+D GENES KO #

  KEGG Orthology (KO) - Streptococcus pyogenes M1 GAS (serotype M1)

% ! A09100 Metabolism B B 09101 Carbohydrate metabolism C 00010 Glycolysis / Gluconeogenesis [PATH:spy00010] D SPy_1529 glcK; glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D SPy_0215 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D SPy_1889 fba; putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D SPy_0613 tpi; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D SPy_0274 plr; glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D SPy_1881 pgk; putative phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D SPy_1429 gpmA; putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D SPy_0731 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D SPy_1282 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D SPy_1026 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D SPy_1028 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D SPy_1029 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1151 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D SPy_0044 adhA; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D SPy_1224 pgmA; putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D SPy_1371 gapN; putative NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D SPy_0574 bglA; beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D SPy_1328 bglA.2; putative beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] C 00020 Citrate cycle (TCA cycle) [PATH:spy00020] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1026 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D SPy_1028 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D SPy_1029 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] C 00030 Pentose phosphate pathway [PATH:spy00030] D SPy_0215 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D SPy_0264 rpe; putative ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] D SPy_1676 tkt; putative transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D SPy_1678 putative transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D SPy_1947 putative transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D SPy_0889 rpiA; putative ribose 5-phosphate isomerase K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6] D SPy_1867 deoC; putative deoxyribose-phosphate aldolase K01619 deoC; deoxyribose-phosphate aldolase [EC:4.1.2.4] D SPy_0890 deoB; putative phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7] D SPy_1224 pgmA; putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D SPy_1123 prs; putative phosphoribosyl pyrophosphate synthetase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D SPy_0020 prsA.2; putative ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D SPy_0639 kgdA; putative 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] D SPy_1371 gapN; putative NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D SPy_0638 kdgK; putative 2-keto-3-deoxygluconate kinase K00874 kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] D SPy_1889 fba; putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] C 00040 Pentose and glucuronate interconversions [PATH:spy00040] D SPy_2201 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_0542 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_2202 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_0224 hasC.2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_0177 putative hexulose-6-phosphate synthase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85] D SPy_0178 putative hexulose-6-phosphate isomerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22] D SPy_0179 araD; putative L-ribulose 5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] D SPy_0264 rpe; putative ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] C 00051 Fructose and mannose metabolism [PATH:spy00051] D SPy_1811 scrK; putative fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D SPy_1810 pmi; putative mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D SPy_1503 putative phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D SPy_0854 fruB; putative fructose-1-phosphate kinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56] D SPy_1889 fba; putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D SPy_0613 tpi; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D SPy_0855 putative fructose-specific enzyme II, PTS system BC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D SPy_1057 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D SPy_1738 manL; mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D SPy_1739 manM; putative mannose-specific phosphotransferase system component IIC K02795 manY; mannose PTS system EIIC component D SPy_1059 putative phospotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D SPy_1740 manN; putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D SPy_1060 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component C 00052 Galactose metabolism [PATH:spy00052] D SPy_2202 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_0224 hasC.2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_1224 pgmA; putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D SPy_1529 glcK; glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D SPy_1586 putative beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D SPy_1921 lacC.2; putative tagatose 6-phosphate kinase K00917 lacC; tagatose 6-phosphate kinase [EC:2.7.1.144] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D SPy_1919 lacD.2; putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D SPy_1704 lacD.1; putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D SPy_1922 lacB.2; putative galactose-6-phosphate isomerase (B subunit) K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D SPy_1923 lacA.2; galactosidase acetyltransferase K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D SPy_1707 lacB.1; putative galactose-6-phosphate isomerase K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D SPy_1708 lacA.1; putative galactose-6-phosphate isomerase K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D SPy_1916 lacG; putative phospho-beta-D-galactosidase K01220 E3.2.1.85; 6-phospho-beta-galactosidase [EC:3.2.1.85] D SPy_1918 lacF; putative PTS system, lactose-specific component IIA K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D SPy_1917 lacE; putative PTS system, lactose-specific component IIBC K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D SPy_1816 scrB; putative sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26] D SPy_0634 agaF; putative PTS dependent N-acetyl-galactosamine- and galactosamine IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D SPy_0631 agaV; putative PTS dependent N-acetyl-galactosamine-IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D SPy_0630 agaW; putative PTS dependent N-acetyl-galactosamine-IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D SPy_0629 agaD; putative PTS dependent galactosamine IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D SPy_0716 agaS; putative tagatose-6-phosphate aldose/ketose isomerase K02082 agaS; D-galactosamine 6-phosphate deaminase/isomerase [EC:3.5.99.-] C 00053 Ascorbate and aldarate metabolism [PATH:spy00053] D SPy_2201 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_0542 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_0176 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D SPy_1952 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D SPy_0175 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D SPy_1950 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D SPy_0174 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D SPy_1949 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D SPy_0182 conserved hypothetical protein K03476 ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-] D SPy_0177 putative hexulose-6-phosphate synthase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85] D SPy_0178 putative hexulose-6-phosphate isomerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22] D SPy_0179 araD; putative L-ribulose 5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] C 00500 Starch and sucrose metabolism [PATH:spy00500] D SPy_1815 scrA; putative sucrose-specific PTS permease, enzyme II K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D SPy_1816 scrB; putative sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26] D SPy_2202 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_0224 hasC.2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_1599 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D SPy_2052 putative PTS system, enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D SPy_1323 putative PTS enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D SPy_2051 putative PTS system, enzyme IIB K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D SPy_1324 putative PTS system enzyme II K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D SPy_2050 putative PTS system, enzyme IIC component K02761 celB; cellobiose PTS system EIIC component D SPy_0574 bglA; beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D SPy_1328 bglA.2; putative beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D SPy_1291 glgP; putative glycogen phosphorylase K00688 PYG; glycogen phosphorylase [EC:2.4.1.1] D SPy_1304 amyB; putative cyclomaltodextrinase K01208 cd; cyclomaltodextrinase / maltogenic alpha-amylase / neopullulanase [EC:3.2.1.54 3.2.1.133 3.2.1.135] D SPy_1292 malM; putative 4-alpha-glucanotransferase K00705 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] D SPy_1986 putative PTS system, enzyme II, A component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D SPy_1985 hypothetical protein K06896 mapP; maltose 6'-phosphate phosphatase [EC:3.1.3.90] D SPy_1302 amyA; putative cyclomaltodextrin glucanotransferase K00701 cgt; cyclomaltodextrin glucanotransferase [EC:2.4.1.19] D SPy_2097 putative PTS system enzyme II K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D SPy_2096 dexS; putative dextran glucosidase K01226 treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93] D SPy_1224 pgmA; putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D SPy_1529 glcK; glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D SPy_0215 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D SPy_1811 scrK; putative fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] C 00520 Amino sugar and nucleotide sugar metabolism [PATH:spy00520] D SPy_1694 nagA; putative N-acetylglucosamine-6-phosphate deacetylase K01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25] D SPy_1399 nagB; putative N-acetylglucosamine-6-phosphate isomerase K02564 nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6] D SPy_1811 scrK; putative fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D SPy_1280 glmS; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D SPy_1038 putative phospho-sugar mutase K03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10] D SPy_0443 gcaD; putative UDP-N-acetylglucosamine pyrophosphorylase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] D SPy_1358 murZ; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D SPy_0763 putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D SPy_1101 murB; putative UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D SPy_0251 putative N-acetylmannosamine-6-P epimerase K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9] D SPy_0257 nanH; putative acylneuraminate lyase K01639 E4.1.3.3; N-acetylneuraminate lyase [EC:4.1.3.3] D SPy_1529 glcK; glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D SPy_1224 pgmA; putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D SPy_2202 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_0224 hasC.2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_2201 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_0542 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_1057 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D SPy_1738 manL; mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D SPy_1739 manM; putative mannose-specific phosphotransferase system component IIC K02795 manY; mannose PTS system EIIC component D SPy_1059 putative phospotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D SPy_1740 manN; putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D SPy_1060 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component D SPy_0215 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D SPy_1810 pmi; putative mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D SPy_1503 putative phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8] C 00620 Pyruvate metabolism [PATH:spy00620] D SPy_1026 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D SPy_1028 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D SPy_1029 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1849 pfl; putative pyruvate formate-lyase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D SPy_0044 adhA; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D SPy_0109 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D SPy_1128 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D SPy_1282 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D SPy_1743 accA; putative acetyl-CoA carboxylase alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D SPy_1747 accB; putative biotoin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D SPy_1745 accC; putative acetyl-CoA carboxylase biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D SPy_1744 accD; putative acetyl-CoA carboxylase beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D SPy_0352 putative acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D SPy_1151 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D SPy_1170 ddh; putative D-specific D-2-hydroxyacid dehydrogenase K03778 ldhA; D-lactate dehydrogenase [EC:1.1.1.28] D SPy_0511 gloA; putative lactoylglutathione lyase K01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5] D SPy_0646 conserved hypothetical protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6] D SPy_1110 putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating)) K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] D SPy_1174 putative transcarboxylase subunit K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D SPy_1191 oadA; putative oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D SPy_1177 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1184 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1175 hypothetical protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma D SPy_0608 ppc; putative phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00630 Glyoxylate and dicarboxylate metabolism [PATH:spy00630] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_1877 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D SPy_1145 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1903 conserved hypothetical protein K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D SPy_0639 kgdA; putative 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] C 00640 Propanoate metabolism [PATH:spy00640] D SPy_0109 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D SPy_1128 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1849 pfl; putative pyruvate formate-lyase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D SPy_1743 accA; putative acetyl-CoA carboxylase alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D SPy_1747 accB; putative biotoin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D SPy_1745 accC; putative acetyl-CoA carboxylase biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D SPy_1744 accD; putative acetyl-CoA carboxylase beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D SPy_1151 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D SPy_2047 gldA; putative glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6] C 00650 Butanoate metabolism [PATH:spy00650] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0141 atoD.2; putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_1638 atoD.1; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_0142 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D SPy_1639 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D SPy_1177 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1184 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1176 putative methylmalonyl-CoA decarboxylase, gamma-subunit K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D SPy_1183 putative decarboxylase, gamma chain K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D SPy_1067 gabD; putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D SPy_1849 pfl; putative pyruvate formate-lyase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D SPy_0881 mvaS.2; putative 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMG-CoA synthase) K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] D SPy_1640 putative oxidoreductase K00019 BDH1; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30] D SPy_1111 putative zinc-containing alcohol dehydrogenase K18369 adh2; alcohol dehydrogenase [EC:1.1.1.-] C 00660 C5-Branched dibasic acid metabolism C 00562 Inositol phosphate metabolism [PATH:spy00562] D SPy_1247 putative myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D SPy_0613 tpi; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] B B 09102 Energy metabolism C 00190 Oxidative phosphorylation [PATH:spy00190] D SPy_0758 atpA; putative proton-translocating ATPase, alpha subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D SPy_0760 atpD; putative proton-translocating ATPase, beta subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D SPy_0759 atpG; putative proton-translocating ATPase, gamma subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D SPy_0757 atpH; putative proton-translocating ATPase, delta subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D SPy_0761 atpC; putative proton-translocating ATPase, epsiron subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D SPy_0755 atpB; putative proton-translocating ATPase a subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a D SPy_0756 atpF; putative proton-translocating ATPase, subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b D SPy_0754 atpE; H+-transporting ATP synthase chain C K02110 ATPF0C; F-type H+-transporting ATPase subunit c D SPy_0154 ntpA; putative V-type Na+ -ATPase alpha subunit K02117 ATPVA; V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1] D SPy_0155 ntpB; putative V-type Na+ -ATPase subunit B K02118 ATPVB; V/A-type H+/Na+-transporting ATPase subunit B D SPy_0151 ntpC; putative V-type Na+ -ATPase subunit C K02119 ATPVC; V/A-type H+/Na+-transporting ATPase subunit C D SPy_0157 ntpD; putative V-type Na+ -ATPase subunit D K02120 ATPVD; V/A-type H+/Na+-transporting ATPase subunit D D SPy_0150 ntpE; putative V-type Na+ -ATPase subunit E K02121 ATPVE; V/A-type H+/Na+-transporting ATPase subunit E D SPy_0148 ntpI; V-type Na+ -ATPase subunit I K02123 ATPVI; V/A-type H+/Na+-transporting ATPase subunit I D SPy_0149 ntpK; V-type Na+ -ATPase subunit K K02124 ATPVK; V/A-type H+/Na+-transporting ATPase subunit K D SPy_0380 putative manganese-dependent inorganic pyrophosphatase (intrageneric coaggregation-relevant adhesin) K15986 ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1] C 00195 Photosynthesis C 00196 Photosynthesis - antenna proteins C 00710 Carbon fixation in photosynthetic organisms C 00720 Carbon fixation pathways in prokaryotes C 00680 Methane metabolism [PATH:spy00680] D SPy_1145 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D SPy_0731 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D SPy_0608 ppc; putative phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D SPy_1889 fba; putative fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D SPy_0109 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D SPy_1128 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D SPy_1429 gpmA; putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D SPy_0536 conserved hypothetical protein K12234 cofE; coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34] C 00910 Nitrogen metabolism [PATH:spy00910] D SPy_1877 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D SPy_1541 arcC; putative carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] D SPy_0237 conserved hypothetical protein K01673 cynT; carbonic anhydrase [EC:4.2.1.1] C 00920 Sulfur metabolism [PATH:spy00920] D SPy_0720 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] D SPy_1944 cysE; putative serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D SPy_1618 cysM; putative O-acetylserine lyase K01738 cysK; cysteine synthase [EC:2.5.1.47] B B 09103 Lipid metabolism C 00061 Fatty acid biosynthesis [PATH:spy00061] D SPy_1743 accA; putative acetyl-CoA carboxylase alpha subunit K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D SPy_1747 accB; putative biotoin carboxyl carrier protein K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D SPy_1745 accC; putative acetyl-CoA carboxylase biotin carboxylase subunit K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D SPy_1744 accD; putative acetyl-CoA carboxylase beta subunit K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D SPy_1753 acpP; putative acyl carrier protein K02078 acpP; acyl carrier protein D SPy_0023 acpP.2; putative acyl carrier protein K02078 acpP; acyl carrier protein D SPy_1750 fabD; putative malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D SPy_1754 fabH; putative beta-ketoacyl-[ACP] synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D SPy_1748 fabF; putative beta-ketoacyl-ACP synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D SPy_0440 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D SPy_1749 fabG; putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D SPy_1746 fabZ; putative beta-hydroxyacyl-ACP dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D SPy_1751 fabK; putative trans-2-enoyl-ACP reductase II K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] D SPy_1758 phaB; putative enoyl CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] C 00062 Fatty acid elongation C 00071 Fatty acid degradation [PATH:spy00071] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0044 adhA; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] C 00073 Cutin, suberine and wax biosynthesis C 00100 Steroid biosynthesis C 00120 Primary bile acid biosynthesis C 00121 Secondary bile acid biosynthesis C 00140 Steroid hormone biosynthesis C 00561 Glycerolipid metabolism [PATH:spy00561] D SPy_1903 conserved hypothetical protein K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D SPy_2047 gldA; putative glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6] D SPy_1684 glpK; putative glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D SPy_0022 plsX; putative fatty acid/phospholipid synthesis protein K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D SPy_0908 conserved hypothetical protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D SPy_1410 putative 1-acylglycerol-3-phosphate O-acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D SPy_0752 conserved hypothetical protein K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] D SPy_0516 putative glucosyl transferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] D SPy_0515 putative sugar transferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208] D SPy_0807 conserved hypothetical protein K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20] C 00564 Glycerophospholipid metabolism [PATH:spy00564] D SPy_0226 gpsA; putative NAD(P)H-dependent glycerol-3-phosphate dehydrogenase K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] D SPy_1683 glpO; putative alpha-glycerophosphate oxidase K00105 E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21] D SPy_0908 conserved hypothetical protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D SPy_1410 putative 1-acylglycerol-3-phosphate O-acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D SPy_0752 conserved hypothetical protein K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] D SPy_0839 putative glycerophosphodiester phosphodiesterase K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] D SPy_1964 cdsA; putative phosphatidate cytidylyltransferase (CDP-diglyceride synthase) K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41] D SPy_2196 pgsA; phosphatidylglycerophosphate synthase K00995 pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] D SPy_1212 putative cardiolipin synthetase K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] C 00565 Ether lipid metabolism C 00600 Sphingolipid metabolism D SPy_1586 putative beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] C 00590 Arachidonic acid metabolism C 00591 Linoleic acid metabolism C 00592 alpha-Linolenic acid metabolism C 01040 Biosynthesis of unsaturated fatty acids B B 09104 Nucleotide metabolism C 00230 Purine metabolism [PATH:spy00230] D SPy_0444 conserved hypothetical protein K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] D SPy_0890 deoB; putative phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7] D SPy_1224 pgmA; putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D SPy_1123 prs; putative phosphoribosyl pyrophosphate synthetase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D SPy_0020 prsA.2; putative ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D SPy_0026 purF; putative phosphoribosylpyrophosphate amidotransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D SPy_0032 purD; phosphoribosylamine-glycine ligase K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13] D SPy_0028 purN; Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D SPy_0025 putative phosphoribosylformylglycinamidine synthase II K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] D SPy_0027 purM; putative phosphoribosylformylglycinamide cyclo-ligase K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] D SPy_0034 purK; phosphoribosylaminoimidazole carboxylase II K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18] D SPy_0033 purE; putative phosphoribosylaminoimidazole carboxylase I K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] D SPy_0024 purC; putative phosphoribosylaminoimidazole - succinocarboxamide synthase (SAICAR synthetase) K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] D SPy_0036 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D SPy_0927 apt; putative adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D SPy_0872 putative secreted 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D SPy_0892 punA; putative purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D SPy_0894 deoD2; putative purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1] D SPy_2206 guaB; inosine monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D SPy_0362 hypothetical protein K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] D SPy_1136 xpt; putative xanthine phosphoribosyltransferase K03816 xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] D SPy_1204 guaA; putative GMP synthase K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D SPy_1135 putative GMP reductase K00364 guaC; GMP reductase [EC:1.7.1.7] D SPy_1632 gmk; putative guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8] D SPy_1375 nrdE.2; putative ribonucleotide reductase alpha-chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D SPy_0427 nrdE.1; ribonucleoside-diphosphate reductase, large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D SPy_1378 nrdF.2; ribonucleotide diphosphate reductase small subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D SPy_0425 nrdF.1; putative ribonucleotide reductase 2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D SPy_2110 nrdD; putative anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] D SPy_1981 relA; (p)ppGpp synthetase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D SPy_1125 putative GTP pyrophosphokinase K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5] D SPy_0160 purA; putative adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D SPy_0074 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D SPy_1541 arcC; putative carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] C 00240 Pyrimidine metabolism [PATH:spy00240] D SPy_0835 carB; putative carbamoylphosphate synthetase K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D SPy_0833 carA; putative carbamoyl phosphate synthetase small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D SPy_0832 pyrB; putative aspartate transcarbamoylase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D SPy_0907 pyrC; putative dihydroorotase K01465 URA4; dihydroorotase [EC:3.5.2.3] D SPy_1432 pyrD; putative dihydroorotate dehydrogenase K00226 pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1] D SPy_0901 pyrE; putative orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] D SPy_0900 pyrF; putative orotidine-5'-decarboxylase PyrF K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] D SPy_0462 pyrH; putative uridylate kinase (UMP-kinase) K09903 pyrH; uridylate kinase [EC:2.7.4.22] D SPy_1894 pyrG; putative CTP synthetase K01937 pyrG; CTP synthase [EC:6.3.4.2] D SPy_0803 cmk; putative cytidylate kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25] D SPy_1368 udk; putative uridine kinase K00876 udk; uridine kinase [EC:2.7.1.48] D SPy_0872 putative secreted 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D SPy_1066 conserved hypothetical protein K25434 pynA; pyrimidine 5'-nucleotidase [EC:3.1.3.-] D SPy_1869 udp; putative uridine phosphorylase K00757 udp; uridine phosphorylase [EC:2.4.2.3] D SPy_0392 upp; putative uracil phosphoribosyltransferase K00761 upp; uracil phosphoribosyltransferase [EC:2.4.2.9] D SPy_0830 pyrR; putative pyrimidine regulatory protein K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D SPy_1230 cdd; putative cytidine deaminase K01489 cdd; cytidine deaminase [EC:3.5.4.5] D SPy_2110 nrdD; putative anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] D SPy_1375 nrdE.2; putative ribonucleotide reductase alpha-chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D SPy_0427 nrdE.1; ribonucleoside-diphosphate reductase, large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D SPy_1378 nrdF.2; ribonucleotide diphosphate reductase small subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D SPy_0425 nrdF.1; putative ribonucleotide reductase 2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D SPy_1823 comEB; putative late competence protein required for DNA binding K01493 comEB; dCMP deaminase [EC:3.5.4.12] D SPy_0399 tmk; putative thymidylate kinase K00943 tmk; dTMP kinase [EC:2.7.4.9] D SPy_0235 putative dUTPase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23] D SPy_1140 tdk2; putative thymidine kinase K00857 tdk; thymidine kinase [EC:2.7.1.21] D SPy_0882 thyA; putative thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] B B 09105 Amino acid metabolism C 00250 Alanine, aspartate and glutamate metabolism [PATH:spy00250] D SPy_1782 asnB; putative L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D SPy_1539 asnA; putative asparagine synthetase A K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1] D SPy_0650 aspC; putative aspartate aminotransferase K22457 E2.6.1.14; asparagine---oxo-acid transaminase [EC:2.6.1.14] D SPy_1779 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] D SPy_0160 purA; putative adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D SPy_0036 purB; adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D SPy_0832 pyrB; putative aspartate transcarbamoylase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D SPy_1067 gabD; putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D SPy_1877 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D SPy_0835 carB; putative carbamoylphosphate synthetase K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D SPy_0833 carA; putative carbamoyl phosphate synthetase small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D SPy_1280 glmS; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D SPy_0026 purF; putative phosphoribosylpyrophosphate amidotransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] C 00260 Glycine, serine and threonine metabolism [PATH:spy00260] D SPy_1145 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D SPy_1903 conserved hypothetical protein K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D SPy_1429 gpmA; putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_2189 sdhB; putative L-serine dehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D SPy_2190 sdhA; putative L-serine dehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] C 00270 Cysteine and methionine metabolism [PATH:spy00270] D SPy_1944 cysE; putative serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D SPy_1618 cysM; putative O-acetylserine lyase K01738 cysK; cysteine synthase [EC:2.5.1.47] D SPy_0172 metB; putative cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D SPy_1359 metK; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D SPy_0538 putative S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D SPy_0447 pfs; putative MTA/SAH nucleosidase (5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase) K01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9] D SPy_1365 conserved hypothetical protein K08968 msrC; L-methionine (R)-S-oxide reductase [EC:1.8.4.14] D SPy_1077 putative methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D SPy_1642 luxS; autoinducer-2 production protein K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] D SPy_0911 bcaT; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D SPy_1151 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D SPy_2189 sdhB; putative L-serine dehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D SPy_2190 sdhA; putative L-serine dehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] C 00280 Valine, leucine and isoleucine degradation [PATH:spy00280] D SPy_0911 bcaT; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0881 mvaS.2; putative 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMG-CoA synthase) K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] C 00290 Valine, leucine and isoleucine biosynthesis [PATH:spy00290] D SPy_0911 bcaT; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D SPy_1779 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] C 00300 Lysine biosynthesis D SPy_1420 murF; putative D-Ala-D-Ala adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] C 00310 Lysine degradation [PATH:spy00310] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_1067 gabD; putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D SPy_0141 atoD.2; putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_1638 atoD.1; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_0142 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D SPy_1639 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] C 00220 Arginine biosynthesis [PATH:spy00220] D SPy_1544 arcB; putative ornithine transcarbamylase K00611 OTC; ornithine carbamoyltransferase [EC:2.1.3.3] D SPy_1547 sagP; streptococcal antitumor protein K01478 arcA; arginine deiminase [EC:3.5.3.6] D SPy_1877 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D SPy_1541 arcC; putative carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] D SPy_1779 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] C 00330 Arginine and proline metabolism [PATH:spy00330] D SPy_0902 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D SPy_0112 proC; putative pyrroline carboxylate reductase K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] D SPy_1672 proB; putative gamma-glutamyl kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D SPy_1670 proA; putative gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] C 00340 Histidine metabolism [PATH:spy00340] D SPy_2089 hutH; putative histidine ammonia-lyase K01745 hutH; histidine ammonia-lyase [EC:4.3.1.3] D SPy_2082 hutU; putative urocanate hydratase K01712 hutU; urocanate hydratase [EC:4.2.1.49] D SPy_2081 hutI; putative imidazolonepropionase (imidazolone-5-propionate hydrolase) K01468 hutI; imidazolonepropionase [EC:3.5.2.7] D SPy_2090 hutG; putative formiminoglutamate hydrolase K01479 hutG; formiminoglutamase [EC:3.5.3.8] D SPy_2083 putative formiminotransferase cyclodeaminase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] C 00350 Tyrosine metabolism [PATH:spy00350] D SPy_0044 adhA; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D SPy_1067 gabD; putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00360 Phenylalanine metabolism D SPy_0902 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] C 00380 Tryptophan metabolism [PATH:spy00380] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0902 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:spy00400] D SPy_1576 putative chorismate mutase K03856 AROA2; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] D SPy_1577 aroB; 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4] D SPy_0809 aroD; putative 3-dehydroquinate dehydratase K03785 aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10] D SPy_0534 aroE.2; putative shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25] D SPy_1351 aroK; putative shikimate kinase K00891 aroK; shikimate kinase [EC:2.7.1.71] D SPy_1352 aroA; putative 3-phosphoshikimate 1-carboxyvinyltransferase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] D SPy_0810 aroF; putative chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5] D SPy_1991 trpG; anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D SPy_0722 conserved hypothetical protein K04516 AROA1; chorismate mutase [EC:5.4.99.5] B B 09106 Metabolism of other amino acids C 00410 beta-Alanine metabolism C 00430 Taurine and hypotaurine metabolism [PATH:spy00430] D SPy_1128 pta; putative phosphotransacetylase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D SPy_0109 ackA; acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] C 00440 Phosphonate and phosphinate metabolism C 00450 Selenocompound metabolism [PATH:spy00450] D SPy_0172 metB; putative cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D SPy_0288 putative aminotransferase K11717 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] D SPy_0422 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] C 00460 Cyanoamino acid metabolism [PATH:spy00460] D SPy_1599 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D SPy_1782 asnB; putative L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D SPy_1539 asnA; putative asparagine synthetase A K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1] D SPy_1145 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] C 00470 D-Amino acid metabolism [PATH:spy00470] D SPy_1802 alr; putative alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D SPy_1421 ddlA; putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D SPy_1312 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D SPy_1310 dltC; putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D SPy_0361 glr; putative glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D SPy_1525 murD; putative UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] C 00480 Glutathione metabolism [PATH:spy00480] D SPy_1239 pepN; putative lysyl-aminopeptidase; aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2] D SPy_0917 hypothetical protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] D SPy_0813 gor; putative glutathione reductase (GR) K00383 GSR; glutathione reductase (NADPH) [EC:1.8.1.7] D SPy_0605 bsaA; putative glutathione peroxidase K00432 gpx; glutathione peroxidase [EC:1.11.1.9] B B 09107 Glycan biosynthesis and metabolism C 00510 N-Glycan biosynthesis C 00513 Various types of N-glycan biosynthesis C 00512 Mucin type O-glycan biosynthesis C 00515 Mannose type O-glycan biosynthesis C 00514 Other types of O-glycan biosynthesis C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin C 00533 Glycosaminoglycan biosynthesis - keratan sulfate C 00531 Glycosaminoglycan degradation C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series C 00604 Glycosphingolipid biosynthesis - ganglio series C 00511 Other glycan degradation [PATH:spy00511] D SPy_1586 putative beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D SPy_1604 conserved hypothetical protein K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] C 00540 Lipopolysaccharide biosynthesis C 00542 O-Antigen repeat unit biosynthesis [PATH:spy00542] D SPy_0282 rgpG; possibly involved in regulation of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 00541 O-Antigen nucleotide sugar biosynthesis [PATH:spy00541] D SPy_2202 hasC; UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_0224 hasC.2; putative UDP-glucose pyrophosphorylase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D SPy_2201 hasB; UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_0542 putative nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D SPy_0933 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D SPy_0936 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D SPy_0935 cpsFP; putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D SPy_0784 rmlD; putative dTDP-4-keto-L-rhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] D SPy_1810 pmi; putative mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D SPy_1503 putative phosphomannomutase K01840 manB; phosphomannomutase [EC:5.4.2.8] D SPy_0443 gcaD; putative UDP-N-acetylglucosamine pyrophosphorylase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] C 00550 Peptidoglycan biosynthesis [PATH:spy00550] D SPy_1358 murZ; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D SPy_0763 putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D SPy_1101 murB; putative UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D SPy_0345 murC; putative UDP-N-acetyl muramate-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D SPy_1525 murD; putative UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D SPy_1421 ddlA; putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D SPy_1420 murF; putative D-Ala-D-Ala adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D SPy_0475 dgk; putative diacylglycerol kinase K00887 dgkA; undecaprenol kinase [EC:2.7.1.66] D SPy_1965 uppS; putative undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D SPy_0280 bacA; putative undecaprenol kinase (bacitracin resistance protein) K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D SPy_0374 conserved hypothetical protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D SPy_1662 mraY; putative undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D SPy_1524 murG; putative undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D SPy_1649 pbp1A; putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D SPy_2059 pbp2A; penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D SPy_1093 putative D,D-carboxypeptidase, penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D SPy_0292 dacA; penicillin-binding protein (D-alanyl-D-alanine carboxypeptidase) K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D SPy_1765 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D SPy_0388 murE; putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] D SPy_1035 putative UDP-N-acetylmuramyl tripeptide synthetase K23393 murT; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13] D SPy_1034 hypothetical protein K07009 gatD; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13] D SPy_1205 putative antimicrobial resistance factor K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D SPy_0616 murM; putative peptidoglycan branched peptide synthesis protein, serine/alanine adding enzyme K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D SPy_0615 murN; putative peptidoglycan branched peptide synthesis protein, alanine adding enzyme K12554 murN; alanine adding enzyme [EC:2.3.2.-] D SPy_0097 pbp1b; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D SPy_1664 pbpX; putative penicillin binding protein 2X K12556 pbp2X; penicillin-binding protein 2X C 00552 Teichoic acid biosynthesis [PATH:spy00552] D SPy_0280 bacA; putative undecaprenol kinase (bacitracin resistance protein) K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D SPy_0374 conserved hypothetical protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D SPy_0282 rgpG; possibly involved in regulation of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D SPy_1312 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D SPy_1310 dltC; putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D SPy_1311 dltB; putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D SPy_1309 dltD; putative extramembranal protein K03740 dltD; D-alanine transfer protein D SPy_1733 putative transcription regulator K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-] D SPy_1350 psr; putative PBP 5 synthesis repressor K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-] D SPy_0807 conserved hypothetical protein K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20] D SPy_0516 putative glucosyl transferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] C 00571 Lipoarabinomannan (LAM) biosynthesis C 00572 Arabinogalactan biosynthesis - Mycobacterium C 00543 Exopolysaccharide biosynthesis [PATH:spy00543] D SPy_0282 rgpG; possibly involved in regulation of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D SPy_1944 cysE; putative serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] B B 09108 Metabolism of cofactors and vitamins C 00730 Thiamine metabolism [PATH:spy00730] D SPy_0816 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_1122 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_0817 thiI; putative thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] D SPy_0263 conserved hypothetical protein K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D SPy_0265 conserved hypothetical protein K00949 thiN; thiamine pyrophosphokinase [EC:2.7.6.2] D SPy_0074 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] C 00740 Riboflavin metabolism [PATH:spy00740] D SPy_1737 conserved hypothetical protein K21064 ycsE; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104] D SPy_1250 mreA; putative macrolide-efflux protein K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] D SPy_1113 putative acid phosphatase (class B) K03788 aphA; acid phosphatase (class B) [EC:3.1.3.2] D SPy_0444 conserved hypothetical protein K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] C 00750 Vitamin B6 metabolism [PATH:spy00750] D SPy_1209 pdxK; putative pyridoxal kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35] D SPy_1900 thiD; putative phosphomethylpyrimidine kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35] C 00760 Nicotinate and nicotinamide metabolism [PATH:spy00760] D SPy_0197 nadC; putative nicotinate-nucleotide pyrophosphorylase K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] D SPy_1653 putative nicotinate phosphoribosyltransferase K00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21] D SPy_0892 punA; putative purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D SPy_0894 deoD2; putative purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1] D SPy_0872 putative secreted 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D SPy_0308 conserved hypothetical protein K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] D SPy_1652 nadE; putative NAD+ synthase K01916 nadE; NAD+ synthase [EC:6.3.1.5] D SPy_0165 nga; nicotine adenine dinucleotide glycohydrolase precursor K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5] D SPy_1126 conserved hypothetical protein K00858 ppnK; NAD+ kinase [EC:2.7.1.23] D SPy_1067 gabD; putative succinic semialdehyde dehydrogenase K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00770 Pantothenate and CoA biosynthesis [PATH:spy00770] D SPy_0852 apbA; putative 2-dehydropantoate 2-reductase K00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169] D SPy_1233 coaA; putative pantothenate kinase K00867 coaA; type I pantothenate kinase [EC:2.7.1.33] D SPy_1221 dpfB; putative flavoprotein K21977 coaB; phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5] D SPy_1222 dfp; putative DNA/pantothenate metabolism flavoprotein K01598 PPCDC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36] D SPy_1537 kdtB; putative 3-deoxy-D-manno-octulosonic-acid transferase K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] D SPy_0498 conserved hypothetical protein K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24] D SPy_1804 acpS; putative holo-(acyl carrier protein) synthase K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7] D SPy_0911 bcaT; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] C 00780 Biotin metabolism [PATH:spy00780] D SPy_1748 fabF; putative beta-ketoacyl-ACP synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D SPy_0440 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D SPy_1749 fabG; putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D SPy_1746 fabZ; putative beta-hydroxyacyl-ACP dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D SPy_1362 birA; putative biotin operon repressor K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] C 00785 Lipoic acid metabolism [PATH:spy00785] D SPy_1033 putative lipoate-protein ligase K03800 lplA; lipoate---protein ligase [EC:6.3.1.20] D SPy_1214 lplA; putative lipoate-protein ligase K03800 lplA; lipoate---protein ligase [EC:6.3.1.20] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_1026 acoA; putative acetoin dehydrogenase (TPP-dependent) alpha chain K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D SPy_1028 acoB; putative acetoin dehydrogenase (TPP-dependent) beta chain K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D SPy_1029 acoC; putative dihydrolipoamide S-acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] C 00790 Folate biosynthesis [PATH:spy00790] D SPy_1097 folE; GTP cyclohydrolase K01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16] D SPy_1099 folQ; dihydroneopterin aldolase K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] D SPy_1100 folK; hydroxymethylpterin pyrophosphokinase K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] D SPy_1098 folP; dihydropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15] D SPy_0883 dyr; putative dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D SPy_0814 folC.2; putative folyl-polyglutamate synthetase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] D SPy_1096 folC.1; putative folyl-polyglutamate synthetase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] D SPy_1990 pabB; putative para-aminobenzoate synthetase K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] C 00670 One carbon pool by folate [PATH:spy00670] D SPy_0883 dyr; putative dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D SPy_2085 fhs.2; putative formate-tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] D SPy_1213 fhs.1; putative formate-tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] D SPy_1502 folD; putative bifunctional methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cyclohydrolase K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] D SPy_2084 putative serine cycle enzyme K01500 fchA; methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9] D SPy_1145 glyA; putative serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D SPy_0028 purN; Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D SPy_2083 putative formiminotransferase cyclodeaminase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] D SPy_1628 fmt; putative methionyl tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D SPy_0882 thyA; putative thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] C 00830 Retinol metabolism C 00860 Porphyrin metabolism C 00130 Ubiquinone and other terpenoid-quinone biosynthesis B B 09109 Metabolism of terpenoids and polyketides C 00900 Terpenoid backbone biosynthesis [PATH:spy00900] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0881 mvaS.2; putative 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMG-CoA synthase) K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] D SPy_0880 mvaS.1; putative 3-hydroxy-3-methylglutaryl-coenzyme A K00054 mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88] D SPy_0876 mvaK1; mevalonate kinase K00869 MVK; mevalonate kinase [EC:2.7.1.36] D SPy_0878 mvaK2; phosphomevalonate kinase K00938 E2.7.4.2; phosphomevalonate kinase [EC:2.7.4.2] D SPy_0877 mvaD; mevalonate pyrophosphate decarboxylase K01597 MVD; diphosphomevalonate decarboxylase [EC:4.1.1.33] D SPy_0879 conserved hypothetical protein K01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2] D SPy_1498 fps; putative geranyltranstransferase (farnesyl diphosphate synthase) K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D SPy_1965 uppS; putative undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] C 00902 Monoterpenoid biosynthesis C 00909 Sesquiterpenoid and triterpenoid biosynthesis C 00904 Diterpenoid biosynthesis C 00906 Carotenoid biosynthesis C 00905 Brassinosteroid biosynthesis C 00981 Insect hormone biosynthesis C 00908 Zeatin biosynthesis C 00903 Limonene degradation C 00907 Pinene, camphor and geraniol degradation C 01052 Type I polyketide structures C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides C 01051 Biosynthesis of ansamycins D SPy_1676 tkt; putative transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] C 01059 Biosynthesis of enediyne antibiotics C 01056 Biosynthesis of type II polyketide backbone C 01057 Biosynthesis of type II polyketide products C 00253 Tetracycline biosynthesis C 00523 Polyketide sugar unit biosynthesis [PATH:spy00523] D SPy_0933 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D SPy_0936 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D SPy_0935 cpsFP; putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D SPy_0784 rmlD; putative dTDP-4-keto-L-rhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 01054 Nonribosomal peptide structures C 01053 Biosynthesis of siderophore group nonribosomal peptides C 01055 Biosynthesis of vancomycin group antibiotics D SPy_0936 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] B B 09110 Biosynthesis of other secondary metabolites C 00940 Phenylpropanoid biosynthesis C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis C 00941 Flavonoid biosynthesis C 00944 Flavone and flavonol biosynthesis C 00942 Anthocyanin biosynthesis C 00943 Isoflavonoid biosynthesis C 00946 Degradation of flavonoids [PATH:spy00946] D SPy_1599 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] C 00901 Indole alkaloid biosynthesis C 00403 Indole diterpene alkaloid biosynthesis C 00950 Isoquinoline alkaloid biosynthesis C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis C 00996 Biosynthesis of various alkaloids C 00232 Caffeine metabolism C 00965 Betalain biosynthesis C 00966 Glucosinolate biosynthesis C 00402 Benzoxazinoid biosynthesis C 00311 Penicillin and cephalosporin biosynthesis C 00332 Carbapenem biosynthesis [PATH:spy00332] D SPy_1672 proB; putative gamma-glutamyl kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D SPy_1670 proA; putative gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] C 00261 Monobactam biosynthesis C 00331 Clavulanic acid biosynthesis C 00521 Streptomycin biosynthesis [PATH:spy00521] D SPy_1529 glcK; glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] D SPy_1224 pgmA; putative phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D SPy_1247 putative myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D SPy_0933 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D SPy_0936 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D SPy_0935 cpsFP; putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D SPy_0784 rmlD; putative dTDP-4-keto-L-rhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 00524 Neomycin, kanamycin and gentamicin biosynthesis D SPy_1529 glcK; glucose kinase K25026 glk; glucokinase [EC:2.7.1.2] C 00525 Acarbose and validamycin biosynthesis [PATH:spy00525] D SPy_0933 cpsFO; glucose-1-phosphate thymidyl transferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D SPy_0936 cpsFQ; putative dTDP-glucose-4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] C 00401 Novobiocin biosynthesis C 00404 Staurosporine biosynthesis C 00405 Phenazine biosynthesis D SPy_1991 trpG; anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] C 00333 Prodigiosin biosynthesis D SPy_1750 fabD; putative malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D SPy_0440 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D SPy_1749 fabG; putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] C 00254 Aflatoxin biosynthesis C 00998 Biosynthesis of various antibiotics D SPy_1753 acpP; putative acyl carrier protein K02078 acpP; acyl carrier protein D SPy_0023 acpP.2; putative acyl carrier protein K02078 acpP; acyl carrier protein C 00999 Biosynthesis of various plant secondary metabolites [PATH:spy00999] D SPy_1359 metK; S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D SPy_0538 putative S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D SPy_0534 aroE.2; putative shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25] D SPy_1599 putative beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] C 00997 Biosynthesis of various other secondary metabolites B B 09111 Xenobiotics biodegradation and metabolism C 00362 Benzoate degradation [PATH:spy00362] D SPy_2103 conserved hypothetical protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] D SPy_1139 putative 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] D SPy_1177 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1184 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1176 putative methylmalonyl-CoA decarboxylase, gamma-subunit K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D SPy_1183 putative decarboxylase, gamma chain K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00627 Aminobenzoate degradation [PATH:spy00627] D SPy_0902 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D SPy_0352 putative acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D SPy_0141 atoD.2; putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_1638 atoD.1; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_0142 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D SPy_1639 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] C 00364 Fluorobenzoate degradation C 00625 Chloroalkane and chloroalkene degradation [PATH:spy00625] D SPy_0044 adhA; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] C 00361 Chlorocyclohexane and chlorobenzene degradation D SPy_2103 conserved hypothetical protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] C 00623 Toluene degradation C 00622 Xylene degradation [PATH:spy00622] D SPy_2103 conserved hypothetical protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] D SPy_1139 putative 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] C 00633 Nitrotoluene degradation C 00642 Ethylbenzene degradation C 00643 Styrene degradation [PATH:spy00643] D SPy_0902 amiC; putative amidase K01426 E3.5.1.4; amidase [EC:3.5.1.4] D SPy_2103 conserved hypothetical protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] C 00791 Atrazine degradation C 00930 Caprolactam degradation C 00363 Bisphenol degradation C 00621 Dioxin degradation D SPy_1139 putative 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] C 00626 Naphthalene degradation [PATH:spy00626] D SPy_0044 adhA; putative alcohol dehydrogenase I K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] C 00624 Polycyclic aromatic hydrocarbon degradation C 00365 Furfural degradation C 00984 Steroid degradation C 00980 Metabolism of xenobiotics by cytochrome P450 C 00982 Drug metabolism - cytochrome P450 C 00983 Drug metabolism - other enzymes B B 09112 Not included in regular maps C 09113 Global maps only # A09120 Genetic Information Processing B B 09121 Transcription C 03020 RNA polymerase [PATH:spy03020] D SPy_0098 rpoB; putative DNA-dependent RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D SPy_0099 rpoC; DNA-dependent RNA polymerase, B' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D SPy_0080 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D SPy_1630 conserved hypothetical protein K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D SPy_1895 rpoE; putative DNA-directed RNA polymerase (delta subunit) K03048 rpoE; DNA-directed RNA polymerase subunit delta C 03022 Basal transcription factors C 03040 Spliceosome B B 09122 Translation C 03010 Ribosome [PATH:spy03010] D SPy_0913 putative ribosomal protein S1-like DNA-binding protein K02945 RP-S1; small subunit ribosomal protein S1 D SPy_2092 rpsB; 30S ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2 D SPy_0056 rpsC; 30S ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3 D SPy_2178 rpsD; 30S ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4 D SPy_0069 rpsE; 30S ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5 D SPy_1831 rpsF; 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6 D SPy_0272 rpsG; 30S ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7 D SPy_0065 rpsH; 30S ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8 D SPy_1931 rpsI; ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9 D SPy_0047 rpsJ; 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10 D SPy_0078 rpsK; 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11 D SPy_0271 rpsL; 30S ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12 D SPy_0077 rpsM; 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13 D SPy_1871 rpsN2; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D SPy_0064 rpsN; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D SPy_1955 rpsO; 30S ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15 D SPy_0840 rpsP; 30S ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16 D SPy_0060 rpsQ; 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17 D SPy_1829 rpsR; 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18 D SPy_0053 rpsS; 30S ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19 D SPy_1234 rpsT; 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20 D SPy_0779 rpsU; 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21 D SPy_0461 rplA; 50S ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1 D SPy_0052 rplB; 50S ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2 D SPy_0049 rplC; 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3 D SPy_0050 rplD; 50S ribosomal protein L4 K02926 RP-L4; large subunit ribosomal protein L4 D SPy_0063 rplE; 50S ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5 D SPy_0066 rplF; 50S ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6 D SPy_1073 rplL; 50S ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12 D SPy_2183 rplI; 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9 D SPy_1072 rplJ; 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10 D SPy_0460 rplK; 50S ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11 D SPy_1932 rplM; 50S ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13 D SPy_0061 50S ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14 D SPy_0072 rplO; 50S ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15 D SPy_0057 rplP; 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16 D SPy_0067 rplR; 50S ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18 D SPy_0724 rplS; 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19 D SPy_0806 rplT; 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20 D SPy_0819 rplU; 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21 D SPy_0055 rplV; 50S ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22 D SPy_0051 rplW; 50S ribosomal protein L23 K02892 RP-L23; large subunit ribosomal protein L23 D SPy_0062 rplX; 50S ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24 D SPy_0822 rpmA; 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27 D SPy_1888 rpmB; 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28 D SPy_0059 rpmC; 50S ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29 D SPy_0071 rpmD; 50S ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30 D SPy_0717 rpmE; 50S ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31 D SPy_2159 rpmF; 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32 D SPy_2160 rpmG; 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33 D SPy_0250 rpmH; 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34 D SPy_0805 rpmI; 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35 D SPy_0076 rpmJ; 50S ribosomal protein B K02919 RP-L36; large subunit ribosomal protein L36 D SPy_r01 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r03 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r05 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r07 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r10 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r12 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r02 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r04 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r06 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r08 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r09 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r11 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA C 00970 Aminoacyl-tRNA biosynthesis [PATH:spy00970] D SPy_t01 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t11 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t35 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t55 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t22 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t50 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t41 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t60 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t38 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t09 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t37 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t53 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t58 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D SPy_t36 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D SPy_t54 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D SPy_t03 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D SPy_t48 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D SPy_t57 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D SPy_t40 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D SPy_t33 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D SPy_t15 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t59 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t43 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t26 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t13 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t24 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t19 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t07 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t32 tRNA-His K14226 tRNA-His; tRNA His D SPy_t14 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t25 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t20 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t44 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t08 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t34 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t05 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t46 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t52 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t04 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D SPy_t47 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D SPy_t56 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D SPy_t17 tRNA-Met K14230 tRNA-Met; tRNA Met D SPy_t28 tRNA-Met K14230 tRNA-Met; tRNA Met D SPy_t18 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D SPy_t29 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D SPy_t10 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D SPy_t16 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t27 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t51 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t21 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t42 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D SPy_t06 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D SPy_t45 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D SPy_t31 tRNA-Trp K14235 tRNA-Trp; tRNA Trp D SPy_t30 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D SPy_t39 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D SPy_t02 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_t23 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_t12 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_t49 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_0239 gltX; putative glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D SPy_1771 gatA; putative Glutamyl-tRNA Gln amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] D SPy_1770 gatB; putative Glu-tRNAGln amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] D SPy_1772 gatC; putative Glu-tRNA Gln amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] D SPy_1389 alaS; putative alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D SPy_2156 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D SPy_0651 asnS; putative asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D SPy_0559 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D SPy_1689 glyQ; putative glycyl-tRNA synthetase (alpha subunit) K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D SPy_1688 glyS; putative glycyl-tRNA synthetase (beta subunit) K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D SPy_0517 thrS; putative threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D SPy_1742 serS; putative seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D SPy_1941 cysS; putative cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D SPy_0422 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D SPy_1628 fmt; putative methionyl tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D SPy_1568 valS; putative valine-tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D SPy_0173 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D SPy_1513 ileS; putative isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D SPy_0595 lysS; putative lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D SPy_2151 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D SPy_1962 proS; putative prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D SPy_2157 hisS; putative histidine-tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D SPy_0768 pheS; putative phenylalanyl-tRNA synthetase (alpha subunit) K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D SPy_0769 pheT; phenylalanyl-tRNA synthetase (beta subunit) K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D SPy_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D SPy_2207 trsA; putative tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] C 03013 Nucleocytoplasmic transport C 03015 mRNA surveillance pathway C 03008 Ribosome biogenesis in eukaryotes B B 09123 Folding, sorting and degradation C 03060 Protein export [PATH:spy03060] D SPy_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D SPy_2058 hypothetical protein K03073 secE; preprotein translocase subunit SecE D SPy_0502 hypothetical protein K03075 secG; preprotein translocase subunit SecG D SPy_1968 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D SPy_0247 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_0351 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_1805 secA; putative preprotein translocase binding subunit (ATPase) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D SPy_1200 ffh; putative signal recognition particle K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D SPy_0569 ftsY; putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D SPy_1842 spi; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D SPy_1281 sipC; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D SPy_0127 putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D SPy_0826 lsp; putative prolipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] C 04141 Protein processing in endoplasmic reticulum C 04130 SNARE interactions in vesicular transport C 04120 Ubiquitin mediated proteolysis C 04122 Sulfur relay system [PATH:spy04122] D SPy_0816 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_1122 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_2188 putative tRNA-(5-methylaminomethyl-2-thiouridylate) K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D SPy_0817 thiI; putative thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] C 03050 Proteasome C 03018 RNA degradation [PATH:spy03018] D SPy_0731 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D SPy_1946 pnpA; putative polynucleotide phosphorylase, alpha chain K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D SPy_0503 putative exoribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D SPy_1415 deaD; putative ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D SPy_1633 conserved hypothetical protein K18682 rny; ribonucrease Y [EC:3.1.-.-] D SPy_1876 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D SPy_1020 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D SPy_1760 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D SPy_2070 groEL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] B B 09124 Replication and repair C 03030 DNA replication [PATH:spy03030] D SPy_1864 dnaQ; putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D SPy_1284 dnaE; putative DNA polymerase III (alpha subunit) K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D SPy_1961 polC; DNA polymerase III (alpha subunit) K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D SPy_1364 dnaX; DNA polymerase III subunits gamma / tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D SPy_0400 putative DNA polymerase III delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D SPy_1407 holA; DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D SPy_0003 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D SPy_2182 holB; DNA polymerase III delta prime subunit K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D SPy_0781 dnaG; putative DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D SPy_1830 putative single strand binding protein - phage associated K03111 ssb; single-strand DNA-binding protein D SPy_1162 rnh; putative ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D SPy_1841 putative ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4] D SPy_0185 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D SPy_0751 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03410 Base excision repair [PATH:spy03410] D SPy_0929 nth; putative endonuclease III (DNA repair) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D SPy_0905 ung; putative uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D SPy_1833 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D SPy_0497 fpg; putative formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D SPy_2118 tag; putative 3-methyl-adenine DNA glycosylase I, constitutive K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D SPy_0412 exoA; putative 3'-exo-deoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D SPy_0185 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D SPy_0926 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D SPy_0751 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03420 Nucleotide excision repair [PATH:spy03420] D SPy_0008 trcF; putative transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D SPy_1825 uvrA; putative excinuclease ABC (subunit A) K03701 uvrA; excinuclease ABC subunit A D SPy_1314 uvrB; putative excinuclease ABC (subunit B) K03702 uvrB; excinuclease ABC subunit B D SPy_1068 uvrC; excinuclease ABC (subunit C) K03703 uvrC; excinuclease ABC subunit C D SPy_1267 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D SPy_0185 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D SPy_0751 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03430 Mismatch repair [PATH:spy03430] D SPy_2148 mutS; putative DNA mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS D SPy_1837 mutS2; putative DNA mismatch repair protein K07456 mutS2; DNA mismatch repair protein MutS2 D SPy_2121 mutL; putative DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL D SPy_1267 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D SPy_1500 xseA; putative exodeoxyribonuclease VII (large subunit) K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D SPy_1499 xseB; exodeoxyribonuclease VII (small subunit) K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D SPy_0926 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D SPy_1830 putative single strand binding protein - phage associated K03111 ssb; single-strand DNA-binding protein D SPy_1284 dnaE; putative DNA polymerase III (alpha subunit) K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D SPy_1961 polC; DNA polymerase III (alpha subunit) K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D SPy_0003 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D SPy_1364 dnaX; DNA polymerase III subunits gamma / tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D SPy_1407 holA; DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D SPy_0400 putative DNA polymerase III delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D SPy_1864 dnaQ; putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D SPy_0751 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03440 Homologous recombination [PATH:spy03440] D SPy_0926 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D SPy_1830 putative single strand binding protein - phage associated K03111 ssb; single-strand DNA-binding protein D SPy_2204 recF; RecF protein K03629 recF; DNA replication and repair protein RecF D SPy_0021 conserved hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O) D SPy_1422 recR; putative recombination protein K06187 recR; recombination protein RecR D SPy_2116 recA; recombination protein K03553 recA; recombination protein RecA D SPy_0185 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D SPy_2119 ruvA; putative Holiday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA D SPy_0038 ruvB; putative Holliday junction DNA helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D SPy_1785 recG; putative ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D SPy_1844 putative exodeoxyribonuclease V (alpha subunit) K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] D SPy_1284 dnaE; putative DNA polymerase III (alpha subunit) K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D SPy_1961 polC; DNA polymerase III (alpha subunit) K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D SPy_0003 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D SPy_1364 dnaX; DNA polymerase III subunits gamma / tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D SPy_1407 holA; DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D SPy_0400 putative DNA polymerase III delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D SPy_1864 dnaQ; putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D SPy_1629 priA; putative primosomal replication factor Y K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] C 03450 Non-homologous end-joining C 03460 Fanconi anemia pathway B B 09126 Chromosome C 03082 ATP-dependent chromatin remodeling C 03083 Polycomb repressive complex B B 09125 Information processing in viruses C 03230 Viral genome structure C 03240 Viral replication C 03250 Viral life cycle - HIV-1 [PATH:spy03250] D SPy_0457 putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] C 03260 Virion - Human immunodeficiency virus C 03271 Virion - Rotavirus C 03262 Virion - Coronavirus C 03261 Virion - Influenza virus C 03263 Virion - Enterovirus C 03264 Virion - Flavivirus C 03265 Virion - Ebolavirus and Lyssavirus C 03266 Virion - Herpesvirus C 03268 Virion - Orthopoxvirus C 03267 Virion - Adenovirus C 03259 Virion - Bacteriophages T4 and T7 C 03258 Virion - Bacteriophage lambda # A09130 Environmental Information Processing B B 09131 Membrane transport C 02010 ABC transporters [PATH:spy02010] D SPy_1063 putative periplasmic-iron-binding protein K02012 afuA; iron(III) transport system substrate-binding protein D SPy_1105 potD; putative spermidine/putrescine ABC transporter (periplasmic transport protein) K11069 potD; spermidine/putrescine transport system substrate-binding protein D SPy_1104 potC; putative spermidine/putrescine ABC transporter (permease protein) K11070 potC; spermidine/putrescine transport system permease protein D SPy_1103 potB; putative spermidine / putrescine ABC transporter (permease protein) K11071 potB; spermidine/putrescine transport system permease protein D SPy_1102 potA; putative spermidine / putrescine ABC transporter (ATP-binding protein) K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11] D SPy_0184 opuABC; putative glycine-betaine binding permease protein K02001 proW; glycine betaine/proline transport system permease protein D SPy_0183 opuAA; putative glycine betaine/proline ABC transporter (ATP-binding protein) K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D SPy_1134 putative ABC transporter (binding protein) K05845 opuC; osmoprotectant transport system substrate-binding protein D SPy_1133 putative ABC transporter (ATP-binding protein) K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D SPy_1976 msmK; multiple sugar-binding ABC transport system (ATP-binding protein) K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] D SPy_1306 malX; maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D SPy_1294 putative maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D SPy_1295 malF; putative maltose/maltodextrin ABC transport system (permease) K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1301 malC; maltodextrin transport system permease K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1296 malG; putative maltose/maltodextrin ABC transport system (permease) K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1299 malD; putative maltodextrin transport system permease K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1592 putative ABC transporter substrate binding lipoprotein K17318 lplA; putative aldouronate transport system substrate-binding protein D SPy_1595 putative sugar-binding transport protein K17319 lplB; putative aldouronate transport system permease protein D SPy_1593 putative sugar-binding transport protein K17320 lplC; putative aldouronate transport system permease protein D SPy_1228 putative lipoprotein K07335 bmpA; basic membrane protein A and related proteins D SPy_0163 putative ABC transporter (lipoprotein) K07335 bmpA; basic membrane protein A and related proteins D SPy_1226 putative sugar ABC transporter (permease protein) K23535 nupB; general nucleoside transport system permease protein D SPy_1225 putative sugar ABC transporter (permease protein) K23536 nupC; general nucleoside transport system permease protein D SPy_1227 putative sugar ABC transporter (ATP-binding protein) K23537 nupA; general nucleoside transport system ATP-binding protein D SPy_1245 pstS; putative phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D SPy_1244 pstC2; putative phosphate ABC transporter (permease protein) K02037 pstC; phosphate transport system permease protein D SPy_1243 pstC; putative phosphate ABC transporter (permease protein) K02038 pstA; phosphate transport system permease protein D SPy_1241 pstB; phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D SPy_1242 pstB2; putative phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D SPy_1315 hypothetical protein K10036 glnH; glutamine transport system substrate-binding protein D SPy_1316 putative ABC transporter (ATP-binding protein) K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] D SPy_0903 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D SPy_0317 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein D SPy_0904 putative ABC transporter (permease) K10009 tcyB; L-cystine transport system permease protein D SPy_1658 putative amino acid ABC transproter (permease protein) K10009 tcyB; L-cystine transport system permease protein D SPy_1657 putative amino acid ABC transport system (ATP-binding protein) K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] D SPy_0778 putative ABC transporter (substrate-binding protein) K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein D SPy_1507 putative amino acid ABC transporter (permease protein) K17077 artQ; arginine/lysine/histidine transport system permease protein D SPy_1506 putative amino acid ABC transporter (ATP-binding protein) K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1] D SPy_0277 putative glutamine-binding periplasmic protein K17073 lysX1; putative lysine transport system substrate-binding protein D SPy_0276 putative amino acid ABC transporter (ATP-binding protein) K17076 lysY; putative lysine transport system ATP-binding protein D SPy_0319 conserved hypothetical protein K02073 metQ; D-methionine transport system substrate-binding protein D SPy_0321 putative ABC transporter (permease protein) K02072 metI; D-methionine transport system permease protein D SPy_0320 putative ABC transporter (ATP-binding protein)h K02071 metN; D-methionine transport system ATP-binding protein D SPy_0294 oppB; oligopeptidepermease K15581 oppB; oligopeptide transport system permease protein D SPy_0295 oppC; oligopeptidepermease K15582 oppC; oligopeptide transport system permease protein D SPy_0296 oppD; oligopeptidepermease (ATP-binding protein) K15583 oppD; oligopeptide transport system ATP-binding protein D SPy_0297 oppF; oligopeptidepermease K10823 oppF; oligopeptide transport system ATP-binding protein D SPy_0714 adcA; putative adhesion protein K09815 znuA; zinc transport system substrate-binding protein D SPy_2007 lmb; putative laminin adhesion K09815 znuA; zinc transport system substrate-binding protein D SPy_0094 adcB; putative ABC transporter (permease) K09816 znuB; zinc transport system permease protein D SPy_0093 adcC; ABC transporter (ATP-binding protein) K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20] D SPy_0453 mtsA; metal binding protein of ABC transporter (lipoprotein) K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein D SPy_0456 mtsC; ABC transporter (permease protein) K11705 mtsC; iron/zinc/manganese/copper transport system permease protein D SPy_0454 mtsB; ABC transporter (ATP-binding protein) K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein D SPy_0207 putative biotin synthase K03523 bioY; biotin transport system substrate-specific component D SPy_2193 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D SPy_1788 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D SPy_2195 ABC transporter (ATP-binding protein) K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D SPy_2194 putative ABC transporter (ATP-binding protein) K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D SPy_1086 srtE; conserved hypothetical protein - lantibiotic associated K20491 nisE; lantibiotic transport system permease protein D SPy_1087 srtG; conserved hypothetical protein - lantibiotics associated K20492 nisG; lantibiotic transport system permease protein D SPy_1085 srtF; ABC transporter (ATP-binding) - lantibiotic associated K20490 nisF; lantibiotic transport system ATP-binding protein D SPy_0645 ftsX; putative cell-division protein K09811 ftsX; cell division transport system permease protein D SPy_0644 ftsE; putative cell-division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D SPy_0229 putative ABC transporter, ATP-binding protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump D SPy_0230 putative ABC transporter (ATP-binding protein) K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump D SPy_1148 putative ABC transporter (ATP-binding protein) K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump D SPy_1149 putative ABC transporter (ATP-binding protein) K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump C 02060 Phosphotransferase system (PTS) [PATH:spy02060] D SPy_1372 pstI; putative phosphoenolpyruvate:sugar phosphotransferase system enzyme I K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] D SPy_1373 ptsH; putative phosphotransferase system phosphohistidine-containing protein K02784 ptsH; phosphocarrier protein HPr D SPy_1986 putative PTS system, enzyme II, A component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D SPy_1815 scrA; putative sucrose-specific PTS permease, enzyme II K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D SPy_0572 beta-glucoside permease IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-] D SPy_2097 putative PTS system enzyme II K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D SPy_1918 lacF; putative PTS system, lactose-specific component IIA K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D SPy_1917 lacE; putative PTS system, lactose-specific component IIBC K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D SPy_2052 putative PTS system, enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D SPy_1323 putative PTS enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D SPy_2051 putative PTS system, enzyme IIB K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D SPy_1324 putative PTS system enzyme II K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D SPy_2050 putative PTS system, enzyme IIC component K02761 celB; cellobiose PTS system EIIC component D SPy_1057 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D SPy_1738 manL; mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D SPy_1739 manM; putative mannose-specific phosphotransferase system component IIC K02795 manY; mannose PTS system EIIC component D SPy_1059 putative phospotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D SPy_1740 manN; putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D SPy_1060 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component D SPy_1058 putative phosphotransferase system (PTS), enzyme II component B K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-] D SPy_0634 agaF; putative PTS dependent N-acetyl-galactosamine- and galactosamine IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D SPy_0631 agaV; putative PTS dependent N-acetyl-galactosamine-IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D SPy_0630 agaW; putative PTS dependent N-acetyl-galactosamine-IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D SPy_0629 agaD; putative PTS dependent galactosamine IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D SPy_1711 putative PTS system, enzyme IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204] D SPy_1710 putative PTS system, enzyme IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204] D SPy_1709 putative PTS system, enzyme IIC component K20114 gatC; galactose PTS system EIIC component D SPy_0176 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D SPy_1952 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D SPy_0175 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D SPy_1950 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D SPy_0174 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D SPy_1949 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D SPy_0855 putative fructose-specific enzyme II, PTS system BC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D SPy_0854 fruB; putative fructose-1-phosphate kinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56] C 03070 Bacterial secretion system [PATH:spy03070] D SPy_2058 hypothetical protein K03073 secE; preprotein translocase subunit SecE D SPy_0502 hypothetical protein K03075 secG; preprotein translocase subunit SecG D SPy_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D SPy_1968 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D SPy_0247 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_0351 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_1805 secA; putative preprotein translocase binding subunit (ATPase) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D SPy_0569 ftsY; putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D SPy_1200 ffh; putative signal recognition particle K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] B B 09132 Signal transduction C 02020 Two-component system [PATH:spy02020] D SPy_1245 pstS; putative phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D SPy_2216 htrA; putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D SPy_0529 vicK; two-component sensor histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D SPy_0528 vicR; two-component response regulator K07668 vicR; two-component system, OmpR family, response regulator VicR D SPy_0002 dnaA; Chromosomal initiator protein K02313 dnaA; chromosomal replication initiator protein D SPy_1312 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D SPy_1311 dltB; putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D SPy_1310 dltC; putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D SPy_1309 dltD; putative extramembranal protein K03740 dltD; D-alanine transfer protein D SPy_1236 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D SPy_1237 putative response regulator K14983 ciaR; two-component system, OmpR family, response regulator CiaR D SPy_1765 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D SPy_0336 csrR; putative sensory transduction histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D SPy_2026 putative histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D SPy_2027 putative two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr D SPy_1082 srtK; putative histidine kinase - lantibiotic associated K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3] D SPy_1081 srtR; putative DNA binding regulatory protein - lantibiotic associated K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR D SPy_1085 srtF; ABC transporter (ATP-binding) - lantibiotic associated K20490 nisF; lantibiotic transport system ATP-binding protein D SPy_1086 srtE; conserved hypothetical protein - lantibiotic associated K20491 nisE; lantibiotic transport system permease protein D SPy_1087 srtG; conserved hypothetical protein - lantibiotics associated K20492 nisG; lantibiotic transport system permease protein D SPy_1192 citC; putative citrate lyase synthetase (citrate (pro-3S)-lyase ligase) K01910 citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22] D SPy_1186 citD; putative citrate lyase, gamma subunit K01646 citD; citrate lyase subunit gamma (acyl carrier protein) D SPy_1188 citE; putative citrate lyase, beta subunit K01644 citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] D SPy_1189 citF; putative citrate lyase, alpha subunit K01643 citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] D SPy_1190 citX; conserved hypothetical protein K05964 citX; holo-ACP synthase [EC:2.7.7.61] D SPy_1178 citG; CitG-like protein K05966 citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52] D SPy_1110 putative malic enzyme ((S)-malate:NAD+ oxidoreductase (decarboxylating)) K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] D SPy_1109 malP; putative L-malate permease K11616 maeN; malate:Na+ symporter D SPy_0242 putative histidine kinase, possibly involved in competence K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_1605 putative two-component responsible histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_0244 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_0245 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D SPy_0300 comX1.1; putative competence protein K12296 comX1_2; competence protein ComX D SPy_1902 comX1.2; ComX1-like protein K12296 comX1_2; competence protein ComX D SPy_0012 hypothetical protein K01467 ampC; beta-lactamase class C [EC:3.5.2.6] D SPy_1622 putative two-component sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D SPy_1621 putative two-component response regulator K11618 liaR; two-component system, NarL family, response regulator LiaR D SPy_1908 salR; putative response regulator of salavaricin regulon K14989 salR; two-component system, NarL family, secretion system response regulator SalR D SPy_1877 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D SPy_0141 atoD.2; putative acetyl-CoA:acetoacetyl-CoA transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_1638 atoD.1; putative Acetyl-CoA:acetoacetyl-CoA transferase A subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D SPy_0142 butyrate-acetoacetate CoA-transferase, beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D SPy_1639 atoA; putative Acetyl-CoA:acetoacetyl-CoA transferase b subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D SPy_0137 atoE; putative short-chain fatty acids transporter K02106 atoE; short-chain fatty acids transporter D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_1587 putative two-component sensor response regulator K07720 yesN; two-component system, response regulator YesN D SPy_1062 putative two-component response regulator K07720 yesN; two-component system, response regulator YesN D SPy_0039 putative protein-tyrosine phosphatase K25307 wzb; low molecular weight protein-tyrosine phosphatase [EC:3.1.3.48] C 04010 MAPK signaling pathway C 04013 MAPK signaling pathway - fly C 04016 MAPK signaling pathway - plant C 04011 MAPK signaling pathway - yeast C 04012 ErbB signaling pathway C 04014 Ras signaling pathway C 04015 Rap1 signaling pathway C 04310 Wnt signaling pathway C 04330 Notch signaling pathway C 04340 Hedgehog signaling pathway C 04341 Hedgehog signaling pathway - fly C 04350 TGF-beta signaling pathway C 04390 Hippo signaling pathway C 04391 Hippo signaling pathway - fly C 04392 Hippo signaling pathway - multiple species C 04370 VEGF signaling pathway C 04371 Apelin signaling pathway C 04630 JAK-STAT signaling pathway C 04064 NF-kappa B signaling pathway C 04668 TNF signaling pathway C 04066 HIF-1 signaling pathway C 04068 FoxO signaling pathway C 04020 Calcium signaling pathway C 04070 Phosphatidylinositol signaling system C 04072 Phospholipase D signaling pathway C 04071 Sphingolipid signaling pathway C 04024 cAMP signaling pathway C 04022 cGMP-PKG signaling pathway C 04151 PI3K-Akt signaling pathway C 04152 AMPK signaling pathway C 04150 mTOR signaling pathway C 04075 Plant hormone signal transduction B B 09133 Signaling molecules and interaction C 04080 Neuroactive ligand-receptor interaction C 04060 Cytokine-cytokine receptor interaction C 04061 Viral protein interaction with cytokine and cytokine receptor C 04512 ECM-receptor interaction C 04514 Cell adhesion molecules # A09140 Cellular Processes B B 09141 Transport and catabolism C 04144 Endocytosis C 04145 Phagosome C 04142 Lysosome C 04146 Peroxisome C 04140 Autophagy - animal C 04138 Autophagy - yeast C 04136 Autophagy - other C 04137 Mitophagy - animal C 04139 Mitophagy - yeast C 04148 Efferocytosis B B 09143 Cell growth and death C 04110 Cell cycle C 04111 Cell cycle - yeast C 04112 Cell cycle - Caulobacter C 04113 Meiosis - yeast C 04114 Oocyte meiosis C 04210 Apoptosis C 04214 Apoptosis - fly C 04215 Apoptosis - multiple species C 04216 Ferroptosis C 04217 Necroptosis C 04115 p53 signaling pathway C 04218 Cellular senescence B B 09144 Cellular community - eukaryotes C 04510 Focal adhesion C 04520 Adherens junction C 04530 Tight junction C 04540 Gap junction C 04550 Signaling pathways regulating pluripotency of stem cells B B 09145 Cellular community - prokaryotes C 02024 Quorum sensing [PATH:spy02024] D SPy_1642 luxS; autoinducer-2 production protein K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] D SPy_1991 trpG; anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D SPy_0242 putative histidine kinase, possibly involved in competence K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_1605 putative two-component responsible histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_0244 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_0245 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D SPy_0167 slo; streptolysin O precursor K11031 slo; thiol-activated cytolysin D SPy_1236 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D SPy_1237 putative response regulator K14983 ciaR; two-component system, OmpR family, response regulator CiaR D SPy_0294 oppB; oligopeptidepermease K15581 oppB; oligopeptide transport system permease protein D SPy_0295 oppC; oligopeptidepermease K15582 oppC; oligopeptide transport system permease protein D SPy_0296 oppD; oligopeptidepermease (ATP-binding protein) K15583 oppD; oligopeptide transport system ATP-binding protein D SPy_0297 oppF; oligopeptidepermease K10823 oppF; oligopeptide transport system ATP-binding protein D SPy_0037 hypothetical protein K20342 comR; HTH-type transcriptional regulator, regulator for ComX D SPy_0300 comX1.1; putative competence protein K12296 comX1_2; competence protein ComX D SPy_1902 comX1.2; ComX1-like protein K12296 comX1_2; competence protein ComX D SPy_0496 mutR; putative positive transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator D SPy_0533 putative positive regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor D SPy_2000 dppA; surface lipoprotein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D SPy_2001 dppB; transmembrane transport protein K02033 ABC.PE.P; peptide/nickel transport system permease protein D SPy_2002 dppC; transmembrane transport protein K02034 ABC.PE.P1; peptide/nickel transport system permease protein D SPy_2003 dppD; ATPase protein K02031 ddpD; peptide/nickel transport system ATP-binding protein D SPy_2004 dppE; ATPase protein K02032 ddpF; peptide/nickel transport system ATP-binding protein D SPy_2042 ropB; putative transcription regulator K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator D SPy_2039 speB; pyrogenic exotoxin B K01364 speB; streptopain [EC:3.4.22.10] D SPy_1919 lacD.2; putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D SPy_1704 lacD.1; putative tagatose 1,6-diphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D SPy_0247 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_0351 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_2058 hypothetical protein K03073 secE; preprotein translocase subunit SecE D SPy_0502 hypothetical protein K03075 secG; preprotein translocase subunit SecG D SPy_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D SPy_1968 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D SPy_1805 secA; putative preprotein translocase binding subunit (ATPase) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D SPy_0569 ftsY; putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D SPy_1200 ffh; putative signal recognition particle K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D SPy_1082 srtK; putative histidine kinase - lantibiotic associated K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3] D SPy_1081 srtR; putative DNA binding regulatory protein - lantibiotic associated K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR D SPy_1085 srtF; ABC transporter (ATP-binding) - lantibiotic associated K20490 nisF; lantibiotic transport system ATP-binding protein D SPy_1086 srtE; conserved hypothetical protein - lantibiotic associated K20491 nisE; lantibiotic transport system permease protein D SPy_1087 srtG; conserved hypothetical protein - lantibiotics associated K20492 nisG; lantibiotic transport system permease protein C 05111 Biofilm formation - Vibrio cholerae C 02025 Biofilm formation - Pseudomonas aeruginosa C 02026 Biofilm formation - Escherichia coli B B 09142 Cell motility C 02030 Bacterial chemotaxis C 02040 Flagellar assembly [PATH:spy02040] D SPy_0903 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D SPy_0317 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein D SPy_0782 rpoD; putative RNA polymerase sigma 42 protein K03086 rpoD; RNA polymerase primary sigma factor C 04814 Motor proteins C 04820 Cytoskeleton in muscle cells D SPy_0731 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] C 04810 Regulation of actin cytoskeleton # A09150 Organismal Systems B B 09151 Immune system C 04640 Hematopoietic cell lineage C 04610 Complement and coagulation cascades C 04611 Platelet activation C 04613 Neutrophil extracellular trap formation C 04620 Toll-like receptor signaling pathway C 04624 Toll and Imd signaling pathway C 04621 NOD-like receptor signaling pathway C 04622 RIG-I-like receptor signaling pathway C 04623 Cytosolic DNA-sensing pathway C 04625 C-type lectin receptor signaling pathway C 04650 Natural killer cell mediated cytotoxicity C 04612 Antigen processing and presentation C 04660 T cell receptor signaling pathway C 04658 Th1 and Th2 cell differentiation C 04659 Th17 cell differentiation C 04657 IL-17 signaling pathway C 04662 B cell receptor signaling pathway C 04664 Fc epsilon RI signaling pathway C 04666 Fc gamma R-mediated phagocytosis C 04670 Leukocyte transendothelial migration C 04672 Intestinal immune network for IgA production C 04062 Chemokine signaling pathway B B 09152 Endocrine system C 04911 Insulin secretion C 04910 Insulin signaling pathway C 04922 Glucagon signaling pathway C 04923 Regulation of lipolysis in adipocytes C 04920 Adipocytokine signaling pathway C 03320 PPAR signaling pathway C 04929 GnRH secretion C 04912 GnRH signaling pathway C 04913 Ovarian steroidogenesis C 04915 Estrogen signaling pathway C 04914 Progesterone-mediated oocyte maturation C 04917 Prolactin signaling pathway C 04921 Oxytocin signaling pathway C 04926 Relaxin signaling pathway C 04935 Growth hormone synthesis, secretion and action C 04918 Thyroid hormone synthesis C 04919 Thyroid hormone signaling pathway C 04928 Parathyroid hormone synthesis, secretion and action C 04916 Melanogenesis C 04924 Renin secretion C 04614 Renin-angiotensin system C 04925 Aldosterone synthesis and secretion C 04927 Cortisol synthesis and secretion B B 09153 Circulatory system C 04260 Cardiac muscle contraction C 04261 Adrenergic signaling in cardiomyocytes C 04270 Vascular smooth muscle contraction B B 09154 Digestive system C 04970 Salivary secretion C 04971 Gastric acid secretion C 04972 Pancreatic secretion C 04976 Bile secretion C 04973 Carbohydrate digestion and absorption C 04974 Protein digestion and absorption C 04975 Fat digestion and absorption C 04979 Cholesterol metabolism C 04977 Vitamin digestion and absorption C 04980 Cobalamin transport and metabolism C 04978 Mineral absorption B B 09155 Excretory system C 04962 Vasopressin-regulated water reabsorption C 04960 Aldosterone-regulated sodium reabsorption C 04961 Endocrine and other factor-regulated calcium reabsorption C 04964 Proximal tubule bicarbonate reclamation C 04966 Collecting duct acid secretion B B 09156 Nervous system C 04724 Glutamatergic synapse C 04727 GABAergic synapse C 04725 Cholinergic synapse C 04728 Dopaminergic synapse C 04726 Serotonergic synapse C 04720 Long-term potentiation C 04730 Long-term depression C 04723 Retrograde endocannabinoid signaling C 04721 Synaptic vesicle cycle C 04722 Neurotrophin signaling pathway B B 09157 Sensory system C 04744 Phototransduction C 04745 Phototransduction - fly C 04740 Olfactory transduction C 04742 Taste transduction C 04750 Inflammatory mediator regulation of TRP channels B B 09158 Development and regeneration C 04320 Dorso-ventral axis formation C 04360 Axon guidance C 04361 Axon regeneration C 04380 Osteoclast differentiation B B 09149 Aging C 04211 Longevity regulating pathway C 04212 Longevity regulating pathway - worm C 04213 Longevity regulating pathway - multiple species B B 09159 Environmental adaptation C 04710 Circadian rhythm C 04713 Circadian entrainment C 04711 Circadian rhythm - fly C 04712 Circadian rhythm - plant C 04714 Thermogenesis C 04626 Plant-pathogen interaction # A09160 Human Diseases B B 09161 Cancer: overview C 05200 Pathways in cancer C 05202 Transcriptional misregulation in cancer C 05206 MicroRNAs in cancer C 05205 Proteoglycans in cancer C 05204 Chemical carcinogenesis - DNA adducts C 05207 Chemical carcinogenesis - receptor activation C 05208 Chemical carcinogenesis - reactive oxygen species C 05203 Viral carcinogenesis C 05230 Central carbon metabolism in cancer C 05231 Choline metabolism in cancer C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer B B 09162 Cancer: specific types C 05210 Colorectal cancer C 05212 Pancreatic cancer C 05225 Hepatocellular carcinoma C 05226 Gastric cancer C 05214 Glioma C 05216 Thyroid cancer C 05221 Acute myeloid leukemia C 05220 Chronic myeloid leukemia C 05217 Basal cell carcinoma C 05218 Melanoma C 05211 Renal cell carcinoma C 05219 Bladder cancer C 05215 Prostate cancer C 05213 Endometrial cancer C 05224 Breast cancer C 05222 Small cell lung cancer C 05223 Non-small cell lung cancer B B 09172 Infectious disease: viral C 05166 Human T-cell leukemia virus 1 infection C 05170 Human immunodeficiency virus 1 infection C 05161 Hepatitis B C 05160 Hepatitis C C 05171 Coronavirus disease - COVID-19 C 05164 Influenza A C 05162 Measles C 05168 Herpes simplex virus 1 infection C 05163 Human cytomegalovirus infection C 05167 Kaposi sarcoma-associated herpesvirus infection C 05169 Epstein-Barr virus infection C 05165 Human papillomavirus infection B B 09171 Infectious disease: bacterial C 05110 Vibrio cholerae infection C 05120 Epithelial cell signaling in Helicobacter pylori infection C 05130 Pathogenic Escherichia coli infection C 05132 Salmonella infection C 05131 Shigellosis C 05135 Yersinia infection C 05133 Pertussis C 05134 Legionellosis C 05150 Staphylococcus aureus infection C 05152 Tuberculosis C 05100 Bacterial invasion of epithelial cells B B 09174 Infectious disease: parasitic C 05146 Amoebiasis C 05144 Malaria C 05145 Toxoplasmosis C 05140 Leishmaniasis C 05142 Chagas disease C 05143 African trypanosomiasis B B 09163 Immune disease C 05310 Asthma C 05322 Systemic lupus erythematosus C 05323 Rheumatoid arthritis C 05320 Autoimmune thyroid disease C 05321 Inflammatory bowel disease C 05330 Allograft rejection C 05332 Graft-versus-host disease C 05340 Primary immunodeficiency B B 09164 Neurodegenerative disease C 05010 Alzheimer disease C 05012 Parkinson disease C 05014 Amyotrophic lateral sclerosis C 05016 Huntington disease C 05017 Spinocerebellar ataxia C 05020 Prion disease C 05022 Pathways of neurodegeneration - multiple diseases B B 09165 Substance dependence C 05030 Cocaine addiction C 05031 Amphetamine addiction C 05032 Morphine addiction C 05033 Nicotine addiction C 05034 Alcoholism B B 09166 Cardiovascular disease C 05417 Lipid and atherosclerosis C 05418 Fluid shear stress and atherosclerosis C 05410 Hypertrophic cardiomyopathy C 05412 Arrhythmogenic right ventricular cardiomyopathy C 05414 Dilated cardiomyopathy C 05415 Diabetic cardiomyopathy C 05416 Viral myocarditis B B 09167 Endocrine and metabolic disease C 04930 Type II diabetes mellitus C 04940 Type I diabetes mellitus C 04950 Maturity onset diabetes of the young C 04936 Alcoholic liver disease C 04932 Non-alcoholic fatty liver disease C 04931 Insulin resistance C 04933 AGE-RAGE signaling pathway in diabetic complications C 04934 Cushing syndrome B B 09175 Drug resistance: antimicrobial C 01501 beta-Lactam resistance [PATH:spy01501] D SPy_0012 hypothetical protein K01467 ampC; beta-lactamase class C [EC:3.5.2.6] D SPy_0294 oppB; oligopeptidepermease K15581 oppB; oligopeptide transport system permease protein D SPy_0295 oppC; oligopeptidepermease K15582 oppC; oligopeptide transport system permease protein D SPy_0296 oppD; oligopeptidepermease (ATP-binding protein) K15583 oppD; oligopeptide transport system ATP-binding protein D SPy_0297 oppF; oligopeptidepermease K10823 oppF; oligopeptide transport system ATP-binding protein D SPy_1649 pbp1A; putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D SPy_0097 pbp1b; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D SPy_2059 pbp2A; penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D SPy_1664 pbpX; putative penicillin binding protein 2X K12556 pbp2X; penicillin-binding protein 2X C 01502 Vancomycin resistance [PATH:spy01502] D SPy_1421 ddlA; putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D SPy_1802 alr; putative alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D SPy_1420 murF; putative D-Ala-D-Ala adding enzyme K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D SPy_1662 mraY; putative undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D SPy_1524 murG; putative undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D SPy_1765 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:spy01503] D SPy_2216 htrA; putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D SPy_0457 putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D SPy_1312 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D SPy_1311 dltB; putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D SPy_1310 dltC; putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D SPy_1309 dltD; putative extramembranal protein K03740 dltD; D-alanine transfer protein D SPy_2016 sic; inhibitor of complement-mediated lysis K19240 sic; inhibitor of complement-mediated lysis D SPy_2039 speB; pyrogenic exotoxin B K01364 speB; streptopain [EC:3.4.22.10] B B 09176 Drug resistance: antineoplastic C 01521 EGFR tyrosine kinase inhibitor resistance C 01524 Platinum drug resistance C 01523 Antifolate resistance C 01522 Endocrine resistance # A09180 Brite Hierarchies B B 09181 Protein families: metabolism C 01000 Enzymes [BR:spy01000] C 01001 Protein kinases [BR:spy01001] D SPy_1625 putative protein kinase K12132 prkC; eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1] D SPy_0529 vicK; two-component sensor histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D SPy_1236 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D SPy_0336 csrR; putative sensory transduction histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D SPy_2026 putative histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D SPy_1082 srtK; putative histidine kinase - lantibiotic associated K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3] D SPy_1622 putative two-component sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D SPy_1107 putative two-component sensor histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] D SPy_0242 putative histidine kinase, possibly involved in competence K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_1605 putative two-component responsible histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_0244 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] C 01009 Protein phosphatases and associated proteins [BR:spy01009] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D SPy_1626 pppL; putative phosphoprotein phosphatase K20074 prpC; PPM family protein phosphatase [EC:3.1.3.16] C 01002 Peptidases and inhibitors [BR:spy01002] D SPy_0826 lsp; putative prolipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] D SPy_1651 pepC; putative cysteine aminopeptidase C K01372 BLMH; bleomycin hydrolase [EC:3.4.22.40] D SPy_2039 speB; pyrogenic exotoxin B K01364 speB; streptopain [EC:3.4.22.10] D SPy_0506 pcp; putative pyrrolidone carboxyl peptidase K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3] D SPy_1204 guaA; putative GMP synthase K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D SPy_1119 conserved hypothetical protein K07010 K07010; putative glutamine amidotransferase D SPy_0019 putative secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D SPy_0026 purF; putative phosphoribosylpyrophosphate amidotransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D SPy_1280 glmS; putative L-glutamine-D-fructose-6-phosphate amidotransferase K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D SPy_0135 putative fimbria-associated protein K07284 srtA; sortase A [EC:3.4.22.70] D SPy_1154 hypothetical protein K07284 srtA; sortase A [EC:3.4.22.70] D SPy_0129 hypothetical protein K08600 srtB; sortase B [EC:3.4.22.71] D SPy_0713 pepD; putative dipeptidase K08659 pepDA; dipeptidase [EC:3.4.-.-] D SPy_0742 hypothetical protein K07052 K07052; CAAX protease family protein D SPy_1384 hypothetical protein K07052 K07052; CAAX protease family protein D SPy_1239 pepN; putative lysyl-aminopeptidase; aminopeptidase N K01256 pepN; aminopeptidase N [EC:3.4.11.2] D SPy_1393 pepB; putative oligopeptidase K08602 pepF; oligoendopeptidase F [EC:3.4.24.-] D SPy_2095 pepO; putative endopeptidase O K07386 pepO; putative endopeptidase [EC:3.4.24.-] D SPy_1765 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D SPy_1070 putative dipeptidase K01274 pepV; beta-Ala-Xaa dipeptidase [EC:3.4.13.-] D SPy_0799 pepT; putative tripeptidase K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4] D SPy_1354 map; putative methionine aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18] D SPy_0513 pepQ; putative XAA-PRO dipeptidase; X-PRO dipeptidase K01271 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9] D SPy_1824 pepP; putative aminopeptidase P; XAA-pro aminopeptidase K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] D SPy_0015 ftsH; putative cell division protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] D SPy_0115 pepA; putative glutamyl-aminopeptidase K01261 pepA; glutamyl aminopeptidase [EC:3.4.11.7] D SPy_0331 htpX; putative heat shock protein K03799 htpX; heat shock protein HtpX [EC:3.4.24.-] D SPy_1963 may be involved in production of a peptide sex pheromone K11749 rseP; regulator of sigma E protease [EC:3.4.24.-] D SPy_2216 htrA; putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D SPy_0416 prtS; putative cell envelope proteinase K01361 E3.4.21.96; lactocepin [EC:3.4.21.96] D SPy_2010 scpA; C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110] D SPy_1093 putative D,D-carboxypeptidase, penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D SPy_0292 dacA; penicillin-binding protein (D-alanyl-D-alanine carboxypeptidase) K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D SPy_0395 clpP; putative ATP-dependent protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] D SPy_1858 pepXP; putative X-Pro dipeptidyl-peptidase IV K01281 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11] D SPy_1536 conserved hypothetical protein K07177 K07177; Lon-like protease D SPy_1842 spi; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D SPy_1281 sipC; putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D SPy_0127 putative signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D SPy_0591 putative protease K08303 prtC; U32 family peptidase [EC:3.4.-.-] C 01003 Glycosyltransferases [BR:spy01003] D SPy_0516 putative glucosyl transferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] D SPy_2200 hasA; hyaluronate synthase K00752 hasA; hyaluronan synthase [EC:2.4.1.212] D SPy_0515 putative sugar transferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208] D SPy_1649 pbp1A; putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D SPy_0097 pbp1b; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D SPy_2059 pbp2A; penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D SPy_0282 rgpG; possibly involved in regulation of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 01005 Lipopolysaccharide biosynthesis proteins [BR:spy01005] D SPy_0786 rgpAc; conserved hypothetical protein - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide K12996 rgpA; rhamnosyltransferase [EC:2.4.1.-] D SPy_0787 rgpBc; putative rhamnosyltransferase - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide K12997 rgpB; rhamnosyltransferase [EC:2.4.1.-] D SPy_0791 rgpEc; putative glycosyltransferase - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide K12998 rgpE; glucosyltransferase [EC:2.4.1.-] D SPy_0792 rgpFc; conserved hypothetical protein - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide K07272 rgpF; rhamnosyltransferase [EC:2.4.1.-] D SPy_0282 rgpG; possibly involved in regulation of genetic competence K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D SPy_0510 putative sugar transferase K12999 rgpI; glucosyltransferase [EC:2.4.1.-] C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:spy01011] D SPy_1358 murZ; putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D SPy_0763 putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D SPy_1101 murB; putative UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D SPy_0345 murC; putative UDP-N-acetyl muramate-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D SPy_1525 murD; putative UDP-N-acetylmuramoylalanine-D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D SPy_0388 murE; putative UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] D SPy_1421 ddlA; putative D-ala,D-ala ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D SPy_1205 putative antimicrobial resistance factor K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D SPy_0616 murM; putative peptidoglycan branched peptide synthesis protein, serine/alanine adding enzyme K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D SPy_0615 murN; putative peptidoglycan branched peptide synthesis protein, alanine adding enzyme K12554 murN; alanine adding enzyme [EC:2.3.2.-] D SPy_1802 alr; putative alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D SPy_0361 glr; putative glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D SPy_1662 mraY; putative undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D SPy_1524 murG; putative undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D SPy_0280 bacA; putative undecaprenol kinase (bacitracin resistance protein) K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D SPy_0374 conserved hypothetical protein K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D SPy_1649 pbp1A; putative penicillin-binding protein 1a K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D SPy_0097 pbp1b; putative penicillin-binding protein 1b K03693 pbp1b; penicillin-binding protein 1B D SPy_2059 pbp2A; penicillin-binding protein 2a K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D SPy_1664 pbpX; putative penicillin binding protein 2X K12556 pbp2X; penicillin-binding protein 2X D SPy_1093 putative D,D-carboxypeptidase, penicillin-binding protein K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D SPy_0292 dacA; penicillin-binding protein (D-alanyl-D-alanine carboxypeptidase) K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D SPy_1765 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D SPy_0019 putative secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D SPy_0135 putative fimbria-associated protein K07284 srtA; sortase A [EC:3.4.22.70] D SPy_1154 hypothetical protein K07284 srtA; sortase A [EC:3.4.22.70] D SPy_0129 hypothetical protein K08600 srtB; sortase B [EC:3.4.22.71] D SPy_0348 putative aminodeoxychorismate lyase K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29] C 01004 Lipid biosynthesis proteins [BR:spy01004] D SPy_1750 fabD; putative malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D SPy_1754 fabH; putative beta-ketoacyl-[ACP] synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D SPy_1748 fabF; putative beta-ketoacyl-ACP synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D SPy_0440 putative dehydrogenease / oxidoreductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D SPy_1749 fabG; putative beta-ketoacyl-ACP reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D SPy_1746 fabZ; putative beta-hydroxyacyl-ACP dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D SPy_1751 fabK; putative trans-2-enoyl-ACP reductase II K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] D SPy_1758 phaB; putative enoyl CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] D SPy_0022 plsX; putative fatty acid/phospholipid synthesis protein K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D SPy_0908 conserved hypothetical protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D SPy_1410 putative 1-acylglycerol-3-phosphate O-acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] C 01008 Polyketide biosynthesis proteins C 01006 Prenyltransferases [BR:spy01006] D SPy_1498 fps; putative geranyltranstransferase (farnesyl diphosphate synthase) K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D SPy_1965 uppS; putative undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D SPy_0921 miaA; putative tRNA isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] C 01007 Amino acid related enzymes [BR:spy01007] D SPy_0239 gltX; putative glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D SPy_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D SPy_2207 trsA; putative tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D SPy_1941 cysS; putative cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D SPy_2151 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D SPy_0422 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D SPy_1513 ileS; putative isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D SPy_1568 valS; putative valine-tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D SPy_0173 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D SPy_0595 lysS; putative lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D SPy_2156 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D SPy_0651 asnS; putative asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D SPy_0559 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D SPy_2157 hisS; putative histidine-tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D SPy_1689 glyQ; putative glycyl-tRNA synthetase (alpha subunit) K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D SPy_1688 glyS; putative glycyl-tRNA synthetase (beta subunit) K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D SPy_1742 serS; putative seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D SPy_1962 proS; putative prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D SPy_0517 thrS; putative threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D SPy_1389 alaS; putative alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D SPy_0768 pheS; putative phenylalanyl-tRNA synthetase (alpha subunit) K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D SPy_0769 pheT; phenylalanyl-tRNA synthetase (beta subunit) K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D SPy_1779 putative aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] D SPy_0911 bcaT; putative branched-chain-amino-acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D SPy_1990 pabB; putative para-aminobenzoate synthetase K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] C 00199 Cytochrome P450 C 00194 Photosynthesis proteins [BR:spy00194] D SPy_0761 atpC; putative proton-translocating ATPase, epsiron subunit K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D SPy_0760 atpD; putative proton-translocating ATPase, beta subunit K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D SPy_0759 atpG; putative proton-translocating ATPase, gamma subunit K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D SPy_0758 atpA; putative proton-translocating ATPase, alpha subunit K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D SPy_0757 atpH; putative proton-translocating ATPase, delta subunit K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D SPy_0756 atpF; putative proton-translocating ATPase, subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b D SPy_0754 atpE; H+-transporting ATP synthase chain C K02110 ATPF0C; F-type H+-transporting ATPase subunit c D SPy_0755 atpB; putative proton-translocating ATPase a subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a B B 09182 Protein families: genetic information processing C 03000 Transcription factors [BR:spy03000] D SPy_1077 putative methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D SPy_1924 lacR.2; putative lactose phosphotransferase system repressor protein K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor D SPy_1712 lacR.1; putative lactose phosphotransferase system repressor protein K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor D SPy_0853 putative transcriptional repressor K03436 fruR2; DeoR family transcriptional regulator, fructose operon transcriptional repressor D SPy_1293 malR; putative maltose operon transcriptional repressor K02529 galR; LacI family transcriptional regulator, galactose operon repressor D SPy_0514 ccpA; catabolite control protein A K02529 galR; LacI family transcriptional regulator, galactose operon repressor D SPy_1535 putative ribose transport operon repressor K02529 galR; LacI family transcriptional regulator, galactose operon repressor D SPy_1817 scrR; putative sucrose operon repressor K03484 scrR; LacI family transcriptional regulator, sucrose operon repressor D SPy_2099 putative transcriptional regulator (GntR family) K03486 treR2; GntR family transcriptional regulator, trehalose operon transcriptional repressor D SPy_1202 putative transcription regulator, GntR family K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator D SPy_0715 putative transcriptional regulator (GntR family) K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator D SPy_1878 putative transcriptional regulator K03713 glnR; MerR family transcriptional regulator, glutamine synthetase repressor D SPy_0187 spf; Ferric transport regulator protein K09825 perR; Fur family transcriptional regulator, peroxide stress response regulator D SPy_1548 hypothetical protein K21828 arcR; CRP/FNR family transcriptional regulator, arginine deiminase pathway regulator D SPy_2172 conserved hypothetical protein K10947 K10947; PadR family transcriptional regulator D SPy_0450 putative metal-dependent transcriptional regulator K03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator D SPy_1362 birA; putative biotin operon repressor K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] D SPy_0037 hypothetical protein K20342 comR; HTH-type transcriptional regulator, regulator for ComX D SPy_0496 mutR; putative positive transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator D SPy_0533 putative positive regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor D SPy_2042 ropB; putative transcription regulator K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator D SPy_0268 purR; putative purine operon repressor K09685 purR; HTH-type transcriptional regulator, purine operon repressor D SPy_1120 conserved hypothetical protein K01926 rex; redox-sensing transcriptional repressor D SPy_1777 codY; putative transcriptional pleiotropic repressor K03706 codY; transcriptional pleiotropic repressor D SPy_1386 putative transcriptional regulator protein K07729 K07729; putative transcriptional regulator D SPy_1934 putative transcription regulator K07729 K07729; putative transcriptional regulator D SPy_0571 licT; putative transcription antiterminator K03488 licT; beta-glucoside operon transcriptional antiterminator D SPy_0181 putative transcriptional regulator K03493 bglG1; transcriptional antiterminator D SPy_1325 putative transcriptional antiterminator (BglG family) K03491 licR; probable licABCH operon transcriptional regulator D SPy_2217 spoJ; putative chromosome segregation protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D SPy_2150 ahrC; putative arginine repressor K03402 argR; transcriptional regulator of arginine metabolism D SPy_1549 ahrC.2; putative arginine repressor K03402 argR; transcriptional regulator of arginine metabolism D SPy_1763 hrcA; putative heat shock transcription repressor protein K03705 hrcA; heat-inducible transcriptional repressor D SPy_2074 ctsR; putative transcriptional regulator K03708 ctsR; transcriptional regulator of stress and heat shock response D SPy_0830 pyrR; putative pyrimidine regulatory protein K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D SPy_0338 conserved hypothetical protein K07738 nrdR; transcriptional repressor NrdR D SPy_0300 comX1.1; putative competence protein K12296 comX1_2; competence protein ComX D SPy_1902 comX1.2; ComX1-like protein K12296 comX1_2; competence protein ComX C 03021 Transcription machinery [BR:spy03021] D SPy_0080 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D SPy_0098 rpoB; putative DNA-dependent RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D SPy_0099 rpoC; DNA-dependent RNA polymerase, B' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D SPy_1895 rpoE; putative DNA-directed RNA polymerase (delta subunit) K03048 rpoE; DNA-directed RNA polymerase subunit delta D SPy_1630 conserved hypothetical protein K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D SPy_0782 rpoD; putative RNA polymerase sigma 42 protein K03086 rpoD; RNA polymerase primary sigma factor D SPy_1724 nusA; transcription termination-antitermination factor K02600 nusA; transcription termination/antitermination protein NusA D SPy_1818 nusB; putative transcriptional terminator K03625 nusB; transcription antitermination protein NusB D SPy_0164 nusG; putative transcription antitermination factor K02601 nusG; transcription termination/antitermination protein NusG D SPy_0349 greA; putative transcription elongation factor K03624 greA; transcription elongation factor GreA C 03019 Messenger RNA biogenesis [BR:spy03019] D SPy_0531 acpA; putative ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D SPy_1876 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D SPy_1020 conserved hypothetical protein K12574 rnj; ribonuclease J [EC:3.1.-.-] D SPy_1633 conserved hypothetical protein K18682 rny; ribonucrease Y [EC:3.1.-.-] D SPy_0503 putative exoribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D SPy_0267 cbf; putative CMP-binding factor K03698 cbf; 3'-5' exoribonuclease [EC:3.1.-.-] D SPy_1415 deaD; putative ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D SPy_1659 putative ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7] D SPy_0731 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D SPy_1946 pnpA; putative polynucleotide phosphorylase, alpha chain K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D SPy_1283 pfk; putative 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D SPy_1760 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D SPy_2070 groEL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D SPy_0652 conserved hypothetical protein K06958 rapZ; RNase adapter protein RapZ C 03041 Spliceosome C 03011 Ribosome [BR:spy03011] D SPy_0913 putative ribosomal protein S1-like DNA-binding protein K02945 RP-S1; small subunit ribosomal protein S1 D SPy_2092 rpsB; 30S ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2 D SPy_0056 rpsC; 30S ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3 D SPy_2178 rpsD; 30S ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4 D SPy_0069 rpsE; 30S ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5 D SPy_1831 rpsF; 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6 D SPy_0272 rpsG; 30S ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7 D SPy_0065 rpsH; 30S ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8 D SPy_1931 rpsI; ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9 D SPy_0047 rpsJ; 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10 D SPy_0078 rpsK; 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11 D SPy_0271 rpsL; 30S ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12 D SPy_0077 rpsM; 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13 D SPy_1871 rpsN2; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D SPy_0064 rpsN; 30S ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14 D SPy_1955 rpsO; 30S ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15 D SPy_0840 rpsP; 30S ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16 D SPy_0060 rpsQ; 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17 D SPy_1829 rpsR; 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18 D SPy_0053 rpsS; 30S ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19 D SPy_1234 rpsT; 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20 D SPy_0779 rpsU; 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21 D SPy_0461 rplA; 50S ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1 D SPy_0052 rplB; 50S ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2 D SPy_0049 rplC; 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3 D SPy_0050 rplD; 50S ribosomal protein L4 K02926 RP-L4; large subunit ribosomal protein L4 D SPy_0063 rplE; 50S ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5 D SPy_0066 rplF; 50S ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6 D SPy_2183 rplI; 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9 D SPy_1072 rplJ; 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10 D SPy_0460 rplK; 50S ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11 D SPy_1073 rplL; 50S ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12 D SPy_1932 rplM; 50S ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13 D SPy_0061 50S ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14 D SPy_0072 rplO; 50S ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15 D SPy_0057 rplP; 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16 D SPy_0067 rplR; 50S ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18 D SPy_0724 rplS; 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19 D SPy_0806 rplT; 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20 D SPy_0819 rplU; 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21 D SPy_0055 rplV; 50S ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22 D SPy_0051 rplW; 50S ribosomal protein L23 K02892 RP-L23; large subunit ribosomal protein L23 D SPy_0062 rplX; 50S ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24 D SPy_0822 rpmA; 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27 D SPy_1888 rpmB; 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28 D SPy_0059 rpmC; 50S ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29 D SPy_0071 rpmD; 50S ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30 D SPy_0717 rpmE; 50S ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31 D SPy_2159 rpmF; 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32 D SPy_2160 rpmG; 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33 D SPy_0250 rpmH; 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34 D SPy_0805 rpmI; 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35 D SPy_0076 rpmJ; 50S ribosomal protein B K02919 RP-L36; large subunit ribosomal protein L36 D SPy_r01 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r03 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r05 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r07 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r10 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r12 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r02 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r04 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r06 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r08 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r09 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r11 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA C 03009 Ribosome biogenesis [BR:spy03009] D SPy_0531 acpA; putative ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D SPy_0476 era; GTP-binding protein (GTPase) K03595 era; GTPase D SPy_1333 putative GTP-binding protein K03979 obgE; GTPase [EC:3.6.5.-] D SPy_1724 nusA; transcription termination-antitermination factor K02600 nusA; transcription termination/antitermination protein NusA D SPy_1818 nusB; putative transcriptional terminator K03625 nusB; transcription antitermination protein NusB D SPy_0164 nusG; putative transcription antitermination factor K02601 nusG; transcription termination/antitermination protein NusG D SPy_1398 putative 16S pseudouridylate synthetase K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19] D SPy_1337 rsuA; putative 16S pseudouridylate synthase K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19] D SPy_0262 ksgA; putative dimethyladenosine transferase K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] D SPy_1627 sunL; putative RNA-binding Sun protein K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176] D SPy_1232 conserved hypothetical protein K00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172] D SPy_1538 conserved hypothetical protein K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171] D SPy_1987 conserved hypothetical protein K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] D SPy_0329 gidB; putative glucose-inhibited division protein K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D SPy_1666 conserved hypothetical protein K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] D SPy_0406 conserved hypothetical protein K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198] D SPy_1497 hlyA1; putative hemolysin K06442 tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227] D SPy_1938 putative tRNA/rRNA methyltransferase K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185] D SPy_2215 conserved hypothetical protein K00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] D SPy_0808 conserved hypothetical protein K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] D SPy_1533 conserved hypothetical protein K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] D SPy_1346 putative RNA methyltransferase K03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] D SPy_0369 putative hypothetical protein K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] D SPy_0827 conserved hypothetical protein K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D SPy_2063 conserved hypothetical protein K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D SPy_1127 conserved hypothetical protein K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D SPy_1873 putative ribosomal-protein-alanine acetyltransferase K03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266] D SPy_0847 putative 16S rRNA processing protein K02860 rimM; 16S rRNA processing protein RimM D SPy_1988 putative methyltransferase K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] D SPy_2113 conserved hypothetical protein K07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-] D SPy_1940 conserved hypothetical proteins K11145 mrnC; mini-ribonuclease III [EC:3.1.26.-] D SPy_1415 deaD; putative ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D SPy_1659 putative ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7] D SPy_0263 conserved hypothetical protein K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D SPy_0341 pgdA; putative phosphoglycerate dehydrogenase K03977 engA; GTPase D SPy_1161 conserved hypothetical protein K14540 rbgA; ribosome biogenesis GTPase A D SPy_0922 putative GTP-binding protein K03665 hflX; GTPase D SPy_0306 conserved hypothetical protein K06948 yqeH; 30S ribosome assembly GTPase D SPy_1143 hypothetical protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D SPy_1981 relA; (p)ppGpp synthetase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D SPy_1719 rbfA; putative ribosome binding factor A K02834 rbfA; ribosome-binding factor A D SPy_1725 conserved hypothetical protein K09748 rimP; ribosome maturation factor RimP D SPy_2203 conserved hypothetical protein K14761 rlbA; ribosome-associated protein D SPy_0310 conserved hypothetical protein K09710 ybeB; ribosome-associated protein D SPy_0473 conserved hypothetical protein K07042 ybeY; probable rRNA maturation factor D SPy_0307 conserved hypothetical protein K07574 yhbY; RNA-binding protein D SPy_1613 conserved protein - function unknown K05808 hpf; ribosome hibernation promoting factor D SPy_0006 putative GTP-binding protein K06942 ychF; ribosome-binding ATPase D SPy_0334 conserved hypothetical protein K07040 yceD; DUF177 domain-containing protein C 03016 Transfer RNA biogenesis [BR:spy03016] D SPy_0924 conserved hypothetical proteins K00784 rnz; ribonuclease Z [EC:3.1.26.11] D SPy_0866 papS; putative poly(A) polymerase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-] D SPy_1962 proS; putative prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D SPy_1513 ileS; putative isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D SPy_0173 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D SPy_0422 metS; putative methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D SPy_2151 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D SPy_0595 lysS; putative lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D SPy_2156 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D SPy_1389 alaS; putative alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D SPy_0651 asnS; putative asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D SPy_0559 hypothetical protein K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D SPy_0517 thrS; putative threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D SPy_1742 serS; putative seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D SPy_1941 cysS; putative cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D SPy_1568 valS; putative valine-tRNA ligase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D SPy_2157 hisS; putative histidine-tRNA ligase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D SPy_0768 pheS; putative phenylalanyl-tRNA synthetase (alpha subunit) K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D SPy_0769 pheT; phenylalanyl-tRNA synthetase (beta subunit) K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D SPy_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D SPy_2207 trsA; putative tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D SPy_1980 conserved hypothetical protein K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96] D SPy_1730 hit; putative cell-cycle regulation histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D SPy_1726 conserved hypothetical protein K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] D SPy_1901 truA; putative tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] D SPy_1251 truB; putative tRNA pseudouridine 55 synthase K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25] D SPy_0816 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_1122 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_1143 hypothetical protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D SPy_0921 miaA; putative tRNA isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] D SPy_1071 thdF; putative thiophene degradation protein F K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-] D SPy_2185 gidA; glucose inhibited division protein K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D SPy_0246 rnpA; putative ribonuclease P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5] D SPy_1689 glyQ; putative glycyl-tRNA synthetase (alpha subunit) K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D SPy_1688 glyS; putative glycyl-tRNA synthetase (beta subunit) K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D SPy_0239 gltX; putative glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D SPy_0599 putative transcription regulator K03976 ybaK; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] D SPy_0122 possible transcriptional regulator K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-] D SPy_1173 gid; putative glucose-inhibited division protein K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74] D SPy_0849 trmD; putative tRNA (guanine-N1)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] D SPy_0930 conserved hypothetical protein K06967 trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217] D SPy_0371 putative rRNA methylase K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207] D SPy_0356 putative rRNA methylase K03437 spoU; RNA methyltransferase, TrmH family D SPy_2188 putative tRNA-(5-methylaminomethyl-2-thiouridylate) K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D SPy_1400 queA; putative S-adenosylmethionine-tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] D SPy_0642 conserved hypothetical protein K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6] D SPy_0233 conserved hypothetical protein K09765 queH; epoxyqueuosine reductase [EC:1.17.99.6] D SPy_0203 tgt; putative tRNA-guanine transglycosylase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29] D SPy_0817 thiI; putative thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] D SPy_0013 putative cell-cycle protein K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] D SPy_1874 putative glycoprotein endopeptidase K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB D SPy_1872 putative glycoprotein endopeptidase K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234] D SPy_1735 conserved hypothetical protein K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE D SPy_0314 conserved hypothetical protein K27343 tmcAL; tRNA(Met) cytidine acetate ligase [EC:6.3.4.-] D SPy_0503 putative exoribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1] D SPy_1946 pnpA; putative polynucleotide phosphorylase, alpha chain K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] C 03012 Translation factors [BR:spy03012] D SPy_1721 infB; putative initiation factor 2 K02519 infB; translation initiation factor IF-2 D SPy_0804 infC; putative translation initiation factor 3 (IF3) K02520 infC; translation initiation factor IF-3 D SPy_1025 putative ABC transporter (ATP-binding protein) K06158 ABCF3; ATP-binding cassette, subfamily F, member 3 D SPy_2093 tsf; putative elongation factor TS K02357 tsf; elongation factor Ts D SPy_0611 tufA; putative translation elongation factor EF-Tu K02358 tuf; elongation factor Tu D SPy_0273 fus; translation elongation factor G, EF-G K02355 fusA; elongation factor G D SPy_1141 prfA; putative peptide chain release factor 1 K02835 prfA; peptide chain release factor 1 D SPy_0463 rrf; putative ribosome recycling factor K02838 frr; ribosome recycling factor D SPy_1142 hemK; putative protoporphyrinogen oxidase K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297] D SPy_0007 pth; putative peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] D SPy_0075 infA; putative translation initiation factor IF-1 K02518 infA; translation initiation factor IF-1 D SPy_1821 efp; putative translation elongation factor EF-P K02356 efp; elongation factor P D SPy_0643 prfB; putative peptide chain release factor 2 K02836 prfB; peptide chain release factor 2 D SPy_1416 prfC; putative peptide-chain-release factor 3 K02837 prfC; peptide chain release factor 3 C 03110 Chaperones and folding catalysts [BR:spy03110] D SPy_2073 clpC; putative endopeptidase Clp ATP-binding chain C K03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC D SPy_1509 clpE; putative ATP-dependent protease K03697 clpE; ATP-dependent Clp protease ATP-binding subunit ClpE D SPy_0888 clpL; putative ATP-dependent Clp proteinase (ATP-binding subunit) K04086 clpL; ATP-dependent Clp protease ATP-binding subunit ClpL D SPy_0885 clpX; putative ATP-dependent Clp protease subunit X K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX D SPy_1760 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D SPy_2070 groEL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D SPy_1759 dnaJ; heat-shock (chaperone) protein K03686 dnaJ; molecular chaperone DnaJ D SPy_0123 putative heat shock protein HSP33 K04083 hslO; molecular chaperone Hsp33 D SPy_1761 grpE; putative Hsp-70 cofactor K03687 GRPE; molecular chaperone GrpE D SPy_2072 groES; heat shock protein - cochaperonin K04078 groES; chaperonin GroES D SPy_2216 htrA; putative serine protease K04771 degP; serine protease Do [EC:3.4.21.107] D SPy_0015 ftsH; putative cell division protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] D SPy_0755 atpB; putative proton-translocating ATPase a subunit K02108 ATPF0A; F-type H+-transporting ATPase subunit a D SPy_0416 prtS; putative cell envelope proteinase K01361 E3.4.21.96; lactocepin [EC:3.4.21.96] D SPy_2010 scpA; C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110] D SPy_0457 putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D SPy_1390 putative protease maturation protein K07533 prsA; foldase protein PrsA [EC:5.2.1.8] D SPy_2037 conserved hypothetical K07533 prsA; foldase protein PrsA [EC:5.2.1.8] D SPy_1835 trx; putative thioredoxin K03671 TXN; thioredoxin C 04131 Membrane trafficking [BR:spy04131] D SPy_1604 conserved hypothetical protein K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] D SPy_0274 plr; glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D SPy_1429 gpmA; putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D SPy_1282 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] C 04121 Ubiquitin system C 03051 Proteasome C 03032 DNA replication proteins [BR:spy03032] D SPy_1077 putative methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D SPy_1489 hlpA; histone-like DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D SPy_0002 dnaA; Chromosomal initiator protein K02313 dnaA; chromosomal replication initiator protein D SPy_2182 holB; DNA polymerase III delta prime subunit K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D SPy_0781 dnaG; putative DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D SPy_0339 hypothetical protein K03346 dnaB; replication initiation and membrane attachment protein D SPy_0340 dnaI; putative primosome component (helicase loader) K11144 dnaI; primosomal protein DnaI D SPy_1830 putative single strand binding protein - phage associated K03111 ssb; single-strand DNA-binding protein D SPy_1284 dnaE; putative DNA polymerase III (alpha subunit) K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D SPy_1961 polC; DNA polymerase III (alpha subunit) K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D SPy_0003 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D SPy_1407 holA; DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D SPy_0400 putative DNA polymerase III delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D SPy_1864 dnaQ; putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D SPy_1364 dnaX; DNA polymerase III subunits gamma / tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D SPy_1162 rnh; putative ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D SPy_1841 putative ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4] D SPy_0185 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D SPy_0751 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D SPy_1152 gyrA; DNA gyrase A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D SPy_0727 gyrB; putative DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D SPy_0910 parC; putative DNA topoisomerase IV (subunit C) K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D SPy_0909 parE; putative DNA topoisomerase IV (subunit B) K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D SPy_1164 topA; putative DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] C 03036 Chromosome and associated proteins [BR:spy03036] D SPy_1077 putative methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D SPy_0531 acpA; putative ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D SPy_1489 hlpA; histone-like DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D SPy_0002 dnaA; Chromosomal initiator protein K02313 dnaA; chromosomal replication initiator protein D SPy_1531 dpr; putative peroxide resistance protein K04047 dps; starvation-inducible DNA-binding protein D SPy_0532 smc; putative chromosome segregation SMC protein K03529 smc; chromosome segregation protein D SPy_0366 conserved hypothetical protein K05896 scpA; segregation and condensation protein A D SPy_0367 conserved hypothetical protein K06024 scpB; segregation and condensation protein B D SPy_1521 ftsA; cell division protein K03590 ftsA; cell division protein FtsA D SPy_0010 divIC; putative cell division protein (DivIC) K13052 divIC; cell division protein DivIC D SPy_0644 ftsE; putative cell-division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D SPy_0458 conserved hypothetical protein K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family D SPy_1665 ftsL; putative cell division protein K03586 ftsL; cell division protein FtsL D SPy_1523 divIB; cell division protein K03589 ftsQ; cell division protein FtsQ D SPy_0609 ftsW; putative cell division protein K03588 ftsW; cell division protein FtsW D SPy_0645 ftsX; putative cell-division protein K09811 ftsX; cell division transport system permease protein D SPy_1520 ftsZ; putative cell division protein K03531 ftsZ; cell division protein FtsZ D SPy_0728 conserved hypothetical protein K06286 ezrA; septation ring formation regulator D SPy_1514 divIVAS; cell-division initiation protein (septum placement) K04074 divIVA; cell division initiation protein D SPy_1518 conserved hypothetical protein K09772 sepF; cell division inhibitor SepF D SPy_2217 spoJ; putative chromosome segregation protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D SPy_0910 parC; putative DNA topoisomerase IV (subunit C) K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D SPy_0909 parE; putative DNA topoisomerase IV (subunit B) K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D SPy_2185 gidA; glucose inhibited division protein K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D SPy_0329 gidB; putative glucose-inhibited division protein K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D SPy_1173 gid; putative glucose-inhibited division protein K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74] D SPy_0886 conserved hypothetical GTP-binding protein K03978 engB; GTP-binding protein D SPy_0654 conserved hypothetical protein K09762 whiA; cell division protein WhiA C 03400 DNA repair and recombination proteins [BR:spy03400] D SPy_1505 phr; putative deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] D SPy_0905 ung; putative uracil DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D SPy_1833 mutY; putative A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D SPy_0929 nth; putative endonuclease III (DNA repair) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D SPy_1010 mutX; putative 7,8-dihydro-8-oxoguanine-triphosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D SPy_1510 mutT; putative mutator protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D SPy_0235 putative dUTPase, phage associated K01520 dut; dUTP diphosphatase [EC:3.6.1.23] D SPy_2118 tag; putative 3-methyl-adenine DNA glycosylase I, constitutive K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D SPy_0497 fpg; putative formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D SPy_0412 exoA; putative 3'-exo-deoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D SPy_0926 recJ; putative single-strand DNA-specific exonuclease K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D SPy_0751 lig; putative DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D SPy_0185 polA; DNA-directed DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D SPy_1825 uvrA; putative excinuclease ABC (subunit A) K03701 uvrA; excinuclease ABC subunit A D SPy_1314 uvrB; putative excinuclease ABC (subunit B) K03702 uvrB; excinuclease ABC subunit B D SPy_1068 uvrC; excinuclease ABC (subunit C) K03703 uvrC; excinuclease ABC subunit C D SPy_1267 pcrA; putative ATP-dependent DNA helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D SPy_0098 rpoB; putative DNA-dependent RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D SPy_0099 rpoC; DNA-dependent RNA polymerase, B' subunit K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D SPy_0080 rpoA; DNA-directed RNA polymerase alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D SPy_1895 rpoE; putative DNA-directed RNA polymerase (delta subunit) K03048 rpoE; DNA-directed RNA polymerase subunit delta D SPy_1630 conserved hypothetical protein K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D SPy_0008 trcF; putative transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D SPy_2148 mutS; putative DNA mismatch repair protein K03555 mutS; DNA mismatch repair protein MutS D SPy_1837 mutS2; putative DNA mismatch repair protein K07456 mutS2; DNA mismatch repair protein MutS2 D SPy_2121 mutL; putative DNA mismatch repair protein K03572 mutL; DNA mismatch repair protein MutL D SPy_1500 xseA; putative exodeoxyribonuclease VII (large subunit) K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D SPy_1499 xseB; exodeoxyribonuclease VII (small subunit) K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D SPy_1284 dnaE; putative DNA polymerase III (alpha subunit) K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D SPy_1961 polC; DNA polymerase III (alpha subunit) K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D SPy_0003 dnaN; beta subunit of DNA polymerase III K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D SPy_1407 holA; DNA polymerase III delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D SPy_0400 putative DNA polymerase III delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D SPy_1864 dnaQ; putative DNA polymerase III epsilon subunit K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D SPy_1364 dnaX; DNA polymerase III subunits gamma / tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D SPy_1830 putative single strand binding protein - phage associated K03111 ssb; single-strand DNA-binding protein D SPy_1844 putative exodeoxyribonuclease V (alpha subunit) K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] D SPy_2116 recA; recombination protein K03553 recA; recombination protein RecA D SPy_2119 ruvA; putative Holiday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA D SPy_0038 ruvB; putative Holliday junction DNA helicase, subunit B K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D SPy_1629 priA; putative primosomal replication factor Y K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] D SPy_0236 sms; putative DNA repair protein K04485 radA; DNA repair protein RadA/Sms D SPy_2204 recF; RecF protein K03629 recF; DNA replication and repair protein RecF D SPy_1785 recG; putative ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D SPy_0021 conserved hypothetical protein K03584 recO; DNA repair protein RecO (recombination protein O) D SPy_1422 recR; putative recombination protein K06187 recR; recombination protein RecR D SPy_1495 recN; putative DNA repair and genetic recombination protein K03631 recN; DNA repair protein RecN (Recombination protein N) D SPy_1648 recU; putative recombination protein U K03700 recU; recombination protein U D SPy_0777 rexA; putative ATP-dependent exonuclease, subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-] D SPy_0776 rexB; putative ATP-dependent exonuclease, subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-] D SPy_1562 conserved hypothetical protein K15342 cas1; CRISP-associated protein Cas1 D SPy_0500 conserved hypothetical protein K06915 herA; DNA double-strand break repair helicase HerA and related ATPase D SPy_1152 gyrA; DNA gyrase A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D SPy_0727 gyrB; putative DNA gyrase, subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D SPy_1164 topA; putative DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] D SPy_1489 hlpA; histone-like DNA-binding protein K03530 hupB; DNA-binding protein HU-beta D SPy_1477 putative recombinase - phage associated K07455 recT; recombination protein RecT D SPy_1846 dinP; putative DNA-damage-inducible protein P K02346 dinB; DNA polymerase IV [EC:2.7.7.7] D SPy_1607 conserved hypothetical protein K03565 recX; regulatory protein D SPy_0649 dinG; putative ATP-dependent DNA helicase K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3] D SPy_1375 nrdE.2; putative ribonucleotide reductase alpha-chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D SPy_0427 nrdE.1; ribonucleoside-diphosphate reductase, large chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D SPy_1378 nrdF.2; ribonucleotide diphosphate reductase small subunit K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D SPy_0425 nrdF.1; putative ribonucleotide reductase 2 K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D SPy_0720 conserved hypothetical protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] C 03029 Mitochondrial biogenesis [BR:spy03029] D SPy_1721 infB; putative initiation factor 2 K02519 infB; translation initiation factor IF-2 D SPy_0804 infC; putative translation initiation factor 3 (IF3) K02520 infC; translation initiation factor IF-3 D SPy_2093 tsf; putative elongation factor TS K02357 tsf; elongation factor Ts D SPy_0611 tufA; putative translation elongation factor EF-Tu K02358 tuf; elongation factor Tu D SPy_0273 fus; translation elongation factor G, EF-G K02355 fusA; elongation factor G D SPy_0476 era; GTP-binding protein (GTPase) K03595 era; GTPase D SPy_0096 tyrS; putative tyrosine-tRNA ligase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D SPy_0173 leuS; putative leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D SPy_2156 aspS; putative aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D SPy_2151 argS; putative arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D SPy_1771 gatA; putative Glutamyl-tRNA Gln amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] D SPy_1770 gatB; putative Glu-tRNAGln amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] D SPy_1772 gatC; putative Glu-tRNA Gln amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] D SPy_1830 putative single strand binding protein - phage associated K03111 ssb; single-strand DNA-binding protein D SPy_1760 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D SPy_1761 grpE; putative Hsp-70 cofactor K03687 GRPE; molecular chaperone GrpE D SPy_2070 groEL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D SPy_2072 groES; heat shock protein - cochaperonin K04078 groES; chaperonin GroES D SPy_1759 dnaJ; heat-shock (chaperone) protein K03686 dnaJ; molecular chaperone DnaJ D SPy_0816 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_1122 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_0247 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_0351 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase B B 09183 Protein families: signaling and cellular processes C 02000 Transporters [BR:spy02000] D SPy_0229 putative ABC transporter, ATP-binding protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump D SPy_0230 putative ABC transporter (ATP-binding protein) K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump D SPy_1148 putative ABC transporter (ATP-binding protein) K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump D SPy_1149 putative ABC transporter (ATP-binding protein) K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump D SPy_1790 putative ABC transporter (ATP-binding protein) K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial D SPy_1791 putative ABC transporter (ATP-binding protein) K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial D SPy_0867 putative ABC transporter (ATP-binding protein) K15738 uup; ABC transport system ATP-binding/permease protein D SPy_1084 srtT; ABC transporter (ATP binding) - lantibiotic associated K02021 ABC.MR; putative ABC transport system ATP-binding protein D SPy_1063 putative periplasmic-iron-binding protein K02012 afuA; iron(III) transport system substrate-binding protein D SPy_1105 potD; putative spermidine/putrescine ABC transporter (periplasmic transport protein) K11069 potD; spermidine/putrescine transport system substrate-binding protein D SPy_1104 potC; putative spermidine/putrescine ABC transporter (permease protein) K11070 potC; spermidine/putrescine transport system permease protein D SPy_1103 potB; putative spermidine / putrescine ABC transporter (permease protein) K11071 potB; spermidine/putrescine transport system permease protein D SPy_1102 potA; putative spermidine / putrescine ABC transporter (ATP-binding protein) K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11] D SPy_0184 opuABC; putative glycine-betaine binding permease protein K02001 proW; glycine betaine/proline transport system permease protein D SPy_0183 opuAA; putative glycine betaine/proline ABC transporter (ATP-binding protein) K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D SPy_1134 putative ABC transporter (binding protein) K05845 opuC; osmoprotectant transport system substrate-binding protein D SPy_1133 putative ABC transporter (ATP-binding protein) K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D SPy_1976 msmK; multiple sugar-binding ABC transport system (ATP-binding protein) K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] D SPy_1306 malX; maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D SPy_1294 putative maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D SPy_1295 malF; putative maltose/maltodextrin ABC transport system (permease) K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1301 malC; maltodextrin transport system permease K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1296 malG; putative maltose/maltodextrin ABC transport system (permease) K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1299 malD; putative maltodextrin transport system permease K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D SPy_1592 putative ABC transporter substrate binding lipoprotein K17318 lplA; putative aldouronate transport system substrate-binding protein D SPy_1595 putative sugar-binding transport protein K17319 lplB; putative aldouronate transport system permease protein D SPy_1593 putative sugar-binding transport protein K17320 lplC; putative aldouronate transport system permease protein D SPy_1228 putative lipoprotein K07335 bmpA; basic membrane protein A and related proteins D SPy_0163 putative ABC transporter (lipoprotein) K07335 bmpA; basic membrane protein A and related proteins D SPy_1226 putative sugar ABC transporter (permease protein) K23535 nupB; general nucleoside transport system permease protein D SPy_1225 putative sugar ABC transporter (permease protein) K23536 nupC; general nucleoside transport system permease protein D SPy_1227 putative sugar ABC transporter (ATP-binding protein) K23537 nupA; general nucleoside transport system ATP-binding protein D SPy_0252 putative sugar transporter sugar binding lipoprotein K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein D SPy_0254 sugar transport system (permease) K02025 ABC.MS.P; multiple sugar transport system permease protein D SPy_0255 probable sugar transport protein (permease) K02026 ABC.MS.P1; multiple sugar transport system permease protein D SPy_1245 pstS; putative phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D SPy_1244 pstC2; putative phosphate ABC transporter (permease protein) K02037 pstC; phosphate transport system permease protein D SPy_1243 pstC; putative phosphate ABC transporter (permease protein) K02038 pstA; phosphate transport system permease protein D SPy_1241 pstB; phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D SPy_1242 pstB2; putative phosphate ABC transporter (ATP-binding protein) K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D SPy_1315 hypothetical protein K10036 glnH; glutamine transport system substrate-binding protein D SPy_1316 putative ABC transporter (ATP-binding protein) K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] D SPy_0903 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D SPy_0317 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein D SPy_0904 putative ABC transporter (permease) K10009 tcyB; L-cystine transport system permease protein D SPy_1658 putative amino acid ABC transproter (permease protein) K10009 tcyB; L-cystine transport system permease protein D SPy_1657 putative amino acid ABC transport system (ATP-binding protein) K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] D SPy_0778 putative ABC transporter (substrate-binding protein) K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein D SPy_1507 putative amino acid ABC transporter (permease protein) K17077 artQ; arginine/lysine/histidine transport system permease protein D SPy_1506 putative amino acid ABC transporter (ATP-binding protein) K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1] D SPy_0319 conserved hypothetical protein K02073 metQ; D-methionine transport system substrate-binding protein D SPy_0321 putative ABC transporter (permease protein) K02072 metI; D-methionine transport system permease protein D SPy_0320 putative ABC transporter (ATP-binding protein)h K02071 metN; D-methionine transport system ATP-binding protein D SPy_1016 conserved hypothetical protein K01989 K01989; putative tryptophan/tyrosine transport system substrate-binding protein D SPy_1018 putative ABC transport protein (permease) K05832 K05832; putative tryptophan/tyrosine transport system permease protein D SPy_1019 putative ABC transporter (ATP-binding protein) K05833 K05833; putative tryptophan/tyrosine transport system ATP-binding protein D SPy_0277 putative glutamine-binding periplasmic protein K17073 lysX1; putative lysine transport system substrate-binding protein D SPy_0276 putative amino acid ABC transporter (ATP-binding protein) K17076 lysY; putative lysine transport system ATP-binding protein D SPy_1274 putative amino acid ABC transporter, periplasmic amino acid-binding protein K02030 ABC.PA.S; polar amino acid transport system substrate-binding protein D SPy_1276 putative amino acid ABC transporter (permease protein) K02029 ABC.PA.P; polar amino acid transport system permease protein D SPy_1275 putative amino acid ABC transporter (ATP-binding protein) K02028 ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:7.4.2.1] D SPy_0294 oppB; oligopeptidepermease K15581 oppB; oligopeptide transport system permease protein D SPy_0295 oppC; oligopeptidepermease K15582 oppC; oligopeptide transport system permease protein D SPy_0296 oppD; oligopeptidepermease (ATP-binding protein) K15583 oppD; oligopeptide transport system ATP-binding protein D SPy_0297 oppF; oligopeptidepermease K10823 oppF; oligopeptide transport system ATP-binding protein D SPy_2000 dppA; surface lipoprotein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D SPy_2001 dppB; transmembrane transport protein K02033 ABC.PE.P; peptide/nickel transport system permease protein D SPy_2002 dppC; transmembrane transport protein K02034 ABC.PE.P1; peptide/nickel transport system permease protein D SPy_2003 dppD; ATPase protein K02031 ddpD; peptide/nickel transport system ATP-binding protein D SPy_2004 dppE; ATPase protein K02032 ddpF; peptide/nickel transport system ATP-binding protein D SPy_0385 fhuD; ferrichrome ABC transporter (ferrichrome-binding protein) K25308 fhuD; ferric hydroxamate/heme transport system substrate-binding protein D SPy_0384 fhuB.1; putative ferrichrome ABC transporter (permease) K25288 fhuB; ferric hydroxamate/heme transport system permease protein D SPy_0383 fhuG; putative ferrichrome ABC transporter (permease) K25289 fhuG; ferric hydroxamate/heme transport system permease protein D SPy_0386 fhuA; putative ferrichrome ABC transporter (ATP-binding protein) K25290 fhuA; ferric hydroxamate/heme transport system ATP-binding protein [EC:7.2.2.16] D SPy_1795 putative ABC transporter (periplasmic binding protein) K25113 htsA; heme transport system substrate-binding protein D SPy_1794 putative ABC transporter (permease) K25114 htsB; heme transport system permease protein D SPy_1793 putative ABC transporter (ATP-binding protein) K25115 htsC; heme transport system ATP-binding protein [EC:7.6.2.5] D SPy_1796 hypothetical protein K25119 shp; heme transport system cell surface heme-binding protein D SPy_1798 hypothetical protein sharing similarity with several eukaryotic proteins K25120 shr; heme sequestration protein D SPy_0714 adcA; putative adhesion protein K09815 znuA; zinc transport system substrate-binding protein D SPy_2007 lmb; putative laminin adhesion K09815 znuA; zinc transport system substrate-binding protein D SPy_0094 adcB; putative ABC transporter (permease) K09816 znuB; zinc transport system permease protein D SPy_0093 adcC; ABC transporter (ATP-binding protein) K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20] D SPy_0453 mtsA; metal binding protein of ABC transporter (lipoprotein) K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein D SPy_0456 mtsC; ABC transporter (permease protein) K11705 mtsC; iron/zinc/manganese/copper transport system permease protein D SPy_0454 mtsB; ABC transporter (ATP-binding protein) K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein D SPy_0207 putative biotin synthase K03523 bioY; biotin transport system substrate-specific component D SPy_1789 hypothetical protein K16926 htsT; energy-coupling factor transport system substrate-specific component D SPy_0603 hypothetical protein K16927 cbrT; energy-coupling factor transport system substrate-specific component D SPy_2193 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D SPy_1788 conserved hypothetical protein K16785 ecfT; energy-coupling factor transport system permease protein D SPy_2195 ABC transporter (ATP-binding protein) K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D SPy_2194 putative ABC transporter (ATP-binding protein) K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D SPy_1787 putative ABC transporter (ATP-binding protein) K01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D SPy_1086 srtE; conserved hypothetical protein - lantibiotic associated K20491 nisE; lantibiotic transport system permease protein D SPy_1087 srtG; conserved hypothetical protein - lantibiotics associated K20492 nisG; lantibiotic transport system permease protein D SPy_1085 srtF; ABC transporter (ATP-binding) - lantibiotic associated K20490 nisF; lantibiotic transport system ATP-binding protein D SPy_0746 putative ABC transporter (ATP-binding protein) K25142 lnrN; linearmycin/streptolysin S transport system permease protein D SPy_0745 sagH; ABC transporter (ATP-binding protein) - streptolysin S associated ORF K25143 lnrM; linearmycin/streptolysin S transport system permease protein D SPy_0744 putative ABC transporter (ATP-binding protein) K25144 lnrL; linearmycin/streptolysin S transport system ATP-binding protein D SPy_0838 conserved hypothetical protein K24948 yknZ; antimicrobial peptide resistance transport system permease protein D SPy_2029 putative ABC transporter (ATP-binding protein) K24948 yknZ; antimicrobial peptide resistance transport system permease protein D SPy_0837 putative ABC transporter (ATP-binding protein) K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-] D SPy_2031 putative ABC transporter (ATP-binding protein) K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-] D SPy_0645 ftsX; putative cell-division protein K09811 ftsX; cell division transport system permease protein D SPy_0644 ftsE; putative cell-division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D SPy_0521 conserved hypothetical protein K25154 evrC; viologen exporter family transport system permease protein D SPy_0519 conserved hypothetical protein K25155 evrB; viologen exporter family transport system permease protein D SPy_0518 putative ABC transporter (ATP-binding protein) K25156 evrA; viologen exporter family transport system ATP-binding protein D SPy_1728 putative ABC transporter (permease) K25157 ecsB; ABC-2 type transport system permease protein D SPy_1729 putative ABC transporter (ATP-binding protein) K25158 ecsA; ABC-2 type transport system ATP-binding protein D SPy_0789 rgpCc; putative ABC-transporter (permease protein) - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide K01992 ABC-2.P; ABC-2 type transport system permease protein D SPy_1673 hypothetical protein K01992 ABC-2.P; ABC-2 type transport system permease protein D SPy_1783 hypothetical protein K01992 ABC-2.P; ABC-2 type transport system permease protein D SPy_1286 putative ABC transporter (ATP-binding protein) K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D SPy_0790 rgpDc; ABC-transporter (ATP-binding protein) - possibly involved in cell wall localization and side chain formation of rhamnose-glucose polysaccharide K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D SPy_1674 putative ABC transporter (ATP-binding protein) K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D SPy_1784 putative ABC transporter (ATP-binding protein) K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D SPy_1255 hypothetical protein K02004 ABC.CD.P; putative ABC transport system permease protein D SPy_1911 salY; putative ABC transporter (permease) associated with salivaricin lantibiotic K02004 ABC.CD.P; putative ABC transport system permease protein D SPy_0772 conserved hypothetical protein K02004 ABC.CD.P; putative ABC transport system permease protein D SPy_1257 putative ABC transporter (ATP-binding protein) K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D SPy_1912 salX; putative salivaricin A ABC transporter (ATP-binding protein) K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D SPy_0773 putative ABC transporter (ATP-binding protein) K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D SPy_0285 putative ABC transporter (ATP-binding protein) K09013 sufC; Fe-S cluster assembly ATP-binding protein D SPy_0045 conserved hypothetical protein K26937 dinF; MATE family, multidrug efflux pump D SPy_1392 putative oxalate:formate antiporter K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter D SPy_0442 putative glycerol-3-phosphate transporter K02445 glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter D SPy_0501 putative multi-drug resistance efflux pump K08161 mdtG; MFS transporter, DHA1 family, multidrug resistance protein D SPy_2120 lmrP; putative integral membrane protein K08152 lmrP; MFS transporter, DHA1 family, multidrug resistance protein B D SPy_0570 putative drug resistance protein K18926 lmrB; MFS transporter, DHA2 family, lincomycin resistance protein D SPy_1372 pstI; putative phosphoenolpyruvate:sugar phosphotransferase system enzyme I K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] D SPy_1373 ptsH; putative phosphotransferase system phosphohistidine-containing protein K02784 ptsH; phosphocarrier protein HPr D SPy_1986 putative PTS system, enzyme II, A component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D SPy_1815 scrA; putative sucrose-specific PTS permease, enzyme II K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D SPy_0572 beta-glucoside permease IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-] D SPy_2097 putative PTS system enzyme II K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D SPy_0855 putative fructose-specific enzyme II, PTS system BC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D SPy_1918 lacF; putative PTS system, lactose-specific component IIA K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D SPy_1917 lacE; putative PTS system, lactose-specific component IIBC K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D SPy_2052 putative PTS system, enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D SPy_1323 putative PTS enzyme III K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D SPy_2051 putative PTS system, enzyme IIB K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D SPy_1324 putative PTS system enzyme II K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D SPy_2050 putative PTS system, enzyme IIC component K02761 celB; cellobiose PTS system EIIC component D SPy_1711 putative PTS system, enzyme IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204] D SPy_1710 putative PTS system, enzyme IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204] D SPy_1709 putative PTS system, enzyme IIC component K20114 gatC; galactose PTS system EIIC component D SPy_1738 manL; mannose-specific phosphotransferase system component IIAB K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D SPy_1057 hypothetical protein K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D SPy_1739 manM; putative mannose-specific phosphotransferase system component IIC K02795 manY; mannose PTS system EIIC component D SPy_1059 putative phospotransferase system (PTS), enzyme II, component C K02795 manY; mannose PTS system EIIC component D SPy_1740 manN; putative mannose-specific phosphotransferase system component IID K02796 manZ; mannose PTS system EIID component D SPy_1060 putative phospotransferase system (PTS), enzyme II component D K02796 manZ; mannose PTS system EIID component D SPy_1058 putative phosphotransferase system (PTS), enzyme II component B K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-] D SPy_0634 agaF; putative PTS dependent N-acetyl-galactosamine- and galactosamine IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D SPy_0631 agaV; putative PTS dependent N-acetyl-galactosamine-IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D SPy_0630 agaW; putative PTS dependent N-acetyl-galactosamine-IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D SPy_0629 agaD; putative PTS dependent galactosamine IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D SPy_0176 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D SPy_1952 conserved hypothetical protein K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D SPy_0175 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D SPy_1950 conserved hypothetical protein K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D SPy_0174 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D SPy_1949 conserved hypothetical protein K03475 ulaA; ascorbate PTS system EIIC component D SPy_1854 glpF.2; putative glycerol uptake facilitator protein K02440 glpF; glycerol uptake facilitator D SPy_1682 glpF; putative glycerol uptake facilitator K02440 glpF; glycerol uptake facilitator D SPy_0917 hypothetical protein K00799 GST; glutathione S-transferase [EC:2.5.1.18] D SPy_1424 putative formate dehydrogenase K21993 fdhC; formate transporter D SPy_0780 mscL; putative large conductance mechanosensitive channel K03282 mscL; large conductance mechanosensitive channel D SPy_1897 conserved hypothetical protein K22044 ybiO; moderate conductance mechanosensitive channel D SPy_1827 putative divalent cation transport protein K03284 corA; magnesium transporter D SPy_0378 hlyX; putative hemolysin K03699 tlyC; magnesium and cobalt exporter, CNNM family D SPy_0845 czcD; putative cation-efflux system membrane protein K16264 czcD; cobalt-zinc-cadmium efflux system protein D SPy_2205 conserved hypothetical protein K05340 glcU; glucose uptake protein D SPy_0324 putative sodium/dicarboxylate symporter K07862 sstT; serine/threonine transporter D SPy_0327 ntpJ; putative V-type Na+ -ATPase subunit J K03498 trkH; trk/ktr system potassium uptake protein D SPy_0326 conserved hypothetical protein K03499 trkA; trk/ktr system potassium uptake protein D SPy_0831 pyrP; putative uracil permease K02824 uraA; uracil permease D SPy_1137 putative purine permease K16169 pbuX; xanthine permease D SPy_1736 conserved hypothetical protein K06901 pbuG; adenine/guanine/hypoxanthine permease D SPy_1114 conserved hypothetical protein K03281 clcA; chloride channel protein, CIC family D SPy_1379 putative chloride channel protein K03281 clcA; chloride channel protein, CIC family D SPy_0723 putative transposase K03281 clcA; chloride channel protein, CIC family D SPy_1695 conserved hypothetical protein K03324 yjbB; phosphate:Na+ symporter D SPy_1414 putative cation (K+) transport protein K03549 kup; KUP system potassium uptake protein D SPy_0373 conserved hypothetical protein K23675 fmnP; riboflavin transporter D SPy_0600 conserved hypothetical protein K16789 thiT; thiamine transporter D SPy_1425 hypothetical protein K16788 niaX; niacin transporter D SPy_0609 ftsW; putative cell division protein K03588 ftsW; cell division protein FtsW D SPy_1177 putative methylmalonyl-CoA decarboxylase, beta-subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1184 putative decarboxylase, beta subunit K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D SPy_1174 putative transcarboxylase subunit K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D SPy_1191 oadA; putative oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D SPy_1175 hypothetical protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma D SPy_1176 putative methylmalonyl-CoA decarboxylase, gamma-subunit K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D SPy_1183 putative decarboxylase, gamma chain K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D SPy_1559 ccdA; putative cytochrome C-type biogenesis protein K06196 ccdA; cytochrome c-type biogenesis protein D SPy_2032 putative ATP-binding cassette transporter-like protein K24950 yknX; membrane fusion protein, antimicrobial resistance system D SPy_0836 conserved hypothetical protein K24950 yknX; membrane fusion protein, antimicrobial resistance system C 02044 Secretion system [BR:spy02044] D SPy_1516 conserved hypothetical protein K02221 yggT; YggT family protein D SPy_1409 comEA; putative competence protein K02237 comEA; competence protein ComEA D SPy_1823 comEB; putative late competence protein required for DNA binding K01493 comEB; dCMP deaminase [EC:3.5.4.12] D SPy_1408 comEC; putative competence protein K02238 comEC; competence protein ComEC D SPy_1616 comFA; putative late competence protein required for DNA uptake K02240 comFA; competence protein ComFA D SPy_1615 comFC; putative late competence protein K02242 comFC; competence protein ComFC D SPy_0101 comYA; putative ABC transporter subunit ComYA K02243 comGA; competence protein ComGA D SPy_0102 comYB; putative competence protein, ABC transporter subunit K02244 comGB; competence protein ComGB D SPy_0103 comYC; putative competence protein K02245 comGC; competence protein ComGC D SPy_0104 putative competence protein K02246 comGD; competence protein ComGD D SPy_0106 comYD; putative competence protein K02248 comGF; competence protein ComGF D SPy_1532 hypothetical protein K02236 comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-] D SPy_1805 secA; putative preprotein translocase binding subunit (ATPase) K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D SPy_2058 hypothetical protein K03073 secE; preprotein translocase subunit SecE D SPy_0502 hypothetical protein K03075 secG; preprotein translocase subunit SecG D SPy_0073 secY; putative preprotein translocase K03076 secY; preprotein translocase subunit SecY D SPy_1200 ffh; putative signal recognition particle K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D SPy_0569 ftsY; putative signal recognition particle (docking protein) K03110 ftsY; fused signal recognition particle receptor D SPy_1968 hypothetical protein K03210 yajC; preprotein translocase subunit YajC D SPy_0247 conserved hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D SPy_0351 hypothetical protein K03217 yidC; YidC/Oxa1 family membrane protein insertase C 02042 Bacterial toxins [BR:spy02042] D SPy_0428 conserved hypothetical protein K11044 spyA; C3 family ADP-ribosyltransferase [EC:2.4.2.-] D SPy_0918 putative exfoliative toxin K11041 eta; exfoliative toxin A/B D SPy_0167 slo; streptolysin O precursor K11031 slo; thiol-activated cytolysin D SPy_0378 hlyX; putative hemolysin K03699 tlyC; magnesium and cobalt exporter, CNNM family D SPy_1273 cfa; CAMP factor K11045 cfa; cAMP factor D SPy_0738 sagA; streptolysin S associated protein K11046 sagA; streptolysin S associated protein D SPy_1159 hlyIII; putative hemolysin III K11068 hlyIII; hemolysin III D SPy_1007 speI; streptococcal exotoxin I K11040 se; staphylococcal enterotoxin D SPy_1008 speH; streptococcal exotoxin H precursor K11040 se; staphylococcal enterotoxin D SPy_1998 smeZ; mitogenic exotoxin Z K11040 se; staphylococcal enterotoxin D SPy_0212 speG; exotoxin G precursor K11040 se; staphylococcal enterotoxin D SPy_0436 speJ; putative exotoxin (superantigen) K11040 se; staphylococcal enterotoxin D SPy_0711 speC; pyrogenic exotoxin C precursor, phage associated K11040 se; staphylococcal enterotoxin D SPy_0701 hylP1; hyaluronidase, phage associated K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D SPy_1600 putative hyaluronidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 02022 Two-component system [BR:spy02022] D SPy_0529 vicK; two-component sensor histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D SPy_0528 vicR; two-component response regulator K07668 vicR; two-component system, OmpR family, response regulator VicR D SPy_1236 putative histidine kinase protein K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D SPy_1237 putative response regulator K14983 ciaR; two-component system, OmpR family, response regulator CiaR D SPy_0336 csrR; putative sensory transduction histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D SPy_2026 putative histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D SPy_2027 putative two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr D SPy_1082 srtK; putative histidine kinase - lantibiotic associated K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3] D SPy_1081 srtR; putative DNA binding regulatory protein - lantibiotic associated K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR D SPy_1622 putative two-component sensor histidine kinase K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D SPy_1621 putative two-component response regulator K11618 liaR; two-component system, NarL family, response regulator LiaR D SPy_1908 salR; putative response regulator of salavaricin regulon K14989 salR; two-component system, NarL family, secretion system response regulator SalR D SPy_1107 putative two-component sensor histidine kinase K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] D SPy_1106 putative two-component response regulator K02475 K02475; two-component system, CitB family, response regulator D SPy_0242 putative histidine kinase, possibly involved in competence K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_1605 putative two-component responsible histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_0244 putative histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D SPy_0245 putative response regulator K07707 agrA; two-component system, LytTR family, response regulator AgrA D SPy_1587 putative two-component sensor response regulator K07720 yesN; two-component system, response regulator YesN D SPy_1062 putative two-component response regulator K07720 yesN; two-component system, response regulator YesN C 02035 Bacterial motility proteins [BR:spy02035] D SPy_0903 putative ABC transporter (binding protein) K02424 tcyA; L-cystine transport system substrate-binding protein D SPy_0317 conserved hypothetical protein K02424 tcyA; L-cystine transport system substrate-binding protein C 03037 Cilium and associated proteins C 04812 Cytoskeleton proteins [BR:spy04812] D SPy_1520 ftsZ; putative cell division protein K03531 ftsZ; cell division protein FtsZ D SPy_1521 ftsA; cell division protein K03590 ftsA; cell division protein FtsA D SPy_2217 spoJ; putative chromosome segregation protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein C 04147 Exosome [BR:spy04147] D SPy_0731 eno; putative enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D SPy_0274 plr; glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D SPy_1881 pgk; putative phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D SPy_1282 pyk; putative pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D SPy_0457 putative cyclophilin-type protein K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D SPy_2070 groEL; heat shock protein (chaperonin) K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D SPy_1760 dnaK; heat shock protein 70 K04043 dnaK; molecular chaperone DnaK D SPy_0215 pgi; glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D SPy_2206 guaB; inosine monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D SPy_0611 tufA; putative translation elongation factor EF-Tu K02358 tuf; elongation factor Tu D SPy_1730 hit; putative cell-cycle regulation histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D SPy_1151 ldh; putative L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D SPy_1637 atoB; putative acetyl-CoA:acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0140 putative acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0524 putative acetyl-CoA c-acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D SPy_0074 adk; adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D SPy_0927 apt; putative adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D SPy_1684 glpK; putative glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D SPy_1877 glnA; putative glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D SPy_1031 acoL; putative dihydrolipoamide dehydrogenase, component E3 K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D SPy_0613 tpi; putative triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D SPy_1429 gpmA; putative phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] C 02048 Prokaryotic defense system [BR:spy02048] D SPy_1562 conserved hypothetical protein K15342 cas1; CRISP-associated protein Cas1 D SPy_1048 hypothetical protein K09951 cas2; CRISPR-associated protein Cas2 D SPy_1561 conserved hypothetical protein K09951 cas2; CRISPR-associated protein Cas2 D SPy_1567 conserved hypothetical protein K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4] D SPy_1563 conserved hypothetical protein K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] D SPy_1565 conserved hypothetical protein K19117 csd1; CRISPR-associated protein Csd1 D SPy_1564 conserved hypothetical protein K19118 csd2; CRISPR-associated protein Csd2 D SPy_1566 conserved hypothetical protein K19119 cas5d; CRISPR-associated protein Cas5d D SPy_1046 conserved hypothetical protein K09952 csn1; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] D SPy_1049 hypothetical protein K19137 csn2; CRISPR-associated protein Csn2 D SPy_1904 hsdR; putative type I site-specific deoxyribonuclease K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] D SPy_1905 hsdS; putative type I site-specific deoxyribonuclease K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] D SPy_1906 hsdM; putative type I site-specific deoxyribonuclease K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] D SPy_0108 conserved hypothetical protein K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] D SPy_1077 putative methyl transferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D SPy_1520 ftsZ; putative cell division protein K03531 ftsZ; cell division protein FtsZ D SPy_0910 parC; putative DNA topoisomerase IV (subunit C) K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D SPy_0909 parE; putative DNA topoisomerase IV (subunit B) K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D SPy_0816 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D SPy_1122 putative iron-sulfur cofactor synthesis protein K04487 iscS; cysteine desulfurase [EC:2.8.1.7] C 04030 G protein-coupled receptors C 04050 Cytokine receptors C 04054 Pattern recognition receptors C 03310 Nuclear receptors C 04040 Ion channels [BR:spy04040] C 04031 GTP-binding proteins C 04052 Cytokines and neuropeptides C 04515 Cell adhesion molecules C 04090 CD molecules [BR:spy04090] C 01504 Antimicrobial resistance genes [BR:spy01504] D SPy_1765 putative D,D-carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D SPy_1312 dltA; putative D-alanine-D-alanyl carrier protein ligase K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D SPy_1311 dltB; putative integral membrane protein K03739 dltB; membrane protein involved in D-alanine export D SPy_1310 dltC; putative D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D SPy_1309 dltD; putative extramembranal protein K03740 dltD; D-alanine transfer protein C 00535 Proteoglycans C 00536 Glycosaminoglycan binding proteins [BR:spy00536] D SPy_0701 hylP1; hyaluronidase, phage associated K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D SPy_1600 putative hyaluronidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:spy00537] D SPy_0701 hylP1; hyaluronidase, phage associated K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D SPy_1600 putative hyaluronidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D SPy_0165 nga; nicotine adenine dinucleotide glycohydrolase precursor K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5] C 04091 Lectins C 04990 Domain-containing proteins not elsewhere classified B B 09185 Viral protein families C 03200 Viral proteins C 03210 Viral fusion proteins B B 09184 RNA family C 03100 Non-coding RNAs [BR:spy03100] D SPy_t01 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t11 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t35 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t55 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t22 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t50 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D SPy_t41 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t60 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t38 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t09 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t37 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t53 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D SPy_t58 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D SPy_t36 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D SPy_t54 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D SPy_t03 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D SPy_t48 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D SPy_t57 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D SPy_t40 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D SPy_t33 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D SPy_t15 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t59 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t43 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t26 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D SPy_t13 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t24 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t19 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t07 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D SPy_t32 tRNA-His K14226 tRNA-His; tRNA His D SPy_t14 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t25 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t20 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t44 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D SPy_t08 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t34 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t05 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t46 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t52 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D SPy_t04 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D SPy_t47 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D SPy_t56 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D SPy_t17 tRNA-Met K14230 tRNA-Met; tRNA Met D SPy_t28 tRNA-Met K14230 tRNA-Met; tRNA Met D SPy_t18 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D SPy_t29 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D SPy_t10 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D SPy_t16 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t27 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t51 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t21 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D SPy_t42 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D SPy_t06 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D SPy_t45 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D SPy_t31 tRNA-Trp K14235 tRNA-Trp; tRNA Trp D SPy_t30 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D SPy_t39 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D SPy_t02 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_t23 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_t12 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_t49 tRNA-Val K14237 tRNA-Val; tRNA Val D SPy_r01 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r03 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r05 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r07 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r10 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r12 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D SPy_r02 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r04 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r06 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r08 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r09 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_r11 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D SPy_s01 The tmRNA gene is the integration site for bacteriophage T12 K15035 ssrA; transfer-messenger RNA # A09190 Not Included in Pathway or Brite B B 09191 Unclassified: metabolism C 99980 Enzymes with EC numbers D SPy_0636 idnO; putative 5-keto-D-gluconate 5-reductase K00046 idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] D SPy_0414 lctO; putative lactate oxidase K10530 lctO; L-lactate oxidase [EC:1.1.3.2] D SPy_2080 nox1; putative NADH oxidase/alkyl hydroperoxidase reductase K03387 ahpF; NADH-dependent peroxiredoxin subunit F [EC:1.8.1.-] D SPy_0466 msrA.2; putative peptide methionine sulfoxide reductase K07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11] D SPy_1557 msrA; putative peptide methionine sulfoxide reductase K12267 msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] D SPy_1055 csrA; putative heavy metal stress response protein K07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12] D SPy_2079 ahpC; putative alkyl hydroperoxidase K24119 ahpC; NADH-dependent peroxiredoxin subunit C [EC:1.11.1.26] D SPy_0850 putative thioredoxin reductase K21567 fnr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1] D SPy_0891 arsC; putative arsenate reductase K00537 arsC; arsenate reductase (glutaredoxin) [EC:1.20.4.1] D SPy_2105 nrdG; putative anaerobic ribonucleotide reductase activator K04068 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] D SPy_2055 putative pyruvate formate-lyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4] D SPy_0379 pflC; putative pyruvate-formate lyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4] D SPy_1644 conserved hypothetical protein K07444 ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] D SPy_0505 putative glutamine cyclotransferase K22757 QCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5] D SPy_0540 conserved hypothetical protein K21349 ggs; glucosylglycerate synthase [EC:2.4.1.268] D SPy_0585 lgt; putative prolipoprotein diacylglycerol transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145] D SPy_1138 putative thiamine biosynthesis lipoprotein precursor K03734 apbE; FAD:protein FMN transferase [EC:2.7.1.180] D SPy_1885 conserved hypothetical protein K07030 fakA; fatty acid kinase [EC:2.7.2.18] D SPy_1036 conserved hypothetical protein K18672 dacA; diadenylate cyclase [EC:2.7.7.85] D SPy_0584 ptsK; Hpr kinase/phosphatase K06023 hprK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-] D SPy_1022 estA; putative tributyrin esterase K03930 estA; putative tributyrin esterase [EC:3.1.1.-] D SPy_0305 conserved hypothetical protein K07015 yqeG; putative phosphatase [EC:3.1.3.-] D SPy_2184 conserved hypothetical protein K22927 gdpP; cyclic-di-AMP phosphodiesterase [EC:3.1.4.59] D SPy_0260 conserved hypothetical protein K03424 tatD; TatD DNase family protein [EC:3.1.21.-] D SPy_0261 conserved hypothetical protein K05985 rnmV; ribonuclease M5 [EC:3.1.26.8] D SPy_1973 dexB; dextran glucosidase K01215 dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70] D SPy_0632 ugl; putative unsaturated glucuronyl hydrolase K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D SPy_1979 ska; streptokinase A precursor K14745 ska; streptokinase A [EC:3.4.-.-] D SPy_1958 def; putative polypeptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D SPy_0870 fms; putative polypeptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D SPy_1370 putative deacetylase K22278 pgdA; peptidoglycan-N-acetylglucosamine deacetylase [EC:3.5.1.104] D SPy_0470 67 kDa Myosin-crossreactive streptococcal antigen K10254 ohyA; oleate hydratase [EC:4.2.1.53] D SPy_1032 hylA; extracellular hyaluronate lyase K01727 hysA; hyaluronate lyase [EC:4.2.2.1] D SPy_0623 pacL; putative calcium-transporting ATPase K01537 ATP2C; P-type Ca2+ transporter type 2C [EC:7.2.2.10] D SPy_1434 putative heavy metal-transporting ATPase K01534 zntA; Zn2+/Cd2+-exporting ATPase [EC:7.2.2.12 7.2.2.21] C 99981 Carbohydrate metabolism C 99982 Energy metabolism D SPy_0801 ferredoxin K05337 fer; ferredoxin D SPy_0289 NifU-like protein K04488 iscU; nitrogen fixation protein NifU and related proteins C 99983 Lipid metabolism D SPy_0865 conserved hypothetical protein K25232 fakB; fatty acid kinase fatty acid binding subunit D SPy_1493 conserved hypothetical protein K25232 fakB; fatty acid kinase fatty acid binding subunit C 99984 Nucleotide metabolism D SPy_0426 nrdI; putative ribonucleotide reductase (NrdI protein) K03647 nrdI; protein involved in ribonucleotide reduction D SPy_0766 endA; putative competence associated membrane nuclease K15051 endA; DNA-entry nuclease D SPy_2043 mf; mitogenic factor K15051 endA; DNA-entry nuclease D SPy_1436 mf3; putative deoxyribonuclease K15051 endA; DNA-entry nuclease D SPy_0712 mf2; putative DNase K15051 endA; DNA-entry nuclease C 99985 Amino acid metabolism D SPy_1155 conserved hypothetical protein K08234 yaeR; glyoxylase I family protein D SPy_1519 conserved hypothetical protein K06997 yggS; PLP dependent protein C 99986 Glycan metabolism C 99987 Cofactor metabolism C 99988 Secondary metabolism C 99999 Others B B 09192 Unclassified: genetic information processing C 99973 Transcription D SPy_2077 csp; putative cold shock protein K03704 cspA; cold shock protein D SPy_0946 putative P1-type antirepressor - phage associated K07741 antB; anti-repressor protein D SPy_1249 conserved hypothetical protein K16509 spxA; regulatory protein spx D SPy_0580 conserved hypothetical protein K06959 tex; protein Tex C 99974 Translation D SPy_1619 putative polyribonucleotide nucleotidyltransferase (general stress protein) K07570 GSP13; general stress protein 13 C 99975 Protein processing D SPy_1896 ropA; transcription regulator - (trigger factor (prolyl isomerase)) K03545 tig; trigger factor D SPy_0504 conserved hypothetical protein K03664 smpB; SsrA-binding protein D SPy_1374 nrdH; putative glutaredoxin K06191 nrdH; glutaredoxin-like protein NrdH D SPy_0281 mecA; putative negative regulator of genetic competence K16511 mecA1_2; adapter protein MecA 1/2 C 99976 Replication and repair D SPy_1118 radC; putative DNA repair protein K03630 radC; DNA repair protein RadC D SPy_0266 conserved hypothetical protein K09760 rmuC; DNA recombination protein RmuC D SPy_1412 conserved hypothetical protein K07461 K07461; putative endonuclease D SPy_1163 smf; putative DNA processing protein (Smf family) K04096 smf; DNA processing protein D SPy_0928 conserved hypothetical protein K02086 dnaD; DNA replication protein D SPy_0971 putative terminase, small subunit - phage associated K07474 xtmA; phage terminase small subunit D SPy_0972 putative terminase, large subunit - phage associated K06909 xtmB; phage terminase large subunit D SPy_1992 conserved hypothetical protein K07478 ycaJ; putative ATPase D SPy_2136 putative DNA primase - phage associated K06919 K06919; putative DNA primase/helicase D SPy_0671 hypothetical protein, phage associated K07505 repA; regulatory protein RepA D SPy_0195 conserved hypothetical protein K07483 K07483; transposase D SPy_0199 conserved hypothetical protein, IS861 associated K07483 K07483; transposase D SPy_1335 conserved hypothetical protein - transposon IS861 associated K07483 K07483; transposase D SPy_0131 conserved hypothetical protein K07484 K07484; transposase D SPy_0133 conserved hypothetical protein K07484 K07484; transposase D SPy_0732 conserved hypothetical protein K07486 K07486; transposase D SPy_2013 transposase - IS1562 K07487 K07487; transposase D SPy_0198 putative transposase, IS861 K07497 K07497; putative transposase D SPy_1336 putative transposase - IS861 associated K07497 K07497; putative transposase C 99979 Viral proteins C 99998 Others D SPy_1862 conserved hypothetical protein K09747 ebfC; nucleoid-associated protein EbfC B B 09193 Unclassified: signaling and cellular processes C 99977 Transport D SPy_1654 aapA; putative amino acid permease K03293 TC.AAT; amino acid transporter, AAT family D SPy_0016 putative amino acid permease K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D SPy_1180 putative Mg2+/citrate complex transporter K03300 TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family D SPy_1270 putative amino acid symporter K03310 TC.AGCS; alanine or glycine:cation symporter, AGCS family D SPy_0323 braB; putative branched-chain amino acid transport protein K03311 TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family D SPy_1868 nupC; putative nucleoside transporter K03317 TC.CNT; concentrative nucleoside transporter, CNT family C 99978 Cell growth D SPy_1643 hypothetical protein K20073 mapZ; mid-cell-anchored protein Z D SPy_0248 hypothetical protein K06346 jag; spoIIIJ-associated protein D SPy_0655 int1; putative integrase; bacteriophage 370.1 K06400 spoIVCA; site-specific DNA recombinase C 99993 Cell motility C 99995 Signaling proteins D SPy_1527 putative GTP-binding protein TypA/BipA (tyrosine phosphorylated protein A) K06207 typA; GTP-binding protein D SPy_0471 phoH; phosphate starvation-induced protein K06217 phoH; phosphate starvation-inducible protein PhoH and related proteins C 99992 Structural proteins D SPy_0601 putative endolysin, phage associated K07273 acm; lysozyme C 99994 Others D SPy_1240 phoU; putative phosphate uptake regulatory protein K02039 phoU; phosphate transport system protein D SPy_0408 hypothetical protein K06201 cutC; copper homeostasis protein B B 09194 Poorly characterized C 99996 General function prediction only D SPy_2107 putative oxidoreductase K03810 mviM; virulence factor D SPy_1395 putative transcription factor K06198 coiA; competence protein CoiA D SPy_0596 conserved hypothetical protein K07025 K07025; putative hydrolase of the HAD superfamily D SPy_0290 conserved hypothetical protein K09014 sufB; Fe-S cluster assembly protein SufB D SPy_0287 conserved hypothetical protein K09015 sufD; Fe-S cluster assembly protein SufD D SPy_1353 conserved hypothetical protein K07058 K07058; membrane protein D SPy_0915 conserved hypothetical protein K07146 K07146; UPF0176 protein D SPy_0330 lemA; putative cytoplasmic membrane protein K03744 lemA; LemA protein D SPy_0581 conserved hypothetical protein K03095 sprL; SprT-like protein D SPy_2176 conserved hypothetical protein K01421 yhgE; putative membrane protein D SPy_2169 conserved hypothetical protein K08974 K08974; putative membrane protein D SPy_0575 conserved hypothetical protein K08986 ycgQ; putative membrane protein D SPy_1277 conserved hypothetical protein K06193 phnA; protein PhnA C 99997 Function unknown D SPy_0621 conserved hypothetical protein K06885 K06885; uncharacterized protein D SPy_1892 conserved hypothetical protein K06889 K06889; uncharacterized protein D SPy_0358 conserved hypothetical protein (putative membrane spanning protein) K06890 K06890; uncharacterized protein D SPy_0186 conserved hypothetical protein K06929 K06929; uncharacterized protein D SPy_1064 hypothetical protein K06940 K06940; uncharacterized protein D SPy_0357 conserved hypothetical protein K06950 K06950; uncharacterized protein D SPy_0841 conserved hypothetical protein K06960 K06960; uncharacterized protein D SPy_1937 conserved hypothetical protein K06962 K06962; uncharacterized protein D SPy_0747 conserved hypothetical protein K07004 K07004; uncharacterized protein D SPy_0844 conserved hypothetical protein K07006 K07006; uncharacterized protein D SPy_0851 probable regulatory protein K07035 K07035; uncharacterized protein D SPy_1169 hypothetical protein K07035 K07035; uncharacterized protein D SPy_0775 conserved hypothetical protein K07054 K07054; uncharacterized protein D SPy_0576 conserved hypothetical protein K07089 K07089; uncharacterized protein D SPy_0363 conserved hypothetical protein K07095 K07095; uncharacterized protein D SPy_1427 putative transcriptional regulator K07105 K07105; uncharacterized protein D SPy_0925 putative oxidoreductase K07124 K07124; uncharacterized protein D SPy_0376 conserved hypothetical protein K07139 K07139; uncharacterized protein D SPy_0370 conserved hypothetical protein K08998 K08998; uncharacterized protein D SPy_1603 conserved hypothetical protein K09704 K09704; uncharacterized protein D SPy_1201 ylxM; putative DNA-binding protein K09787 K09787; uncharacterized protein D SPy_0464 conserved hypothetical protein K00243 K00243; uncharacterized protein D SPy_2104 conserved hypothetical protein K09861 K09861; uncharacterized protein D SPy_1326 conserved hypothetical protein K09963 K09963; uncharacterized protein D SPy_0359 hypothetical protein K09976 K09976; uncharacterized protein D SPy_0821 conserved hypothetical protein K07584 ysxB; uncharacterized protein D SPy_1608 conserved hypothetical protein K07586 ygaC; uncharacterized protein D SPy_1723 conserved hypothetical protein K07742 ylxR; uncharacterized protein ! #
#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: April 26, 2024