Species

KNApSAcK Entry

Organism name Berchemia floribunda
Genus Berchemia
Family Rhamnaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Berchemia floribunda
Linked NCBI taxonomy ID 1226760
Linked level species

Family

Family in NCBI taxonomy Rhamnaceae
ID 3608

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000568 External link 512 Chrysophanol
CHEMBL41092
C027113
20 / 17 / 20 1 / 0 No. 41 No. 62
C00002789 External link 512 Aloe emodin
/ Rhabarberone
CHEMBL40275
20 / 21 / 24 No. 41 No. 62
C00019420 External link 512 Physcion
/ 1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone
CHEMBL42624
C008905
18 / 20 / 14 1 / 0 No. 41 No. 62
C00029360 External link 512 1,5,8-Trihydroxy-3-methyl-anthraquinone
No. 41 No. 62
C00032519 External link 512 Xanthorin
No. 41 No. 62
C00030279 External link 512 Floribundiquinone B
/ (+)-Floribundiquinone B
No. 1549
C00030280 External link 512 Floribundiquinone C
/ (+)-Floribundiquinone C
No. 1549
C00030281 External link 512 Floribundiquinone D
/ (-)-Floribundiquinone D
No. 1549
C00030278 External link 512 Floribundiquinone A
/ (+)-Floribundiquinone A
No. 1549

Human Protein / Gene in interactions

42 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08246 Neutrophil elastase S1A C00002789 C00019420 2 / 1
P09619 Platelet-derived growth factor receptor beta Pdgfr C00002789 C00019420 5 / 1
Q92731 Estrogen receptor beta NR3A2 C00002789 C00019420 0 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000568 C00002789 1 / 2
O00255 Menin Unclassified protein C00000568 C00002789 2 / 5
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000568 C00019420 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000568 C00019420 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00000568 C00019420 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000568 C00019420 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000568 C00002789 0 / 0
P08311 Cathepsin G S1A C00002789 C00019420 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000568 C00019420 4 / 3
P03372 Estrogen receptor NR3A1 C00002789 C00019420 1 / 1
Q9H244 P2Y purinoceptor 12 Purine receptor C00002789 C00019420 1 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000568 C00019420 0 / 0
P16234 Platelet-derived growth factor receptor alpha Pdgfr C00002789 C00019420 2 / 1
P04150 Glucocorticoid receptor NR3C1 C00000568 0 / 1
P06280 Alpha-galactosidase A Enzyme C00019420 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000568 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00002789 0 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00019420 2 / 2
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00002789 3 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00002789 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00019420 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000568 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00002789 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000568 0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00002789 0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00000568 4 / 2
O43451 Maltase-glucoamylase, intestinal Hydrolase C00019420 0 / 0
P10275 Androgen receptor NR3C4 C00002789 3 / 4
P06239 Tyrosine-protein kinase Lck Src C00019420 0 / 1
P39748 Flap endonuclease 1 Enzyme C00002789 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002789 1 / 8
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000568 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000568 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000568 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00000568 3 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00000568 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002789 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00002789 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000568 0 / 0

2 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00019420
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000568

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#609821 Bleeding disorder, platelet-type, 8; bdplt8 Q9H244
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#162800 Cyclic neutropenia P08246
#119900 Digital clubbing, isolated congenital P15428
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P16234
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#601626 Leukemia, acute myeloid; aml P09619
#211980 Lung cancer P00533
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (41)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
P16234 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00100 Neutropenic disorders P08246 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01235 Bleeding disorder platelet-type Q9H244 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)