Network variation - Cytoskeleton in muscle cells |
ENTRY | nt06539 |
Name | Cytoskeleton in muscle cells |
Category | Pathway view; Cellular process |
Pathway | hsa04820 Cytoskeleton in muscle cells |
Disease | H00294 Dilated cardiomyopathy H00292 Hypertrophic cardiomyopathy H01219 Restrictive cardiomyopathy H00293 Arrhythmogenic right ventricular cardiomyopathy H01810 Congenital myopathy H00562 Dystrophinopathies H00593 Limb-girdle muscular dystrophy |
Display | drug-target relation disease type |
Disease name | Disease category | ||
OI1/2/3/4/OST/ICH/EDSARTH1/OIEDS1 | H00506 | Osteogenesis imperfecta | Congenital malformation |
H01593 | Osteoporosis | Musculoskeletal disease | |
H00613 | Infantile cortical hyperostosis | Musculoskeletal disease | |
H02243 | Ehlers-Danlos syndrome arthrochalasia type | Congenital malformation | |
H02724 | Combined osteogenesis imperfecta and Ehlers-Danlos syndrome | Congenital malformation | |
OI2/3/4/OST/EDSCV/EDSARTH2/OIEDS2 | H00506 | Osteogenesis imperfecta | Congenital malformation |
H01593 | Osteoporosis | Musculoskeletal disease | |
H02241 | Ehlers-Danlos syndrome cardiac valvular type | Congenital malformation | |
H02243 | Ehlers-Danlos syndrome arthrochalasia type | Congenital malformation | |
H02724 | Combined osteogenesis imperfecta and Ehlers-Danlos syndrome | Congenital malformation | |
PMGEDSV/EDSVASC | H00271 | Polymicrogyria | Congenital malformation |
H02242 | Ehlers-Danlos syndrome vascular type | Congenital malformation | |
EDSCL1/FMDMF | H00802 | Ehlers-Danlos syndrome | Congenital malformation |
H02719 | Multifocal fibromuscular dysplasia | Cardiovascular disease | |
EDSCL2 | H00802 | Ehlers-Danlos syndrome | Congenital malformation |
EDM6/STL4 | H00476 | Multiple epiphyseal dysplasia | Congenital malformation |
H02072 | Stickler syndrome | Congenital malformation | |
EDM2/STL5 | H00476 | Multiple epiphyseal dysplasia | Congenital malformation |
H02072 | Stickler syndrome | Congenital malformation | |
EDM3/STL6/IDD | H00476 | Multiple epiphyseal dysplasia | Congenital malformation |
H02072 | Stickler syndrome | Congenital malformation | |
H02539 | Intervertebral disc disease | Musculoskeletal disease | |
DFNA37/STL2/FBCG1/MRSHS/IDD | H00604 | Deafness, autosomal dominant | Nervous system disease |
H00805 | Vitreoretinal degeneration | Nervous system disease | |
H02080 | Fibrochondrogenesis | Congenital malformation | |
H02081 | Marshall syndrome | Congenital malformation | |
H02539 | Intervertebral disc disease | Musculoskeletal disease | |
DFNA13/DFNB53/STL3/OSMED/FBCG2 | H00604 | Deafness, autosomal dominant | Nervous system disease |
H00605 | Deafness, autosomal recessive | Nervous system disease | |
H02072 | Stickler syndrome | Congenital malformation | |
H02079 | Oto-spondylo-megaepiphyseal dysplasia | Congenital malformation | |
H02080 | Fibrochondrogenesis | Congenital malformation | |
CSCD | H00958 | Congenital stromal corneal dystrophy | Nervous system disease |
WGVRP | H00805 | Vitreoretinal degeneration | Nervous system disease |
SVAS/ADCL1 | H00553 | Congenital supravalvular aortic stenosis | Congenital malformation |
H00557 | Cutis laxa | Congenital malformation | |
UCMD1A/BTHLM1A | H01341 | Collagen VI myopathy | Nervous system disease |
UCMD1B/BTHLM1B | H01341 | Collagen VI myopathy | Nervous system disease |
UCMD1/BTHLM1/DYT27 | H01341 | Collagen VI myopathy | Nervous system disease |
H00831 | Primary dystonia | Nervous system disease | |
IDD/EDSCL3 | H02539 | Intervertebral disc disease | Musculoskeletal disease |
H00802 | Ehlers-Danlos syndrome | Congenital malformation | |
EDM1/PSACH/CTS2 | H00476 | Multiple epiphyseal dysplasia | Congenital malformation |
H00477 | Pseudoachondroplasia | Congenital malformation | |
H00798 | Familial carpal tunnel syndrome | Nervous system disease | |
HANAC/BSVD1 | H00579 | Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC) | Congenital malformation |
H00877 | Brain small vessel disease | Cardiovascular disease | |
PADMAL | H02718 | Autosomal dominant pontine microangiopathy and leukoencephalopathy | Congenital malformation |
BSVD2 | H00877 | Brain small vessel disease | Cardiovascular disease |
ATS3/BFH2 | H00581 | Alport syndrome | Congenital malformation |
H00582 | Benign familial hematuria | Urinary system disease | |
ATS2/BFH1 | H00581 | Alport syndrome | Congenital malformation |
H00582 | Benign familial hematuria | Urinary system disease | |
ATS1 | H00581 | Alport syndrome | Congenital malformation |
DFNX6 | H01209 | Deafness, X-linked | Nervous system disease |
SPD2 | H00459 | Synpolydactyly | Congenital malformation |
DDSH/SJS1 | H00493 | Heparan sulfate proteoglycan gene defects | Congenital malformation |
GFND/SMDCF | H01260 | Glomerulopathy with fibronectin deposits | Urinary system disease |
H02185 | Spondylometaphyseal dysplasia | Congenital malformation | |
CMS8 | H00770 | Congenital myasthenic syndrome | Nervous system disease |
SEMDX/MRLS | H02187 | Spondyloepimetaphyseal dysplasia | Congenital malformation |
H02720 | Meester-Loeys syndrome | Cardiovascular disease | |
MFS/WMS2/SSS/GPHYSD2/ACMICD | H00653 | Marfan syndrome | Congenital malformation |
H00673 | Weill-Marchesani syndrome | Congenital malformation | |
H01173 | Stiff skin syndrome | Skin disease | |
H00900 | Geleophysic dysplasia | Congenital malformation | |
H02228 | Acromicric dysplasia | Congenital malformation | |
DA9 | H00811 | Distal arthrogryposis | Congenital malformation |
ARVD11 | H00293 | Arrhythmogenic right ventricular cardiomyopathy | Cardiovascular disease |
ARVD10/CMD1BB | H00293 | Arrhythmogenic right ventricular cardiomyopathy | Cardiovascular disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
ARVD9 | H00293 | Arrhythmogenic right ventricular cardiomyopathy | Cardiovascular disease |
ARVD12/NXD | H00293 | Arrhythmogenic right ventricular cardiomyopathy | Cardiovascular disease |
H00669 | Naxos disease | Congenital malformation | |
ARVD8/PPKS2/EBLA/DCWHK | H00293 | Arrhythmogenic right ventricular cardiomyopathy | Cardiovascular disease |
H00717 | Striate palmoplantar keratoderma | Congenital malformation | |
H01737 | Epidermolysis bullosa | Congenital malformation | |
H02094 | Carvajal syndrome | Congenital malformation | |
CMD1I/MFM1/SCPNK | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
H00595 | Myofibrillar myopathies | Nervous system disease | |
H00656 | Scapuloperoneal myopathy | Nervous system disease | |
JEB7 | H00586 | Epidermolysis bullosa, junctional | Congenital malformation |
JEB5 | H00586 | Epidermolysis bullosa, junctional | Congenital malformation |
JEB6 | H00586 | Epidermolysis bullosa, junctional | Congenital malformation |
CMD | H00590 | Congenital muscular dystrophies (CMD/MDC) | Nervous system disease |
CMH15/CMD1W | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
CMH23/CMD1AA/MPD6/CMYP8 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
H00594 | Distal myopathy | Nervous system disease | |
H01810 | Congenital myopathy | Nervous system disease | |
BNS | H02716 | Becker nevus syndrome | Congenital malformation |
VSCM1/MMIHS5 | H02553 | Visceral myopathy | Congenital malformation |
H01869 | Megacystis microcolon intestinal hypoperistalsis syndrome | Congenital malformation | |
BRWS1/DDS1 | H02023 | Baraitser-Winter syndrome | Congenital malformation |
H01255 | Juvenile-onset dystonia | Congenital malformation | |
BRWS2/DFNA20/26 | H02023 | Baraitser-Winter syndrome | Congenital malformation |
H00604 | Deafness, autosomal dominant | Nervous system disease | |
LGMDR23/MDC1A | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
H01958 | Merosin-deficient congenital muscular dystrophy | Nervous system disease | |
LGMDR16/MDDG | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
H02307 | Muscular dystrophy-dystroglycanopathy | Inherited metabolic disorder | |
LGMDR3 | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
LGMDR4 | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
LGMDR6/CMD1L | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
DYT11 | H00831 | Primary dystonia | Nervous system disease |
LGMDR5 | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
DMD/BMD/CMD3B | H00562 | Dystrophinopathies | Nervous system disease |
LVNC1 | H01216 | Left ventricular noncompaction | Cardiovascular disease |
CMH26/MPD4/MFM5/RCM5 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H00594 | Distal myopathy | Nervous system disease | |
H00595 | Myofibrillar myopathies | Nervous system disease | |
H01219 | Restrictive cardiomyopathy | Cardiovascular disease | |
CMYP6 | H01810 | Congenital myopathy | Nervous system disease |
DA2A/B3/CPSFS | H00811 | Distal arthrogryposis | Congenital malformation |
H02717 | Contractures, pterygia, and spondylocarpotarsal fusion syndrome | Congenital malformation | |
CMH14/CMD1EE/ASD3/SSS3 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
H00546 | Atrial septal defect | Congenital malformation | |
H00729 | Sick sinus syndrome | Cardiovascular disease | |
CMH1/CMD1S/MPD1/CMYP7 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
H00594 | Distal myopathy | Nervous system disease | |
H01810 | Congenital myopathy | Nervous system disease | |
DA7 | H00811 | Distal arthrogryposis | Congenital malformation |
AAT4/MMIHS2/VSCM2 | H00801 | Familial thoracic aortic aneurysm and dissection | Cardiovascular disease |
H01869 | Megacystis microcolon intestinal hypoperistalsis syndrome | Congenital malformation | |
H02553 | Visceral myopathy | Congenital malformation | |
CMYP14 | H01810 | Congenital myopathy | Nervous system disease |
CMH10/MFM12 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H00595 | Myofibrillar myopathies | Nervous system disease | |
CMH8 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
ATFB18 | H00731 | Atrial fibrillation | Cardiovascular disease |
MMIHS4 | H01869 | Megacystis microcolon intestinal hypoperistalsis syndrome | Congenital malformation |
DA1C | H00811 | Distal arthrogryposis | Congenital malformation |
DA1B/LCCS4/CMYP16 | H00811 | Distal arthrogryposis | Congenital malformation |
H00865 | Lethal congenital contractural syndrome | Congenital malformation | |
H01810 | Congenital myopathy | Nervous system disease | |
CMH4/CMD1MM | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
CMD1G/LGMDR10/MFM9/CMYP5 | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
H00593 | Limb-girdle muscular dystrophy | Nervous system disease | |
H00595 | Myofibrillar myopathies | Nervous system disease | |
H01810 | Congenital myopathy | Nervous system disease | |
CMH9 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
LGMDR7 | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
CMH25 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
CMD1Z | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
CMYP15 | H01810 | Congenital myopathy | Nervous system disease |
CMD1FF/CMD2A/RCM1 | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
H01219 | Restrictive cardiomyopathy | Cardiovascular disease | |
NEM5 | H00698 | Nemaline myopathy | Nervous system disease |
CMD1D/RCM3 | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
H01219 | Restrictive cardiomyopathy | Cardiovascular disease | |
CMH13 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
DA2B1 | H00811 | Distal arthrogryposis | Congenital malformation |
CMH7 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
RCM3/CMH2 | H01219 | Restrictive cardiomyopathy | Cardiovascular disease |
H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease | |
DA2B2 | H00811 | Distal arthrogryposis | Congenital malformation |
CMD1Y | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
CMYP4 | H01810 | Congenital myopathy | Nervous system disease |
CMH3 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
CMYP4A | H01810 | Congenital myopathy | Nervous system disease |
CMYP2/SHPM | H01810 | Congenital myopathy | Nervous system disease |
H02721 | Scapulohumeroperoneal myopathy | Nervous system disease | |
CMD1R/ASD5 | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
H00546 | Atrial septal defect | Congenital malformation | |
CMH11 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
MMIHS3 | H01869 | Megacystis microcolon intestinal hypoperistalsis syndrome | Congenital malformation |
CMD2G | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
NEM2/AMC6 | H00698 | Nemaline myopathy | Nervous system disease |
H02299 | Arthrogryposis multiplex congenita | Congenital malformation | |
MFM3 | H00595 | Myofibrillar myopathies | Nervous system disease |
CMD1M/CMH12 | H00294 | Dilated cardiomyopathy | Cardiovascular disease |
H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease | |
CMH16 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
CMH22/CMYP24/CMD1KK/RCM4 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
H01810 | Congenital myopathy | Nervous system disease | |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
H01219 | Restrictive cardiomyopathy | Cardiovascular disease | |
CMH28 | H00292 | Hypertrophic cardiomyopathy | Cardiovascular disease |
SPG76 | H00266 | Hereditary spastic paraplegia | Nervous system disease |
LGMDD4/R1 | H00593 | Limb-girdle muscular dystrophy | Nervous system disease |
NEM7 | H00698 | Nemaline myopathy | Nervous system disease |
EBS5/LGMDR17 | H00584 | Epidermolysis bullosa simplex | Congenital malformation |
H00593 | Limb-girdle muscular dystrophy | Nervous system disease | |
EDMD5 | H00563 | Emery-Dreifuss muscular dystrophy | Nervous system disease |
ARVD5/EDMD7/AUNA3 | H00293 | Arrhythmogenic right ventricular cardiomyopathy | Cardiovascular disease |
H00563 | Emery-Dreifuss muscular dystrophy | Nervous system disease | |
H02339 | Auditory neuropathy | Nervous system disease | |
EDMD1 | H00563 | Emery-Dreifuss muscular dystrophy | Nervous system disease |
PHA/REYNOLDS/SKPHA | H00234 | Pelger-Huet anomaly | Hematologic disease |
H01133 | Reynolds syndrome | Immune system disease | |
H02732 | Rhizomelic skeletal dysplasia with or without Pelger-Huet anomaly | Congenital malformation | |
EDMD2/3/CMD1A/FPLD2/CMT2B1/CMD/HGPS/RSDM2/MADA/HHS-S | H00563 | Emery-Dreifuss muscular dystrophy | Nervous system disease |
H00294 | Dilated cardiomyopathy | Cardiovascular disease | |
H00420 | Familial partial lipodystrophy | Inherited metabolic disorder | |
H00264 | Charcot-Marie-Tooth disease | Neurodegenerative disease | |
H00590 | Congenital muscular dystrophies (CMD/MDC) | Nervous system disease | |
H00601 | Hutchinson-Gilford progeria syndrome | Inherited metabolic disorder | |
H00663 | Restrictive dermopathy | Congenital malformation | |
H00665 | Mandibuloacral dysplasia | Congenital malformation | |
H02725 | Heart-hand syndrome | Congenital malformation | |
MCPH27/APLD/EPM9 | H00269 | Primary microcephaly | Congenital malformation |
H00420 | Familial partial lipodystrophy | Inherited metabolic disorder | |
H00810 | Progressive myoclonic epilepsy | Nervous system disease | |
MCPH26 | H00269 | Primary microcephaly | Congenital malformation |
ADLD | H01230 | Adult-onset autosomal dominant leukodystrophy | Nervous system disease |
Drug name | ||
D1 | D09900 | Eteplirsen (USAN/INN) |
D2 | D11528 | Viltolarsen (JAN/USAN) |
D3 | D11707 | Golodirsen (USAN/INN) |
D4 | D11988 | Casimersen (USAN/INN) |
D5 | D12902 | Sevasemten (USAN/INN) |