 1. Oxidoreductases
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2. Transferases
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3. Hydrolases
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4. Lyases
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 5. Isomerases
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5.1 Racemases and epimerases
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5.2 cis-trans-Isomerases
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5.3 Intramolecular oxidoreductases
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5.4 Intramolecular transferases
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5.5 Intramolecular lyases
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5.6 Isomerases altering macromolecular conformation
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5.6.1 Enzymes altering polypeptide conformation or assembly
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5.6.2 Enzymes altering nucleic acid conformation
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5.6.2.1 DNA topoisomerase
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5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
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5.6.2.3 DNA 5'-3' helicase
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5.6.2.4 DNA 3'-5' helicase
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 K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
K03657 uvrD, pcrA; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
K03658 helD; DNA helicase IV [EC:5.6.2.4]
K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
K03726 helS; ATP-dependent DNA helicase [EC:5.6.2.4]
K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
K04499 RUVBL1, RVB1, INO80H; RuvB-like protein 1 [EC:5.6.2.4]
K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
K10300 FBH1, FBXO18; F-box DNA helicase 1 [EC:5.6.2.4]
K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
K10843 ERCC3, XPB; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
K10900 WRN, RECQL2; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
K10901 BLM, RECQL3, SGS1; bloom syndrome protein [EC:5.6.2.4]
K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
K13184 DHX9; ATP-dependent RNA/DNA helicase DHX9 [EC:5.6.2.6 5.6.2.4]
K14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
K15271 HFM1, MER3; ATP-dependent DNA helicase HFM1/MER3 [EC:5.6.2.4]
K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-]
K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-]
K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
K18959 uvsW; Straboviridae ATP-dependent DNA helicase UvsW [EC:5.6.2.4]
K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
K19781 HMI1; ATP-dependent DNA helicase HMI1, mitochondrial [EC:5.6.2.4]
K21519 A18R; Poxviridae transcript termination protein [EC:5.6.2.4]
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5.6.2.5 RNA 5'-3' helicase
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5.6.2.6 RNA 3'-5' helicase
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5.6.2.7 DEAD-box RNA helicase
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5.99 Other isomerases
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6. Ligases
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7. Translocases
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Enzymes