KNApSAcK Metabolite C00001055
Metabolite
KNApSAcK Entry
| id | C00001055 |
|---|---|
| Name | Isoorientin / Homoorientin / Lespecapitioside / Luteolin 6-C-beta-D-glucopyranoside / 2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one |
| CAS RN | 4261-42-1 |
| Standard InChI | InChI=1S/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2/t14?,17-,19+,20?,21+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2 |
Cluster
| Phytochemical cluster | No. 15 |
|---|---|
| KCF-S cluster | No. 22 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL239559 CHEMBL1302308 |
KEGG
| By LinkDB | C01821 |
|---|
CTD
| By CAS RN | C057912 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 69 |
| asterids | 16 |
| eudicotyledons | 3 |
| Liliopsida | 3 |
| Magnoliophyta | 1 |
Family (Top 10)
| family name | count |
|---|---|
| Fabaceae | 66 |
| Gentianaceae | 7 |
| Asteraceae | 4 |
| Lamiaceae | 3 |
| Chloranthaceae | 1 |
| Passifloraceae | 1 |
| Ranunculaceae | 1 |
| Arecaceae | 1 |
| Caryophyllaceae | 1 |
| Acanthaceae | 1 |
List (92)
* NCBI
Human Protein / Gene in interaction
23 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL1302308 |
CHEMBL1738312
(1)
|
0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | CHEMBL1302308 |
CHEMBL1614079
(1)
|
0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | CHEMBL1302308 |
CHEMBL1614076
(1)
|
1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL1794585
(2)
|
0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL1302308 |
CHEMBL1614166
(1)
|
1 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL1794486
(3)
|
0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL1794569
(2)
|
1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | CHEMBL239559 CHEMBL1302308 |
CHEMBL1614280
(2)
|
0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL239559 |
CHEMBL1738588
(1)
|
0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL1794483
(3)
|
0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL1737991
(3)
|
0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL1614466
(1)
CHEMBL1614211
(2)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL1302308 |
CHEMBL1614421
(1)
|
4 / 3 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL1794536
(3)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL1302308 |
CHEMBL1613914
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL239559 |
CHEMBL1614364
(1)
|
1 / 1 |
| O00255 | Menin | Unclassified protein | CHEMBL1302308 |
CHEMBL1614257
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1302308 |
CHEMBL1614257
(1)
|
1 / 3 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | CHEMBL239559 |
CHEMBL1613933
(1)
|
0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | CHEMBL239559 |
CHEMBL1613933
(1)
|
1 / 6 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | CHEMBL239559 CHEMBL1302308 |
CHEMBL2114738
(2)
|
0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | CHEMBL239559 CHEMBL1302308 |
CHEMBL2114881
(2)
|
0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | CHEMBL1302308 |
CHEMBL2114796
(1)
|
2 / 1 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (14)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (17)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|