PCIDB

KNApSAcK Metabolite C00002785

Metabolite

KNApSAcK Entry

id C00002785
Name Alizarin
CAS RN 72-48-0
Standard InChI InChI=1S/C14H8O4/c15-10-6-5-9-11(14(10)18)13(17)8-4-2-1-3-7(8)12(9)16/h1-6,15,18H
Standard InChI (Main Layer) InChI=1S/C14H8O4/c15-10-6-5-9-11(14(10)18)13(17)8-4-2-1-3-7(8)12(9)16/h1-6,15,18H

Cluster

Phytochemical cluster No. 62
KCF-S cluster No. 41

Link

ChEMBL

By standard InChI CHEMBL55814
By standard InChI Main Layer CHEMBL55814

KEGG

By LinkDB C01474

CTD

By CAS RN C010078

Human Protein / Gene in interaction

44 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL55814 CHEMBL1908081 (1) CHEMBL1908082 (1)
3 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL55814 CHEMBL2188686 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL55814 CHEMBL1613842 (1)
4 / 2
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL55814 CHEMBL1908087 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL55814 CHEMBL2114784 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL55814 CHEMBL1794585 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL55814 CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL55814 CHEMBL1614458 (2)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL55814 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL55814 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL55814 CHEMBL2114843 (1)
0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL55814 CHEMBL1908086 (2)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL55814 CHEMBL1908090 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL55814 CHEMBL2114817 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL55814 CHEMBL1794569 (1)
1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL55814 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL55814 CHEMBL1794467 (2)
0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein CHEMBL55814 CHEMBL1738574 (1) CHEMBL2114930 (1)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL55814 CHEMBL1614252 (1)
2 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL55814 CHEMBL1614521 (1) CHEMBL1613808 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL55814 CHEMBL1613910 (2)
3 / 3
Q99873 Protein arginine N-methyltransferase 1 Enzyme CHEMBL55814 CHEMBL919884 (1)
0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL55814 CHEMBL1614038 (2)
2 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL55814 CHEMBL1908085 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL55814 CHEMBL1614240 (2)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL55814 CHEMBL1614108 (2) CHEMBL1613886 (2)
0 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL55814 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL55814 CHEMBL1614466 (1) CHEMBL1614211 (2)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL55814 CHEMBL1908080 (3)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL55814 CHEMBL1614421 (2) CHEMBL1614502 (2)
4 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL55814 CHEMBL1908083 (2)
0 / 0
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein CHEMBL55814 CHEMBL2188685 (1)
0 / 7
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL55814 CHEMBL1794536 (2)
0 / 0
Q14145 Kelch-like ECH-associated protein 1 Unclassified protein CHEMBL55814 CHEMBL2114882 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL55814 CHEMBL1613914 (2)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL55814 CHEMBL1613829 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL55814 CHEMBL1614319 (1) CHEMBL1613809 (1)
CHEMBL1613988 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL55814 CHEMBL1614319 (1) CHEMBL1613809 (1)
CHEMBL1613988 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL55814 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL55814 CHEMBL1613933 (1)
1 / 6
Q92731 Estrogen receptor beta NR3A2 CHEMBL55814 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1)
0 / 1
P03372 Estrogen receptor NR3A1 CHEMBL55814 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1)
1 / 1
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL55814 CHEMBL2114796 (1)
2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL55814 CHEMBL2354287 (1)
1 / 1

CTD interaction (12)

compound gene gene name gene description interaction interaction type form reference
pmid
C010078 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) alizarin results in decreased activity of CYP1A1 protein decreases activity
protein 12379470
C010078 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) alizarin results in decreased activity of CYP1A2 protein decreases activity
protein 12379470
C010078 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) alizarin results in decreased activity of CYP1B1 protein decreases activity
protein 12379470
C010078 1548 CYP2A6
CPA6
CYP2A
CYP2A3
CYPIIA6
P450C2A
P450PB
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) alizarin results in decreased activity of CYP2A6 protein decreases activity
protein 12379470
C010078 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) alizarin results in decreased activity of CYP2E1 protein decreases activity
protein 12379470
C010078 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 alizarin binds to and results in increased activity of ESR1 protein affects binding
/ increases activity
protein 20707409
C010078 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of alizarin increases glucuronidation
protein 14557274
C010078 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of alizarin increases glucuronidation
protein 14557274
C010078 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of alizarin increases glucuronidation
protein 14557274
C010078 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of alizarin increases glucuronidation
protein 14557274
C010078 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of alizarin increases glucuronidation
protein 14557274
C010078 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of alizarin increases metabolic processing
protein 7835232

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#114500 Colorectal cancer; crc P18054
Q14191
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (35)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00036 Osteosarcoma P08684 (marker)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
H00013 Small cell lung cancer P10415 (related)
H00018 Gastric cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)