PCIDB

KNApSAcK Metabolite C00008026

Metabolite

KNApSAcK Entry

id C00008026
Name Sulfuretin / Sulphuretin / 6,3',4'-Trihydroxyaurone
CAS RN 120-05-8
Standard InChI InChI=1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H
Standard InChI (Main Layer) InChI=1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 450

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL490355 CHEMBL513487

KEGG

By LinkDB C08730

CTD

By CAS RN C054989

Human Protein / Gene in interaction

42 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL490355 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL490355 CHEMBL1738312 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL490355 CHEMBL1614076 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL490355 CHEMBL1794585 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL513487 CHEMBL1613776 (1)
3 / 1
Q9HBX9 Relaxin receptor 1 Relaxin receptor CHEMBL490355 CHEMBL1738202 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL490355 CHEMBL1614166 (1)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL513487 CHEMBL1794311 (1)
2 / 3
P47901 Vasopressin V1b receptor Vasopressin and oxytocin receptor CHEMBL490355 CHEMBL1738422 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL490355 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL513487 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL490355 CHEMBL1794584 (1)
2 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL490355 CHEMBL2114807 (1)
4 / 2
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL490355 CHEMBL2114788 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL490355 CHEMBL2114810 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL490355 CHEMBL1794569 (1)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL490355 CHEMBL1738679 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL490355 CHEMBL1738602 (1)
3 / 1
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL490355 CHEMBL2114924 (1)
1 / 2
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL490355 CHEMBL513487 CHEMBL1614257 (1) CHEMBL1614410 (1)
CHEMBL1614531 (2)
1 / 3
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL490355 CHEMBL1963863 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL513487 CHEMBL1963893 (1)
0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL490355 CHEMBL1738040 (1)
0 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL490355 CHEMBL1964000 (1)
1 / 3
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL490355 CHEMBL1614342 (1)
1 / 1
Q8WXD0 Relaxin receptor 2 Relaxin receptor CHEMBL490355 CHEMBL1738172 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL490355 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL490355 CHEMBL1794483 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL490355 CHEMBL513487 CHEMBL1614466 (1) CHEMBL1614211 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL490355 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL490355 CHEMBL513487 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL490355 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL490355 CHEMBL513487 CHEMBL1613829 (2) CHEMBL1794433 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL490355 CHEMBL1738442 (1)
0 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL490355 CHEMBL1963966 (1)
0 / 0
O00487 26S proteasome non-ATPase regulatory subunit 14 Enzyme CHEMBL490355 CHEMBL1963965 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL490355 CHEMBL513487 CHEMBL1614257 (1) CHEMBL1614531 (2)
2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL513487 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL513487 CHEMBL1613933 (1)
1 / 6
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL490355 CHEMBL2114738 (1)
0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein CHEMBL490355 CHEMBL2114881 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL490355 CHEMBL2114796 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (37)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P84022
Q14191
#219050 Cryptorchidism, unilateral or bilateral Q8WXD0
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#166350 Osseous heteroplasia, progressive; poh P63092
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (34)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00213 Hypophosphatasia P05186 (related)
H00025 Penile cancer P08253 (related)
H00028 Choriocarcinoma P08253 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00609 46,XY disorders of sex development (Other) Q8WXD0 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)