Species

KNApSAcK Entry

Organism name Bulbine narcissifolia
Genus Bulbine
Family Asphodelaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Bulbine
Linked NCBI taxonomy ID 49703
Linked level genus

Family

Family in NCBI taxonomy Xanthorrhoeaceae
ID 27232

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000568 External link 512 Chrysophanol
CHEMBL41092
C027113
20 / 17 / 20 1 / 0 No. 41 No. 62
C00044201 External link 512 Isoknipholone
/ (-)-Isoknipholone
No. 684 No. 62
C00002834 External link 512 Knipholone
CHEMBL514883
No. 684 No. 62
C00002686 External link 512 Acetosyringone
CHEMBL224146
C051667
3 / 11 / 10 No. 1180
C00045767 External link 512 Chrysalodin
No. 3543

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00000568 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002686 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000568 3 / 2
P11473 Vitamin D3 receptor NR1I1 C00000568 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00000568 0 / 0
O75496 Geminin Unclassified protein C00002686 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000568 4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000568 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000568 0 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000568 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000568 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000568 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000568 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000568 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000568 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000568 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000568 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000568 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000568 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000568 1 / 1
O00255 Menin Unclassified protein C00000568 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000568 1 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002686 0 / 0

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000568

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (30)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)