Species

KNApSAcK Entry

Organism name Chenopodium fremontii
Genus Chenopodium
Family Chenopodiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Chenopodium fremontii
Linked NCBI taxonomy ID 1072215
Linked level species

Family

Family in NCBI taxonomy Amaranthaceae
ID 3563

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005506 External link 512 Rhamnetin 3-glucoside
C00005160 External link 512 Kaempferol 3-robinobioside
CHEMBL431610
CHEMBL79790
CHEMBL255020
CHEMBL501550
CHEMBL498879
CHEMBL1419228
CHEMBL1875691
22 / 10 / 12 No. 1 No. 15
C00005165 External link 512 Sophoraflavonoloside
/ Kaempferol 3-O-sophoroside
/ Kaempferol 3-O-beta-sophoroside
CHEMBL500233
CHEMBL1375795
CHEMBL2032411
C064309
12 / 2 / 2 6 / 4 No. 1 No. 15
C00005409 External link 512 Quercetin 3-O-sophoroside
CHEMBL452919
C055545
No. 1 No. 15
C00005401 External link 512 Quercetin 3-robinoside
/ Quercetin 3-O-robinoside
/ Quercetin 3-O-robinobioside
/ Quercetin 3-O-rhamnosyl-(1->6)-galactoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
25 / 18 / 16 No. 1 No. 15
C00005159 External link 512 Kaempferol 3-rhamnosyl-(1->2)-galactoside
CHEMBL507493
C064704
No. 1 No. 15
C00005270 External link 512 Rhamnocitrin 3-galactoside
No. 2 No. 15
C00005271 External link 512 Rhamnocitrin 3-glucoside
No. 2 No. 15

Human Protein / Gene in interactions

42 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00005160 C00005165 C00005401 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005160 C00005165 C00005401 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005160 C00005165 C00005401 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005160 C00005165 C00005401 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005160 C00005165 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005160 C00005165 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005165 C00005401 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005160 C00005401 1 / 1
Q9UNA4 DNA polymerase iota Enzyme C00005160 C00005165 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005160 C00005165 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005160 C00005401 1 / 0
O75496 Geminin Unclassified protein C00005160 C00005165 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005160 C00005165 0 / 0
P14679 Tyrosinase Oxidoreductase C00005401 4 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00005165 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00005401 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005401 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005401 0 / 1
P07237 Protein disulfide-isomerase Enzyme C00005160 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005160 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00005401 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00005160 2 / 3
P06276 Cholinesterase Hydrolase C00005401 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005401 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00005401 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005401 2 / 0
P03372 Estrogen receptor NR3A1 C00005401 1 / 1
P22303 Acetylcholinesterase Hydrolase C00005401 1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00005401 0 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005401 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00005160 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00005401 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005401 4 / 3
P48147 Prolyl endopeptidase S9A C00005401 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005401 0 / 3
Q99700 Ataxin-2 Unclassified protein C00005160 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005160 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005401 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00005160 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005160 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005160 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00005160 2 / 1

6 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00005165
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00005165
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00005165
7097 TLR2, CD282, TIL4 toll-like receptor 2 C00005165
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00005165
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00005165

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (25)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614490 Blood group, junior system; jr Q9UNQ0
#114500 Colorectal cancer; crc Q14191
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (26)

KEGG name UniProt
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00032 Thyroid cancer P27487 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

4 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003920 Diabetes Mellitus C00005165
D006967 Hypersensitivity C00005165
D007249 Inflammation C00005165
D009369 Neoplasms C00005165