Confidence assignment for VFC functional annotations
VFC annotations are aggregated from member VSC descriptions and weighted by VSC gene count.
High-confidence annotations are assigned when one functional category contributes at least 50% of the gene-count weight and hypothetical or uncharacterized proteins contribute less than 40%.
Medium-confidence annotations are assigned when the dominant functional category contributes at least 30% but does not satisfy the high-confidence rule.
Low-confidence annotations are assigned when no category reaches 30%, or when hypothetical or uncharacterized proteins contribute at least 50% of the gene-count weight.
KO profiles are descriptive associations from member VSC consensus KOs. They do not increase confidence and are not single-KO fold assignments.