Species

KNApSAcK Entry

Organism name Libertia caerulescens
Genus Libertia
Family Iridaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Libertia
Linked NCBI taxonomy ID 58959
Linked level genus

Family

Family in NCBI taxonomy Iridaceae
ID 26339

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002785 External link 512 Alizarin
CHEMBL55814
C010078
44 / 36 / 35 12 / 0 No. 41 No. 62

Human Protein / Gene in interactions

44 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00002785 3 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00002785 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00002785 4 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00002785 0 / 0
Q99700 Ataxin-2 Unclassified protein C00002785 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002785 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00002785 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002785 0 / 0
P39748 Flap endonuclease 1 Enzyme C00002785 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002785 0 / 0
O75496 Geminin Unclassified protein C00002785 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002785 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002785 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00002785 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00002785 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00002785 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002785 0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein C00002785 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002785 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002785 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002785 3 / 3
Q99873 Protein arginine N-methyltransferase 1 Enzyme C00002785 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002785 2 / 2
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00002785 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002785 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002785 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00002785 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00002785 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002785 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00002785 4 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002785 0 / 0
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00002785 0 / 7
Q9UBT6 DNA polymerase kappa Enzyme C00002785 0 / 0
Q14145 Kelch-like ECH-associated protein 1 Unclassified protein C00002785 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002785 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002785 0 / 0
O00255 Menin Unclassified protein C00002785 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002785 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00002785 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002785 1 / 4
Q92731 Estrogen receptor beta NR3A2 C00002785 0 / 1
P03372 Estrogen receptor NR3A1 C00002785 1 / 1
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00002785 2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein C00002785 1 / 1

12 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00002785
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00002785
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00002785
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) C00002785
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00002785
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00002785
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00002785
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002785
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002785
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002785
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00002785
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00002785

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#114500 Colorectal cancer; crc P18054
Q14191
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#166350 Osseous heteroplasia, progressive; poh P63092
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (35)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00036 Osteosarcoma P08684 (marker)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
H00013 Small cell lung cancer P10415 (related)
H00018 Gastric cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)