhythm
C 04713 Circadian entrainment
C 04711 Circadian rhythm - fly
C 04712 Circadian rhythm - plant
C 04714 Thermogenesis
C 04626 Plant-pathogen interaction
#
A09160 Human Diseases
B
B 09161 Cancer: overview
C 05200 Pathways in cancer
C 05202 Transcriptional misregulation in cancer
C 05206 MicroRNAs in cancer
C 05205 Proteoglycans in cancer
C 05204 Chemical carcinogenesis - DNA adducts
C 05207 Chemical carcinogenesis - receptor activation
C 05208 Chemical carcinogenesis - reactive oxygen species
C 05203 Viral carcinogenesis
C 05230 Central carbon metabolism in cancer
C 05231 Choline metabolism in cancer
C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
B
B 09162 Cancer: specific types
C 05210 Colorectal cancer
C 05212 Pancreatic cancer
C 05225 Hepatocellular carcinoma
C 05226 Gastric cancer
C 05214 Glioma
C 05216 Thyroid cancer
C 05221 Acute myeloid leukemia
C 05220 Chronic myeloid leukemia
C 05217 Basal cell carcinoma
C 05218 Melanoma
C 05211 Renal cell carcinoma
C 05219 Bladder cancer
C 05215 Prostate cancer
C 05213 Endometrial cancer
C 05224 Breast cancer
C 05222 Small cell lung cancer
C 05223 Non-small cell lung cancer
B
B 09172 Infectious disease: viral
C 05166 Human T-cell leukemia virus 1 infection
C 05170 Human immunodeficiency virus 1 infection
C 05161 Hepatitis B
C 05160 Hepatitis C
C 05171 Coronavirus disease - COVID-19
C 05164 Influenza A
C 05162 Measles
C 05168 Herpes simplex virus 1 infection
C 05163 Human cytomegalovirus infection
C 05167 Kaposi sarcoma-associated herpesvirus infection
C 05169 Epstein-Barr virus infection
C 05165 Human papillomavirus infection
B
B 09171 Infectious disease: bacterial
C 05110 Vibrio cholerae infection
C 05120 Epithelial cell signaling in Helicobacter pylori infection
C 05130 Pathogenic Escherichia coli infection
C 05132 Salmonella infection
C 05131 Shigellosis
C 05135 Yersinia infection
C 05133 Pertussis
C 05134 Legionellosis
C 05150 Staphylococcus aureus infection
C 05152 Tuberculosis
C 05100 Bacterial invasion of epithelial cells
D MGAS10750_Spy0114 Fibronectin-binding protein K13734 sfb1; fibronectin-binding protein 1
D MGAS10750_Spy1822 Fibronectin-binding protein K13734 sfb1; fibronectin-binding protein 1
D MGAS10750_Spy1823 Fibronectin-binding protein K13734 sfb1; fibronectin-binding protein 1
B
B 09174 Infectious disease: parasitic
C 05146 Amoebiasis
C 05144 Malaria
C 05145 Toxoplasmosis
C 05140 Leishmaniasis
C 05142 Chagas disease
C 05143 African trypanosomiasis
B
B 09163 Immune disease
C 05310 Asthma
C 05322 Systemic lupus erythematosus
C 05323 Rheumatoid arthritis
C 05320 Autoimmune thyroid disease
C 05321 Inflammatory bowel disease
C 05330 Allograft rejection
C 05332 Graft-versus-host disease
C 05340 Primary immunodeficiency
B
B 09164 Neurodegenerative disease
C 05010 Alzheimer disease
C 05012 Parkinson disease
C 05014 Amyotrophic lateral sclerosis
C 05016 Huntington disease
C 05017 Spinocerebellar ataxia
C 05020 Prion disease
C 05022 Pathways of neurodegeneration - multiple diseases
B
B 09165 Substance dependence
C 05030 Cocaine addiction
C 05031 Amphetamine addiction
C 05032 Morphine addiction
C 05033 Nicotine addiction
C 05034 Alcoholism
B
B 09166 Cardiovascular disease
C 05417 Lipid and atherosclerosis
C 05418 Fluid shear stress and atherosclerosis
C 05410 Hypertrophic cardiomyopathy
C 05412 Arrhythmogenic right ventricular cardiomyopathy
C 05414 Dilated cardiomyopathy
C 05415 Diabetic cardiomyopathy
C 05416 Viral myocarditis
B
B 09167 Endocrine and metabolic disease
C 04930 Type II diabetes mellitus
C 04940 Type I diabetes mellitus
C 04950 Maturity onset diabetes of the young
C 04936 Alcoholic liver disease
C 04932 Non-alcoholic fatty liver disease
C 04931 Insulin resistance
C 04933 AGE-RAGE signaling pathway in diabetic complications
C 04934 Cushing syndrome
B
B 09175 Drug resistance: antimicrobial
C 01501 beta-Lactam resistance [PATH:spi01501]
D MGAS10750_Spy0010 Beta-lactamase K01467 ampC; beta-lactamase class C [EC:3.5.2.6]
D MGAS10750_Spy0246 oppA; Oligopeptide-binding protein oppA K15580 oppA; oligopeptide transport system substrate-binding protein
D MGAS10750_Spy0247 oppB; Oligopeptide transport system permease protein oppB K15581 oppB; oligopeptide transport system permease protein
D MGAS10750_Spy0248 oppC; Oligopeptide transport system permease protein oppC K15582 oppC; oligopeptide transport system permease protein
D MGAS10750_Spy0249 oppD; Oligopeptide transport ATP-binding protein oppD K15583 oppD; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy0250 oppF; Oligopeptide transport ATP-binding protein oppF K10823 oppF; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy1464 pbp1A; Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy0089 pbp1b; Multimodular transpeptidase-transglycosylase PBP 1B K03693 pbp1b; penicillin-binding protein 1B
D MGAS10750_Spy1847 pbp2A; Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy1476 Division specific D,D-transpeptidase / Cell division protein ftsI K12556 pbp2X; penicillin-binding protein 2X
C 01502 Vancomycin resistance [PATH:spi01502]
D MGAS10750_Spy1266 ddlA; D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D MGAS10750_Spy1591 acpS; Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D MGAS10750_Spy1265 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D MGAS10750_Spy1475 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D MGAS10750_Spy1360 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D MGAS10750_Spy1562 D-alanyl-D-alanine metallocarboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:spi01503]
D MGAS10750_Spy1978 htrA; Endopeptidase degP K04771 degP; serine protease Do [EC:3.4.21.107]
D MGAS10750_Spy0373 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
D MGAS10750_Spy1166 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D MGAS10750_Spy1165 Protein dltB K03739 dltB; membrane protein involved in D-alanine export
D MGAS10750_Spy1164 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D MGAS10750_Spy1163 dltD; Protein dltD precursor K03740 dltD; D-alanine transfer protein
D MGAS10750_Spy1828 speB; Streptopain precursor K01364 speB; streptopain [EC:3.4.22.10]
B
B 09176 Drug resistance: antineoplastic
C 01521 EGFR tyrosine kinase inhibitor resistance
C 01524 Platinum drug resistance
C 01523 Antifolate resistance
C 01522 Endocrine resistance
#
A09180 Brite Hierarchies
B
B 09181 Protein families: metabolism
C 01000 Enzymes [BR:spi01000]
C 01001 Protein kinases [BR:spi01001]
D MGAS10750_Spy1444 Serine/threonine protein kinase K12132 prkC; eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1]
D MGAS10750_Spy0456 vicK; Two-component sensor histidine kinase VicK K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
D MGAS10750_Spy1096 ciaH; Sensor protein ciaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D MGAS10750_Spy0278 covS; Transmembrane histidine kinase CsrS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
D MGAS10750_Spy1815 ihk; two-component system histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3]
D MGAS10750_Spy0954 srtK; Lantibiotic biosynthesis sensor protein K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3]
D MGAS10750_Spy1442 yvqE; Two-component sensor protein yvqE K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
D MGAS10750_Spy1723 Sensory transduction protein kinase K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK
D MGAS10750_Spy0982 dpiB; Sensor kinase dpiB K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
D MGAS10750_Spy1427 rocA; Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0404 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0199 fasB; Sensory transduction protein kinase FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0200 fasC; Sensory transduction protein kinase FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy1415 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D MGAS10750_Spy1387 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C 01009 Protein phosphatases and associated proteins [BR:spi01009]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D MGAS10750_Spy1445 pppL; Protein phosphatase 2C K20074 prpC; PPM family protein phosphatase [EC:3.1.3.16]
C 01002 Peptidases and inhibitors [BR:spi01002]
D MGAS10750_Spy0726 lsp; Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36]
D MGAS10750_Spy1465 pepC; Aminopeptidase C K01372 BLMH; bleomycin hydrolase [EC:3.4.22.40]
D MGAS10750_Spy1828 speB; Streptopain precursor K01364 speB; streptopain [EC:3.4.22.10]
D MGAS10750_Spy0430 pcp; Pyrrolidone-carboxylate peptidase K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3]
D MGAS10750_Spy1068 guaA; GMP synthase (glutamine-hydrolyzing) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D MGAS10750_Spy0992 Glutamine amidotransferase, class I K07010 K07010; putative glutamine amidotransferase
D MGAS10750_Spy0408 Bacteriocin processing peptidase / Bacteriocin export ABC transporter K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D MGAS10750_Spy0395 Bacteriocin processing peptidase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D MGAS10750_Spy0017 sibA; Secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D MGAS10750_Spy1810 M protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D MGAS10750_Spy1692 NlpC/P60 family protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D MGAS10750_Spy0024 purF; Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D MGAS10750_Spy1136 glmS; Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D MGAS10750_Spy1024 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0118 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0119 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0120 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0623 pepD; Dipeptidase A K08659 pepDA; dipeptidase [EC:3.4.-.-]
D MGAS10750_Spy1236 CAAX amino terminal protease family K07052 K07052; CAAX protease family protein
D MGAS10750_Spy0648 sagE; Streptolysin S putative self-immunity protein SagE K07052 K07052; CAAX protease family protein
D MGAS10750_Spy1098 pepN; Lysyl aminopeptidase / alanine aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2]
D MGAS10750_Spy1243 pepB; Oligoendopeptidase F K08602 pepF; oligoendopeptidase F [EC:3.4.24.-]
D MGAS10750_Spy1874 pepO; Oligoendopeptidase O K07386 pepO; putative endopeptidase [EC:3.4.24.-]
D MGAS10750_Spy1562 D-alanyl-D-alanine metallocarboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D MGAS10750_Spy0941 Xaa-His dipeptidase K01274 pepV; beta-Ala-Xaa dipeptidase [EC:3.4.13.-]
D MGAS10750_Spy0701 pepT; Tripeptidase T K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4]
D MGAS10750_Spy1202 map; Methionine aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
D MGAS10750_Spy0436 pepQ; Xaa-Pro aminopeptidase K01271 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]
D MGAS10750_Spy1608 Xaa-Pro dipeptidase K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
D MGAS10750_Spy0013 ftsH; Cell division protein ftsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D MGAS10750_Spy0104 pepA; Glutamyl aminopeptidase K01261 pepA; glutamyl aminopeptidase [EC:3.4.11.7]
D MGAS10750_Spy0275 Endopeptidase htpX K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
D MGAS10750_Spy1768 Membrane endopeptidase, M50 family K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
D MGAS10750_Spy1978 htrA; Endopeptidase degP K04771 degP; serine protease Do [EC:3.4.21.107]
D MGAS10750_Spy0339 Endopeptidase lactocepin K01361 E3.4.21.96; lactocepin [EC:3.4.21.96]
D MGAS10750_Spy1807 scpA; C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110]
D MGAS10750_Spy0968 dacA1; D-alanyl-D-alanine serine-type carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D MGAS10750_Spy0245 dacA2; D-alanyl-D-alanine serine-type carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D MGAS10750_Spy0324 clpP; ATP-dependent endopeptidase clp proteolytic subunit clpP K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
D MGAS10750_Spy1635 pepXP; Xaa-Pro dipeptidyl-peptidase K01281 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11]
D MGAS10750_Spy1373 ATP-dependent endopeptidase Lon K07177 K07177; Lon-like protease
D MGAS10750_Spy1063 phage transcriptional repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D MGAS10750_Spy1137 sipC; Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D MGAS10750_Spy1624 spi; Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D MGAS10750_Spy0485 mccF; Microcin C7 self-immunity protein mccF K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
D MGAS10750_Spy0511 Peptidase family U32 K08303 prtC; U32 family peptidase [EC:3.4.-.-]
C 01003 Glycosyltransferases [BR:spi01003]
D MGAS10750_Spy0439 1,2-diacylglycerol 3-glucosyltransferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]
D MGAS10750_Spy0438 Glycosyltransferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208]
D MGAS10750_Spy1464 pbp1A; Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy0089 pbp1b; Multimodular transpeptidase-transglycosylase PBP 1B K03693 pbp1b; penicillin-binding protein 1B
D MGAS10750_Spy1847 pbp2A; Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy0237 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
C 01005 Lipopolysaccharide biosynthesis proteins [BR:spi01005]
D MGAS10750_Spy0690 rgpAc; alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase K12996 rgpA; rhamnosyltransferase [EC:2.4.1.-]
D MGAS10750_Spy0691 rgpBc; alpha-L-Rha alpha-1,3-L-rhamnosyltransferase K12997 rgpB; rhamnosyltransferase [EC:2.4.1.-]
D MGAS10750_Spy0694 rgpEc; Glycosyltransferase K12998 rgpE; glucosyltransferase [EC:2.4.1.-]
D MGAS10750_Spy0695 rgpFc; alpha-L-Rha alpha-1,2-L-rhamnosyltransferase / alpha-L-Rha alpha-1,3-L-rhamnosyltransferase K07272 rgpF; rhamnosyltransferase [EC:2.4.1.-]
D MGAS10750_Spy0237 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]
D MGAS10750_Spy0433 Bactoprenol glucosyl transferase K12999 rgpI; glucosyltransferase [EC:2.4.1.-]
C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:spi01011]
D MGAS10750_Spy0668 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D MGAS10750_Spy1206 murZ; UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D MGAS10750_Spy0976 murB; UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D MGAS10750_Spy0285 murC; UDP-N-acetylmuramate--alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D MGAS10750_Spy1361 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D MGAS10750_Spy0321 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--lysine ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7]
D MGAS10750_Spy1266 ddlA; D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D MGAS10750_Spy1069 UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10]
D MGAS10750_Spy0530 murM; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10]
D MGAS10750_Spy0529 Factor essential for expression of methicillin resistance K12554 murN; alanine adding enzyme [EC:2.3.2.-]
D MGAS10750_Spy1591 acpS; Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D MGAS10750_Spy0297 glr; Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D MGAS10750_Spy0485 mccF; Microcin C7 self-immunity protein mccF K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
D MGAS10750_Spy1475 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D MGAS10750_Spy1360 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D MGAS10750_Spy0235 bacA; Bacitracin resistance protein K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D MGAS10750_Spy0308 Membrane-associated phospholipid phosphatase K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]
D MGAS10750_Spy1464 pbp1A; Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy0089 pbp1b; Multimodular transpeptidase-transglycosylase PBP 1B K03693 pbp1b; penicillin-binding protein 1B
D MGAS10750_Spy1847 pbp2A; Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4]
D MGAS10750_Spy1476 Division specific D,D-transpeptidase / Cell division protein ftsI K12556 pbp2X; penicillin-binding protein 2X
D MGAS10750_Spy0968 dacA1; D-alanyl-D-alanine serine-type carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D MGAS10750_Spy0245 dacA2; D-alanyl-D-alanine serine-type carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D MGAS10750_Spy1562 D-alanyl-D-alanine metallocarboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D MGAS10750_Spy0017 sibA; Secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D MGAS10750_Spy1810 M protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D MGAS10750_Spy1692 NlpC/P60 family protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-]
D MGAS10750_Spy1024 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0118 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0119 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0120 Sortase K07284 srtA; sortase A [EC:3.4.22.70]
D MGAS10750_Spy0287 hypothetical membrane associated protein K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29]
C 01004 Lipid biosynthesis proteins [BR:spi01004]
D MGAS10750_Spy1550 fabD; Malonyl-CoA-(acyl-carrier-protein) transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D MGAS10750_Spy1554 fabH; 3-oxoacyl-(acyl-carrier-protein) synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D MGAS10750_Spy1548 fabF; 3-oxoacyl-(acyl-carrier-protein) synthase K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D MGAS10750_Spy1549 3-oxoacyl-reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D MGAS10750_Spy0361 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D MGAS10750_Spy1546 fabZ; (3R)-hydroxyacyl-dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D MGAS10750_Spy1551 fabK; Enoyl-reductase (NADH) K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
D MGAS10750_Spy1552 Enoyl-reductase (NADH) K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]
D MGAS10750_Spy1556 phaB; Enoyl-CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14]
D MGAS10750_Spy0453 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D MGAS10750_Spy0020 plsX; Fatty acid/phospholipid synthesis protein plsX K03621 plsX; phosphate acyltransferase [EC:2.3.1.274]
D MGAS10750_Spy0802 hypothetical membrane spanning protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D MGAS10750_Spy1257 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
C 01008 Polyketide biosynthesis proteins
C 01006 Prenyltransferases [BR:spi01006]
D MGAS10750_Spy1338 fps; Dimethylallyltransferase / Geranyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]
D MGAS10750_Spy1770 uppS; Undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D MGAS10750_Spy0816 miaA; tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
C 01007 Amino acid related enzymes [BR:spi01007]
D MGAS10750_Spy0198 gltX; Glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
D MGAS10750_Spy0088 tyrS; Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MGAS10750_Spy1971 trsA; Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D MGAS10750_Spy1749 cysS; Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D MGAS10750_Spy1925 argS; Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D MGAS10750_Spy0347 metS; Methionyl-tRNA synthetase / Protein secretion chaperonin CsaA K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D MGAS10750_Spy1350 ileS; Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D MGAS10750_Spy1400 valS; Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D MGAS10750_Spy0153 leuS; Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MGAS10750_Spy0514 lysS; Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D MGAS10750_Spy1930 aspS; Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D MGAS10750_Spy0482 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D MGAS10750_Spy0556 asnS; Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D MGAS10750_Spy1931 hisS; Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D MGAS10750_Spy1496 glyQ; Glycyl-tRNA synthetase alpha chain K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D MGAS10750_Spy1495 glyS; Glycyl-tRNA synthetase beta chain K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D MGAS10750_Spy1542 serS; Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D MGAS10750_Spy1767 proS; Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D MGAS10750_Spy0440 thrS; Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D MGAS10750_Spy1239 alaS; Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D MGAS10750_Spy0672 pheS; Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D MGAS10750_Spy0673 pheT; Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D MGAS10750_Spy1573 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D MGAS10750_Spy0805 bcaT; Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D MGAS10750_Spy1789 Para-aminobenzoate synthetase component I / 4-amino-4-deoxychorismate lyase K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38]
C 00199 Cytochrome P450
C 00194 Photosynthesis proteins [BR:spi00194]
D MGAS10750_Spy0666 atpC; ATP synthase epsilon chain K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D MGAS10750_Spy0665 atpD; ATP synthase beta chain K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D MGAS10750_Spy0664 atpG; ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D MGAS10750_Spy0663 atpA; ATP synthase alpha chain K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D MGAS10750_Spy0662 atpH; ATP synthase delta chain K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D MGAS10750_Spy0661 atpF; ATP synthase B chain K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D MGAS10750_Spy0659 atpE; ATP synthase C chain K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D MGAS10750_Spy0660 atpB; ATP synthase A chain K02108 ATPF0A; F-type H+-transporting ATPase subunit a
B
B 09182 Protein families: genetic information processing
C 03000 Transcription factors [BR:spi03000]
D MGAS10750_Spy1697 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy0948 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy1515 lacR1; Lactose phosphotransferase system repressor K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor
D MGAS10750_Spy1736 lacR2; Lactose phosphotransferase system repressor K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor
D MGAS10750_Spy0751 fruR; Fructose repressor K03436 fruR2; DeoR family transcriptional regulator, fructose operon transcriptional repressor
D MGAS10750_Spy1372 Ribose operon repressor K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D MGAS10750_Spy0437 ccpA; Catabolite control protein A K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D MGAS10750_Spy1149 malR; Transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor
D MGAS10750_Spy0536 regR; Transcriptional regulator, LacI family K02525 kdgR; LacI family transcriptional regulator, kdg operon repressor
D MGAS10750_Spy1603 scrR; Sucrose operon repressor K03484 scrR; LacI family transcriptional regulator, sucrose operon repressor
D MGAS10750_Spy1424 Transcriptional regulator, GntR family / Transcriptional regulator, LacI family K02103 araR; GntR family transcriptional regulator, arabinose operon transcriptional repressor
D MGAS10750_Spy1877 Trehalose operon transcriptional repressor K03486 treR2; GntR family transcriptional regulator, trehalose operon transcriptional repressor
D MGAS10750_Spy1066 Transcriptional regulator, GntR family K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator
D MGAS10750_Spy0627 Transcriptional regulator, GntR family K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator
D MGAS10750_Spy1700 Transcriptional regulator, TetR family K09017 rutR; TetR/AcrR family transcriptional regulator
D MGAS10750_Spy1655 Transcriptional regulator, MerR family K03713 glnR; MerR family transcriptional regulator, glutamine synthetase repressor
D MGAS10750_Spy0167 perR; Ferric uptake regulation protein K09825 perR; Fur family transcriptional regulator, peroxide stress response regulator
D MGAS10750_Spy1383 Transcription regulator, crp family K21828 arcR; CRP/FNR family transcriptional regulator, arginine deiminase pathway regulator
D MGAS10750_Spy1935 cadC; Cadmium efflux system accessory protein K21903 cadC; ArsR family transcriptional regulator, lead/cadmium/zinc/bismuth-responsive transcriptional repressor
D MGAS10750_Spy1944 Transcriptional regulator, PadR family K10947 K10947; PadR family transcriptional regulator
D MGAS10750_Spy0369 scaR; Iron-dependent repressor K03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator
D MGAS10750_Spy1209 birA; Biotin operon repressor / Biotin--(acetyl-CoA-carboxylase) synthetase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
D MGAS10750_Spy0036 Transcriptional regulator K20342 comR; HTH-type transcriptional regulator, regulator for ComX
D MGAS10750_Spy0420 mutR; Transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator
D MGAS10750_Spy0460 Transcriptional regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor
D MGAS10750_Spy1831 rgg; Transcriptional regulator K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator
D MGAS10750_Spy0223 purR; Pur operon repressor K09685 purR; HTH-type transcriptional regulator, purine operon repressor
D MGAS10750_Spy0993 Redox-sensitive transcriptional regulator Rex K01926 rex; redox-sensing transcriptional repressor
D MGAS10750_Spy1572 codY; Transcription pleiotropic repressor codY K03706 codY; transcriptional pleiotropic repressor
D MGAS10750_Spy1900 Transcriptional regulator, Cro/CI family K07727 K07727; putative transcriptional regulator
D MGAS10750_Spy1742 Transcriptional regulator, Cro/CI family K07729 K07729; putative transcriptional regulator
D MGAS10750_Spy1238 Transcriptional regulator, Cro/CI family K07729 K07729; putative transcriptional regulator
D MGAS10750_Spy0496 licT; Transcription antiterminator, BglG family K03488 licT; beta-glucoside operon transcriptional antiterminator
D MGAS10750_Spy0161 Transcription antiterminator, BglG family K03493 bglG1; transcriptional antiterminator
D MGAS10750_Spy1176 Transcription antiterminator, BglG family / PTS system, mannitol (Cryptic)-specific IIA component K03491 licR; probable licABCH operon transcriptional regulator
D MGAS10750_Spy1979 parB; Chromosome partitioning protein parB K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D MGAS10750_Spy1336 argR1; Arginine repressor, argR K03402 argR; transcriptional regulator of arginine metabolism
D MGAS10750_Spy1384 ahrC2; Arginine repressor, argR K03402 argR; transcriptional regulator of arginine metabolism
D MGAS10750_Spy1924 argR2; Arginine repressor, argR K03402 argR; transcriptional regulator of arginine metabolism
D MGAS10750_Spy1560 hrcA; Heat-inducible transcription repressor hrcA K03705 hrcA; heat-inducible transcriptional repressor
D MGAS10750_Spy1858 ctsR; Transcriptional regulator ctsR K03708 ctsR; transcriptional regulator of stress and heat shock response
D MGAS10750_Spy0728 pyrR; Uracil phosphoribosyltransferase / Pyrimidine operon regulatory protein pyrR K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
D MGAS10750_Spy0279 Putative regulatory protein K07738 nrdR; transcriptional repressor NrdR
D MGAS10750_Spy0253 Competence-specific sigma factor ComX K12296 comX1_2; competence protein ComX
D MGAS10750_Spy1673 comX2; Competence-specific sigma factor ComX K12296 comX1_2; competence protein ComX
C 03021 Transcription machinery [BR:spi03021]
D MGAS10750_Spy0074 rpoA; DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D MGAS10750_Spy0090 rpoB; DNA-directed RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D MGAS10750_Spy0091 rpoC; DNA-directed RNA polymerase beta' chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D MGAS10750_Spy1666 rpoE; DNA-directed RNA polymerase delta chain K03048 rpoE; DNA-directed RNA polymerase subunit delta
D MGAS10750_Spy1449 DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D MGAS10750_Spy0687 rpoD; RNA polymerase sigma factor rpoD K03086 rpoD; RNA polymerase primary sigma factor
D MGAS10750_Spy1525 nusA; N utilization substance protein A K02600 nusA; transcription termination/antitermination protein NusA
D MGAS10750_Spy1604 nusB; N utilization substance protein B K03625 nusB; transcription antitermination protein NusB
D MGAS10750_Spy0144 nusG; Transcription antitermination protein nusG K02601 nusG; transcription termination/antitermination protein NusG
D MGAS10750_Spy0288 greA; Transcription elongation factor greA K03624 greA; transcription elongation factor GreA
C 03019 Messenger RNA biogenesis [BR:spi03019]
D MGAS10750_Spy0458 acpA; Ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
D MGAS10750_Spy1653 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-]
D MGAS10750_Spy0899 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-]
D MGAS10750_Spy1451 Hydrolase K18682 rny; ribonucrease Y [EC:3.1.-.-]
D MGAS10750_Spy0427 Exoribonuclease II K12573 rnr; ribonuclease R [EC:3.1.13.1]
D MGAS10750_Spy0222 cbf; CMP-binding factor K03698 cbf; 3'-5' exoribonuclease [EC:3.1.-.-]
D MGAS10750_Spy1261 deaD; ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D MGAS10750_Spy1474 ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7]
D MGAS10750_Spy0639 eno; Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D MGAS10750_Spy1754 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D MGAS10750_Spy1139 pfk; 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D MGAS10750_Spy1558 dnaK; Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D MGAS10750_Spy1855 groEL; 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D MGAS10750_Spy0557 ATP-binding protein K06958 rapZ; RNase adapter protein RapZ
C 03041 Spliceosome
C 03011 Ribosome [BR:spi03011]
D MGAS10750_Spy0809 SSU ribosomal protein S1P K02945 RP-S1; small subunit ribosomal protein S1
D MGAS10750_Spy1872 rpsB; SSU ribosomal protein S2P K02967 RP-S2; small subunit ribosomal protein S2
D MGAS10750_Spy0053 rpsC; SSU ribosomal protein S3P K02982 RP-S3; small subunit ribosomal protein S3
D MGAS10750_Spy1949 rpsD; SSU ribosomal protein S4P K02986 RP-S4; small subunit ribosomal protein S4
D MGAS10750_Spy0065 rpsE; SSU ribosomal protein S5P K02988 RP-S5; small subunit ribosomal protein S5
D MGAS10750_Spy1614 rpsF; SSU ribosomal protein S6P K02990 RP-S6; small subunit ribosomal protein S6
D MGAS10750_Spy0226 rpsG; SSU ribosomal protein S7P K02992 RP-S7; small subunit ribosomal protein S7
D MGAS10750_Spy0062 rpsH; SSU ribosomal protein S8P K02994 RP-S8; small subunit ribosomal protein S8
D MGAS10750_Spy1740 rpsI; SSU ribosomal protein S9P K02996 RP-S9; small subunit ribosomal protein S9
D MGAS10750_Spy0044 rpsJ; SSU ribosomal protein S10P K02946 RP-S10; small subunit ribosomal protein S10
D MGAS10750_Spy0073 rpsK; SSU ribosomal protein S11P K02948 RP-S11; small subunit ribosomal protein S11
D MGAS10750_Spy0225 rpsL; SSU ribosomal protein S12P K02950 RP-S12; small subunit ribosomal protein S12
D MGAS10750_Spy0072 rpsM; SSU ribosomal protein S13P K02952 RP-S13; small subunit ribosomal protein S13
D MGAS10750_Spy1648 rpsN2; SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14
D MGAS10750_Spy0061 rpsN; SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14
D MGAS10750_Spy1760 SSU ribosomal protein S15P K02956 RP-S15; small subunit ribosomal protein S15
D MGAS10750_Spy0738 rpsP; SSU ribosomal protein S16P K02959 RP-S16; small subunit ribosomal protein S16
D MGAS10750_Spy0056 rpsQ; SSU ribosomal protein S17P K02961 RP-S17; small subunit ribosomal protein S17
D MGAS10750_Spy1612 rpsR; SSU ribosomal protein S18P K02963 RP-S18; small subunit ribosomal protein S18
D MGAS10750_Spy0051 rpsS; SSU ribosomal protein S19P K02965 RP-S19; small subunit ribosomal protein S19
D MGAS10750_Spy1095 rpsT; SSU ribosomal protein S20P K02968 RP-S20; small subunit ribosomal protein S20
D MGAS10750_Spy0682 SSU ribosomal protein S21P K02970 RP-S21; small subunit ribosomal protein S21
D MGAS10750_Spy0377 rplA; LSU ribosomal protein L1P K02863 RP-L1; large subunit ribosomal protein L1
D MGAS10750_Spy0050 rplB; LSU ribosomal protein L2P K02886 RP-L2; large subunit ribosomal protein L2
D MGAS10750_Spy0045 rplC; LSU ribosomal protein L3P K02906 RP-L3; large subunit ribosomal protein L3
D MGAS10750_Spy0048 rplD; LSU ribosomal protein L1E (L4P) K02926 RP-L4; large subunit ribosomal protein L4
D MGAS10750_Spy0047 LSU ribosomal protein L1E (L4P) K02926 RP-L4; large subunit ribosomal protein L4
D MGAS10750_Spy0060 rplE; LSU ribosomal protein L5P K02931 RP-L5; large subunit ribosomal protein L5
D MGAS10750_Spy0063 rplF; LSU ribosomal protein L6P K02933 RP-L6; large subunit ribosomal protein L6
D MGAS10750_Spy1952 rplI; LSU ribosomal protein L9P K02939 RP-L9; large subunit ribosomal protein L9
D MGAS10750_Spy0943 rplJ; LSU ribosomal protein L10P K02864 RP-L10; large subunit ribosomal protein L10
D MGAS10750_Spy0376 rplK; LSU ribosomal protein L11P K02867 RP-L11; large subunit ribosomal protein L11
D MGAS10750_Spy0944 rplL; LSU ribosomal protein L12P (L7/L12) K02935 RP-L7; large subunit ribosomal protein L7/L12
D MGAS10750_Spy1741 rplM; LSU ribosomal protein L13P K02871 RP-L13; large subunit ribosomal protein L13
D MGAS10750_Spy0057 rplN; LSU ribosomal protein L14P K02874 RP-L14; large subunit ribosomal protein L14
D MGAS10750_Spy0058 LSU ribosomal protein L14P K02874 RP-L14; large subunit ribosomal protein L14
D MGAS10750_Spy0067 rplO; LSU ribosomal protein L15P K02876 RP-L15; large subunit ribosomal protein L15
D MGAS10750_Spy0054 rplP; LSU ribosomal protein L16P K02878 RP-L16; large subunit ribosomal protein L16
D MGAS10750_Spy0075 rplQ; LSU ribosomal protein L17P K02879 RP-L17; large subunit ribosomal protein L17
D MGAS10750_Spy0064 rplR; LSU ribosomal protein L18P K02881 RP-L18; large subunit ribosomal protein L18
D MGAS10750_Spy0634 rplS; LSU ribosomal protein L19P K02884 RP-L19; large subunit ribosomal protein L19
D MGAS10750_Spy0708 rplT; LSU ribosomal protein L20P K02887 RP-L20; large subunit ribosomal protein L20
D MGAS10750_Spy0722 rplU; LSU ribosomal protein L21P K02888 RP-L21; large subunit ribosomal protein L21
D MGAS10750_Spy0052 rplV; LSU ribosomal protein L22P K02890 RP-L22; large subunit ribosomal protein L22
D MGAS10750_Spy0049 rplW; LSU ribosomal protein L23P K02892 RP-L23; large subunit ribosomal protein L23
D MGAS10750_Spy0059 rplX; LSU ribosomal protein L24P K02895 RP-L24; large subunit ribosomal protein L24
D MGAS10750_Spy0724 rpmA; LSU ribosomal protein L27P K02899 RP-L27; large subunit ribosomal protein L27
D MGAS10750_Spy1662 rpmB; LSU ribosomal protein L28P K02902 RP-L28; large subunit ribosomal protein L28
D MGAS10750_Spy0055 rpmC; LSU ribosomal protein L29P K02904 RP-L29; large subunit ribosomal protein L29
D MGAS10750_Spy0066 rpmD; LSU ribosomal protein L30P K02907 RP-L30; large subunit ribosomal protein L30
D MGAS10750_Spy0629 rpmE; LSU ribosomal protein L31P K02909 RP-L31; large subunit ribosomal protein L31
D MGAS10750_Spy1932 rpmF; LSU ribosomal protein L32P K02911 RP-L32; large subunit ribosomal protein L32
D MGAS10750_Spy1846 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33
D MGAS10750_Spy1933 rpmG; LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33
D MGAS10750_Spy0425 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33
D MGAS10750_Spy0205 rpmH; LSU ribosomal protein L34P K02914 RP-L34; large subunit ribosomal protein L34
D MGAS10750_Spy0707 rpl36; LSU ribosomal protein L35P K02916 RP-L35; large subunit ribosomal protein L35
D MGAS10750_Spy0071 rpmJ; LSU ribosomal protein L36P K02919 RP-L36; large subunit ribosomal protein L36
D MGAS10750SpyR2227 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2274 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2239 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2259 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2289 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2297 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2237 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2272 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2257 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2292 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2300 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2225 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2226 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2273 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2238 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2258 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2298 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2290 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
C 03009 Ribosome biogenesis [BR:spi03009]
D MGAS10750_Spy0458 acpA; Ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
D MGAS10750_Spy0389 era; GTP-binding protein era K03595 era; GTPase
D MGAS10750_Spy1181 obg; GTP-binding protein CgtA K03979 obgE; GTPase [EC:3.6.5.-]
D MGAS10750_Spy1525 nusA; N utilization substance protein A K02600 nusA; transcription termination/antitermination protein NusA
D MGAS10750_Spy1604 nusB; N utilization substance protein B K03625 nusB; transcription antitermination protein NusB
D MGAS10750_Spy0144 nusG; Transcription antitermination protein nusG K02601 nusG; transcription termination/antitermination protein NusG
D MGAS10750_Spy1191 rsuA; Ribosomal small subunit pseudouridine synthase A K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]
D MGAS10750_Spy1245 Ribosomal small subunit pseudouridine synthase A K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]
D MGAS10750_Spy0217 ksgA; Dimethyladenosine transferase K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]
D MGAS10750_Spy1446 sunL; 16S rRNA m(5)C 967 methyltransferase K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]
D MGAS10750_Spy1093 16S rRNA m(2)G 1207 methyltransferase K00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]
D MGAS10750_Spy1375 Methyltransferase K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]
D MGAS10750_Spy1785 hypothetical cytosolic protein K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]
D MGAS10750_Spy0273 gidB; Methyltransferase gidB K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]
D MGAS10750_Spy1478 mraW; S-adenosyl-methyltransferase mraW K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]
D MGAS10750_Spy0332 Tetrapyrrole (Corrin/Porphyrin) methylase family protein K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]
D MGAS10750_Spy1337 Lantibotic precursor K06442 tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]
D MGAS10750_Spy1746 23S rRNA Gm2251 methyltransferase K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]
D MGAS10750_Spy1977 hypothetical cytosolic protein K00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]
D MGAS10750_Spy0710 Methyltransferase K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]
D MGAS10750_Spy1369 Radical SAM family enzyme K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]
D MGAS10750_Spy1197 23S rRNA m(5)U 1939 methyltransferase K03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]
D MGAS10750_Spy0304 Ribosomal large subunit pseudouridine synthase B K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]
D MGAS10750_Spy0727 Ribosomal large subunit pseudouridine synthase D K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D MGAS10750_Spy1000 Ribosomal large subunit pseudouridine synthase D K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D MGAS10750_Spy1850 Ribosomal large subunit pseudouridine synthase D K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D MGAS10750_Spy1703 rRNA adenine N-6-methyltransferase K00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]
D MGAS10750_Spy1650 Ribosomal-protein-S18-alanine acetyltransferase K03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]
D MGAS10750_Spy0746 rimM; 16S rRNA processing protein rimM K02860 rimM; 16S rRNA processing protein RimM
D MGAS10750_Spy1786 Ribosomal protein L11 methyltransferase K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]
D MGAS10750_Spy1888 Endonuclease involved in recombination K07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-]
D MGAS10750_Spy1748 hypothetical protein K11145 mrnC; mini-ribonuclease III [EC:3.1.26.-]
D MGAS10750_Spy1261 deaD; ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
D MGAS10750_Spy1474 ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7]
D MGAS10750_Spy0218 GTPase K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]
D MGAS10750_Spy0282 pgdA; GTP-binding protein K03977 engA; GTPase
D MGAS10750_Spy1031 GTP-binding protein K14540 rbgA; ribosome biogenesis GTPase A
D MGAS10750_Spy0817 hflX; GTP-binding protein hflX K03665 hflX; GTPase
D MGAS10750_Spy0255 GTP-binding protein K06948 yqeH; 30S ribosome assembly GTPase
D MGAS10750_Spy1014 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D MGAS10750_Spy1780 relA; GTP pyrophosphokinase / Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D MGAS10750_Spy1521 rbfA; Ribosome-binding factor A K02834 rbfA; ribosome-binding factor A
D MGAS10750_Spy1526 hypothetical cytosolic protein K09748 rimP; ribosome maturation factor RimP
D MGAS10750_Spy1967 hypothetical cytosolic protein K14761 rlbA; ribosome-associated protein
D MGAS10750_Spy0260 iojap protein family K09710 ybeB; ribosome-associated protein
D MGAS10750_Spy0387 hypothetical metal-binding protein K07042 ybeY; probable rRNA maturation factor
D MGAS10750_Spy0256 hypothetical RNA binding protein K07574 yhbY; RNA-binding protein
D MGAS10750_Spy1434 Ribosome-associated factor Y K05808 hpf; ribosome hibernation promoting factor
D MGAS10750_Spy0004 GTP-binding protein, probable translation factor K06942 ychF; ribosome-binding ATPase
D MGAS10750_Spy0276 hypothetical cytosolic protein K07040 yceD; DUF177 domain-containing protein
C 03016 Transfer RNA biogenesis [BR:spi03016]
D MGAS10750_Spy0819 elaC; Ribonuclease Z K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D MGAS10750_Spy0764 papS; poly(A) polymerase / tRNA nucleotidyltransferase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
D MGAS10750_Spy1767 proS; Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D MGAS10750_Spy1350 ileS; Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D MGAS10750_Spy0153 leuS; Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MGAS10750_Spy0347 metS; Methionyl-tRNA synthetase / Protein secretion chaperonin CsaA K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D MGAS10750_Spy1925 argS; Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D MGAS10750_Spy0514 lysS; Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D MGAS10750_Spy1930 aspS; Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D MGAS10750_Spy1239 alaS; Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D MGAS10750_Spy0482 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D MGAS10750_Spy0556 asnS; Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D MGAS10750_Spy0440 thrS; Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D MGAS10750_Spy1542 serS; Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D MGAS10750_Spy1749 cysS; Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D MGAS10750_Spy1400 valS; Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D MGAS10750_Spy1931 hisS; Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D MGAS10750_Spy0672 pheS; Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D MGAS10750_Spy0673 pheT; Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D MGAS10750_Spy0088 tyrS; Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MGAS10750_Spy1971 trsA; Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D MGAS10750_Spy1779 D-tyrosyl-tRNA(Tyr) deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D MGAS10750_Spy1531 hit; Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D MGAS10750_Spy1527 tRNA (m(7)G46) methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D MGAS10750_Spy1672 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D MGAS10750_Spy1112 truB; tRNA pseudouridine synthase B K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D MGAS10750_Spy0995 nifS2; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy0718 nifS1; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy1014 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D MGAS10750_Spy0816 miaA; tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D MGAS10750_Spy0942 thdF; tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D MGAS10750_Spy1954 gidA; Putative tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase subunit GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D MGAS10750_Spy0202 fasX; Ribonuclease P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]
D MGAS10750_Spy1496 glyQ; Glycyl-tRNA synthetase alpha chain K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D MGAS10750_Spy1495 glyS; Glycyl-tRNA synthetase beta chain K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D MGAS10750_Spy0198 gltX; Glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
D MGAS10750_Spy0517 Transcriptional regulator K03976 ybaK; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]
D MGAS10750_Spy0174 tRNA-specific adenosine deaminase K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
D MGAS10750_Spy0111 tRNA-dihydrouridine synthase K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]
D MGAS10750_Spy1042 gid; Glucose inhibited division protein A K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
D MGAS10750_Spy0747 trmD; tRNA (Guanine-N(1)-)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D MGAS10750_Spy0825 hypothetical cytosolic protein K06967 trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217]
D MGAS10750_Spy0306 23S rRNA methyltransferase K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]
D MGAS10750_Spy0292 23S rRNA methyltransferase K03437 spoU; RNA methyltransferase, TrmH family
D MGAS10750_Spy1956 trmU; tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D MGAS10750_Spy1247 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
D MGAS10750_Spy0548 iron-sulfur cluster-binding protein K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]
D MGAS10750_Spy0193 hypothetical cytosolic protein K09765 queH; epoxyqueuosine reductase [EC:1.17.99.6]
D MGAS10750_Spy0170 tgt; Queuine tRNA-ribosyltransferase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D MGAS10750_Spy0719 thiI; Thiamine biosynthesis protein thiI K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]
D MGAS10750_Spy0011 tilS; tRNA(Ile)-lysidine synthetase TilS K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
D MGAS10750_Spy1651 Non-proteolytic protein, peptidase family M22 K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
D MGAS10750_Spy1649 O-sialoglycoprotein endopeptidase K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
D MGAS10750_Spy1535 ATP/GTP hydrolase K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
D MGAS10750_Spy0262 hypothetical cytosolic protein K27343 tmcAL; tRNA(Met) cytidine acetate ligase [EC:6.3.4.-]
D MGAS10750_Spy0427 Exoribonuclease II K12573 rnr; ribonuclease R [EC:3.1.13.1]
D MGAS10750_Spy1754 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
C 03012 Translation factors [BR:spi03012]
D MGAS10750_Spy1522 infB; Bacterial Protein Translation Initiation Factor 2 (IF-2) K02519 infB; translation initiation factor IF-2
D MGAS10750_Spy0706 infC; Bacterial Protein Translation Initiation Factor 3 (IF-3) K02520 infC; translation initiation factor IF-3
D MGAS10750_Spy0902 ABC transporter ATP-binding protein K06158 ABCF3; ATP-binding cassette, subfamily F, member 3
D MGAS10750_Spy1873 translation elongation factor Ts (EF-Ts) K02357 tsf; elongation factor Ts
D MGAS10750_Spy0527 translation elongation factor Tu (EF-TU) K02358 tuf; elongation factor Tu
D MGAS10750_Spy0227 fus; translation elongation factor G (EF-G) K02355 fusA; elongation factor G
D MGAS10750_Spy1012 prfA; Bacterial Peptide Chain Release Factor 1 (RF-1) K02835 prfA; peptide chain release factor 1
D MGAS10750_Spy0379 rrf; Ribosome Recycling Factor (RRF) K02838 frr; ribosome recycling factor
D MGAS10750_Spy1013 hemK; Peptide release factor-glutamine N5-methyltransferase K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297]
D MGAS10750_Spy0005 pth; Peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]
D MGAS10750_Spy0070 infA; Bacterial Protein Translation Initiation Factor 1 (IF-1) K02518 infA; translation initiation factor IF-1
D MGAS10750_Spy1606 efp; translation elongation factor P (EF-P) K02356 efp; elongation factor P
D MGAS10750_Spy0549 prfB; Bacterial Peptide Chain Release Factor 2 (RF-2) K02836 prfB; peptide chain release factor 2
D MGAS10750_Spy1263 prfC; Bacterial Peptide Chain Release Factor 3 (RF-3) K02837 prfC; peptide chain release factor 3
C 03110 Chaperones and folding catalysts [BR:spi03110]
D MGAS10750_Spy1857 clpC; Negative regulator of genetic competence clpC/mecB K03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC
D MGAS10750_Spy1347 clpE; ATP-dependent endopeptidase clp ATP-binding subunit clpE K03697 clpE; ATP-dependent Clp protease ATP-binding subunit ClpE
D MGAS10750_Spy0786 clpL; ATP-dependent endopeptidase clp ATP-binding subunit clpL K04086 clpL; ATP-dependent Clp protease ATP-binding subunit ClpL
D MGAS10750_Spy0783 clpX; ATP-dependent endopeptidase clp ATP-binding subunit clpX K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
D MGAS10750_Spy1558 dnaK; Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D MGAS10750_Spy1855 groEL; 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D MGAS10750_Spy1557 dnaJ; Chaperone protein dnaJ K03686 dnaJ; molecular chaperone DnaJ
D MGAS10750_Spy0112 33 kDa chaperonin K04083 hslO; molecular chaperone Hsp33
D MGAS10750_Spy1559 grpE; GrpE protein K03687 GRPE; molecular chaperone GrpE
D MGAS10750_Spy1856 groES; 10 kDa chaperonin GROES K04078 groES; chaperonin GroES
D MGAS10750_Spy1978 htrA; Endopeptidase degP K04771 degP; serine protease Do [EC:3.4.21.107]
D MGAS10750_Spy0013 ftsH; Cell division protein ftsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D MGAS10750_Spy0660 atpB; ATP synthase A chain K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D MGAS10750_Spy0339 Endopeptidase lactocepin K01361 E3.4.21.96; lactocepin [EC:3.4.21.96]
D MGAS10750_Spy1807 scpA; C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110]
D MGAS10750_Spy0373 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
D MGAS10750_Spy1440 Peptidyl-prolyl cis-trans isomerase K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
D MGAS10750_Spy1240 surA; Peptidyl-prolyl cis-trans isomerase K07533 prsA; foldase protein PrsA [EC:5.2.1.8]
D MGAS10750_Spy1825 Peptidyl-prolyl cis-trans isomerase K07533 prsA; foldase protein PrsA [EC:5.2.1.8]
D MGAS10750_Spy1618 trx; Thioredoxin K03671 TXN; thioredoxin
C 04131 Membrane trafficking [BR:spi04131]
D MGAS10750_Spy1426 Alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24]
D MGAS10750_Spy0228 plr; Glyceraldehyde 3-phosphate dehydrogenase K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D MGAS10750_Spy1272 gpmA; Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
D MGAS10750_Spy1138 pyk; Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
C 04121 Ubiquitin system
C 03051 Proteasome
C 03032 DNA replication proteins [BR:spi03032]
D MGAS10750_Spy1697 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy0948 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy1329 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D MGAS10750_Spy0001 dnaA; Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein
D MGAS10750_Spy1951 holB; Replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D MGAS10750_Spy1680 Replicative DNA helicase K02315 dnaC; DNA replication protein DnaC
D MGAS10750_Spy0686 dnaG; DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D MGAS10750_Spy0280 dnaB; Replicative DNA helicase K03346 dnaB; replication initiation and membrane attachment protein
D MGAS10750_Spy0281 dnaI; Primosomal protein dnaI K11144 dnaI; primosomal protein DnaI
D MGAS10750_Spy1613 ssb2; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy0109 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy1140 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D MGAS10750_Spy1766 polC; DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D MGAS10750_Spy0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D MGAS10750_Spy1253 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D MGAS10750_Spy0327 dnaX; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D MGAS10750_Spy1640 dnaQ; DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D MGAS10750_Spy1211 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D MGAS10750_Spy1032 Ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D MGAS10750_Spy1623 Ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4]
D MGAS10750_Spy0165 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D MGAS10750_Spy0655 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D MGAS10750_Spy1023 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D MGAS10750_Spy0636 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D MGAS10750_Spy0804 parC; Topoisomerase IV subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D MGAS10750_Spy0803 parE; Topoisomerase IV subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D MGAS10750_Spy1034 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
D MGAS10750_Spy1696 DNA topoisomerase III K03169 topB; DNA topoisomerase III [EC:5.6.2.1]
C 03036 Chromosome and associated proteins [BR:spi03036]
D MGAS10750_Spy1697 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy0948 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy0458 acpA; Ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3]
D MGAS10750_Spy1329 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D MGAS10750_Spy0001 dnaA; Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein
D MGAS10750_Spy1367 dpr; Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase K04047 dps; starvation-inducible DNA-binding protein
D MGAS10750_Spy0459 smc; Chromosome partition protein smc K03529 smc; chromosome segregation protein
D MGAS10750_Spy0302 Segregation and condensation protein ScpA K05896 scpA; segregation and condensation protein A
D MGAS10750_Spy0303 Segregation and condensation protein ScpB K06024 scpB; segregation and condensation protein B
D MGAS10750_Spy1358 ftsA; Cell division protein ftsA K03590 ftsA; cell division protein FtsA
D MGAS10750_Spy0008 divIC; Cell division protein DivIC K13052 divIC; cell division protein DivIC
D MGAS10750_Spy0550 ftsE; Cell division ATP-binding protein ftsE K09812 ftsE; cell division transport system ATP-binding protein
D MGAS10750_Spy0374 ftsK; Cell division protein ftsK K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family
D MGAS10750_Spy1477 ftsL; Cell division protein ftsL K03586 ftsL; cell division protein FtsL
D MGAS10750_Spy1359 divIB; Cell-division initiation protein DivIB K03589 ftsQ; cell division protein FtsQ
D MGAS10750_Spy0525 ftsW; Cell division protein ftsW K03588 ftsW; cell division protein FtsW
D MGAS10750_Spy0551 ftsX; Cell division protein ftsX K09811 ftsX; cell division transport system permease protein
D MGAS10750_Spy1356 ftsZ; Cell division protein ftsZ K03531 ftsZ; cell division protein FtsZ
D MGAS10750_Spy0637 Septation ring formation regulator K06286 ezrA; septation ring formation regulator
D MGAS10750_Spy1351 divIVAS; Cell division initiation protein DivIVA K04074 divIVA; cell division initiation protein
D MGAS10750_Spy1354 hypothetical cytosolic protein K09772 sepF; cell division inhibitor SepF
D MGAS10750_Spy1979 parB; Chromosome partitioning protein parB K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D MGAS10750_Spy0804 parC; Topoisomerase IV subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D MGAS10750_Spy0803 parE; Topoisomerase IV subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D MGAS10750_Spy1954 gidA; Putative tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase subunit GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D MGAS10750_Spy0273 gidB; Methyltransferase gidB K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]
D MGAS10750_Spy1042 gid; Glucose inhibited division protein A K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
D MGAS10750_Spy1278 phage protein, Fic family K04095 fic; cell filamentation protein, protein adenylyltransferase [EC:2.7.7.108]
D MGAS10750_Spy0784 GTP-binding protein YihA K03978 engB; GTP-binding protein
D MGAS10750_Spy0559 hypothetical cytosolic protein K09762 whiA; cell division protein WhiA
C 03400 DNA repair and recombination proteins [BR:spi03400]
D MGAS10750_Spy1343 phr; Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
D MGAS10750_Spy0800 ung; Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
D MGAS10750_Spy1616 mutY; A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
D MGAS10750_Spy0824 nth; Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D MGAS10750_Spy0890 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MGAS10750_Spy1348 mutT; Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MGAS10750_Spy0194 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D MGAS10750_Spy1893 tag; DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
D MGAS10750_Spy0421 fpg; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
D MGAS10750_Spy0337 exoA; Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D MGAS10750_Spy0821 recJ; Single-stranded-DNA-specific exonuclease recJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D MGAS10750_Spy0655 lig; NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D MGAS10750_Spy0165 polA; DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D MGAS10750_Spy1609 uvrA; Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A
D MGAS10750_Spy1168 uvrB; Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
D MGAS10750_Spy0939 uvrC; Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
D MGAS10750_Spy1127 pcrA; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D MGAS10750_Spy0090 rpoB; DNA-directed RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D MGAS10750_Spy0091 rpoC; DNA-directed RNA polymerase beta' chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D MGAS10750_Spy0074 rpoA; DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D MGAS10750_Spy1666 rpoE; DNA-directed RNA polymerase delta chain K03048 rpoE; DNA-directed RNA polymerase subunit delta
D MGAS10750_Spy1449 DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D MGAS10750_Spy0006 trcF; Transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D MGAS10750_Spy1922 mutS; DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS
D MGAS10750_Spy1620 mutS2; DNA mismatch repair protein mutS K07456 mutS2; DNA mismatch repair protein MutS2
D MGAS10750_Spy1896 mutL; DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL
D MGAS10750_Spy1340 Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D MGAS10750_Spy1339 xseB; Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D MGAS10750_Spy1140 dnaE; DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D MGAS10750_Spy1766 polC; DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
D MGAS10750_Spy0002 dnaN; DNA polymerase III, beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D MGAS10750_Spy1253 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D MGAS10750_Spy0327 dnaX; DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D MGAS10750_Spy1640 dnaQ; DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
D MGAS10750_Spy1211 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D MGAS10750_Spy1613 ssb2; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy0109 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy1625 recD; Exodeoxyribonuclease V alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
D MGAS10750_Spy1891 recA; RecA protein K03553 recA; recombination protein RecA
D MGAS10750_Spy1894 ruvA; Holliday junction DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
D MGAS10750_Spy0037 ruvB; Holliday junction DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D MGAS10750_Spy1448 priA; Primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D MGAS10750_Spy0195 radA; DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
D MGAS10750_Spy1968 recF; DNA replication and repair protein recF K03629 recF; DNA replication and repair protein RecF
D MGAS10750_Spy1579 recG; ATP-dependent DNA helicase recG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D MGAS10750_Spy0019 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
D MGAS10750_Spy1267 recR; Recombination protein recR K06187 recR; recombination protein RecR
D MGAS10750_Spy1334 recN; DNA repair protein recN K03631 recN; DNA repair protein RecN (Recombination protein N)
D MGAS10750_Spy1463 recU; Recombination protein recU K03700 recU; recombination protein U
D MGAS10750_Spy0680 rexA; ATP-dependent nuclease subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
D MGAS10750_Spy0679 rexB; ATP-dependent nuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
D MGAS10750_Spy1393 hypothetical protein K15342 cas1; CRISP-associated protein Cas1
D MGAS10750_Spy0922 hypothetical cytosolic protein K15342 cas1; CRISP-associated protein Cas1
D MGAS10750_Spy0423 ATPase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
D MGAS10750_Spy1023 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D MGAS10750_Spy0636 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D MGAS10750_Spy1034 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
D MGAS10750_Spy1329 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta
D MGAS10750_Spy1316 RecT protein K07455 recT; recombination protein RecT
D MGAS10750_Spy1627 dinP; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D MGAS10750_Spy1063 phage transcriptional repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D MGAS10750_Spy1429 recX; Regulatory protein recX K03565 recX; regulatory protein
D MGAS10750_Spy0554 dinG; ATP-dependent helicase, DinG family K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D MGAS10750_Spy0351 nrdE1; Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MGAS10750_Spy1226 nrdE2; Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D MGAS10750_Spy1228 nrdF2; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MGAS10750_Spy0349 nrdF1; Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]
D MGAS10750_Spy0630 Phosphoesterase, DHH family protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
C 03029 Mitochondrial biogenesis [BR:spi03029]
D MGAS10750_Spy1522 infB; Bacterial Protein Translation Initiation Factor 2 (IF-2) K02519 infB; translation initiation factor IF-2
D MGAS10750_Spy0706 infC; Bacterial Protein Translation Initiation Factor 3 (IF-3) K02520 infC; translation initiation factor IF-3
D MGAS10750_Spy1873 translation elongation factor Ts (EF-Ts) K02357 tsf; elongation factor Ts
D MGAS10750_Spy0527 translation elongation factor Tu (EF-TU) K02358 tuf; elongation factor Tu
D MGAS10750_Spy0227 fus; translation elongation factor G (EF-G) K02355 fusA; elongation factor G
D MGAS10750_Spy0389 era; GTP-binding protein era K03595 era; GTPase
D MGAS10750_Spy0088 tyrS; Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D MGAS10750_Spy0153 leuS; Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D MGAS10750_Spy1930 aspS; Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D MGAS10750_Spy1925 argS; Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D MGAS10750_Spy1567 gatA; Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
D MGAS10750_Spy1566 gatB; Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
D MGAS10750_Spy1568 gatC; Glutamyl-tRNA(Gln) amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
D MGAS10750_Spy1613 ssb2; Single strand binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy0109 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein
D MGAS10750_Spy1558 dnaK; Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D MGAS10750_Spy1559 grpE; GrpE protein K03687 GRPE; molecular chaperone GrpE
D MGAS10750_Spy1855 groEL; 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D MGAS10750_Spy1856 groES; 10 kDa chaperonin GROES K04078 groES; chaperonin GroES
D MGAS10750_Spy1557 dnaJ; Chaperone protein dnaJ K03686 dnaJ; molecular chaperone DnaJ
D MGAS10750_Spy0995 nifS2; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy0718 nifS1; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy0203 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy0290 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
B
B 09183 Protein families: signaling and cellular processes
C 02000 Transporters [BR:spi02000]
D MGAS10750_Spy0956 srtT; Lantibiotic transport permease protein / Lantibiotic transport ATP-binding protein K20485 nisT; ATP-binding cassette, subfamily B, bacterial NisT/SpaT
D MGAS10750_Spy0191 Multidrug resistance ABC transporter ATP-binding and permease protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy0192 Multidrug/protein/lipid ABC transporter family, ATP-binding and permease protein K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy1019 Multidrug resistance ABC transporter ATP-binding and permease protein K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy1020 Multidrug/protein/lipid ABC transporter family, ATP-binding and permease protein K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump
D MGAS10750_Spy0408 Bacteriocin processing peptidase / Bacteriocin export ABC transporter K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D MGAS10750_Spy0395 Bacteriocin processing peptidase K20344 blpA; ATP-binding cassette, subfamily C, bacteriocin exporter
D MGAS10750_Spy1583 ABC transporter ATP-binding protein K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial
D MGAS10750_Spy1584 ABC transporter ATP-binding protein K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial
D MGAS10750_Spy0765 ABC transporter ATP-binding protein uup K15738 uup; ABC transport system ATP-binding/permease protein
D MGAS10750_Spy0937 Iron(III)-binding protein K02012 afuA; iron(III) transport system substrate-binding protein
D MGAS10750_Spy0980 Spermidine/putrescine-binding protein K11069 potD; spermidine/putrescine transport system substrate-binding protein
D MGAS10750_Spy0979 potC; Spermidine/putrescine transport system permease protein potC K11070 potC; spermidine/putrescine transport system permease protein
D MGAS10750_Spy0978 potB; Spermidine/putrescine transport system permease protein potB K11071 potB; spermidine/putrescine transport system permease protein
D MGAS10750_Spy0977 potA; Spermidine/putrescine transport ATP-binding protein potA K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11]
D MGAS10750_Spy0164 opuABC; Glycine betaine-binding protein / Glycine betaine transport system permease protein K02001 proW; glycine betaine/proline transport system permease protein
D MGAS10750_Spy0163 opuAA; Glycine betaine transport ATP-binding protein K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9]
D MGAS10750_Spy1005 Glycine betaine transport system permease protein / Glycine betaine-binding protein K05845 opuC; osmoprotectant transport system substrate-binding protein
D MGAS10750_Spy1004 proV; Glycine betaine transport ATP-binding protein K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9]
D MGAS10750_Spy1776 msmK; Multiple sugar transport ATP-binding protein msmK K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-]
D MGAS10750_Spy1160 malX; Maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein
D MGAS10750_Spy1150 malE; Maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein
D MGAS10750_Spy1151 malF; Maltodextrin transport system permease protein malC K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1156 malC; Maltodextrin transport system permease protein malC K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1152 malG; Maltose transport system permease protein malG K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1155 malD; Maltodextrin transport system permease protein malD K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein
D MGAS10750_Spy1417 Sugar-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein
D MGAS10750_Spy1419 Sugar transport system permease protein K17319 lplB; putative aldouronate transport system permease protein
D MGAS10750_Spy1418 Sugar transport system permease protein K17320 lplC; putative aldouronate transport system permease protein
D MGAS10750_Spy0142 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins
D MGAS10750_Spy1091 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins
D MGAS10750_Spy1089 Nucleoside transport system permease protein K23535 nupB; general nucleoside transport system permease protein
D MGAS10750_Spy1088 Nucleoside transport system permease protein K23536 nupC; general nucleoside transport system permease protein
D MGAS10750_Spy1090 Nucleoside transport ATP-binding protein K23537 nupA; general nucleoside transport system ATP-binding protein
D MGAS10750_Spy0207 N-acetylneuraminate-binding protein K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein
D MGAS10750_Spy0208 N-acetylneuraminate transport system permease protein K02025 ABC.MS.P; multiple sugar transport system permease protein
D MGAS10750_Spy0209 N-acetylneuraminate transport system permease protein K02026 ABC.MS.P1; multiple sugar transport system permease protein
D MGAS10750_Spy1105 pstS; Phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein
D MGAS10750_Spy1104 pstC; Phosphate transport system permease protein pstC K02037 pstC; phosphate transport system permease protein
D MGAS10750_Spy1103 pstA; Phosphate transport system permease protein pstA K02038 pstA; phosphate transport system permease protein
D MGAS10750_Spy1101 pstB; Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D MGAS10750_Spy1102 pstB2; Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D MGAS10750_Spy1169 glnH; Glutamine-binding protein / Glutamine transport system permease protein glnP K10036 glnH; glutamine transport system substrate-binding protein
D MGAS10750_Spy1170 glnQ2; Glutamine transport ATP-binding protein glnQ K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1]
D MGAS10750_Spy0798 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
D MGAS10750_Spy0265 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
D MGAS10750_Spy0799 Cystine transport system permease protein K10009 tcyB; L-cystine transport system permease protein
D MGAS10750_Spy1472 Amino acid ABC transporter permease protein K10009 tcyB; L-cystine transport system permease protein
D MGAS10750_Spy1471 Amino acid transport ATP-binding protein K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1]
D MGAS10750_Spy0681 Arginine-binding protein K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein
D MGAS10750_Spy1345 artQ; Arginine transport system permease protein artQ K17077 artQ; arginine/lysine/histidine transport system permease protein
D MGAS10750_Spy1344 artP; Arginine transport ATP-binding protein artP K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1]
D MGAS10750_Spy0266 ABC transporter substrate-binding protein K02073 metQ; D-methionine transport system substrate-binding protein
D MGAS10750_Spy0268 ABC transporter permease protein K02072 metI; D-methionine transport system permease protein
D MGAS10750_Spy0267 ABC transporter ATP-binding protein K02071 metN; D-methionine transport system ATP-binding protein
D MGAS10750_Spy0895 ABC transporter substrate-binding protein K01989 K01989; putative tryptophan/tyrosine transport system substrate-binding protein
D MGAS10750_Spy0897 ABC transporter permease protein K05832 K05832; putative tryptophan/tyrosine transport system permease protein
D MGAS10750_Spy0898 ABC transporter ATP-binding protein K05833 K05833; putative tryptophan/tyrosine transport system ATP-binding protein
D MGAS10750_Spy0231 ABC transporter amino acid-binding protein / Amino acid ABC transporter permease protein K17073 lysX1; putative lysine transport system substrate-binding protein
D MGAS10750_Spy0230 Amino acid transport ATP-binding protein K17076 lysY; putative lysine transport system ATP-binding protein
D MGAS10750_Spy1132 Histidine-binding protein K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein
D MGAS10750_Spy1134 Histidine transport system permease protein hisM K02029 ABC.PA.P; polar amino acid transport system permease protein
D MGAS10750_Spy1133 Histidine transport ATP-binding protein hisP K02028 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1]
D MGAS10750_Spy0246 oppA; Oligopeptide-binding protein oppA K15580 oppA; oligopeptide transport system substrate-binding protein
D MGAS10750_Spy0247 oppB; Oligopeptide transport system permease protein oppB K15581 oppB; oligopeptide transport system permease protein
D MGAS10750_Spy0248 oppC; Oligopeptide transport system permease protein oppC K15582 oppC; oligopeptide transport system permease protein
D MGAS10750_Spy0249 oppD; Oligopeptide transport ATP-binding protein oppD K15583 oppD; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy0250 oppF; Oligopeptide transport ATP-binding protein oppF K10823 oppF; oligopeptide transport system ATP-binding protein
D MGAS10750_Spy1797 dppA; Dipeptide-binding protein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein
D MGAS10750_Spy1798 dppB; Dipeptide transport system permease protein dppB K02033 ABC.PE.P; peptide/nickel transport system permease protein
D MGAS10750_Spy1799 dppC; Dipeptide transport system permease protein dppC K02034 ABC.PE.P1; peptide/nickel transport system permease protein
D MGAS10750_Spy1800 dppD; Dipeptide transport ATP-binding protein dppD K02031 ddpD; peptide/nickel transport system ATP-binding protein
D MGAS10750_Spy1801 dppE; Dipeptide transport ATP-binding protein dppF K02032 ddpF; peptide/nickel transport system ATP-binding protein
D MGAS10750_Spy0317 fhuD; Ferrichrome-binding protein K25308 fhuD; ferric hydroxamate/heme transport system substrate-binding protein
D MGAS10750_Spy0316 fhuB; Ferrichrome transport system permease protein fhuB K25288 fhuB; ferric hydroxamate/heme transport system permease protein
D MGAS10750_Spy0315 fhuG; Ferrichrome transport system permease protein fhuG K25289 fhuG; ferric hydroxamate/heme transport system permease protein
D MGAS10750_Spy0318 fhuA; Ferrichrome transport ATP-binding protein fhuC K25290 fhuA; ferric hydroxamate/heme transport system ATP-binding protein [EC:7.2.2.16]
D MGAS10750_Spy1587 Ferrichrome-binding protein K25113 htsA; heme transport system substrate-binding protein
D MGAS10750_Spy1586 Ferrichrome transport system permease protein fhuB K25114 htsB; heme transport system permease protein
D MGAS10750_Spy1585 fhuC; Ferrichrome transport ATP-binding protein fhuC K25115 htsC; heme transport system ATP-binding protein [EC:7.6.2.5]
D MGAS10750_Spy1588 shp; hypothetical protein K25119 shp; heme transport system cell surface heme-binding protein
D MGAS10750_Spy1589 Putative Fe3+-siderophore transport protein K25120 shr; heme sequestration protein
D MGAS10750_Spy0624 High-affinity zinc uptake system protein znuA precursor / hypothetical exported protein K09815 znuA; zinc transport system substrate-binding protein
D MGAS10750_Spy1805 lmb; Laminin-binding surface protein K09815 znuA; zinc transport system substrate-binding protein
D MGAS10750_Spy0086 adcB; High-affinity zinc uptake system membrane protein znuB K09816 znuB; zinc transport system permease protein
D MGAS10750_Spy0085 adcC; High-affinity zinc uptake system ATP-binding protein znuC K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D MGAS10750_Spy0370 mtsA; Manganese-binding protein K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein
D MGAS10750_Spy0372 mtsC; Manganese transport system membrane protein K11705 mtsC; iron/zinc/manganese/copper transport system permease protein
D MGAS10750_Spy0371 mtsB; Manganese transport system ATP-binding protein K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein
D MGAS10750_Spy0172 BioY protein K03523 bioY; biotin transport system substrate-specific component
D MGAS10750_Spy1582 membrane-bound protein K16926 htsT; energy-coupling factor transport system substrate-specific component
D MGAS10750_Spy0520 Integral membrane protein K16927 cbrT; energy-coupling factor transport system substrate-specific component
D MGAS10750_Spy1960 cbiQ; Hyaluronan ABC exporter permease protein K16785 ecfT; energy-coupling factor transport system permease protein
D MGAS10750_Spy1581 Cobalt transport protein cbiQ K16785 ecfT; energy-coupling factor transport system permease protein
D MGAS10750_Spy1962 cbiO1; Hyaluronan ABC exporter ATP-binding protein K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D MGAS10750_Spy1961 cbiO2; Hyaluronan ABC exporter ATP-binding protein K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D MGAS10750_Spy1580 Cobalt transport ATP-binding protein cbiO K01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-]
D MGAS10750_Spy0960 srtE; Lantibiotic transport permease protein K20491 nisE; lantibiotic transport system permease protein
D MGAS10750_Spy0961 srtG; Lantibiotic transport permease protein K20492 nisG; lantibiotic transport system permease protein
D MGAS10750_Spy0959 srtF; Lantibiotic transport ATP-binding protein K20490 nisF; lantibiotic transport system ATP-binding protein
D MGAS10750_Spy0652 sagI; Streptolysin S export transmembrane protein SagI K25142 lnrN; linearmycin/streptolysin S transport system permease protein
D MGAS10750_Spy0651 sagH; Streptolysin S export transmembrane protein SagH K25143 lnrM; linearmycin/streptolysin S transport system permease protein
D MGAS10750_Spy0650 sagG; Streptolysin S export ATP-binding protein SagG K25144 lnrL; linearmycin/streptolysin S transport system ATP-binding protein
D MGAS10750_Spy1702 Tetronasin resistance transmembrane protein K25149 narB; polyether ionophore transport system permease protein
D MGAS10750_Spy1701 Tetronasin resistance ATP-binding protein K25150 narA; polyether ionophore transport system ATP-binding protein
D MGAS10750_Spy0736 ABC transporter permease protein K24948 yknZ; antimicrobial peptide resistance transport system permease protein
D MGAS10750_Spy1817 ABC transporter permease protein K24948 yknZ; antimicrobial peptide resistance transport system permease protein
D MGAS10750_Spy1818 ABC transporter ATP-binding protein K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-]
D MGAS10750_Spy0735 ABC transporter ATP-binding protein K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-]
D MGAS10750_Spy0551 ftsX; Cell division protein ftsX K09811 ftsX; cell division transport system permease protein
D MGAS10750_Spy0550 ftsE; Cell division ATP-binding protein ftsE K09812 ftsE; cell division transport system ATP-binding protein
D MGAS10750_Spy0444 ABC transporter permease protein K25154 evrC; viologen exporter family transport system permease protein
D MGAS10750_Spy0443 Daunorubicin resistance transmembrane protein K25155 evrB; viologen exporter family transport system permease protein
D MGAS10750_Spy0441 drrA; Daunorubicin resistance ATP-binding protein drrA K25156 evrA; viologen exporter family transport system ATP-binding protein
D MGAS10750_Spy1529 Protein ecsB K25157 ecsB; ABC-2 type transport system permease protein
D MGAS10750_Spy1530 ABC-type transporter ATP-binding protein ecsA K25158 ecsA; ABC-2 type transport system ATP-binding protein
D MGAS10750_Spy0692 rgpCc; Polysaccharide export ABC transporter permease protein K01992 ABC-2.P; ABC-2 type transport system permease protein
D MGAS10750_Spy1482 proB; ABC transporter permease protein K01992 ABC-2.P; ABC-2 type transport system permease protein
D MGAS10750_Spy1577 ABC transporter permease protein K01992 ABC-2.P; ABC-2 type transport system permease protein
D MGAS10750_Spy1142 ABC transporter ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D MGAS10750_Spy1483 ABC transporter ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D MGAS10750_Spy0693 rgpDc; Polysaccharide export ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D MGAS10750_Spy1578 ABC transporter ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D MGAS10750_Spy1116 ABC transporter permease protein K02004 ABC.CD.P; putative ABC transport system permease protein
D MGAS10750_Spy1724 salY; ABC transporter permease protein K02004 ABC.CD.P; putative ABC transport system permease protein
D MGAS10750_Spy0676 ABC transporter permease protein K02004 ABC.CD.P; putative ABC transport system permease protein
D MGAS10750_Spy1117 ABC transporter ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D MGAS10750_Spy0677 ABC transporter ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D MGAS10750_Spy1725 ABC transporter ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D MGAS10750_Spy0239 ATP-dependent transporter sufC K09013 sufC; Fe-S cluster assembly ATP-binding protein
D MGAS10750_Spy0043 Na+ driven multidrug efflux pump K26937 dinF; MATE family, multidrug efflux pump
D MGAS10750_Spy1242 Permease MFS superfamily K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter
D MGAS10750_Spy0363 Phosphoglycerate transporter protein K02445 glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter
D MGAS10750_Spy0424 Multidrug resistance efflux pump K08161 mdtG; MFS transporter, DHA1 family, multidrug resistance protein
D MGAS10750_Spy1895 lmrP; Multidrug resistance protein imrP K08152 lmrP; MFS transporter, DHA1 family, multidrug resistance protein B
D MGAS10750_Spy0495 Multidrug resistance protein B K18926 lmrB; MFS transporter, DHA2 family, lincomycin resistance protein
D MGAS10750_Spy1222 pstI; Phosphoenolpyruvate-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9]
D MGAS10750_Spy1223 ptsH; Phosphocarrier protein HPr K02784 ptsH; phosphocarrier protein HPr
D MGAS10750_Spy1784 PTS system, glucose-specific IIABC component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208]
D MGAS10750_Spy1601 scrA; PTS system, sucrose-specific IIABC component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211]
D MGAS10750_Spy0497 PTS system, beta-glucoside-specific IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-]
D MGAS10750_Spy1876 PTS system, trehalose-specific IIBC component / PTS system, trehalose-specific IIA component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201]
D MGAS10750_Spy0753 fruA; PTS system, fructose-specific IIABC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202]
D MGAS10750_Spy1731 lacF; PTS system, lactose-specific IIA component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207]
D MGAS10750_Spy1730 lacE; PTS system, lactose-specific IIBC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207]
D MGAS10750_Spy1840 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1174 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1839 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1175 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205]
D MGAS10750_Spy1172 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D MGAS10750_Spy1838 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component
D MGAS10750_Spy1514 PTS system, galactose-specific IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204]
D MGAS10750_Spy1513 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204]
D MGAS10750_Spy1512 PTS system, galactose-specific IIC component K20114 gatC; galactose PTS system EIIC component
D MGAS10750_Spy1538 manL; PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191]
D MGAS10750_Spy0931 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191]
D MGAS10750_Spy1539 manM; PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy0933 ptsC; PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component
D MGAS10750_Spy1540 manN; PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component
D MGAS10750_Spy0934 ptsD; PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component
D MGAS10750_Spy0932 ptsB; PTS system, mannose/fructose family IIB component K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-]
D MGAS10750_Spy0540 agaV; PTS system, N-acetylgalactosamine-specific IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-]
D MGAS10750_Spy0539 PTS system, N-acetylgalactosamine-specific IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component
D MGAS10750_Spy0538 agaD; PTS system, N-acetylgalactosamine-specific IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component
D MGAS10750_Spy0156 PTS system, 3-keto-L-gulonate specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D MGAS10750_Spy1758 Transcription antiterminator, BglG family / PTS system, mannitol (Cryptic)-specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194]
D MGAS10750_Spy0155 PTS system, 3-keto-L-gulonate specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D MGAS10750_Spy1757 PTS system, IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194]
D MGAS10750_Spy0154 PTS system, 3-keto-L-gulonate specific IIC component K03475 ulaA; ascorbate PTS system EIIC component
D MGAS10750_Spy1756 Putative transport protein sgaT K03475 ulaA; ascorbate PTS system EIIC component
D MGAS10750_Spy0449 Dihydroxyacetone kinase phosphotransfer protein K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121]
D MGAS10750_Spy1632 glpF2; Aquaporin / Glycerol uptake facilitator protein K02440 glpF; glycerol uptake facilitator
D MGAS10750_Spy1490 glpF; Glycerol uptake facilitator protein K02440 glpF; glycerol uptake facilitator
D MGAS10750_Spy0450 Glycerol uptake facilitator protein K02440 glpF; glycerol uptake facilitator
D MGAS10750_Spy0813 Glutathione S-transferase K00799 GST; glutathione S-transferase [EC:2.5.1.18]
D MGAS10750_Spy1269 Formate transporter K21993 fdhC; formate transporter
D MGAS10750_Spy0683 mscL; Large-conductance mechanosensitive channel K03282 mscL; large conductance mechanosensitive channel
D MGAS10750_Spy1668 Mechanosensitive ion channel K22044 ybiO; moderate conductance mechanosensitive channel
D MGAS10750_Spy1610 corA; Magnesium and cobalt transport protein corA K03284 corA; magnesium transporter
D MGAS10750_Spy0311 hlyX; Magnesium and cobalt efflux protein corC K03699 tlyC; magnesium and cobalt exporter, CNNM family
D MGAS10750_Spy0955 srtA; Lantibiotic srtA precursor K20482 nisA; lantibiotic bacteriocin
D MGAS10750_Spy0744 czcD; Cobalt-zinc-cadmium resistance protein czcD K16264 czcD; cobalt-zinc-cadmium efflux system protein
D MGAS10750_Spy1969 Glucose uptake family protein K05340 glcU; glucose uptake protein
D MGAS10750_Spy0270 Serine/threonine sodium symporter K07862 sstT; serine/threonine transporter
D MGAS10750_Spy0272 Potassium uptake protein ktrB K03498 trkH; trk/ktr system potassium uptake protein
D MGAS10750_Spy0271 Potassium uptake protein ktrA K03499 trkA; trk/ktr system potassium uptake protein
D MGAS10750_Spy0729 pyrP; Uracil permease K02824 uraA; uracil permease
D MGAS10750_Spy1008 Xanthine permease K16169 pbuX; xanthine permease
D MGAS10750_Spy1536 Guanine-hypoxanthine permease K06901 pbuG; adenine/guanine/hypoxanthine permease
D MGAS10750_Spy1232 Chloride channel protein K03281 clcA; chloride channel protein, CIC family
D MGAS10750_Spy0633 Chloride channel protein K03281 clcA; chloride channel protein, CIC family
D MGAS10750_Spy1501 Sodium-dependent phosphate transporter K03324 yjbB; phosphate:Na+ symporter
D MGAS10750_Spy1259 Kup system potassium uptake protein K03549 kup; KUP system potassium uptake protein
D MGAS10750_Spy0307 Riboflavin transporter K23675 fmnP; riboflavin transporter
D MGAS10750_Spy0518 Thiamine transporter K16789 thiT; thiamine transporter
D MGAS10750_Spy1270 hypothetical protein K16788 niaX; niacin transporter
D MGAS10750_Spy0525 ftsW; Cell division protein ftsW K03588 ftsW; cell division protein FtsW
D MGAS10750_Spy1808 M protein K03646 tolA; colicin import membrane protein
D MGAS10750_Spy1809 emm1-0; M protein K03646 tolA; colicin import membrane protein
D MGAS10750_Spy1046 Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1052 oadB; Na+ transporting oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1]
D MGAS10750_Spy1043 oadA2; Na+ transporting oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2]
D MGAS10750_Spy1059 oadA1; Na+ transporting oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2]
D MGAS10750_Spy1044 hypothetical membrane associated protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma
D MGAS10750_Spy1045 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
D MGAS10750_Spy1051 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
D MGAS10750_Spy1391 ccdA; Cytochrome c-type biogenesis protein ccdA K06196 ccdA; cytochrome c-type biogenesis protein
D MGAS10750_Spy0407 Bacteriocin export accessory protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter
D MGAS10750_Spy0406 Bacteriocin export accessory protein K20345 blpB; membrane fusion protein, peptide pheromone/bacteriocin exporter
D MGAS10750_Spy1819 periplasmic component of efflux system K24950 yknX; membrane fusion protein, antimicrobial resistance system
D MGAS10750_Spy0734 periplasmic component of efflux system K24950 yknX; membrane fusion protein, antimicrobial resistance system
D MGAS10750_Spy1179 Nicotinamide mononucleotide transporter K03811 pnuC; nicotinamide mononucleotide transporter
C 02044 Secretion system [BR:spi02044]
D MGAS10750_Spy1353 Integral membrane protein K02221 yggT; YggT family protein
D MGAS10750_Spy1255 COME operon protein 1 K02237 comEA; competence protein ComEA
D MGAS10750_Spy1607 comEB; ComE operon protein 2 K01493 comEB; dCMP deaminase [EC:3.5.4.12]
D MGAS10750_Spy1254 comEC; COME operon protein 3 K02238 comEC; competence protein ComEC
D MGAS10750_Spy1436 comFA; COMF operon protein 1 K02240 comFA; competence protein ComFA
D MGAS10750_Spy1435 comFC; COMF operon protein 3 K02242 comFC; competence protein ComFC
D MGAS10750_Spy0093 comYA; ComG operon protein 1 K02243 comGA; competence protein ComGA
D MGAS10750_Spy0094 comYB; ComG operon protein 2 K02244 comGB; competence protein ComGB
D MGAS10750_Spy0095 comYC; ComG operon protein 3 K02245 comGC; competence protein ComGC
D MGAS10750_Spy0096 ComG operon protein 4 K02246 comGD; competence protein ComGD
D MGAS10750_Spy0098 comYD; ComG operon protein 6 K02248 comGF; competence protein ComGF
D MGAS10750_Spy1368 Type 4 prepilin peptidase pilD K02236 comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D MGAS10750_Spy1683 TraG/TraD family K03205 virD4; type IV secretion system protein VirD4 [EC:7.4.2.8]
D MGAS10750_Spy1593 secA; Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D MGAS10750_Spy1845 secE; Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE
D MGAS10750_Spy0426 secG; Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG
D MGAS10750_Spy0068 secY; Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY
D MGAS10750_Spy1064 ffh; signal recognition particle subunit FFH/SRP54 K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D MGAS10750_Spy0494 ftsY; Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor
D MGAS10750_Spy1771 yajC; Protein translocase subunit YajC K03210 yajC; preprotein translocase subunit YajC
D MGAS10750_Spy0203 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
D MGAS10750_Spy0290 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase
C 02042 Bacterial toxins [BR:spi02042]
D MGAS10750_Spy0353 spyA; C3 family ADP-ribosyltransferase K11044 spyA; C3 family ADP-ribosyltransferase [EC:2.4.2.-]
D MGAS10750_Spy0814 Transporter K11041 eta; exfoliative toxin A/B
D MGAS10750_Spy0147 slo; Streptolysin O K11031 slo; thiol-activated cytolysin
D MGAS10750_Spy0311 hlyX; Magnesium and cobalt efflux protein corC K03699 tlyC; magnesium and cobalt exporter, CNNM family
D MGAS10750_Spy1131 cfa; cAMP factor K11045 cfa; cAMP factor
D MGAS10750_Spy0644 sagA; Streptolysin S precursor K11046 sagA; streptolysin S associated protein
D MGAS10750_Spy1029 Conserved membrane protein K11068 hlyIII; hemolysin III
D MGAS10750_Spy1277 speA2; Enterotoxin K11040 se; staphylococcal enterotoxin
D MGAS10750_Spy1794 smeZ; Enterotoxin K11040 se; staphylococcal enterotoxin
D MGAS10750_Spy0621 speJ; Enterotoxin K11040 se; staphylococcal enterotoxin
D MGAS10750_Spy0615 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
D MGAS10750_Spy1423 hyl; Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
C 02022 Two-component system [BR:spi02022]
D MGAS10750_Spy0456 vicK; Two-component sensor histidine kinase VicK K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
D MGAS10750_Spy0455 vicR; Two-component response regulator VicR K07668 vicR; two-component system, OmpR family, response regulator VicR
D MGAS10750_Spy1096 ciaH; Sensor protein ciaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
D MGAS10750_Spy1097 ciaR; Transcriptional regulatory protein ciaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR
D MGAS10750_Spy0278 covS; Transmembrane histidine kinase CsrS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
D MGAS10750_Spy0277 covR; Response regulator CsrR K18941 arlR; two-component system, OmpR family, response regulator ArlR
D MGAS10750_Spy1815 ihk; two-component system histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3]
D MGAS10750_Spy1816 irr; Two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr
D MGAS10750_Spy0954 srtK; Lantibiotic biosynthesis sensor protein K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3]
D MGAS10750_Spy0953 srtR; Lantibiotic biosynthesis two-component response regulator K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR
D MGAS10750_Spy1442 yvqE; Two-component sensor protein yvqE K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]
D MGAS10750_Spy1441 yvqC; Two-component response regulator yvqC K11618 liaR; two-component system, NarL family, response regulator LiaR
D MGAS10750_Spy1723 Sensory transduction protein kinase K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK
D MGAS10750_Spy1722 salR; Transcriptional regulatory protein degU K14989 salR; two-component system, NarL family, secretion system response regulator SalR
D MGAS10750_Spy0982 dpiB; Sensor kinase dpiB K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
D MGAS10750_Spy0981 dpiA; Transcriptional regulatory protein dpiA K02475 K02475; two-component system, CitB family, response regulator
D MGAS10750_Spy1427 rocA; Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0404 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0199 fasB; Sensory transduction protein kinase FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0200 fasC; Sensory transduction protein kinase FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
D MGAS10750_Spy0403 Response regulator FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA
D MGAS10750_Spy0201 fasA; Response regulator FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA
D MGAS10750_Spy1415 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D MGAS10750_Spy1387 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
D MGAS10750_Spy0936 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN
D MGAS10750_Spy1414 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN
D MGAS10750_Spy1388 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN
C 02035 Bacterial motility proteins [BR:spi02035]
D MGAS10750_Spy0798 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
D MGAS10750_Spy0265 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein
C 03037 Cilium and associated proteins
C 04812 Cytoskeleton proteins [BR:spi04812]
D MGAS10750_Spy1356 ftsZ; Cell division protein ftsZ K03531 ftsZ; cell division protein FtsZ
D MGAS10750_Spy1358 ftsA; Cell division protein ftsA K03590 ftsA; cell division protein FtsA
D MGAS10750_Spy1979 parB; Chromosome partitioning protein parB K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
C 04147 Exosome [BR:spi04147]
D MGAS10750_Spy0639 eno; Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D MGAS10750_Spy0228 plr; Glyceraldehyde 3-phosphate dehydrogenase K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D MGAS10750_Spy1657 pgk; Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D MGAS10750_Spy1138 pyk; Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D MGAS10750_Spy0373 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
D MGAS10750_Spy1855 groEL; 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D MGAS10750_Spy1558 dnaK; Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D MGAS10750_Spy0179 pgi; Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D MGAS10750_Spy1970 guaB; Inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D MGAS10750_Spy0527 translation elongation factor Tu (EF-TU) K02358 tuf; elongation factor Tu
D MGAS10750_Spy1531 hit; Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D MGAS10750_Spy1022 ldh; L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27]
D MGAS10750_Spy0453 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D MGAS10750_Spy0452 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy1453 atoB; Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0124 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
D MGAS10750_Spy0069 adk; Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D MGAS10750_Spy0822 apt; Adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7]
D MGAS10750_Spy1492 glpK; Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30]
D MGAS10750_Spy1654 glnA; Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D MGAS10750_Spy0027 Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D MGAS10750_Spy0907 acoL; Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4]
D MGAS10750_Spy0528 tpi; Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D MGAS10750_Spy1272 gpmA; Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]
C 02048 Prokaryotic defense system [BR:spi02048]
D MGAS10750_Spy1393 hypothetical protein K15342 cas1; CRISP-associated protein Cas1
D MGAS10750_Spy0922 hypothetical cytosolic protein K15342 cas1; CRISP-associated protein Cas1
D MGAS10750_Spy0923 hypothetical cytosolic protein K09951 cas2; CRISPR-associated protein Cas2
D MGAS10750_Spy1392 hypothetical cytosolic protein K09951 cas2; CRISPR-associated protein Cas2
D MGAS10750_Spy1399 ATP-dependent RNA helicase K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
D MGAS10750_Spy1394 hypothetical protein K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
D MGAS10750_Spy1396 hypothetical protein K19117 csd1; CRISPR-associated protein Csd1
D MGAS10750_Spy1395 hypothetical cytosolic protein K19118 csd2; CRISPR-associated protein Csd2
D MGAS10750_Spy1397 hypothetical protein K19119 cas5d; CRISPR-associated protein Cas5d
D MGAS10750_Spy0921 hypothetical cytosolic protein K09952 csn1; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-]
D MGAS10750_Spy0924 hypothetical protein K19137 csn2; CRISPR-associated protein Csn2
D MGAS10750_Spy1676 hsdR; Type I restriction-modification system restriction subunit K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
D MGAS10750_Spy1677 hsdS; Type I restriction-modification system specificity subunit K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
D MGAS10750_Spy1678 Type I restriction-modification system methylation subunit K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
D MGAS10750_Spy1720 hsdM; Type I restriction-modification system methylation subunit K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
D MGAS10750_Spy0588 Adenine-specific methyltransferase K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]
D MGAS10750_Spy0100 Adenine-specific methyltransferase K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]
D MGAS10750_Spy1697 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy0948 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D MGAS10750_Spy0595 phage endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D MGAS10750_Spy0475 Plasmid stabilization system antitoxin protein K07473 dinJ; DNA-damage-inducible protein J
D MGAS10750_Spy0477 Plasmid stabilization system toxin protein K19092 parE1_3_4; toxin ParE1/3/4
D MGAS10750_Spy0952 srtI; Relaxase K21498 higA-1; antitoxin HigA-1
D MGAS10750_Spy1356 ftsZ; Cell division protein ftsZ K03531 ftsZ; cell division protein FtsZ
D MGAS10750_Spy0804 parC; Topoisomerase IV subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]
D MGAS10750_Spy0803 parE; Topoisomerase IV subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]
D MGAS10750_Spy0995 nifS2; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D MGAS10750_Spy0718 nifS1; Cysteine desulfurase / Selenocysteine lyase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C 04030 G protein-coupled receptors
C 04050 Cytokine receptors
C 04054 Pattern recognition receptors
C 03310 Nuclear receptors
C 04040 Ion channels [BR:spi04040]
C 04031 GTP-binding proteins
C 04052 Cytokines and neuropeptides
C 04515 Cell adhesion molecules
C 04090 CD molecules [BR:spi04090]
C 01504 Antimicrobial resistance genes [BR:spi01504]
D MGAS10750_Spy1705 spectinomycin phosphotransferase K18844 aph; spectinomycin phosphotransferase
D MGAS10750_Spy1703 rRNA adenine N-6-methyltransferase K00561 ermC; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184]
D MGAS10750_Spy1562 D-alanyl-D-alanine metallocarboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]
D MGAS10750_Spy1166 dltA; D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]
D MGAS10750_Spy1165 Protein dltB K03739 dltB; membrane protein involved in D-alanine export
D MGAS10750_Spy1164 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]
D MGAS10750_Spy1163 dltD; Protein dltD precursor K03740 dltD; D-alanine transfer protein
C 00535 Proteoglycans
C 00536 Glycosaminoglycan binding proteins [BR:spi00536]
D MGAS10750_Spy0615 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
D MGAS10750_Spy1423 hyl; Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:spi00537]
D MGAS10750_Spy0615 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
D MGAS10750_Spy1423 hyl; Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35]
D MGAS10750_Spy0145 nga; NAD glycohydrolase K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5]
C 04091 Lectins
C 04990 Domain-containing proteins not elsewhere classified
B
B 09185 Viral protein families
C 03200 Viral proteins
C 03210 Viral fusion proteins
B
B 09184 RNA family
C 03100 Non-coding RNAs [BR:spi03100]
D MGAS10750SpyR2291 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D MGAS10750SpyR2299 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D MGAS10750SpyR2237 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2272 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2257 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2280 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2305 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2277 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2235 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2247 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2276 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2295 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D MGAS10750SpyR2303 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D MGAS10750SpyR2275 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D MGAS10750SpyR2296 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D MGAS10750SpyR2229 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D MGAS10750SpyR2287 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D MGAS10750SpyR2241 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D MGAS10750SpyR2302 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D MGAS10750SpyR2279 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D MGAS10750SpyR2270 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D MGAS10750SpyR2282 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D MGAS10750SpyR2304 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D MGAS10750SpyR2263 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D MGAS10750SpyR2254 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2261 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2233 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2245 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D MGAS10750SpyR2269 tRNA-His K14226 tRNA-His; tRNA His
D MGAS10750SpyR2255 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D MGAS10750SpyR2283 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D MGAS10750SpyR2262 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D MGAS10750SpyR2234 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2246 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2271 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2231 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2243 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2285 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2294 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D MGAS10750SpyR2230 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2286 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2242 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2301 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D MGAS10750SpyR2249 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2250 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2252 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2265 tRNA-Met K14230 tRNA-Met; tRNA Met
D MGAS10750SpyR2253 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D MGAS10750SpyR2266 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D MGAS10750SpyR2236 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D MGAS10750SpyR2248 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D MGAS10750SpyR2251 pseudogene K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2264 pseudogene K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2293 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2256 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D MGAS10750SpyR2281 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2232 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2284 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2244 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D MGAS10750SpyR2268 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D MGAS10750SpyR2267 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D MGAS10750SpyR2278 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D MGAS10750SpyR2288 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750SpyR2260 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750SpyR2240 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750SpyR2228 tRNA-Val K14237 tRNA-Val; tRNA Val
D MGAS10750SpyR2292 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2300 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2225 16S small subunit ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D MGAS10750SpyR2226 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2273 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2238 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2258 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2298 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2290 23S large subunit ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D MGAS10750SpyR2227 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2274 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2239 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2259 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2289 5S RNA K01985 5SrRNA; 5S ribosomal RNA
D MGAS10750SpyR2297 5S RNA K01985 5SrRNA; 5S ribosomal RNA
#
A09190 Not Included in Pathway or Brite
B
B 09191 Unclassified: metabolism
C 99980 Enzymes with EC numbers
D MGAS10750_Spy0543 idnO; 2-deoxy-D-gluconate 3-dehydrogenase K00046 idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]
D MGAS10750_Spy0338 lctO; L-lactate oxidase K10530 lctO; L-lactate oxidase [EC:1.1.3.2]
D MGAS10750_Spy1861 ahpF; Peroxiredoxin reductase (NAD(P)H) / NADH oxidase H2O2-forming K03387 ahpF; NADH-dependent peroxiredoxin subunit F [EC:1.8.1.-]
D MGAS10750_Spy0381 msrA2; Peptide methionine sulfoxide reductase msrA K07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11]
D MGAS10750_Spy1389 msrA; Peptide methionine sulfoxide reductase msrA/msrB K12267 msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]
D MGAS10750_Spy0929 msrB; Peptide methionine sulfoxide reductase msrB K07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]
D MGAS10750_Spy1860 ahpC; Peroxiredoxin K24119 ahpC; NADH-dependent peroxiredoxin subunit C [EC:1.11.1.26]
D MGAS10750_Spy0748 trxB; Thioredoxin reductase K21567 fnr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1]
D MGAS10750_Spy0789 arsC; Arsenate reductase K00537 arsC; arsenate reductase (glutaredoxin) [EC:1.20.4.1]
D MGAS10750_Spy1881 nrdG; Anaerobic ribonucleoside-triphosphate reductase activating protein K04068 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]
D MGAS10750_Spy1843 Pyruvate formate-lyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D MGAS10750_Spy0312 pflC; Pyruvate formate-lyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D MGAS10750_Spy1460 Methyltransferase K07444 ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]
D MGAS10750_Spy0429 Glutaminyl-peptide cyclotransferase K22757 QCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5]
D MGAS10750_Spy0467 Glycosyltransferase involved in cell wall biogenesis K21349 ggs; glucosylglycerate synthase [EC:2.4.1.268]
D MGAS10750_Spy0506 lgt; Prolipoprotein diacylglyceryl transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145]
D MGAS10750_Spy1009 apbE; Iron-sulfur cluster assembly/repair protein ApbE K03734 apbE; FAD:protein FMN transferase [EC:2.7.1.180]
D MGAS10750_Spy1660 Dihydroxyacetone kinase family protein K07030 fakA; fatty acid kinase [EC:2.7.2.18]
D MGAS10750_Spy0913 hypothetical membrane spanning protein K18672 dacA; diadenylate cyclase [EC:2.7.7.85]
D MGAS10750_Spy0505 ptsK; HPR(SER) kinase/phosphatase K06023 hprK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]
D MGAS10750_Spy0900 estA; Acetyl esterase K03930 estA; putative tributyrin esterase [EC:3.1.1.-]
D MGAS10750_Spy0254 Putative lipase K07015 yqeG; putative phosphatase [EC:3.1.3.-]
D MGAS10750_Spy1953 Phosphoesterase, DHH family protein K22927 gdpP; cyclic-di-AMP phosphodiesterase [EC:3.1.4.59]
D MGAS10750_Spy0215 tatD; DNase, TatD family K03424 tatD; TatD DNase family protein [EC:3.1.21.-]
D MGAS10750_Spy0216 Ribonuclease M5 K05985 rnmV; ribonuclease M5 [EC:3.1.26.8]
D MGAS10750_Spy1775 dexB; Glucan 1,6-alpha-glucosidase K01215 dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70]
D MGAS10750_Spy0541 Unsaturated glucuronyl hydrolase K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180]
D MGAS10750_Spy0244 D-alanyl-D-alanine carboxypeptidase K01286 E3.4.16.4; D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4]
D MGAS10750_Spy1778 ska; Streptokinase K14745 ska; streptokinase A [EC:3.4.-.-]
D MGAS10750_Spy1763 def; Peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88]
D MGAS10750_Spy0769 fms; Peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88]
D MGAS10750_Spy1220 Peptidoglycan N-acetylglucosamine deacetylase K22278 pgdA; peptidoglycan-N-acetylglucosamine deacetylase [EC:3.5.1.104]
D MGAS10750_Spy0128 Translation initiation inhibitor K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]
D MGAS10750_Spy0384 Myosin-crossreactive antigen K10254 ohyA; oleate hydratase [EC:4.2.1.53]
D MGAS10750_Spy0909 hylA; Hyaluronate lyase precursor K01727 hysA; hyaluronate lyase [EC:4.2.2.1]
D MGAS10750_Spy0535 pacL; Calcium-transporting ATPase K01537 ATP2C; P-type Ca2+ transporter type 2C [EC:7.2.2.10]
D MGAS10750_Spy1275 Lead, cadmium, zinc and mercury transporting ATPase K01534 zntA; Zn2+/Cd2+-exporting ATPase [EC:7.2.2.12 7.2.2.21]
C 99981 Carbohydrate metabolism
C 99982 Energy metabolism
D MGAS10750_Spy0703 Ferredoxin K05337 fer; ferredoxin
D MGAS10750_Spy0242 nifU; IscU protein K04488 iscU; nitrogen fixation protein NifU and related proteins
C 99983 Lipid metabolism
D MGAS10750_Spy0763 DegV family protein K25232 fakB; fatty acid kinase fatty acid binding subunit
D MGAS10750_Spy1332 Fatty acid-binding protein, DegV family K25232 fakB; fatty acid kinase fatty acid binding subunit
C 99984 Nucleotide metabolism
D MGAS10750_Spy1782 NrdI protein K03647 nrdI; protein involved in ribonucleotide reduction
D MGAS10750_Spy0350 nrdI; NrdI protein K03647 nrdI; protein involved in ribonucleotide reduction
D MGAS10750_Spy0670 DNA-entry nuclease K15051 endA; DNA-entry nuclease
D MGAS10750_Spy0671 endA; DNA-entry nuclease K15051 endA; DNA-entry nuclease
D MGAS10750_Spy1832 spd; Deoxyribonuclease precursor K15051 endA; DNA-entry nuclease
D MGAS10750_Spy0888 spd3; Streptodornase K15051 endA; DNA-entry nuclease
D MGAS10750_Spy0622 Streptodornase K15051 endA; DNA-entry nuclease
C 99985 Amino acid metabolism
D MGAS10750_Spy1025 Glyoxalase family protein K08234 yaeR; glyoxylase I family protein
D MGAS10750_Spy1355 Pyridoxal-5'-phosphate family protein K06997 yggS; PLP dependent protein
C 99986 Glycan metabolism
C 99987 Cofactor metabolism
C 99988 Secondary metabolism
C 99999 Others
B
B 09192 Unclassified: genetic information processing
C 99973 Transcription
D MGAS10750_Spy1859 csp; Cold shock protein K03704 cspA; cold shock protein
D MGAS10750_Spy1110 Arsenate reductase family protein K16509 spxA; regulatory protein spx
D MGAS10750_Spy1890 Arsenate reductase family protein K16509 spxA; regulatory protein spx
D MGAS10750_Spy0502 transcription accessory protein K06959 tex; protein Tex
C 99974 Translation
D MGAS10750_Spy1439 S1-type RNA-binding domain K07570 GSP13; general stress protein 13
C 99975 Protein processing
D MGAS10750_Spy1667 ropA; Trigger factor, ppiase K03545 tig; trigger factor
D MGAS10750_Spy0428 SsrA-binding protein K03664 smpB; SsrA-binding protein
D MGAS10750_Spy1224 Glutaredoxin K06191 nrdH; glutaredoxin-like protein NrdH
D MGAS10750_Spy0236 mecA; Negative regulator of genetic competence mecA K16511 mecA1_2; adapter protein MecA 1/2
C 99976 Replication and repair
D MGAS10750_Spy0991 radC; DNA repair protein radC K03630 radC; DNA repair protein RadC
D MGAS10750_Spy0221 RmuC family protein K09760 rmuC; DNA recombination protein RmuC
D MGAS10750_Spy1258 hypothetical protein with endo/excinuclease domain K07461 K07461; putative endonuclease
D MGAS10750_Spy1033 smf; DNA processing protein K04096 smf; DNA processing protein
D MGAS10750_Spy0823 dnaD; DNA replication protein dnaD K02086 dnaD; DNA replication protein
D MGAS10750_Spy1321 DNA replication protein dnaD K02086 dnaD; DNA replication protein
D MGAS10750_Spy0860 Terminase large subunit K06909 xtmB; phage terminase large subunit
D MGAS10750_Spy1791 ATPase, AAA family K07478 ycaJ; putative ATPase
D MGAS10750_Spy1910 DNA primase K06919 K06919; putative DNA primase/helicase
D MGAS10750_Spy0847 DNA primase K06919 K06919; putative DNA primase/helicase
D MGAS10750_Spy0578 DNA primase K06919 K06919; putative DNA primase/helicase
D MGAS10750_Spy0658 Transposase K07480 insB; insertion element IS1 protein InsB
D MGAS10750_Spy1432 Transposase K18320 IS15; transposase, IS6 family
D MGAS10750_Spy0076 Transposase K07482 K07482; transposase, IS30 family
D MGAS10750_Spy1976 Transposase K07482 K07482; transposase, IS30 family
D MGAS10750_Spy0721 Transposase K07482 K07482; transposase, IS30 family
D MGAS10750_Spy1183 Transposase K07483 K07483; transposase
D MGAS10750_Spy1188 Transposase K07483 K07483; transposase
D MGAS10750_Spy1233 Transposase K07483 K07483; transposase
D MGAS10750_Spy0400 Transposase K07483 K07483; transposase
D MGAS10750_Spy0490 Transposase K07483 K07483; transposase
D MGAS10750_Spy0640 Transposase K07486 K07486; transposase
D MGAS10750_Spy1184 Transposase K07497 K07497; putative transposase
D MGAS10750_Spy1190 Transposase K07497 K07497; putative transposase
D MGAS10750_Spy1235 Transposase K07497 K07497; putative transposase
D MGAS10750_Spy0402 Transposase K07497 K07497; putative transposase
D MGAS10750_Spy0489 Transposase K07497 K07497; putative transposase
C 99979 Viral proteins
C 99998 Others
D MGAS10750_Spy1638 hypothetical cytosolic protein K09747 ebfC; nucleoid-associated protein EbfC
B
B 09193 Unclassified: signaling and cellular processes
C 99977 Transport
D MGAS10750_Spy1468 Amino acid permease K03293 TC.AAT; amino acid transporter, AAT family
D MGAS10750_Spy0014 Amino acid permease K03294 TC.APA; basic amino acid/polyamine antiporter, APA family
D MGAS10750_Spy1049 hypothetical cytosolic protein K03300 TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family
D MGAS10750_Spy1128 Na(+)-linked D-alanine glycine permease K03310 TC.AGCS; alanine or glycine:cation symporter, AGCS family
D MGAS10750_Spy0269 braB; Branched-chain amino acid transport system carrier protein K03311 TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family
D MGAS10750_Spy1644 nupC; Nucleoside permease nupC K03317 TC.CNT; concentrative nucleoside transporter, CNT family
C 99978 Cell growth
D MGAS10750_Spy1459 hypothetical protein K20073 mapZ; mid-cell-anchored protein Z
D MGAS10750_Spy0204 Jag protein K06346 jag; spoIIIJ-associated protein
D MGAS10750_Spy0560 Site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase
D MGAS10750_Spy1717 Site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase
D MGAS10750_Spy1718 Site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase
D MGAS10750_Spy1719 Site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase
C 99993 Cell motility
C 99995 Signaling proteins
D MGAS10750_Spy1363 typA; GTP-binding protein TypA/BipA K06207 typA; GTP-binding protein
D MGAS10750_Spy0385 phoH; PhoH protein K06217 phoH; phosphate starvation-inducible protein PhoH and related proteins
C 99992 Structural proteins
D MGAS10750_Spy0519 N-acetylmuramoyl-L-alanine amidase K07273 acm; lysozyme
C 99994 Others
D MGAS10750_Spy1100 phoU; Phosphate transport system protein phoU K02039 phoU; phosphate transport system protein
D MGAS10750_Spy0334 cutC; Copper homeostasis protein cutC K06201 cutC; copper homeostasis protein
B
B 09194 Poorly characterized
C 99996 General function prediction only
D MGAS10750_Spy1883 NAD-dependent oxidoreductase K03810 mviM; virulence factor
D MGAS10750_Spy1244 Putative competence protein/transcription factor K06198 coiA; competence protein CoiA
D MGAS10750_Spy0108 tRNA binding domain protein K06878 K06878; tRNA-binding protein
D MGAS10750_Spy0515 Haloacid dehalogenase-like hydrolase K07025 K07025; putative hydrolase of the HAD superfamily
D MGAS10750_Spy0243 ABC transporter-associated protein sufB K09014 sufB; Fe-S cluster assembly protein SufB
D MGAS10750_Spy0240 SufD protein K09015 sufD; Fe-S cluster assembly protein SufD
D MGAS10750_Spy1201 Ribonuclease BN K07058 K07058; membrane protein
D MGAS10750_Spy0811 Rhodanese-related sulfurtransferases K07146 K07146; UPF0176 protein
D MGAS10750_Spy0274 lemA; LemA protein K03744 lemA; LemA protein
D MGAS10750_Spy0503 Metallopeptidase, SprT family K03095 sprL; SprT-like protein
D MGAS10750_Spy1947 phage infection protein K01421 yhgE; putative membrane protein
D MGAS10750_Spy1941 Integral membrane protein K08974 K08974; putative membrane protein
D MGAS10750_Spy0499 hypothetical membrane spanning protein K08986 ycgQ; putative membrane protein
D MGAS10750_Spy1135 PhnA protein K06193 phnA; protein PhnA
C 99997 Function unknown
D MGAS10750_Spy0533 dGTP triphosphohydrolase K06885 K06885; uncharacterized protein
D MGAS10750_Spy1664 Alpha/beta hydrolase K06889 K06889; uncharacterized protein
D MGAS10750_Spy0294 Integral membrane protein K06890 K06890; uncharacterized protein
D MGAS10750_Spy0166 CoA binding protein K06929 K06929; uncharacterized protein
D MGAS10750_Spy0293 Hydrolase K06950 K06950; uncharacterized protein
D MGAS10750_Spy0739 RNA binding protein K06960 K06960; uncharacterized protein
D MGAS10750_Spy1745 hypothetical cytosolic protein K06962 K06962; uncharacterized protein
D MGAS10750_Spy0653 Endonuclease/Exonuclease/phosphatase family protein K07004 K07004; uncharacterized protein
D MGAS10750_Spy0743 hypothetical cytosolic protein K07006 K07006; uncharacterized protein
D MGAS10750_Spy0749 hypothetical membrane spanning protein K07035 K07035; uncharacterized protein
D MGAS10750_Spy1037 hypothetical membrane spanning protein K07035 K07035; uncharacterized protein
D MGAS10750_Spy0678 Neutral zinc metallopeptidase family K07054 K07054; uncharacterized protein
D MGAS10750_Spy0500 hypothetical membrane spanning protein K07089 K07089; uncharacterized protein
D MGAS10750_Spy0299 putative phosphoesterase K07095 K07095; uncharacterized protein
D MGAS10750_Spy1271 Transcriptional regulator, biotin repressor family K07105 K07105; uncharacterized protein
D MGAS10750_Spy0820 Short chain dehydrogenase K07124 K07124; uncharacterized protein
D MGAS10750_Spy0309 Radical SAM superfamily protein K07139 K07139; uncharacterized protein
D MGAS10750_Spy0305 hypothetical cytosolic protein K08998 K08998; uncharacterized protein
D MGAS10750_Spy1425 hypothetical protein K09704 K09704; uncharacterized protein
D MGAS10750_Spy1065 ylxM; Signal recognition particle associated protein K09787 K09787; uncharacterized protein
D MGAS10750_Spy0380 S1 RNA binding domain K00243 K00243; uncharacterized protein
D MGAS10750_Spy1880 yaaA; hypothetical cytosolic protein K09861 K09861; uncharacterized protein
D MGAS10750_Spy1177 outer surface protein K09963 K09963; uncharacterized protein
D MGAS10750_Spy0295 hypothetical exported protein K09976 K09976; uncharacterized protein
D MGAS10750_Spy1286 phage endopeptidase K01163 K01163; uncharacterized protein
D MGAS10750_Spy0723 hypothetical ribosome-associated protein K07584 ysxB; uncharacterized protein
D MGAS10750_Spy1430 hypothetical cytosolic protein K07586 ygaC; uncharacterized protein
D MGAS10750_Spy1524 hypothetical cytosolic protein K07742 ylxR; uncharacterized protein
!
#
#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: April 23, 2024