 1. Oxidoreductases
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2. Transferases
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3. Hydrolases
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4. Lyases
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 5. Isomerases
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5.1 Racemases and epimerases
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5.2 cis-trans-Isomerases
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5.2.1 cis-trans Isomerases (only sub-subclass identified to date)
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5.2.1.1 maleate isomerase
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5.2.1.2 maleylacetoacetate isomerase
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5.2.1.4 maleylpyruvate isomerase
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 5.2.1.5 linoleate isomerase
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5.2.1.6 furylfuramide isomerase
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5.2.1.8 peptidylprolyl isomerase
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K01802 E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]
K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
K03768 PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]
K03769 ppiC; peptidyl-prolyl cis-trans isomerase C [EC:5.2.1.8]
K03770 ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]
K03771 surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]
K03772 fkpA; FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [EC:5.2.1.8]
K03773 fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8]
K03774 slpA; FKBP-type peptidyl-prolyl cis-trans isomerase SlpA [EC:5.2.1.8]
K03775 slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]
K05864 PPID, CYPD; peptidyl-prolyl isomerase D [EC:5.2.1.8]
K07533 prsA; foldase protein PrsA [EC:5.2.1.8]
K09563 PPIC, CYPC; peptidyl-prolyl isomerase C (cyclophilin C) [EC:5.2.1.8]
K09564 PPIE; peptidyl-prolyl isomerase E (cyclophilin E) [EC:5.2.1.8]
K09565 PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
K09566 PPIG; peptidyl-prolyl isomerase G (cyclophilin G) [EC:5.2.1.8]
K09567 PPIH, CYPH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8]
K09568 FKBP1; FK506-binding protein 1 [EC:5.2.1.8]
K09569 FKBP2; FK506-binding protein 2 [EC:5.2.1.8]
K09570 FKBP3; FK506-binding protein 3 [EC:5.2.1.8]
K09571 FKBP4_5; FK506-binding protein 4/5 [EC:5.2.1.8]
K09572 FKBP6; FK506-binding protein 6 [EC:5.2.1.8]
K09573 FKBP7; FK506-binding protein 7 [EC:5.2.1.8]
K09574 FKBP8; FK506-binding protein 8 [EC:5.2.1.8]
K09575 FKBP9_10; FK506-binding protein 9/10 [EC:5.2.1.8]
K09576 FKBP11; FK506-binding protein 11 [EC:5.2.1.8]
K09577 FKBP14; FK506-binding protein 14 [EC:5.2.1.8]
K09578 PIN1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [EC:5.2.1.8]
K09579 PIN4; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 [EC:5.2.1.8]
K10598 PPIL2, CYC4, CHP60; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
K12733 PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8]
K12734 PPIL3; peptidyl-prolyl cis-trans isomerase-like 3 [EC:5.2.1.8]
K12735 PPIL4; peptidyl-prolyl cis-trans isomerase-like 4 [EC:5.2.1.8]
K12736 PPWD1; peptidylprolyl isomerase domain and WD repeat-containing protein 1 [EC:5.2.1.8]
K12737 SDCCAG10; peptidyl-prolyl cis-trans isomerase SDCCAG10 [EC:5.2.1.8]
K12738 PPIAL4; peptidylprolyl cis-trans isomerase A-like 4 [EC:5.2.1.8]
K12739 PPIL6; peptidyl-prolyl cis-trans isomerase-like 6 [EC:5.2.1.8]
K14826 FPR3_4; FK506-binding nuclear protein [EC:5.2.1.8]
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5.2.1.9 farnesol 2-isomerase
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5.2.1.10 2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
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5.2.1.12 zeta-carotene isomerase
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5.2.1.13 prolycopene isomerase
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5.2.1.14 beta-carotene isomerase
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5.3 Intramolecular oxidoreductases
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5.4 Intramolecular transferases
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5.5 Intramolecular lyases
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5.6 Isomerases altering macromolecular conformation
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5.99 Other isomerases
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6. Ligases
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7. Translocases
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Enzymes