+D	AMR gene	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Antimicrobial Resistance Genes - Shigella sonnei Ss046</h2>
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A<b>Gene variants</b>
B  beta-Lactamase genes
C    Class A [MT]
C    Class D [MT]
C    Class C [MT]
C    Class B [MT]
B  Aminoglycoside resistance genes
C    N-Acetyltransferases
C    Other acetyltransferases
C    O-Nucleotidyltransferases
D      SSON_3896 aadA; aminoglycoside-resistance protein	K00984 aadA; streptomycin 3"-adenylyltransferase [EC:2.7.7.47] 
C    O-Phosphotransferases
D      SSON_PA04 strA; StrA	K10673 strA; streptomycin 3"-kinase [EC:2.7.1.87] 
D      SSON_PA05 strB; StrB	K04343 strB; streptomycin 6-kinase [EC:2.7.1.72] 
C    16S rRNA methyltransferases
B  Tetracycline resistance genes
C    Transporters
D      SSON_PA02 tetA; TetA	K08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein 
C    Others
B  Macrolide resistance genes
C    23S rRNA methyltransferases
C    Transporters
C    Others
B  Phenicol resistance genes
C    Transporters
C    Acetyltransferases
C    Phosphotransferase
C    23S rRNA methyltransferase
B  Sulfonamide resistance genes
C    Dihydropteroate synthase
D      SSON_PA03 sulII; SulII	K18824 sul2; dihydropteroate synthase type 2 [EC:2.5.1.15] 
B  Trimethoprim resistance genes
C    Dihydrofolate reductases
B  Quinolone resistance genes
C    Transporter
C    Other
B  Rifamycin resistance genes
C    ADP-ribosyl transferases
C    Oxygenases
B  Fosfomycin resistance genes
C    Transferases
C    Others
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A<b>Gene sets</b>
B  beta-Lactam resistance modules
C    Methicillin resistance [MD:M00625]
C    beta-Lactam resistance, Bla system [MD:M00627]
C    Imipenem resistance, repression of porin OprD [MD:M00745]
D      SSON_0521 ybcZ; putative 2-component sensor protein	K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3] 
D      SSON_0522 ylcA; putative 2-component transcriptional regulator	K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR 
B  Vancomycin resistance modules
C    Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]
D      SSON_1636 conserved hypothetical protein	K08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] 
C    Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]
D      B  Tetracycline resistance
C    Tetracycline resistance, efflux pump Tet38 [MD:M00704]
B  CAMP resistance modules
C    Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]
C    Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]
C    Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]
C    Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]
D      SSON_1147 phoQ; sensor protein PhoQ	K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3] 
D      SSON_1148 phoP; transcriptional regulatory protein	K07660 phoP; two-component system, OmpR family, response regulator PhoP 
B  Multipdrug resistance modules
C    Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]
D      SSON_0450 acrA; acridine efflux pump	K03585 acrA; membrane fusion protein, multidrug efflux system 
D      SSON_0449 acrB; acridine efflux pump	K18138 acrB; multidrug efflux pump 
C    Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]
C    Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]
C    Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]
C    Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]
C    Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]
D      SSON_0476 ybbI; putative transcriptional regulator	K19591 cueR; MerR family transcriptional regulator, copper efflux regulator 
C    Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]
C    Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]
D      SSON_3405 envR; putative transcriptional regulator	K18140 envR; TetR/AcrR family transcriptional regulator, acrEF/envCD operon repressor 
D      SSON_3406 acrE; AcrE	K18141 acrE; membrane fusion protein, multidrug efflux system 
D      SSON_3173 tolC; TolC	K12340 tolC; outer membrane protein 
C    Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]
D      SSON_2460 evgA; putative positive transcription regulator (sensor EvgS)	K07690 evgA; two-component system, NarL family, response regulator EvgA 
D      SSON_3573 yhiU; putative membrane protein	K18898 mdtE; membrane fusion protein, multidrug efflux system 
D      SSON_3572 yhiV; putative transport system permease protein	K18899 mdtF; multidrug efflux pump 
D      SSON_3173 tolC; TolC	K12340 tolC; outer membrane protein 
C    Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]
C    Multidrug resistance, efflux pump AbcA [MD:M00700]
C    Multidrug resistance, efflux pump NorB [MD:M00702]
C    Multidrug resistance, efflux pump QacA [MD:M00714]
C    Multidrug resistance, efflux pump MepA [MD:M00705]
C    Multidrug resistance, repression of porin OmpF [MD:M00746]
D      SSON_1597 marA; transcriptional activator of defense systems	K13632 marA; AraC family transcriptional regulator, mar-sox-rob regulon activator 
D      SSON_0932 ompF; outer membrane protein 1a (Ia;b;F)	K09476 ompF; outer membrane pore protein F 
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#Last updated: December 28, 2017