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ENTRY	nt06526
Name	MAPK signaling
Category	Pathway view; Signal transduction
Pathway	hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway
Disease	H00523 Noonan syndrome and related disorders H02541 Juvenile myelomonocytic leukemia
Display	drug-target relation   disease type

N01592    GF → RTK → GRB2 → SOS → RAS → RAF → MEK → ERK     Many cancers GF* ↗     Many cancers     RTK* ↗     Many cancers                 RAS* ↗     Many cancers                     BRAF* ↗     HH6 FGF8*     HH20 FGF17*     HH2     FGFR1*     Pfeiffer/JWS     FGFR1* ↗     Pfeiffer/Apert/CS/JWS/BSTVS/SCS/ABS     FGFR2* ↗     CS/Muenke     FGFR3* ↗     PGS/MTC     RET* ↗     HSCR1     RET*     NS4/GINGF1             SOS1* ↗     NS9             SOS2* ↗     CS                 HRAS* ↗     NS3/JMML/MTC/CFC2                 KRAS* ↗     NS11                 MRAS* ↗     NS6/JMML                 NRAS* ↗     NS12                 RRAS2* ↗     NS7/CFC1/LPRD3                     BRAF* ↗     NS5/LPRD2                     RAF1* ↗     CFC3/MEL                         MAP2K1* ↗     CFC4                         MAP2K2* ↗     NS13                             MAPK1* ↗ N01599    CBL ⊣ RTK     JMML/CBL CBL* N01595            (PTPN11,SHC,GAB,GR.. → SOS     NS1/JMML/LPRD1         PTPN11* ↗ N01596                (LZTR1+CUL3) ⊣ (RAS,RIT1)     NS10             LZTR1*     NS8                 RIT1* ↗ N01597                (SPRED+NF1) ⊣ RAS     LS             SPRED1*     JMML/NF1/PGS/NFNS/WTSN             NF1* N01600                RasGAP ⊣ RAS     CMAVM1/PWS             RASA1* N01598                    (MRAS+SHOC2+PP1) → RAF     NSLH1                 SHOC2* ↗     NSLH2                 PPP1CB* ↗ N01593                            (PTP,MKP) ⊣ (ERK,JNK,MAPK14)     HH19                         DUSP6* N01601                                ERK → RSK     CLS                                 RPS6KA3* N01602                                ERK → (MAX+MYC)     PGS                                 MAX* N01594    MLK → MKK4/7 → JNK     SFMMP MAP3K20* N00542    EGF → EGFR → GRB2 → SOS → RAS → MEKK1 → MKK4 → JNK N00186    IL1 → IL1R → MYD88 → IRAK1/4 → TRAF6 → TAB1/2/3 → TAK1 → MKK3/6 → MAPK14 → MK2 ⊣ TTP N00188    IL1 → IL1R → MYD88 → IRAK1/4 → TRAF6 → TAB1/2/3 → TAK1 → MKK4/7 → JNK → AP1

		Disease name	Disease category
HH6	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease
HH20	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease
HH2	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease
Pfeiffer/JWS	H01756	Pfeiffer syndrome	Congenital malformation
	H01988	Jackson-Weiss syndrome	Congenital malformation
Pfeiffer/Apert/CS/JWS/BSTVS/SCS/ABS	H01756	Pfeiffer syndrome	Congenital malformation
	H01755	Apert syndrome	Congenital malformation
	H01754	Crouzon syndrome	Congenital malformation
	H01988	Jackson-Weiss syndrome	Congenital malformation
	H01989	Beare-Stevenson syndrome	Congenital malformation
	H01991	Saethre-Chotzen syndrome	Congenital malformation
	H01753	Antley-Bixler syndrome	Congenital malformation
CS/Muenke	H01754	Crouzon syndrome	Congenital malformation
	H01990	Muenke syndrome	Congenital malformation
PGS/MTC	H01510	Malignant paraganglioma	Cancer
	H01592	Medullary thyroid cancer	Cancer
HSCR1	H00910	Hirschsprung disease	Congenital malformation
NS4/GINGF1	H01738	Noonan syndrome	Congenital malformation
	H01250	Hereditary gingival fibromatosis	Digestive system disease
NS9	H01738	Noonan syndrome	Congenital malformation
CS	H01747	Costello syndrome	Congenital malformation
NS3/JMML/MTC/CFC2	H01738	Noonan syndrome	Congenital malformation
	H02541	Juvenile myelomonocytic leukemia	Cancer
	H01592	Medullary thyroid cancer	Cancer
	H01745	Cardiofaciocutaneous syndrome	Congenital malformation
NS11	H01738	Noonan syndrome	Congenital malformation
NS6/JMML	H01738	Noonan syndrome	Congenital malformation
	H02541	Juvenile myelomonocytic leukemia	Cancer
NS12	H01738	Noonan syndrome	Congenital malformation
NS7/CFC1/LPRD3	H01738	Noonan syndrome	Congenital malformation
	H01745	Cardiofaciocutaneous syndrome	Congenital malformation
	H01984	Leopard syndrome	Congenital malformation
NS5/LPRD2	H01738	Noonan syndrome	Congenital malformation
	H01984	Leopard syndrome	Congenital malformation
CFC3/MEL	H01745	Cardiofaciocutaneous syndrome	Congenital malformation
	H02631	Melorheostosis	Musculoskeletal disease
CFC4	H01745	Cardiofaciocutaneous syndrome	Congenital malformation
NS13	H01738	Noonan syndrome	Congenital malformation
JMML/CBL	H02541	Juvenile myelomonocytic leukemia	Cancer
	H02190	CBL syndrome	Congenital malformation
NS1/JMML/LPRD1	H01738	Noonan syndrome	Congenital malformation
	H02541	Juvenile myelomonocytic leukemia	Cancer
	H01984	Leopard syndrome	Congenital malformation
NS10	H01738	Noonan syndrome	Congenital malformation
NS8	H01738	Noonan syndrome	Congenital malformation
LS	H01986	Legius syndrome	Congenital malformation
JMML/NF1/PGS/NFNS/WTSN	H02541	Juvenile myelomonocytic leukemia	Cancer
	H01437	Neurofibromatosis type 1	Congenital malformation
	H01510	Malignant paraganglioma	Cancer
	H02189	Neurofibromatosis-Noonan syndrome	Congenital malformation
	H02188	Watson syndrome	Congenital malformation
CMAVM1/PWS	H02043	Capillary malformation-arteriovenous malformation	Congenital malformation
	H00532	Parkes Weber syndrome	Congenital malformation
NSLH1	H02191	Noonan-like syndrome with loose anagen hair	Congenital malformation
NSLH2	H02191	Noonan-like syndrome with loose anagen hair	Congenital malformation
HH19	H00255	Hypogonadotropic hypogonadism	Endocrine and metabolic disease
CLS	H00574	Coffin-Lowry syndrome	Congenital malformation
PGS	H01510	Malignant paraganglioma	Cancer
SFMMP	H00471	Split-hand/foot malformation	Congenital malformation