Membrane Trafficking

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 Exocytosis
 
 SNARE
   Syntaxin (Qa)
   SNAP-25[N] (Qb)
   SNAP-25[C] (Qc)
   SNAP-25 (Qb,c)
   VAMP, Ykt6, Sec22 (R)
   SNARE associated proteins
     Syntaxin-binding proteins
     Palmitoyltransferases
     Others
       K20002  SNAPIN, BLOC1S7; SNARE-associated protein Snapin
       K20004  TMEM27; collectrin
       K06027  NSF, SEC18; vesicle-fusing ATPase [EC:3.6.4.6]
       K15296  NAPA, SNAPA, SEC17; alpha-soluble NSF attachment protein
       K26120  NAPB, SNAPB; beta-soluble NSF attachment protein
       K21198  NAPG, SNAPG; gamma-soluble NSF attachment protein
       K14971  NCOA6, ASC2; nuclear receptor coactivator 6
       K20041  GAP43; neuromodulin
       K11828  DLG4, PSD95; discs large protein 4
       K17919  SNX4; sorting nexin-4
       K21996  SNX41_42; sorting nexin-41/42
       K15620  GOLPH3, GPP34; golgi phosphoprotein 3
       K23282  PLEKHM1; pleckstrin homology domain-containing family M member 1
       K22990  TOR1; torsin-1
       K23283  RUSC1, NESCA; RUN and SH3 domain-containing protein 1
       K13525  VCP, CDC48; transitional endoplasmic reticulum ATPase
       K14012  NSFL1C, UBX1, SHP1; UBX domain-containing protein 1
       K24347  UBXN2B; UBX domain-containing protein 2B
       K27407  VTS1; RNA-binding protein VTS1
 
 Endocytosis
 
 Endosome - Lysosome transport
   Rab GTPases and associated proteins
     Rab GTPases
     Retromer subcomplex
     FTS/Hook/FHIP (FHF) complex
     Rab associated proteins
       K13883  RILP; Rab-interacting lysosomal protein
       K20173  RILPL1; RILP-like protein 1
       K11982  RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
       K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
       K02731  PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
       K20162  DENND3; DENN domain-containing protein 3
       K20165  TBC1D2; TBC1 domain family member 2A
       K18469  TBC1D5; TBC1 domain family member 5
       K20168  TBC1D15; TBC1 domain family member 15
       K20174  OSBPL1_2, ORP1_2; oxysterol-binding protein-related protein 1/2
       K20175  ANKRD27; ankyrin repeat domain-containing protein 27
       K23460  CHM, CHML; Rab proteins geranylgeranyltransferase component A
       K14050  RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]
       K05956  RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]
       K20176  SGSM3, MAP; small G protein signaling modulator 3
       K21954  FYCO1; FYVE and coiled-coil domain-containing protein 1
       K15620  GOLPH3, GPP34; golgi phosphoprotein 3
       K26227  ALS2CL; ALS2 C-terminal-like protein
       K26496  RAB5IF; GEL complex subunit OPTI
       K26676  NSG1; neuronal vesicle trafficking-associated protein 1
       K26677  NSG2; neuronal vesicle trafficking-associated protein 2
       K15493  CALY; neuron-specific vesicular protein calcyon
   Arf GTPases and associated proteins
   Endosomal sorting complexes required for transport (ESCRT)
   Tethering complex
   Acidification regulators
   Others
 
 Protein recycling
   Rab GTPases and associated proteins
     Rab GTPases
     Rab4 associated proteins
     Rab11 associated proteins
       K12484  RAB11FIP1_2_5; Rab11 family-interacting protein 1/2/5
       K12485  RAB11FIP3_4; Rab11 family-interacting protein 3/4
       K20241  WDR44, RAB11BP; WD repeat-containing protein 44
       K14004  SEC13; protein transport protein SEC13
       K19985  EXOC6, SEC15; exocyst complex component 6
       K20242  EVI5; ecotropic viral integration site 5 protein
       K24795  TBC1D12; TBC1 domain family member 12
       K20167  TBC1D14; TBC1 domain family member 14
       K15620  GOLPH3, GPP34; golgi phosphoprotein 3
       K23539  UNC119; protein unc-119
       K24313  SH3TC; SH3 domain and tetratricopeptide repeat-containing protein
       K26154  RELCH; RAB11-binding protein RELCH
     Other Rab GTPase associated proteins
   Others
 
 Endosome - Golgi transport
   Rab GTPases and associated proteins
     Rab GTPases
     Rab associated proteins
       K18739  BICD; protein bicaudal D
       K20161  DENND2; DENN domain-containing protein 2
       K20164  DENND5; DENN domain-containing protein 5
       K16072  ERC1, CAST2, ELKS; ELKS/RAB6-interacting/CAST family member 1
       K19878  ERC2, CAST; ELKS/RAB6-interacting/CAST family member 2
       K20281  GCC1; GRIP and coiled-coil domain-containing protein 1
       K20282  GCC2; GRIP and coiled-coil domain-containing protein 2
       K16731  GOLGA1; golgin subfamily A member 1
       K20283  GOLGA4; golgin subfamily A member 4
       K15620  GOLPH3, GPP34; golgi phosphoprotein 3
       K19748  GORAB, SCYL1BP1; RAB6-interacting golgin
       K10402  KIF20; kinesin family member 20
       K17387  KIF23; kinesin family member 23
       K19951  TBC1D8_9; TBC1 domain family member 8/9
       K22555  TBC1D23; TBC1 domain family member 23
       K20284  RABGAP1, GAPCENA; Rab GTPase-activating protein 1
       K20285  RABEPK; Rab9 effector protein with kelch motifs
       K20286  TMF1; TATA element modulatory factor
       K20287  PLIN3; perilipin-3
       K10419  DYNLRB, DNCL2; dynein light chain roadblock-type
       K04648  DCTN1; dynactin 1
       K01099  INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B/F [EC:3.1.3.36]
       K21847  SGSM1, RUTBC2; small G protein signaling modulator 1
       K19525  VPS13A_C; vacuolar protein sorting-associated protein 13A/C
       K19526  VPS13B; vacuolar protein sorting-associated protein 13B
       K19527  VPS13D; vacuolar protein sorting-associated protein 13D
   Arf GTPases and associated proteins
   Tethering complex
   Others
 
 Endoplasmic reticulum (ER) - Golgi transport
   Forward pathways
   Retrieval pathways
   Others
     Oxysterol-binding proteins
     FXYD proteins
     YIPF proteins
     ER membrane protein complex
     SEC61 complex
     TRAP complex
     Multi-pass translocon (MPT) complex
     Post-GPI attachment to proteins factors (PGAP)
     Others
       K19998  SCFD1, SLY1; sec1 family domain-containing protein 1
       K19934  SDF4; calcium-binding protein
       K20479  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules
       K19872  FKTN; fukutin [EC:2.7.8.-]
       K19873  FKRP; fukutin-related protein [EC:2.7.8.-]
       K21957  FAM20A; pseudokinase FAM20A
       K20825  FAM20B; glycosaminoglycan xylosylkinase [EC:2.7.1.-]
       K21958  FAM20C; extracellular serine/threonine protein kinase FAM20C [EC:2.7.11.1]
       K19874  SEPN1; selenoprotein N
       K20392  PRAF2; PRA1 family protein 2
       K20393  ARL6IP5, PRAF3; PRA1 family protein 3
       K24864  ARL6IP1; ADP-ribosylation factor-like protein 6-interacting protein 1
       K20724  TMEM33; transmembrane protein 33
       K20721  RTN1; reticulon-1
       K20722  RTN2; reticulon-2
       K20723  RTN3; reticulon-3
       K20720  RTN4; reticulon-4
       K23554  GRAMD4; GRAM domain-containing protein 4
       K23555  LMF1; lipase maturation factor 1
       K06096  VAPA; vesicle-associated membrane protein-associated protein A
       K21413  ANKS1; ankyrin repeat and SAM domain-containing protein 1
       K21414  ANKS4B, HARP; ankyrin repeat and SAM domain-containing protein 4B
       K21848  ARV1; lipid intermediate transporter
       K21849  KEG1; beta-1,6-glucan synthesis-associated protein KEG1
       K21850  KRE6; beta-glucan synthesis-associated protein KRE6
       K15620  GOLPH3, GPP34; golgi phosphoprotein 3
       K22128  PIEZO1_2, FAM38; piezo-type mechanosensitive ion channel component 1/2
       K22556  MANF, ARMET; mesencephalic astrocyte-derived neurotrophic factor
       K22697  SAMD8; sphingomyelin synthase-related protein 1
       K17339  ATL; atlastin [EC:3.6.5.-]
       K13254  SPAST; spastin [EC:5.6.1.1]
       K23292  LNPK; endoplasmic reticulum junction formation protein lunapark
       K12360  CLN8; ceroid-lipofuscinosis neuronal protein 8
       K23951  DYM; dymeclin
       K24069  PITPNM; membrane-associated phosphatidylinositol transfer protein
       K24996  STEEP1; STING ER exit protein
       K25381  FRRS1L; DOMON domain-contaning protein FRRS1L
       K25789  JAGN; protein jagunal
       K26681  INSIG; insulin-induced protein
       K26682  SCAP; sterol regulatory element-binding protein cleavage-activating protein
       K07197  SREBP1, SREBF1; sterol regulatory element-binding transcription factor 1
       K09107  SREBP2, SREBF2; sterol regulatory element-binding transcription factor 2
       K26683  GOLT1, GOT1; vesicle transport protein GOT1
       K22698  SEY1; protein SEY1 [EC:3.6.5.-]
 
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Last updated: April 10, 2024