Species

KNApSAcK Entry

Organism name Laurus nobilis
Genus Laurus
Family Lauraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Laurus nobilis
Linked NCBI taxonomy ID 85223
Linked level species

Family

Family in NCBI taxonomy Lauraceae
ID 3433

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (20)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00009074 External link 512 Procyanidin B7
/ Catechin-(4beta->6)-catechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00009077 External link 512 Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479580
20 / 7 / 8 10 / 0 No. 16 No. 19
C00009076 External link 512 Procyanidin B5
/ Epicatechin-(4beta-6)-epicatechin
CHEMBL506487
CHEMBL502984
CHEMBL451115
No. 16 No. 19
C00002935 External link 512 Procyanidin B4
/ Catechin-(4alpha->8)-epicatechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
20 / 7 / 8 No. 16 No. 19
C00001790 External link 512 Actinodaphnine
/ (+)-Actinodaphnine
/ 1,2-Methylenedioxy-9-hydroxy-10-methoxynoraporphine
CHEMBL518088
CHEMBL1588263
C060992
30 / 32 / 24 No. 20 No. 4
C00000956 External link 512 (-)-Epicatechin
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
85 / 58 / 54 No. 52 No. 14
C00000947 External link 512 D-Catechol
/ D-Catechin
/ Teafuran 30A
/ (+)-Catechin
/ Dexcyanidanol
/ (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
D002392
85 / 58 / 54 91 / 13 No. 52 No. 14
C00048930 External link 512 (+)-Epigallocatechin
CHEMBL47386
CHEMBL125743
CHEMBL130415
CHEMBL264167
CHEMBL404845
26 / 17 / 29 No. 52 No. 14
C00008817 External link 512 Gallocatechin
/ (+)-Gallocatechin
/ (+)-Gallocatechol
/ (2R,3S)-3,4-Dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol
CHEMBL47386
CHEMBL125743
CHEMBL130415
CHEMBL264167
CHEMBL404845
26 / 17 / 29 No. 52 No. 14
C00004565 External link 512 Kaempferol
/ Nimbecetin
/ Rhamnolutein
/ Pelargidenolon
/ 5,7,4'-Trihydroxyflavonol
/ 3,5,7,4'-Tetrahydroxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL150
C006552
76 / 69 / 87 86 / 8 No. 71 No. 15
C00003240 External link 512 Costunolide
CHEMBL86416
CHEMBL190377
CHEMBL1575037
C002602
10 / 7 / 15 0 / 3 No. 107 No. 38
C00013775 External link 512 Kaempferol 3-(2'',4''-di-(Z)-p-coumaroylrhamnoside)
/ 3-[[6-Deoxy-2,4-bis-O-[(2Z)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-alpha-L-mannopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL1642586
CHEMBL1797052
1 / 1 / 1 No. 231
C00003314 External link 512 Laurenobiolide
No. 249 No. 38
C00000604 External link 512 (-)-Secoisolariciresinol
CHEMBL368347
C060283
2 / 1 / 1 1 / 0 No. 282 No. 21
C00029488 External link 512 3beta-Chlorodehydrocostuslactone
No. 306 No. 38
C00011053 External link 512 (-)-Sabinene
/ (-)-4(10)-Thujene
CHEMBL452687
No. 1343 No. 35
C00010827 External link 512 Dehydro-1,8-cineole
No. 2943
C00010839 External link 512 6,8-Epoxy-p-menth-2-ene
/ 4,7,7-Trimethyl-6-Oxabicyclo[3.2.1]oct-2-ene
No. 2943
C00000136 External link 512 1,8-Cineole
CHEMBL485259
CHEMBL1397305
99 / 57 / 50 No. 5413 No. 35

Human Protein / Gene in interactions

231 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000136 C00000604 C00000947 C00000956 C00002935 C00004565 C00009077 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000947 C00000956 C00001790 C00004565 C00005374 C00008817 C00048930 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000136 C00000604 C00000947 C00000956 C00002935 C00004565 C00009077 0 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00000947 C00000956 C00002935 C00004565 C00008817 C00009077 C00048930 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000947 C00000956 C00001790 C00004565 C00005374 C00008817 C00048930 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000947 C00000956 C00001790 C00004565 C00005374 C00008817 C00048930 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000136 C00000947 C00000956 C00001790 C00004565 C00008817 C00048930 4 / 3
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000136 C00000947 C00000956 C00003240 C00004565 C00008817 C00048930 0 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000947 C00000956 C00002935 C00004565 C00008817 C00009077 C00048930 3 / 3
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000947 C00000956 C00003240 C00004565 C00008817 C00048930 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000947 C00000956 C00001790 C00004565 C00008817 C00048930 2 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000136 C00000947 C00000956 C00004565 C00008817 C00048930 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000136 C00000947 C00000956 C00002935 C00004565 C00009077 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000947 C00000956 C00004565 C00005374 C00008817 C00048930 1 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000136 C00000947 C00000956 C00002935 C00004565 C00009077 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000136 C00000947 C00000956 C00003240 C00008817 C00048930 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000136 C00000947 C00000956 C00002935 C00004565 C00009077 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00000947 C00000956 C00001790 C00005374 C00008817 C00048930 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000947 C00000956 C00001790 C00003240 C00004565 1 / 2
Q9Y253 DNA polymerase eta Enzyme C00000947 C00000956 C00001790 C00004565 C00005374 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000947 C00000956 C00001790 C00004565 C00005374 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000136 C00000947 C00000956 C00008817 C00048930 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000136 C00000947 C00000956 C00008817 C00048930 0 / 0
P17252 Protein kinase C alpha type Alpha C00000136 C00000947 C00000956 C00002935 C00009077 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000136 C00000947 C00000956 C00008817 C00048930 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000947 C00000956 C00004565 C00008817 C00048930 0 / 0
P39748 Flap endonuclease 1 Enzyme C00000947 C00000956 C00001790 C00004565 C00005374 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000947 C00000956 C00003240 C00008817 C00048930 2 / 3
P00374 Dihydrofolate reductase Oxidoreductase C00000947 C00000956 C00008817 C00048930 1 / 1
O00255 Menin Unclassified protein C00000947 C00000956 C00003240 C00004565 2 / 5
P41743 Protein kinase C iota type Iota C00000947 C00000956 C00002935 C00009077 0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00000947 C00000956 C00008817 C00048930 0 / 0
P24723 Protein kinase C eta type Eta C00000947 C00000956 C00002935 C00009077 1 / 0
Q05513 Protein kinase C zeta type Iota C00000947 C00000956 C00002935 C00009077 0 / 0
Q04759 Protein kinase C theta type Delta C00000947 C00000956 C00002935 C00009077 0 / 1
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00000947 C00000956 C00008817 C00048930 2 / 3
P05771 Protein kinase C beta type Alpha C00000947 C00000956 C00002935 C00009077 0 / 0
Q02156 Protein kinase C epsilon type Eta C00000947 C00000956 C00002935 C00009077 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000947 C00000956 C00002935 C00009077 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000947 C00000956 C00002935 C00009077 0 / 0
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00000947 C00000956 C00008817 C00048930 0 / 7
P02768 Serum albumin Secreted protein C00000947 C00000956 C00008817 C00048930 0 / 0
Q05655 Protein kinase C delta type Delta C00000947 C00000956 C00002935 C00009077 0 / 0
P05129 Protein kinase C gamma type Alpha C00000947 C00000956 C00002935 C00009077 1 / 1
P56817 Beta-secretase 1 A1A C00000947 C00000956 C00008817 C00048930 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001790 C00004565 C00005374 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000947 C00000956 C00004565 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000947 C00000956 C00001790 2 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000947 C00000956 C00001790 4 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000947 C00000956 C00001790 0 / 0
P04745 Alpha-amylase 1 Enzyme C00000947 C00000956 C00004565 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000136 C00000947 C00000956 1 / 2
P28482 Mitogen-activated protein kinase 1 Erk C00000136 C00000947 C00000956 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000136 C00000947 C00000956 3 / 2
P02545 Prelamin-A/C Unclassified protein C00000136 C00001790 C00004565 11 / 10
Q9Y3R4 Sialidase-2 Enzyme C00000947 C00000956 C00004565 0 / 0
P06746 DNA polymerase beta Enzyme C00000947 C00000956 C00001790 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000947 C00000956 C00003240 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00000947 C00000956 C00004565 0 / 0
P03372 Estrogen receptor NR3A1 C00000136 C00003240 C00004565 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000947 C00000956 C00001790 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000947 C00000956 0 / 1
Q8N1Q1 Carbonic anhydrase 13 Lyase C00000947 C00000956 0 / 0
P54132 Bloom syndrome protein Enzyme C00000947 C00000956 1 / 2
P43166 Carbonic anhydrase 7 Lyase C00000947 C00000956 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000947 C00000956 5 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000136 C00004565 1 / 8
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00002935 C00009077 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000947 C00000956 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000947 C00000956 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000947 C00000956 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00008817 C00048930 0 / 1
P28907 ADP-ribosyl cyclase 1 Enzyme C00000947 C00000956 0 / 1
P22303 Acetylcholinesterase Hydrolase C00000136 C00004565 1 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00008817 C00048930 1 / 4
P23280 Carbonic anhydrase 6 Lyase C00000947 C00000956 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000947 C00000956 3 / 0
P49327 Fatty acid synthase Transferase C00000947 C00000956 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00000947 C00000956 0 / 1
P98170 E3 ubiquitin-protein ligase XIAP Other cytosolic protein C00004565 C00013775 1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000136 C00004565 2 / 2
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00002935 C00009077 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000947 C00000956 0 / 0
Q99700 Ataxin-2 Unclassified protein C00001790 C00004565 1 / 1
P22748 Carbonic anhydrase 4 Lyase C00000947 C00000956 1 / 1
O43570 Carbonic anhydrase 12 Lyase C00000947 C00000956 1 / 2
P04150 Glucocorticoid receptor NR3C1 C00000136 C00004565 0 / 1
P00734 Prothrombin S1A C00000947 C00000956 4 / 2
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000947 C00000956 1 / 0
P10275 Androgen receptor NR3C4 C00000136 C00004565 3 / 4
P07998 Ribonuclease pancreatic Enzyme C00000947 C00000956 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000947 C00000956 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000947 C00000956 0 / 0
O75496 Geminin Unclassified protein C00000136 C00001790 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001790 C00005374 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000947 C00000956 3 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00000947 C00000956 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000947 C00000956 3 / 0
P07711 Cathepsin L1 C1A C00000947 C00000956 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000947 C00000956 5 / 1
P00915 Carbonic anhydrase 1 Lyase C00000947 C00000956 0 / 0
P15121 Aldose reductase Enzyme C00004565 C00005374 0 / 0
P48147 Prolyl endopeptidase S9A C00004565 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000136 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000136 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000136 1 / 0
Q92731 Estrogen receptor beta NR3A2 C00000136 0 / 1
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000136 0 / 0
P08311 Cathepsin G S1A C00000136 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000136 1 / 0
P27487 Dipeptidyl peptidase 4 S9B C00004565 0 / 1
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000136 1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00001790 0 / 0
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNM, KCa1.x C00004565 1 / 1
P03956 Interstitial collagenase M10A C00000136 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000136 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00003240 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000136 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000136 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000136 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000136 0 / 0
P42858 Huntingtin Unclassified protein C00001790 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000136 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00001790 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00004565 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000136 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00004565 1 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000136 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000136 0 / 0
P14679 Tyrosinase Oxidoreductase C00004565 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000136 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000136 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00004565 5 / 3
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000136 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000136 1 / 0
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00004565 4 / 4
P21452 Substance-K receptor Neurokinin receptor C00000136 0 / 0
P06276 Cholinesterase Hydrolase C00004565 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000136 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000136 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000136 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001790 2 / 2
Q96RI1 Bile acid receptor NR1H4 C00004565 0 / 0
Q13133 Oxysterols receptor LXR-alpha NR1H3 C00000136 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000136 1 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000136 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000136 1 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00004565 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000136 1 / 1
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000136 2 / 1
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000136 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000136 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000136 0 / 0
P55055 Oxysterols receptor LXR-beta NR1H3 C00000136 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000136 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00004565 2 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000136 2 / 0
Q9GZU7 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Enzyme C00004565 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00004565 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001790 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000136 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001790 1 / 0
P07237 Protein disulfide-isomerase Enzyme C00005374 0 / 0
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000136 1 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family C00004565 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000136 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000136 0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 C00004565 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000136 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000136 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000136 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000136 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000136 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000136 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000136 0 / 0
P08183 Multidrug resistance protein 1 drug C00004565 1 / 0
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00004565 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00004565 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000136 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00004565 0 / 0
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family C00004565 1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000136 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000136 0 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000136 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000136 1 / 0
P35367 Histamine H1 receptor Histamine receptor C00000136 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00004565 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00000136 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000136 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000136 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000136 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00004565 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000136 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000136 1 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000136 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000136 0 / 1
Q04760 Lactoylglutathione lyase Enzyme C00004565 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00004565 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000136 0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000136 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000136 0 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00004565 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001790 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000136 2 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00004565 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000136 0 / 0
P29466 Caspase-1 C14 C00000136 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001790 1 / 0
P04062 Glucosylceramidase Enzyme C00004565 6 / 4
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000136 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000136 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000136 0 / 0
P08246 Neutrophil elastase S1A C00000136 2 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00000136 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00004565 0 / 0
Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 Unclassified protein C00000136 0 / 0
Q9NPH5 NADPH oxidase 4 Enzyme C00004565 0 / 0
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00001790 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00004565 7 / 37
P33527 Multidrug resistance-associated protein 1 drugs C00004565 0 / 0
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein C00004565 0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein C00004565 0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 C00004565 0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein C00004565 0 / 0
Q00653 Nuclear factor NF-kappa-B p100 subunit Transcription Factor C00003240 0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk C00004565 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00004565 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005374 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00004565 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001790 2 / 1

162 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000947 C00004565 C00009077
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00000947 C00004565 C00009077
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000947 C00004565 C00005374
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000947 C00004565 C00009077
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000947 C00004565 C00009077
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000947 C00004565 C00009077
581 BAX, BCL2L4 BCL2-associated X protein C00000947 C00004565 C00009077
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000947 C00004565 C00009077
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000947 C00004565
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000947 C00004565
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00000947 C00004565
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000947 C00004565
8856 NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR nuclear receptor subfamily 1, group I, member 2 C00000604 C00004565
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000947 C00004565
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000947 C00004565
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000947 C00004565
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000947 C00004565
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00004565 C00005374
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000947 C00004565
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000947 C00009077
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00000947
1437 CSF2, GMCSF colony stimulating factor 2 (granulocyte-macrophage) C00004565
37618 C00004565
1147 CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) C00004565
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00004565
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00004565
1031 CDKN2C, INK4C, p18, p18-INK4C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) C00004565
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00004565
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00004565
1734 DIO2, 5DII, D2, DIOII, SelY, TXDI2 deiodinase, iodothyronine, type II (EC:1.97.1.10) C00004565
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00004565
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00004565
2203 FBP1, FBP fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) C00004565
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00004565
4616 GADD45B, GADD45BETA, MYD118 growth arrest and DNA-damage-inducible, beta C00004565
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00004565
9687 GREB1 growth regulation by estrogen in breast cancer 1 C00004565
2938 GSTA1, GST2, GSTA1-1, GTH1 glutathione S-transferase alpha 1 (EC:2.5.1.18) C00004565
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00004565
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00004565
3043 HBB, CD113t-C, beta-globin hemoglobin, beta C00004565
3082 HGF, DFNB39, F-TCF, HGFB, HPTA, SF hepatocyte growth factor (hepapoietin A; scatter factor) C00004565
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00004565
891 CCNB1, CCNB cyclin B1 C00004565
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00004565
3567 IL5, EDF, IL-5, TRF interleukin 5 (colony-stimulating factor, eosinophil) C00004565
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00004565
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00004565
4297 KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS lysine (K)-specific methyltransferase 2A (EC:2.1.1.43) C00004565
6352 CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP chemokine (C-C motif) ligand 5 C00004565
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00004565
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00004565
110357 C00004565
4502 MT2A, MT2 metallothionein 2A C00004565
4586 MUC5AC, MUC5, TBM, leB mucin 5AC, oligomeric mucus/gel-forming C00004565
8202 NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP nuclear receptor coactivator 3 (EC:2.3.1.48) C00004565
27113 BBC3, JFY-1, JFY1, PUMA BCL2 binding component 3 C00004565
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00004565
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00004565
239 ALOX12, 12-LOX, 12S-LOX, LOG12 arachidonate 12-lipoxygenase (EC:1.13.11.31) C00004565
9970 NR1I3, CAR, CAR1, MB67 nuclear receptor subfamily 1, group I, member 3 C00004565
5241 PGR, NR3C3, PR progesterone receptor C00004565
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00004565
8000 PSCA, PRO232 prostate stem cell antigen C00004565
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00004565
6119 RPA3, REPA3 replication protein A3, 14kDa C00004565
2810 SFN, YWHAS stratifin C00004565
6513 SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED solute carrier family 2 (facilitated glucose transporter), member 1 C00004565
6773 STAT2, ISGF-3, P113, STAT113 signal transducer and activator of transcription 2, 113kDa C00004565
7019 TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3 transcription factor A, mitochondrial C00004565
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00004565
7039 TGFA, TFGA transforming growth factor, alpha C00004565
196 AHR, bHLHe76 aryl hydrocarbon receptor C00004565
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00004565
9540 TP53I3, PIG3 tumor protein p53 inducible protein 3 C00004565
8626 TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L tumor protein p63 C00004565
7161 TP73, P73 tumor protein p73 C00004565
7352 UCP3, SLC25A9 uncoupling protein 3 (mitochondrial, proton carrier) C00004565
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00004565
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00004565
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00004565
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00004565
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00004565
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00004565
7402 UTRN, DMDL, DRP, DRP1 utrophin C00004565
8839 WISP2, CCN5, CT58, CTGF-L WNT1 inducible signaling pathway protein 2 C00004565
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00009077
4240 MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 milk fat globule-EGF factor 8 protein C00009077
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00004565
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00000947
302 ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV annexin A2 C00000947
393 ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 Rho GTPase activating protein 4 C00000947
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00000947
2683 B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) C00000947
56751 BARHL1 BarH-like homeobox 1 C00000947
637 BID, FP497 BH3 interacting domain death agonist C00000947
388962 BOLA3, MMDS2 bolA family member 3 C00000947
79184 BRCC3, BRCC36, C6.1A, CXorf53 BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) C00000947
694 BTG1 B-cell translocation gene 1, anti-proliferative C00000947
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00000947
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000947
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000947
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000947
930 CD19, B4, CVID3 CD19 molecule C00000947
975 CD81, CVID6, S5.7, TAPA1, TSPAN28 CD81 molecule C00000947
928 CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 CD9 molecule C00000947
1054 CEBPG, GPE1BP, IG/EBP-1 CCAAT/enhancer binding protein (C/EBP), gamma C00000947
10978 CLP1, HEAB, hClp1 cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) C00000947
10063 COX17 COX17 cytochrome c oxidase copper chaperone C00000947
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00000947
7913 DEK, D6S231E DEK oncogene C00000947
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00000947
2130 EWSR1, EWS, bK984G1.4 EWS RNA-binding protein 1 C00000947
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000947
2323 FLT3LG, FL, FLT3L fms-related tyrosine kinase 3 ligand C00000947
2495 FTH1, FHC, FTH, FTHL6, PIG15, PLIF ferritin, heavy polypeptide 1 (EC:1.16.3.1) C00000947
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00000947
3054 HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF host cell factor C1 (VP16-accessory protein) C00000947
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000947
3232 HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 homeobox D3 C00000947
3329 HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 heat shock 60kDa protein 1 (chaperonin) C00000947
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00004565
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00000947
9235 IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd interleukin 32 C00000947
3662 IRF4, LSIRF, MUM1, NF-EM5 interferon regulatory factor 4 C00000947
3683 ITGAL, CD11A, LFA-1, LFA1A integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) C00000947
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00000947
4067 LYN, JTK8, p53Lyn, p56Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) C00000947
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00000947
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00000947
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00000947
64975 MRPL41, BMRP, MRP-L27, MRPL27, RPML27 mitochondrial ribosomal protein L41 C00000947
4493 MT1E, MT1, MTD metallothionein 1E C00000947
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00000947
4851 NOTCH1, TAN1, hN1 notch 1 C00000947
4869 NPM1, B23, NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) C00000947
5175 PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM platelet/endothelial cell adhesion molecule 1 C00000947
5187 PER1, PER, RIGUI, hPER period circadian clock 1 C00000947
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00000947
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00000947
7916 PRRC2A, BAT2, D6S51, D6S51E, G2 proline-rich coiled-coil 2A C00000947
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00000947
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00000947
5915 RARB, HAP, NR1B2, RRB2 retinoic acid receptor, beta C00000947
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000947
6128 RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 ribosomal protein L6 C00000947
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00000947
6286 S100P, MIG9 S100 calcium binding protein P C00000947
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00000947
7536 SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 splicing factor 1 C00000947
6574 SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 solute carrier family 20 (phosphate transporter), member 1 C00000947
6699 SPRR1B, CORNIFIN, GADD33, SPRR1 small proline-rich protein 1B C00000947
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000947
6777 STAT5B, STAT5 signal transducer and activator of transcription 5B C00000947
6778 STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C signal transducer and activator of transcription 6, interleukin-4 induced C00000947
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000947
6932 TCF7, TCF-1 transcription factor 7 (T-cell specific, HMG-box) C00000947
7083 TK1, TK2 thymidine kinase 1, soluble (EC:2.7.1.21) C00000947
943 TNFRSF8, CD30, D1S166E, Ki-1 tumor necrosis factor receptor superfamily, member 8 C00000947
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00000947
2829 XCR1, CCXCR1, GPR5 chemokine (C motif) receptor 1 C00000947
51042 ZNF593, ZT86 zinc finger protein 593 C00000947

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (142)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
Q14191
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#609446 Generalized epilepsy and paroxysmal dyskinesia; gepd Q12791
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
P04626
P37231
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P08581
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#300635 Lymphoproliferative syndrome, x-linked, 2; xlp2 P98170
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (121)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P04637 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
P08581 (related)
P10415 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
P10415 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
P10415 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P08581 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
P10415 (related)
P28907 (marker)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
P10415 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P27487 (marker)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
P10415 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00107 Other well-defined immunodeficiency syndromes P98170 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H01258 Generalized epilepsy and paroxysmal dyskinesia (GEPD) Q12791 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

22 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006943 Hyperglycemia C00003240
C00004565
D001943 Breast Neoplasms C00004565
C00000947
D050197 Atherosclerosis C00004565
C00000947
D002471 Cell Transformation, Neoplastic C00000947
D003921 Diabetes Mellitus, Experimental C00003240
D009202 Cardiomyopathies C00004565
D002318 Cardiovascular Diseases C00004565
D007938 Leukemia C00004565
D010024 Osteoporosis C00004565
D011297 Prenatal Exposure Delayed Effects C00004565
D010146 Pain C00005374
D011230 Precancerous Conditions C00003240
D003556 Cystitis C00000947
D056486 Drug-Induced Liver Injury C00000947
D034381 Hearing Loss C00000947
D006331 Heart Diseases C00000947
D020138 HYPERHOMOCYSTEINEMIA C00000947
D008107 Liver Diseases C00000947
D017114 Liver Failure, Acute C00000947
D008113 Liver Neoplasms C00000947
D008325 Mammary Neoplasms, Experimental C00000947
D009362 Neoplasm Metastasis C00000947