PCIDB

KNApSAcK Metabolite C00000568

Metabolite

KNApSAcK Entry

id C00000568
Name Chrysophanol
CAS RN 481-74-3
Standard InChI InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3
Standard InChI (Main Layer) InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3

Cluster

Phytochemical cluster No. 62
KCF-S cluster No. 41

Link

ChEMBL

By standard InChI CHEMBL41092
By standard InChI Main Layer CHEMBL41092

KEGG

By LinkDB C10315

CTD

By CAS RN C027113

Species

Summary

Plant class

class name count
rosids 48
eudicotyledons 4
Liliopsida 3
asterids 1

Family

family name count
Fabaceae 40
Polygonaceae 4
Rhamnaceae 4
Picramniaceae 4
Xanthorrhoeaceae 3
Phaeosphaeriaceae 1
Lamiaceae 1

List (59)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Abrus pulchellus 192852 Fabaceae rosids Viridiplantae
Alvaradoa haitiensis 85160 Picramniaceae rosids Viridiplantae
Alvaradoa jamaicensis 85160 Picramniaceae rosids Viridiplantae
Asphodeline globifera 49695 Xanthorrhoeaceae Liliopsida Viridiplantae
Berchemia floribunda 1226760 Rhamnaceae rosids Viridiplantae
Bulbine capitata 49703 Xanthorrhoeaceae Liliopsida Viridiplantae
Bulbine narcissifolia 49703 Xanthorrhoeaceae Liliopsida Viridiplantae
Cassia alata L. 53851 Fabaceae rosids Viridiplantae
Cassia angolensis 53851 Fabaceae rosids Viridiplantae
Cassia fistula 53852 Fabaceae rosids Viridiplantae
Cassia grandis 162709 Fabaceae rosids Viridiplantae
Cassia javanica 508996 Fabaceae rosids Viridiplantae
Cassia occidentalis 126820 Fabaceae rosids Viridiplantae
Cassia quinquangulata 53851 Fabaceae rosids Viridiplantae
Cassia renigera 1231245 Fabaceae rosids Viridiplantae
Cassia roxburghii 948717 Fabaceae rosids Viridiplantae
Cassia senna 72402 Fabaceae rosids Viridiplantae
Cassia siamea 346999 Fabaceae rosids Viridiplantae
Cassia sophora 53851 Fabaceae rosids Viridiplantae
Cassia speciosa 1288009 Fabaceae rosids Viridiplantae
Cassia tora 362788 Fabaceae rosids Viridiplantae
Cassia torosa L. 53851 Fabaceae rosids Viridiplantae
Chamaecrista absus 592576 Fabaceae rosids Viridiplantae
Chamaecrista mimosoides 948715 Fabaceae rosids Viridiplantae
Chamaecrista nomame 870201 Fabaceae rosids Viridiplantae
Chamaecrista pumila 53853 Fabaceae rosids Viridiplantae
Hemerocallus minor
Luetzelburgia pallidiflora 53894 Fabaceae rosids Viridiplantae
Monodictys sp.
Picramnia antidesma 1129486 Picramniaceae rosids Viridiplantae
Picramnia latifolia 681474 Picramniaceae rosids Viridiplantae
Pyrenochaeta terrestris 798162 Phaeosphaeriaceae Fungi
Rhamnus nepalensis 3609 Rhamnaceae rosids Viridiplantae
Rhamnus purshiana 55262 Rhamnaceae rosids Viridiplantae
Rheum spp. 3620 Polygonaceae eudicotyledons Viridiplantae
Rumex alpinus 1351827 Polygonaceae eudicotyledons Viridiplantae
Rumex patientia L. 137229 Polygonaceae eudicotyledons Viridiplantae
Rumex spp. 3618 Polygonaceae eudicotyledons Viridiplantae
Senna alata 53923 Fabaceae rosids Viridiplantae
Senna alexandrina 72402 Fabaceae rosids Viridiplantae
Senna angustisiliqua 53922 Fabaceae rosids Viridiplantae
Senna auriculata 948713 Fabaceae rosids Viridiplantae
Senna didymobotrya 72401 Fabaceae rosids Viridiplantae
Senna garrettiana 756587 Fabaceae rosids Viridiplantae
Senna italica 346974 Fabaceae rosids Viridiplantae
Senna macranthera 346975 Fabaceae rosids Viridiplantae
Senna obtusifolia 346985 Fabaceae rosids Viridiplantae
Senna occidentalis 126820 Fabaceae rosids Viridiplantae
Senna podocarpa 53922 Fabaceae rosids Viridiplantae
Senna quinquangulata 346407 Fabaceae rosids Viridiplantae
Senna septemtrionalis 346998 Fabaceae rosids Viridiplantae
Senna siamea 346999 Fabaceae rosids Viridiplantae
Senna singueana 53922 Fabaceae rosids Viridiplantae
Senna sophera 948718 Fabaceae rosids Viridiplantae
Senna spectabilis 347003 Fabaceae rosids Viridiplantae
Senna tora 362788 Fabaceae rosids Viridiplantae
Tectona grandis 41396 Lamiaceae asterids Viridiplantae
Vatairea heteroptera 1224784 Fabaceae rosids Viridiplantae
Ventilago leiocarpa 108868 Rhamnaceae rosids Viridiplantae

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL41092 CHEMBL1614331 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL41092 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL41092 CHEMBL1794311 (2)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL41092 CHEMBL1614458 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL41092 CHEMBL1614303 (1)
4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL41092 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL41092 CHEMBL1794456 (1)
0 / 1
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL41092 CHEMBL1613808 (1)
0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL41092 CHEMBL2114842 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL41092 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL41092 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL41092 CHEMBL1614421 (3)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL41092 CHEMBL2114890 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL41092 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL41092 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL41092 CHEMBL1613829 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL41092 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL41092 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL41092 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL41092 CHEMBL1614531 (1)
1 / 3

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
C027113 196 AHR
bHLHe76
aryl hydrocarbon receptor chrysophanic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] decreases reaction
/ increases activity
protein 19269596

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (20)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)