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KO |
 Ubiquitins and ubiquitin-like proteins
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Ubiquitin-activating enzymes (E1)
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Ubiquitin-conjugating enzymes (E2)
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 Ubiquitin ligases (E3)
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HECT type E3
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U-box type E3
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Single Ring-finger type E3
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BRE1 proteins
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CBL proteins
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SINA (Seven in absentia) proteins
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Ligand of Numb proteins
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March proteins
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MDM2/MDM4 proteins
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NFX1 proteins
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Pellino proteins
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Peripheral membrane proteins
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RBR proteins
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TRAF proteins
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TRIM/RBCC proteins
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UBR box proteins
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 ATL proteins
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Other single Ring-finger type E3
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361367 Amfr; autocrine motility factor receptor
294328 Aire; autoimmune regulator
304709 Bfar; bifunctional apoptosis regulator
60371 Birc2; baculoviral IAP repeat-containing protein 2
78971 Birc3; baculoviral IAP repeat-containing protein 3
63879 Xiap; E3 ubiquitin-protein ligase XIAP
296468 Birc7; baculoviral IAP repeat-containing protein 7
687346 Brap; BRCA1-associated protein
497672 Brca1; breast cancer type 1 susceptibility protein homolog
314028 Cbll1; E3 ubiquitin-protein ligase Hakai isoform 1
498492 Ccnb1ip1; E3 ubiquitin-protein ligase CCNB1IP1
288734 Chfr; E3 ubiquitin-protein ligase CHFR
312227 Cnot4; CCR4-NOT transcription complex subunit 4
295246 Dcst1; E3 ubiquitin-protein ligase DCST1 isoform X1
304591 Dtx2; probable E3 ubiquitin-protein ligase DTX2
687424 Dtx1; E3 ubiquitin-protein ligase DTX1 isoform X1
500847 Dtx3; probable E3 ubiquitin-protein ligase DTX3
498089 Dtx3l; E3 ubiquitin-protein ligase DTX3L
303963 Dzip3; E3 ubiquitin-protein ligase DZIP3
305600 Fancl; E3 ubiquitin-protein ligase FANCL
684322 Kcmf1; E3 ubiquitin-protein ligase KCMF1
311866 Lrsam1; E3 ubiquitin-protein ligase LRSAM1
288308 Ltn1; E3 ubiquitin-protein ligase listerin
116667 Map3k1; mitogen-activated protein kinase kinase kinase 1
299613 Mex3d; RNA-binding protein MEX3D
307271 Mex3c; RNA-binding E3 ubiquitin-protein ligase MEX3C
308790 Mex3b; RNA-binding protein MEX3B
310631 Mex3a; RNA-binding protein MEX3A
302938 Mgrn1; E3 ubiquitin-protein ligase MGRN1
307594 Mib1; E3 ubiquitin-protein ligase MIB1
474147 Mib2; E3 ubiquitin-protein ligase MIB2
292988 Mkrn3; probable E3 ubiquitin-protein ligase makorin-3
296988 Mkrn1; E3 ubiquitin-protein ligase makorin-1 isoform 2
297525 Mkrn2; E3 ubiquitin-protein ligase makorin-2
298576 Mul1; mitochondrial ubiquitin ligase activator of NFKB 1
290447 Mycbp2; E3 ubiquitin-protein ligase MYCBP2
306825 Mylip; E3 ubiquitin-protein ligase MYLIP
303019 Neurl1b; E3 ubiquitin-protein ligase NEURL1B
316326 Neurl3; E3 ubiquitin-protein ligase NEURL3
364682 Nhlrc1; E3 ubiquitin-protein ligase NHLRC1
361088 Obi1; ORC ubiquitin ligase 1
683077 Pja1; E3 ubiquitin-protein ligase Praja-1 isoform 1
192256 Pja2; E3 ubiquitin-protein ligase Praja-2 isoform 1
362412 Rad18; E3 ubiquitin-protein ligase RAD18
84600 Rag1; V(D)J recombination-activating protein 1
289508 Rchy1; RING finger and CHY zinc finger domain-containing protein 1
311909 Rc3h2; roquin-2
680586 Rc3h1; roquin-1
360860 Cop1; E3 ubiquitin-protein ligase COP1
103690025 Rfwd3; E3 ubiquitin-protein ligase RFWD3 isoform 1
309626 Ring1; E3 ubiquitin-protein ligase RING1
304850 Rnf2; E3 ubiquitin-protein ligase RING2
29274 Rnf4; E3 ubiquitin-protein ligase RNF4
407784 Rnf5; E3 ubiquitin-protein ligase RNF5
360967 Rnf185; E3 ubiquitin-protein ligase RNF185
304271 Rnf6; E3 ubiquitin-protein ligase RNF6
361815 Rnf8; E3 ubiquitin-protein ligase RNF8
288710 Rnf10; E3 ubiquitin-protein ligase RNF10 isoform 1
100364162 Rnf11; RING finger protein 11
316552 Rnf11l2; RING finger protein 11
317241 Rlim; E3 ubiquitin-protein ligase RLIM
681578 Rnf13; E3 ubiquitin-protein ligase RNF13 precursor
301515 Rnf25; E3 ubiquitin-protein ligase RNF25
300659 Rnf26; E3 ubiquitin-protein ligase RNF26
361212 Rnf44; RING finger protein 44
171501 Rnf38; E3 ubiquitin-protein ligase RNF38
362814 Rnf41; E3 ubiquitin-protein ligase NRDP1 isoform 1
303412 Rnf43; E3 ubiquitin-protein ligase RNF43 precursor
84508 Rnf103; E3 ubiquitin-protein ligase RNF103
300813 Rnf111; E3 ubiquitin-protein ligase Arkadia
24916 Rnf112; RING finger protein 112
362277 Rnf114; E3 ubiquitin-protein ligase RNF114
362002 Rnf115; E3 ubiquitin-protein ligase RNF115
314613 Rnf126; E3 ubiquitin-protein ligase RNF126
308871 Rnf121; E3 ubiquitin ligase RNF121
502091 Rnf122; RING finger protein 122 isoform 1
100190936 Rnf123; E3 ubiquitin-protein ligase RNF123
361296 Rnf125; E3 ubiquitin-protein ligase RNF125
315911 Rnf128; E3 ubiquitin-protein ligase RNF128 precursor
652955 Rnf130; E3 ubiquitin-protein ligase RNF130 precursor
681395 Rnf133; E3 ubiquitin-protein ligase RNF133
303350 Rnf135; E3 ubiquitin-protein ligase RNF135
317486 Rnf138l1; E3 ubiquitin-protein ligase RNF138-like
94196 Rnf138; E3 ubiquitin-protein ligase RNF138
315000 Rnf139; E3 ubiquitin-protein ligase RNF139
287212 Rnf145; RING finger protein 145
308051 Rnf146; E3 ubiquitin-protein ligase RNF146
363222 Rnf149; E3 ubiquitin-protein ligase RNF149
293561 Rnf152; E3 ubiquitin-protein ligase RNF152
688272 Rnf157; E3 ubiquitin ligase Rnf157
307251 Ark2c; E3 ubiquitin-protein ligase RNF165
365022 Rnf166; E3 ubiquitin-protein ligase RNF166
360554 Rnf167; E3 ubiquitin-protein ligase RNF167 precursor
364654 Rnf170; E3 ubiquitin-protein ligase RNF170
685384 Rnf180; E3 ubiquitin-protein ligase RNF180
297337 Rnf181; E3 ubiquitin-protein ligase RNF181
498726 Rnf182; E3 ubiquitin-protein ligase RNF182
690433 Rnf186; E3 ubiquitin-protein ligase RNF186
360533 Rnf187; E3 ubiquitin-protein ligase RNF187
303735 Rnf213; E3 ubiquitin-protein ligase RNF213 isoform X1
500532 Rnf220; E3 ubiquitin-protein ligase RNF220 isoform X3
360595 Rnft1; E3 ubiquitin-protein ligase RNFT1
29678 Sart1; U4/U6.U5 tri-snRNP-associated protein 1
308282 Shprh; E3 ubiquitin-protein ligase SHPRH
306417 Sh3rf1; E3 ubiquitin-protein ligase SH3RF1
307472 Sh3rf2; E3 ubiquitin-protein ligase SH3RF2
294557 Sh3rf3; E3 ubiquitin-protein ligase SH3RF3 isoform X1
295568 Hltf; helicase-like transcription factor
361712 Syvn1; E3 ubiquitin-protein ligase synoviolin
305458 Tmem129; E3 ubiquitin-protein ligase TM129
362501 Topors; E3 ubiquitin-protein ligase Topors
367167 Traip; E3 ubiquitin-protein ligase TRAIP
360702 Ttc3; E3 ubiquitin-protein ligase TTC3
316129 Uhrf1; E3 ubiquitin-protein ligase UHRF1 isoform 1
309331 Uhrf2; E3 ubiquitin-protein ligase UHRF2
302987 Unkl; putative E3 ubiquitin-protein ligase UNKL isoform X1
287119 Zfp598; zinc finger protein 598
246282 Zfp91; E3 ubiquitin-protein ligase ZFP91
362367 Znrf2; E3 ubiquitin-protein ligase ZNRF2
690769 Znrf1; E3 ubiquitin-protein ligase ZNRF1
685487 Znrf3; E3 ubiquitin-protein ligase ZNRF3
301127 Znrf4; E3 ubiquitin-protein ligase ZNRF4 precursor
296455 Zswim2; E3 ubiquitin-protein ligase ZSWIM2
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K10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]
K10603 AIRE; autoimmune regulator
K15684 BFAR; bifunctional apoptosis regulator
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K16061 BIRC7_8; baculoviral IAP repeat-containing protein 7/8
K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
K10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]
K10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27]
K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
K22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K06058 DTX; deltex [EC:2.3.2.27]
K10642 DZIP3; E3 ubiquitin-protein ligase DZIP3 [EC:2.3.2.27]
K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
K22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]
K10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]
K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
K04416 MAP3K1; mitogen-activated protein kinase kinase kinase 1 [EC:2.7.11.25]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]
K10604 MGRN1; E3 ubiquitin-protein ligase MGRN1 [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]
K15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]
K10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]
K10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]
K01931 NEUR; protein neuralized [EC:2.3.2.27]
K15689 NEURL3; E3 ubiquitin-protein ligase NEURL3 [EC:2.3.2.27]
K10602 NHLRC1; E3 ubiquitin-protein ligase NHLRC1 [EC:2.3.2.27]
K24091 OBI1; ORC ubiquitin ligase 1 [EC:2.3.2.27]
K10633 PJA1; E3 ubiquitin-protein ligase Praja1 [EC:2.3.2.27]
K10634 PJA2; E3 ubiquitin-protein ligase Praja2 [EC:2.3.2.27]
K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
K10628 RAG1; V(D)J recombination-activating protein 1 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K10695 RNF1_2; E3 ubiquitin-protein ligase RNF1/2 [EC:2.3.2.27]
K22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K10666 RNF5_185; E3 ubiquitin-protein ligase RNF5/185 [EC:2.3.2.27]
K22753 RNF6; E3 ubiquitin-protein ligase RNF6 [EC:2.3.2.27]
K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
K26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]
K11980 RNF11; E3 ubiquitin-protein ligase RNF11
K11980 RNF11; E3 ubiquitin-protein ligase RNF11
K16271 RLIM; E3 ubiquitin-protein ligase RLIM [EC:2.3.2.27]
K15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]
K10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]
K15693 RNF26; E3 ubiquitin-protein ligase RNF26 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K19041 RNF38_44; E3 ubiquitin-protein ligase RNF38/44 [EC:2.3.2.27]
K11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]
K15694 RNF43; E3 ubiquitin-protein ligase RNF43 [EC:2.3.2.27]
K15695 RNF103; E3 ubiquitin-protein ligase RNF103 [EC:2.3.2.27]
K10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]
K25173 RNF112; E3 ubiquitin-protein ligase RNF112 [EC:2.3.2.27]
K15697 RNF114; E3 ubiquitin-protein ligase RNF114 [EC:2.3.2.27]
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
K15698 RNF121_175; RING finger protein 121/175
K15699 RNF122; RING finger protein 122
K12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]
K12170 RNF125; E3 ubiquitin-protein ligase RNF125 [EC:2.3.2.27]
K10629 RNF128; E3 ubiquitin-protein ligase RNF128 [EC:2.3.2.27]
K15701 RNF130; E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27]
K15702 RNF133; E3 ubiquitin-protein ligase RNF133 [EC:2.3.2.27]
K16272 RNF135; E3 ubiquitin-protein ligase RNF135 [EC:2.3.2.27]
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]
K10668 RNF138; E3 ubiquitin-protein ligase RNF138 [EC:2.3.2.27]
K15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]
K23789 RNF145; E3 ubiquitin-protein ligase RNF145 [EC:2.3.2.27]
K15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]
K15704 RNF149; E3 ubiquitin-protein ligase RNF149 [EC:2.3.2.27]
K15705 RNF152; E3 ubiquitin-protein ligase RNF152 [EC:2.3.2.27]
K25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]
K17821 RNF165; E3 ubiquitin-protein ligase RNF165 [EC:2.3.2.27]
K17044 RNF166; E3 ubiquitin-protein ligase RNF166 [EC:2.3.2.27]
K15706 RNF167; E3 ubiquitin-protein ligase RNF167 [EC:2.3.2.27]
K15707 RNF170; E3 ubiquitin-protein ligase RNF170 [EC:2.3.2.27]
K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
K22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]
K11983 RNF182; E3 ubiquitin-protein ligase RNF182 [EC:2.3.2.27]
K25214 RNF186; E3 ubiquitin-protein ligase RNF186 [EC:2.3.2.27]
K15709 RNF187; E3 ubiquitin-protein ligase RNF187 [EC:2.3.2.27]
K22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]
K25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]
K22379 RNFT1; E3 ubiquitin-protein ligase RNFT1 [EC:2.3.2.27]
K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]
K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
K22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]
K10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]
K11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]
K15712 TTC3; E3 ubiquitin-protein ligase TTC3 [EC:2.3.2.27]
K10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]
K15713 UHRF2; E3 ubiquitin-protein ligase UHRF2 [EC:2.3.2.27]
K23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]
K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
K25175 ZFP91; E3 ubiquitin-protein ligase ZFP91 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1/2 [EC:2.3.2.27]
K16273 ZNRF3; E3 ubiquitin-protein ligase ZNRF3 [EC:2.3.2.27]
K15715 ZNRF4; E3 ubiquitin-protein ligase ZNRF4 [EC:2.3.2.27]
K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]
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Atypical E3
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UBL E3 ligases
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Multi subunit Ring-finger type E3
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Deubiquitinating enzyme (DUB)
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Ubiquitin System - Rattus norvegicus (rat)