VirGenes

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VFC Structure Cards

Full-atom Foldseek-superposed previews rendered as cartoon structures.

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VFC Annotations

Semantic annotations aggregated from VFC member VSC descriptions.

KO information is shown as an associated profile across member VSC consensus KOs; a single KO is not treated as assigned at the fold level.

Clusters (VSC)
VFC ID Annotation Associated KO Confidence Top Category Hypothetical %

Confidence assignment for VFC functional annotations

VFC annotations are aggregated from member VSC descriptions and weighted by VSC gene count.

High-confidence annotations are assigned when one functional category contributes at least 50% of the gene-count weight and hypothetical or uncharacterized proteins contribute less than 40%.

Medium-confidence annotations are assigned when the dominant functional category contributes at least 30% but does not satisfy the high-confidence rule.

Low-confidence annotations are assigned when no category reaches 30%, or when hypothetical or uncharacterized proteins contribute at least 50% of the gene-count weight.

KO profiles are descriptive associations from member VSC consensus KOs. They do not increase confidence and are not single-KO fold assignments.