PCIDB

KNApSAcK Metabolite C00005165

Metabolite

KNApSAcK Entry

id C00005165
Name Sophoraflavonoloside / Kaempferol 3-O-sophoroside / Kaempferol 3-O-beta-sophoroside
CAS RN 19895-95-5
Standard InChI InChI=1S/C27H30O16/c28-7-14-17(33)20(36)22(38)26(40-14)43-25-21(37)18(34)15(8-29)41-27(25)42-24-19(35)16-12(32)5-11(31)6-13(16)39-23(24)9-1-3-10(30)4-2-9/h1-6,14-15,17-18,20-22,25-34,36-38H,7-8H2/t14?,15?,17-,18-,20?,21?,22-,25?,26+,27+/m1/s1
Standard InChI (Main Layer) InChI=1S/C27H30O16/c28-7-14-17(33)20(36)22(38)26(40-14)43-25-21(37)18(34)15(8-29)41-27(25)42-24-19(35)16-12(32)5-11(31)6-13(16)39-23(24)9-1-3-10(30)4-2-9/h1-6,14-15,17-18,20-22,25-34,36-38H,7-8H2

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 1

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL500233 CHEMBL1375795 CHEMBL2032411

KEGG

By LinkDB C12634

CTD

By CAS RN C064309

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme CHEMBL1375795 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL1375795 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL1375795 CHEMBL1794585 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL1375795 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1375795 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1375795 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL1375795 CHEMBL1794569 (1)
1 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1375795 CHEMBL1794483 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1375795 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL1375795 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1375795 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1375795 CHEMBL1613829 (1)
0 / 0

CTD interaction (12)

compound gene gene name gene description interaction interaction type form reference
pmid
C064309 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 22178603
C064309 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 22178603
C064309 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein] decreases reaction
/ increases expression
protein 22178603
C064309 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein] decreases reaction
/ increases expression
protein 22178603
C064309 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 22178603
C064309 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 kaempferol 3-O-sophoroside inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein] decreases reaction
/ increases secretion
protein 22178603
C064309 3146 HMGB1
HMG1
HMG3
SBP-1
high mobility group box 1 kaempferol 3-O-sophoroside results in decreased susceptibility to HMGB1 protein decreases response to substance
protein 22178603
C064309 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 22178603
C064309 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 22178603
C064309 7097 TLR2
CD282
TIL4
toll-like receptor 2 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein] decreases reaction
/ increases expression
protein 22178603
C064309 7099 TLR4
ARMD10
CD284
TLR-4
TOLL
toll-like receptor 4 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein] decreases reaction
/ increases expression
protein 22178603
C064309 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 22178603

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#232300 Glycogen storage disease ii P10253
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (2)

KEGG disease name UniProt
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003920 C064309 Diabetes Mellitus therapeutic
22178603
D006967 C064309 Hypersensitivity therapeutic
22178603
D007249 C064309 Inflammation therapeutic
22178603
D009369 C064309 Neoplasms therapeutic
22178603