PCIDB

KNApSAcK Metabolite C00003240

Metabolite

KNApSAcK Entry

id C00003240
Name Costunolide
CAS RN 553-21-9
Standard InChI InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3

Cluster

Phytochemical cluster No. 38
KCF-S cluster No. 107

Link

ChEMBL

By standard InChI CHEMBL86416
By standard InChI Main Layer CHEMBL86416 CHEMBL190377 CHEMBL1575037

KEGG

By LinkDB C09382

CTD

By CAS RN C002602

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL86416 CHEMBL1008495 (1)
0 / 3
P11473 Vitamin D3 receptor NR1I1 CHEMBL1575037 CHEMBL1794311 (1)
2 / 3
Q04206 Transcription factor p65 Transcription Factor CHEMBL86416 CHEMBL190377 CHEMBL828644 (1) CHEMBL835063 (1)
CHEMBL861583 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL86416 CHEMBL1941568 (1) CHEMBL1941569 (1)
1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1575037 CHEMBL1613829 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL1575037 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL1575037 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1575037 CHEMBL1614531 (1)
1 / 3
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor CHEMBL190377 CHEMBL828644 (1) CHEMBL835063 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL190377 CHEMBL828644 (1) CHEMBL835063 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (7)

OMIM preferred title UniProt
#615363 Estrogen resistance; estrr P03372
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (15)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00026 Endometrial Cancer P03372 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003921 C002602 Diabetes Mellitus, Experimental therapeutic
20709041
D006943 C002602 Hyperglycemia therapeutic
19007766
D011230 C002602 Precancerous Conditions therapeutic
7882322