+E Replication protein KO
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DNA Replication Proteins - Schizosaccharomyces pombe (fission yeast)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D SPBC29A10.15 orc1; origin recognition complex subunit Orc1 K02603 ORC1; origin recognition complex subunit 1
D SPBC685.09 orc2; origin recognition complex subunit Orc2 K02604 ORC2; origin recognition complex subunit 2
D SPAC3H1.01c orc3; putative origin recognition complex subunit Orp3 K02605 ORC3; origin recognition complex subunit 3
D SPBP23A10.13 orc4; origin recognition complex subunit Orc4 K02606 ORC4; origin recognition complex subunit 4
D SPBC646.14c orc5; origin recognition complex subunit Orc5 K02607 ORC5; origin recognition complex subunit 5
D SPBC2A9.12 orc6; origin recognition complex subunit Orc6 K02608 ORC6; origin recognition complex subunit 6
D SPBC428.18 cdt1; replication licensing factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D SPBC14C8.07c cdc18; MCM loader K02213 CDC6; cell division control protein 6
D SPBC4.04c mcm2; MCM complex subunit Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D SPCC1682.02c mcm3; MCM complex subunit Mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D SPCC16A11.17 mcm4; MCM complex subunit Mcm4/Cdc21 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D SPAC1B2.05 mcm5; MCM complex subunit Mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D SPBC211.04c mcm6; MCM complex subunit Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D SPBC25D12.03c mcm7; MCM complex subunit Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
D SPBC21C3.18 spo4; serine/threonine protein kinase Spo4 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D SPBC776.12c hsk1; Dbf4(Dfp1)-dependent protein kinase Hsk1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D SPCC550.13 dfp1; Hsk1-Dfp1 kinase complex regulatory subunit Dfp1 K02309 DBF4; regulatory subunit for Cdc7p protein kinase
C GINS complex
D SPBP23A10.09 psf1; GINS complex subunit Psf1 K10732 GINS1; GINS complex subunit 1
D SPBC725.13c psf2; GINS complex subunit Psf2 K10733 GINS2; GINS complex subunit 2
D SPAC227.16c psf3; GINS complex subunit Psf3 K10734 GINS3; GINS complex subunit 3
D SPBP4H10.21c sld5; GINS complex subunit Sld5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D SPAC23C4.18c rad4; BRCT domain protein Rad4 K03507 DPB11; DNA replication regulator DPB11
D SPAC6B12.11 drc1; DNA replication checkpoint protein Drc1 K10729 SLD2; DNA replication regulator SLD2
D SPAC17D4.02 cdc45; DNA replication pre-initiation complex subunit Cdc45 K06628 CDC45; cell division control protein 45
D SPBC1347.10 cdc23; MCM-associated protein Mcm10 K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D SPAC3H5.06c pol1; DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D SPCC553.09c spb70; DNA polymerase alpha B-subunit K02321 POLA2; DNA polymerase alpha subunit B
D SPAC6B12.10c spp1; DNA primase catalytic subunit Spp1 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D SPBC17D11.06 spp2; DNA primase large subunit Spp2 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D SPBC25H2.13c cdc20; DNA polymerase epsilon catalytic subunit Pol2 K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D SPBP8B7.14c dpb2; DNA polymerase epsilon catalytic subunit B Dpb2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D SPBC3D6.09 dpb4; DNA polymerase epsilon subunit Dpb4 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D SPBC336.04 cdc6; DNA polymerase delta catalytic subunit Cdc6 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D SPAC27E2.05 cdc1; DNA polymerase delta small subunit Cdc1 K02328 POLD2; DNA polymerase delta subunit 2
D SPBC1734.02c cdc27; DNA polymerase delta subunit Cdc27 K03504 POLD3; DNA polymerase delta subunit 3
D SPBC12D12.02c cdm1; DNA polymerase delta subunit Cdm1 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D SPCC24B10.22 pog1; DNA polymerase K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D SPBC660.13c ssb1; DNA replication factor A subunit Ssb1 K07466 RFA1; replication factor A1
D SPCC1753.01c ssb2; single-stranded DNA-binding protein Ssb2 K10739 RFA2; replication factor A2
D SPCC23B6.05c ssb3; DNA replication factor A subunit Ssb3 K10740 RPA3; replication factor A3
C RFC (replication factor C)
D SPBC23E6.07c rfc1; DNA replication factor C complex subunit Rfc1 K10754 RFC1; replication factor C subunit 1
D SPAC23D3.02 rfc2; DNA replication factor C complex subunit Rfc2 K10755 RFC2_4; replication factor C subunit 2/4
D SPAC1687.03c rfc4; putative DNA replication factor C complex subunit Rfc4 K10755 RFC2_4; replication factor C subunit 2/4
D SPAC27E2.10c rfc3; DNA replication factor C complex subunit Rfc3 K10756 RFC3_5; replication factor C subunit 3/5
D SPBC83.14c rfc5; putative DNA replication factor C complex subunit Rfc5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D SPBC336.06c rnh1; putative ribonuclease H Rnh1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D SPAC4G9.02 rnh201; putative ribonuclease H2 complex subunit Rnh201 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D SPBC1347.08c putative ribonuclease H2 complex subunit K10744 RNASEH2B; ribonuclease H2 subunit B
D SPAC12B10.15c putative ribonuclease H2 complex subunit K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D SPBC16D10.09 pcn1; DNA polymerase delta processivity factor K04802 PCNA; proliferating cell nuclear antigen
D SPBC16D10.04c dna2; DNA replication endonuclease-helicase Dna2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D SPCC737.07c putative DNA polymerase alpha-associated DNA helicase A K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
D SPAC3G6.06c rad2; FEN-1 endonuclease Rad2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D SPBC29A10.05 exo1; exonuclease I Exo1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D SPAC20G8.01 cdc17; ATP-dependent DNA ligase Cdc17 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C DNA methylation enzymes
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
E SPAC26H5.06 pot1; telomere end-binding protein Pot1 K11109 POT1; protection of telomeres protein 1
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
E SPBC16D10.07c sir2; Sir2 family histone deacetylase Sir2 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E SPCC132.02 hst2; Sir2 family histone deacetylase Hst2 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E SPAC1783.04c hst4; Sir2 family histone deacetylase Hst4 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
C Telomerase complex (animals)
D SPBC29A3.14c trt1; telomerase reverse transcriptase 1 protein Trt1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E SPBC20F10.01 gar1; H/ACA snoRNP pseudouridylase subunit Gar1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E SPAC1782.10c nhp2; box H/ACA snoRNP complex subunit Nhp2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E SPAP27G11.13c nop10; putative snoRNP complex protein K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E SPAC29A4.04c cbf5; putative pseudouridylate synthase Cbf5 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D SPBC29A3.14c trt1; telomerase reverse transcriptase 1 protein Trt1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E SPAC26A3.08 smb1; Sm snRNP core protein Smb1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E SPAC27D7.07c smd1; Sm snRNP core protein Smd1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E SPAC2C4.03c smd2; Sm snRNP core protein Smd2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E SPBC19C2.14 smd3; Sm snRNP core protein Smd3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E SPBC11G11.06c sme1; Sm snRNP core protein Sme1 K11097 SNRPE; small nuclear ribonucleoprotein E
E SPBC3E7.14 smf1; Sm snRNP core protein Smf1 K11098 SNRPF; small nuclear ribonucleoprotein F
E SPBC4B4.05 smg1; U4/U6 x U5 tri-snRNP complex Sm snRNP core protein Smg1 K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D SPAC23D3.02 rfc2; DNA replication factor C complex subunit Rfc2 K10755 RFC2_4; replication factor C subunit 2/4
D SPAC1687.03c rfc4; putative DNA replication factor C complex subunit Rfc4 K10755 RFC2_4; replication factor C subunit 2/4
D SPAC27E2.10c rfc3; DNA replication factor C complex subunit Rfc3 K10756 RFC3_5; replication factor C subunit 3/5
D SPBC83.14c rfc5; putative DNA replication factor C complex subunit Rfc5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D SPAC13C5.07 rad32; Rad32 nuclease K10865 MRE11; double-strand break repair protein MRE11
D SPAC1556.01c rad50; DNA repair protein Rad50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D SPCC23B6.03c tel1; ATM checkpoint kinase K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D SPAC2G11.12 rqh1; RecQ type DNA helicase Rqh1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D SPCC970.01 rad16; DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D SPAC890.05 putative PINX1 family ribosome biogenesis protein K11135 PINX1; Pin2-interacting protein X1
D SPAC458.03 tel2; Tel2/Rad-5/Clk-2 family protein Tel2 K11137 TELO2; telomere length regulation protein
D SPBC887.14c pfh1; DNA repair and recombination protein K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D SPCC1020.09 gnr1; heterotrimeric G protein beta subunit Gnr1 K23314 WRAP53; telomerase Cajal body protein 1
D SPAC31G5.18c sde2; silencing defective protein sde2 K25059 SDE2; replication stress response regulator SDE2
D SPAC1D4.09c rtf2; replication termination factor Rtf2 K25186 RTF2; replication termination factor 2
D SPBC19G7.13 tbf1; DNA-binding factor Trf1 K22485 TBF1; protein TBF1
B DNA Topoisomerases
C SPBC1703.14c top1; DNA topoisomerase I K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C SPBC1A4.03c top2; DNA topoisomerase II K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C SPBC16G5.12c top3; DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E SPBC336.06c rnh1; putative ribonuclease H Rnh1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E SPBC336.06c rnh1; putative ribonuclease H Rnh1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E SPBC16D10.04c dna2; DNA replication endonuclease-helicase Dna2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E SPAC3G6.06c rad2; FEN-1 endonuclease Rad2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E SPAC20G8.01 cdc17; ATP-dependent DNA ligase Cdc17 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022