Species

KNApSAcK Entry

Organism name Rhus javanica
Genus Rhus
Family Anacardiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Brucea javanica
Linked NCBI taxonomy ID 210348
Linked level species

Family

Family in NCBI taxonomy Simaroubaceae
ID 23808

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00032984 External link 512 Fouquierone
/ (+)-Fouquierone
CHEMBL224814
No. 23 No. 51
C00033061 External link 512 Isofouquierone peroxide
/ (+)-Isofouquierone peroxide
No. 23 No. 51
C00006941 External link 512 Butein
CHEMBL128000
C040918
17 / 31 / 34 8 / 0 No. 92 No. 13
C00008026 External link 512 Sulfuretin
/ Sulphuretin
/ 6,3',4'-Trihydroxyaurone
CHEMBL490355
CHEMBL513487
C054989
42 / 37 / 34 No. 450 No. 13
C00033379 External link 512 Semialatic acid
No. 827

Human Protein / Gene in interactions

53 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11473 Vitamin D3 receptor NR1I1 C00006941 C00008026 2 / 3
O00255 Menin Unclassified protein C00006941 C00008026 2 / 5
Q9UBT6 DNA polymerase kappa Enzyme C00006941 C00008026 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00006941 C00008026 0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00006941 C00008026 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00006941 C00008026 1 / 2
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00006941 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00006941 0 / 0
Q9HBX9 Relaxin receptor 1 Relaxin receptor C00008026 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00008026 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00006941 1 / 8
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein C00008026 0 / 0
P47901 Vasopressin V1b receptor Vasopressin and oxytocin receptor C00008026 0 / 0
P39748 Flap endonuclease 1 Enzyme C00008026 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00008026 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00008026 2 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme C00008026 4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00008026 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00008026 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00008026 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00008026 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00008026 3 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00008026 1 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00008026 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00008026 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00008026 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00008026 3 / 1
P35968 Vascular endothelial growth factor receptor 2 Vegfr C00006941 1 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00006941 2 / 3
P10696 Alkaline phosphatase, placental-like Enzyme C00008026 0 / 1
P08253 72 kDa type IV collagenase M10A C00008026 1 / 3
O15118 Niemann-Pick C1 protein Unclassified protein C00008026 1 / 1
Q8WXD0 Relaxin receptor 2 Relaxin receptor C00008026 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00008026 0 / 0
P11362 Fibroblast growth factor receptor 1 Fgfr C00006941 4 / 5
Q9UNA4 DNA polymerase iota Enzyme C00008026 0 / 0
P04062 Glucosylceramidase Enzyme C00006941 6 / 4
P10636 Microtubule-associated protein tau Unclassified protein C00008026 4 / 3
P10721 Mast/stem cell growth factor receptor Kit Pdgfr C00006941 4 / 3
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00006941 9 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00008026 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00008026 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00008026 0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme C00008026 0 / 0
O00487 26S proteasome non-ATPase regulatory subunit 14 Enzyme C00008026 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00008026 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00008026 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00008026 1 / 4
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00006941 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00006941 0 / 3
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00008026 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00008026 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00008026 2 / 1

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00006941
1734 DIO2, 5DII, D2, DIOII, SelY, TXDI2 deiodinase, iodothyronine, type II (EC:1.97.1.10) C00006941
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00006941
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00006941
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00006941
23411 SIRT1, SIR2L1 sirtuin 1 C00006941
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00006941
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00006941

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (63)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P84022
Q14191
#123500 Crouzon syndrome P21802
#219050 Cryptorchidism, unilateral or bilateral Q8WXD0
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P10721
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#602089 Hemangioma, capillary infantile P35968
#114550 Hepatocellular carcinoma P08581
#145000 Hyperparathyroidism 1; hrpt1 O00255
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#123150 Jackson-weiss syndrome; jws P21802
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
#601626 Leukemia, acute myeloid; aml P10721
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
#174800 Mccune-albright syndrome; mas P63092
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#166350 Osseous heteroplasia, progressive; poh P63092
#166250 Osteoglophonic dysplasia; ogd P11362
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#101600 Pfeiffer syndrome P11362
P21802
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct P10721
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190440 Trigonocephaly 1; trigno1 P11362
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (54)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00025 Penile cancer P08253 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00021 Renal cell carcinoma P08581 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
P10721 (marker)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00170 Piebaldism P10721 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00609 46,XY disorders of sex development (Other) Q8WXD0 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)