PCIDB

KNApSAcK Metabolite C00001059

Metabolite

KNApSAcK Entry

id C00001059
Name Isovitexin / Saponaretin / Homovitexin / 6-C-beta-D-Glucopyranosylapigenin / 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CAS RN 38953-85-4
Standard InChI InChI=1S/C21H20O10/c22-7-14-17(26)19(28)20(29)21(31-14)16-11(25)6-13-15(18(16)27)10(24)5-12(30-13)8-1-3-9(23)4-2-8/h1-6,14,17,19-23,25-29H,7H2/t14?,17-,19+,20?,21+/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H20O10/c22-7-14-17(26)19(28)20(29)21(31-14)16-11(25)6-13-15(18(16)27)10(24)5-12(30-13)8-1-3-9(23)4-2-8/h1-6,14,17,19-23,25-29H,7H2

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 22

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL465360 CHEMBL1601394

KEGG

By LinkDB C01714

CTD

By CAS RN C049772

Species

Summary

Plant class

class name count
rosids 69
asterids 14
Liliopsida 3
Magnoliophyta 2
eudicotyledons 2

Family (Top 10)

family name count
Fabaceae 57
Gentianaceae 8
Euphorbiaceae 3
Geraniaceae 2
Cucurbitaceae 2
Passifloraceae 2
Lamiaceae 2
Arecaceae 1
Thymelaeaceae 1
Asteraceae 1

List (90)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia caven 72367 Fabaceae rosids Viridiplantae
Acacia furcatispina 370701 Fabaceae rosids Viridiplantae
Anadenanthera peregrina 148672 Fabaceae rosids Viridiplantae
Ascarina lucida 130721 Chloranthaceae Magnoliophyta Viridiplantae
Camellia sinensis (L.) O.KUNTZE 4441 Theaceae asterids Viridiplantae
Centaurea melitensis L. 41503 Asteraceae asterids Viridiplantae
Citrullus colocynthis (L.) 3653 Cucurbitaceae rosids Viridiplantae
Cladogynos orientalis 3977 Euphorbiaceae rosids Viridiplantae
Clinacanthus nutans 714457 Acanthaceae asterids Viridiplantae
Commelina communis L 4743 Commelinaceae Liliopsida Viridiplantae
Crotalaria micans 1127386 Fabaceae rosids Viridiplantae
Crotalaria verrucosa 890036 Fabaceae rosids Viridiplantae
Cucumis sativus 3659 Cucurbitaceae rosids Viridiplantae
Cytisus hirsutus 1211454 Fabaceae rosids Viridiplantae
Dalbergia monetaria 450027 Fabaceae rosids Viridiplantae
Daphne sericea 66679 Thymelaeaceae rosids Viridiplantae
Desmodium triflorum 670328 Fabaceae rosids Viridiplantae
Drymaria diandra 191453 Caryophyllaceae eudicotyledons Viridiplantae
Galactia glaucophylla 100145 Fabaceae rosids Viridiplantae
Garcinia hombroniana 180107 Clusiaceae rosids Viridiplantae
Gentiana argentea 21496 Gentianaceae asterids Viridiplantae
Gentiana arisanensis 1169730 Gentianaceae asterids Viridiplantae
Gentiana depressa 50762 Gentianaceae asterids Viridiplantae
Gentiana elwesii 21496 Gentianaceae asterids Viridiplantae
Gentiana pedicellata 21496 Gentianaceae asterids Viridiplantae
Gentiana prolata 21496 Gentianaceae asterids Viridiplantae
Gentiana sikkimensis 21496 Gentianaceae asterids Viridiplantae
Geranium phaeum 379952 Geraniaceae rosids Viridiplantae
Gleditsia japonica 66093 Fabaceae rosids Viridiplantae
Gleditsia sinensis 66096 Fabaceae rosids Viridiplantae
Glycyrrhiza glabra 49827 Fabaceae rosids Viridiplantae
Hedyotis dichotoma 58416 Rubiaceae asterids Viridiplantae
Hornschuchia citriodora 306963 Annonaceae Magnoliophyta Viridiplantae
Lespedeza capitata 571920 Fabaceae rosids Viridiplantae
Lespedeza hedysaroides 53892 Fabaceae rosids Viridiplantae
Lespedeza juncea 688283 Fabaceae rosids Viridiplantae
Lupinus sericeus 61075 Fabaceae rosids Viridiplantae
Macaranga tanarius 109849 Euphorbiaceae rosids Viridiplantae
Otholobium bracteolatum 458346 Fabaceae rosids Viridiplantae
Otholobium foliosum 53909 Fabaceae rosids Viridiplantae
Otholobium fruticans 53909 Fabaceae rosids Viridiplantae
Otholobium hirtum 53909 Fabaceae rosids Viridiplantae
Otholobium parviflorum 53909 Fabaceae rosids Viridiplantae
Otholobium sericeum 53910 Fabaceae rosids Viridiplantae
Parkinsonia aculeata 58886 Fabaceae rosids Viridiplantae
Passiflora serratodigitata 231192 Passifloraceae rosids Viridiplantae
Passiflora spp. 3684 Passifloraceae rosids Viridiplantae
Pelargonium reniforme 59871 Geraniaceae rosids Viridiplantae
Phoenix hanceana var. formosana 4719 Arecaceae Liliopsida Viridiplantae
Pisum sativum 3888 Fabaceae rosids Viridiplantae
Polygonum affine 487741 Polygonaceae eudicotyledons Viridiplantae
Prosopis alba 207710 Fabaceae rosids Viridiplantae
Prosopis argentina 207712 Fabaceae rosids Viridiplantae
Prosopis chilensis 35716 Fabaceae rosids Viridiplantae
Prosopis fiebrigii 3803 Fabaceae rosids Viridiplantae
Prosopis hassleri 364021 Fabaceae rosids Viridiplantae
Prosopis kuntzei 207715 Fabaceae rosids Viridiplantae
Prosopis nigra 207716 Fabaceae rosids Viridiplantae
Prosopis reptans 207717 Fabaceae rosids Viridiplantae
Prosopis ruscifolia 207718 Fabaceae rosids Viridiplantae
Prosopis strombulifera 433934 Fabaceae rosids Viridiplantae
Prosopis vinalillo 207720 Fabaceae rosids Viridiplantae
Psophocarpus tetragonolobus 3891 Fabaceae rosids Viridiplantae
Psoralea affinis 100167 Fabaceae rosids Viridiplantae
Psoralea arborea 100167 Fabaceae rosids Viridiplantae
Psoralea asarina 100167 Fabaceae rosids Viridiplantae
Psoralea connixa 100167 Fabaceae rosids Viridiplantae
Psoralea effusa 100167 Fabaceae rosids Viridiplantae
Psoralea imbricata 100167 Fabaceae rosids Viridiplantae
Psoralea laxa 100167 Fabaceae rosids Viridiplantae
Psoralea papillosa 100167 Fabaceae rosids Viridiplantae
Psoralea ramulosa 100167 Fabaceae rosids Viridiplantae
Psoralea speciosa 100167 Fabaceae rosids Viridiplantae
Rhynchosia cana 132460 Fabaceae rosids Viridiplantae
Rhynchosia capitata 132460 Fabaceae rosids Viridiplantae
Rhynchosia heynei 132460 Fabaceae rosids Viridiplantae
Rhynchosia jacobii 132460 Fabaceae rosids Viridiplantae
Rhynchosia minima 132461 Fabaceae rosids Viridiplantae
Rhynchosia rothii 132460 Fabaceae rosids Viridiplantae
Rhynchosia suaveolens 132460 Fabaceae rosids Viridiplantae
Securigera varia 53861 Fabaceae rosids Viridiplantae
Smilax bracteata 1045134 Smilacaceae Liliopsida Viridiplantae
Strophioblachia fimbricalyx Boerl 179701 Euphorbiaceae rosids Viridiplantae
Swertia perennis 39379 Gentianaceae asterids Viridiplantae
Tamarindus indica 58860 Fabaceae rosids Viridiplantae
Theobroma cacao L. 3640 Malvaceae rosids Viridiplantae
Vigna mungo 3915 Fabaceae rosids Viridiplantae
Vigna radiata 157791 Fabaceae rosids Viridiplantae
Vitex lucens 384982 Lamiaceae asterids Viridiplantae
Vitex polygama 54476 Lamiaceae asterids Viridiplantae

Human Protein / Gene in interaction

28 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1601394 CHEMBL1738312 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL1601394 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1601394 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1601394 CHEMBL1794585 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL1601394 CHEMBL1614166 (1)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1601394 CHEMBL1614458 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1601394 CHEMBL1794495 (1)
2 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL1601394 CHEMBL1794486 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL465360 CHEMBL2114810 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL1601394 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL1601394 CHEMBL1614280 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1601394 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
P30989 Neurotensin receptor type 1 Neurotensin receptor CHEMBL1601394 CHEMBL1738430 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1601394 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL1601394 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1601394 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1601394 CHEMBL1738184 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1601394 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1601394 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1601394 CHEMBL1613829 (1) CHEMBL1794433 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL465360 CHEMBL1614364 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL465360 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL1601394 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1601394 CHEMBL1614257 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1601394 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1601394 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL1601394 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL1601394 CHEMBL2114796 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc Q14191
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (19)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)