Cotinus coggygria
Species
KNApSAcK Entry
| Organism name | Cotinus coggygria |
|---|---|
| Genus | Cotinus |
| Family | Anacardiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cotinus coggygria |
|---|---|
| Linked NCBI taxonomy ID | 269719 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Anacardiaceae |
|---|---|
| ID | 4011 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (11)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006667
|
Cyanidin 3-glucoside-7-rhamnoside
|
No. 1 | No. 15 |
|
||||
|
C00006722
|
Petunidin 3-glucoside
/ Petunidin 3-O-beta-D-glucopyranoside |
CHEMBL1784264
|
C455107
|
No. 2 | No. 15 |
|
||
|
C00006701
|
Delphinidin 7-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00006652
|
Idaein
/ Cyanidin 3-galactoside / Cyanidin 3-O-galactoside / Cyanidin 3-O-beta-D-galactopyranoside |
CHEMBL257839
CHEMBL1197952 |
1 / 0 / 1 | No. 2 | No. 15 |
|
||
|
C00008043
|
Sulfurein
|
CHEMBL491695
|
No. 36 | No. 13 |
|
|||
|
C00008026
|
Sulfuretin
/ Sulphuretin / 6,3',4'-Trihydroxyaurone |
CHEMBL490355
CHEMBL513487 |
C054989
|
42 / 37 / 34 | No. 450 | No. 13 |
|
|
|
C00002647
|
Gallic acid
|
CHEMBL288114
|
D005707
|
42 / 53 / 68 | 52 / 16 | No. 817 | No. 81 |
|
|
C00000100
|
IAA
/ Indole-3-acetic acid |
CHEMBL82411
|
C030737
|
3 / 0 / 0 | 2 / 1 | No. 1432 | No. 4 |
|
|
C00030754
|
Methyl gallate
/ Methyl 3,4,5-trihydroxybenzoate |
CHEMBL65675
|
C052082
|
16 / 15 / 13 | No. 1722 |
|
||
|
C00000101
|
IAA methyl ester
/ Methyl indole-3-acetate |
No. 4225 |
|
|||||
|
C00014672
|
Disulfuretin
/ (2Z,2'Z)-2,2'-[1,2-Bis(3,4-dihydroxyphenyl)-1,2-ethanediylidene]bis[6-hydroxy-3(2H)-benzofuranone |
CHEMBL523383
|
No. 7311 |
|
Human Protein / Gene in interactions
86 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002647 C00008026 C00030754 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002647 C00008026 C00030754 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002647 C00008026 C00030754 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00008026 C00030754 | 1 / 1 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002647 C00030754 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002647 C00008026 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002647 C00008026 | 4 / 3 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00008026 C00030754 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002647 C00008026 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002647 C00008026 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00008026 C00030754 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002647 C00008026 | 2 / 3 |
| P02768 | Serum albumin | Secreted protein | C00000100 C00030754 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00008026 C00030754 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002647 C00030754 | 11 / 10 |
| P16109 | P-selectin | Adhesion | C00002647 | 1 / 0 |
| P55789 | FAD-linked sulfhydryl oxidase ALR | Enzyme | C00030754 | 1 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00030754 | 1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00008026 | 3 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002647 | 1 / 2 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002647 | 0 / 0 |
| P78536 | Disintegrin and metalloproteinase domain-containing protein 17 | M12B | C00002647 | 1 / 0 |
| Q9HBX9 | Relaxin receptor 1 | Relaxin receptor | C00008026 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00008026 | 1 / 0 |
| Q16773 | Kynurenine--oxoglutarate transaminase 1 | Enzyme | C00000100 | 0 / 0 |
| P47901 | Vasopressin V1b receptor | Vasopressin and oxytocin receptor | C00008026 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002647 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002647 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002647 | 0 / 0 |
| P16581 | E-selectin | Adhesion | C00002647 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002647 | 1 / 2 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002647 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002647 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00008026 | 2 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00008026 | 4 / 2 |
| P15121 | Aldose reductase | Enzyme | C00002647 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002647 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002647 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00008026 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00008026 | 7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00008026 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00008026 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00008026 | 3 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00030754 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00008026 | 1 / 2 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00008026 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00030754 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00008026 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00008026 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002647 | 0 / 1 |
| Q9HBH1 | Peptide deformylase, mitochondrial | Enzyme | C00000100 | 0 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00002647 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002647 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00008026 | 0 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002647 | 0 / 1 |
| P08253 | 72 kDa type IV collagenase | M10A | C00008026 | 1 / 3 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002647 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002647 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00008026 | 1 / 1 |
| Q8WXD0 | Relaxin receptor 2 | Relaxin receptor | C00008026 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00008026 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002647 | 1 / 1 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002647 | 4 / 2 |
| P14151 | L-selectin | Adhesion | C00002647 | 0 / 0 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00006652 | 0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00008026 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00030754 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002647 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002647 | 5 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00030754 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002647 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002647 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002647 | 1 / 1 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002647 | 3 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002647 | 0 / 3 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00008026 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002647 | 7 / 37 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002647 | 4 / 1 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00008026 | 0 / 0 |
| O00487 | 26S proteasome non-ATPase regulatory subunit 14 | Enzyme | C00008026 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00008026 | 2 / 5 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00008026 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00008026 | 1 / 4 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00008026 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00008026 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00008026 | 2 / 1 |
54 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000100
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00000100
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002647
|
| 25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00002647
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00002647
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00002647
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00002647
|
| 545 | ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 | ataxia telangiectasia and Rad3 related (EC:2.7.11.1) |
C00002647
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002647
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002647
|
| 613 | BCR, ALL, BCR1, CML, D22S11, D22S662, PHL | breakpoint cluster region (EC:2.7.11.1) |
C00002647
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002647
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002647
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002647
|
| 998 | CDC42, CDC42Hs, G25K | cell division cycle 42 |
C00002647
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002647
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002647
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00002647
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00002647
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002647
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002647
|
| 2551 | GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 | GA binding protein transcription factor, alpha subunit 60kDa |
C00002647
|
| 2885 | GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 | growth factor receptor-bound protein 2 |
C00002647
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00002647
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002647
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002647
|
| 3949 | LDLR, FH, FHC, LDLCQ2 | low density lipoprotein receptor |
C00002647
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00002647
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002647
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002647
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002647
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002647
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00002647
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002647
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00002647
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00002647
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00002647
|
| 5578 | PRKCA, AAG6, PKC-alpha, PKCA, PRKACA | protein kinase C, alpha (EC:2.7.11.13) |
C00002647
|
| 5591 | PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 | protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) |
C00002647
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002647
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00002647
|
| 19412 |
C00002647
|
||
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002647
|
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00002647
|
| 388 | RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 | ras homolog family member B |
C00002647
|
| 6195 | RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) |
C00002647
|
| 9252 | RPS6KA5, MSK1, MSPK1, RLPK | ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) |
C00002647
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00002647
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002647
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002647
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002647
|
| 7224 | TRPC5, TRP5 | transient receptor potential cation channel, subfamily C, member 5 |
C00002647
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002647
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002647
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (86)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #219050 | Cryptorchidism, unilateral or bilateral |
Q8WXD0
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #614328 | Inflammatory skin and bowel disease, neonatal; nisbd |
P78536
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #613076 | Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay |
P55789
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P12821
P16109 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (91)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) P08581 (related) Q16790 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P28907 (marker) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
P08581 (related) |
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
P08253 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
Q8WXD0
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
17 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D056486 | Drug-Induced Liver Injury |
C00000100
|
| D003921 | Diabetes Mellitus, Experimental |
C00002647
|
| D050171 | Dyslipidemias |
C00002647
|
| D005234 | Fatty Liver |
C00002647
|
| D018149 | Glucose Intolerance |
C00002647
|
| D006937 | Hypercholesterolemia |
C00002647
|
| D006943 | Hyperglycemia |
C00002647
|
| D006949 | Hyperlipidemias |
C00002647
|
| D015228 | Hypertriglyceridemia |
C00002647
|
| D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
C00002647
|
| D008546 | Melanoma, Experimental |
C00002647
|
| D009069 | Movement Disorders |
C00002647
|
| D009203 | Myocardial Infarction |
C00002647
|
| D009361 | Neoplasm Invasiveness |
C00002647
|
| D009362 | Neoplasm Metastasis |
C00002647
|
| D012516 | Osteosarcoma |
C00002647
|
| D010182 | Pancreatic Diseases |
C00002647
|