Juglans regia L.
Species
KNApSAcK Entry
| Organism name | Juglans regia L. |
|---|---|
| Genus | Juglans |
| Family | Juglandaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Juglans regia |
|---|---|
| Linked NCBI taxonomy ID | 51240 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Juglandaceae |
|---|---|
| ID | 16714 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (41)
| Species | Activity |
|---|---|
| Juglans regia L. | Alterative |
| Juglans regia L. | Analgesic |
| Juglans regia L. | Anthelminthic |
| Juglans regia L. | Antiaggregant |
| Juglans regia L. | Antibacterial |
| Juglans regia L. | Anticancer |
| Juglans regia L. | Antidote |
| Juglans regia L. | Antiherpetic |
| Juglans regia L. | Antiinflammatory |
| Juglans regia L. | Antioxidant |
| Juglans regia L. | Antiperspirant |
| Juglans regia L. | Antiradicular |
| Juglans regia L. | Antiseptic |
| Juglans regia L. | Antitumor |
| Juglans regia L. | Antiviral |
| Juglans regia L. | Aphrodisiac |
| Juglans regia L. | Astringent |
| Juglans regia L. | Candidicide |
| Juglans regia L. | Carcinogenic |
| Juglans regia L. | Cholagogue |
| Juglans regia L. | Depurative |
| Juglans regia L. | Digestive |
| Juglans regia L. | Diuretic |
| Juglans regia L. | Emollient |
| Juglans regia L. | Fungicide |
| Juglans regia L. | Hair Dye |
| Juglans regia L. | Hemostat |
| Juglans regia L. | Herbicide |
| Juglans regia L. | Insecticide |
| Juglans regia L. | Laxative |
| Juglans regia L. | Leukoplakogenic |
| Juglans regia L. | Litholytic |
| Juglans regia L. | Molluscicide |
| Juglans regia L. | Mutagenic |
| Juglans regia L. | Myorelaxant |
| Juglans regia L. | Mytotonic |
| Juglans regia L. | Piscicide |
| Juglans regia L. | Stimulant |
| Juglans regia L. | Tonic |
| Juglans regia L. | Vermifuge |
| Juglans regia L. | Vulnerary |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00035077
|
delta-Tocotrienol
|
CHEMBL121305
|
C082097
|
1 / 0 / 0 | 10 / 0 | No. 328 |
|
|
|
C00007365
|
gamma-Tocopherol
|
CHEMBL420898
CHEMBL2151591 |
No. 1290 |
|
||||
|
C00007364
|
beta-Tocopherol
|
No. 1290 |
|
|||||
|
C00007366
|
alpha-Tocopherol
|
CHEMBL47
CHEMBL49563 CHEMBL442800 |
D024502
|
99 / 57 / 52 | 54 / 55 | No. 1290 |
|
|
|
C00007363
|
delta-Tocopherol
|
CHEMBL1451395
CHEMBL1734310 |
C479072
|
3 / 11 / 10 | 1 / 0 | No. 1290 |
|
Human Protein / Gene in interactions
102 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | C00007363 C00007366 | 11 / 10 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00007366 | 1 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00007366 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00007366 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00007366 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00007366 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00007366 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00007366 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00007366 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00007366 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00007366 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00007366 | 2 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00007366 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00007366 | 1 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00007366 | 3 / 1 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00007366 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00007366 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00007366 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00007366 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00007366 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00007366 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00007366 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00007366 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00007366 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00007366 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00007366 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00007366 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00007366 | 0 / 1 |
| P16662 | UDP-glucuronosyltransferase 2B7 | Enzyme | C00007366 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00007366 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00007366 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00007366 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00007366 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00007366 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00007366 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00007366 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00007366 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00007366 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00007366 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00007366 | 1 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00007366 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00007363 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00007366 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00007366 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00007366 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00007366 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00007366 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00007366 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00007366 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00007366 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00007366 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00007366 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00007366 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00007366 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00007366 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00007366 | 1 / 0 |
| P03956 | Interstitial collagenase | M10A | C00007366 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00007366 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00007366 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00007366 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00007366 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00007366 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00007366 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00007366 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00007366 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00007366 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00007366 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00007366 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00007366 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00007366 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00007366 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00007366 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00007366 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00007366 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00007366 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00007366 | 1 / 1 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00007366 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00007366 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00007366 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00007366 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00007366 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00007366 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00007366 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00007366 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00007366 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00007366 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00007366 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00007366 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00007363 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00007366 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00007366 | 4 / 3 |
| O43451 | Maltase-glucoamylase, intestinal | Hydrolase | C00035077 | 0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00007366 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00007366 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00007366 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00007366 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00007366 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00007366 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00007366 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00007366 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00007366 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00007366 | 1 / 2 |
63 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00007366
C00035077
|
| 1382 | CRABP2, CRABP-II, RBP6 | cellular retinoic acid binding protein 2 |
C00007363
C00007366
|
| 142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00007366
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00035077
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00035077
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00035077
|
| 9611 | NCOR1, N-CoR, N-CoR1, TRAC1, hN-CoR | nuclear receptor corepressor 1 |
C00035077
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00035077
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00035077
|
| 7471 | WNT1, BMND16, INT1, OI15 | wingless-type MMTV integration site family, member 1 |
C00035077
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00035077
|
| 335 | APOA1 | apolipoprotein A-I |
C00007366
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00007366
|
| 351 | APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 | amyloid beta (A4) precursor protein |
C00007366
|
| 1386 | ATF2, CRE-BP1, CREB2, HB16, TREB7 | activating transcription factor 2 (EC:2.3.1.48) |
C00007366
|
| 23621 | BACE1, ASP2, BACE, HSPC104 | beta-site APP-cleaving enzyme 1 (EC:3.4.23.46) |
C00007366
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00007366
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00007366
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00007366
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00007366
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00007366
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00007366
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00007366
|
| 1080 | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) |
C00007366
|
| 1401 | CRP, PTX1 | C-reactive protein, pentraxin-related |
C00007366
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00007366
|
| 83939 | EIF2A, EIF-2A, MST089, MSTP004, MSTP089 | eukaryotic translation initiation factor 2A, 65kDa |
C00007366
|
| 2335 | FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF | fibronectin 1 |
C00007366
|
| 2534 | FYN, SLK, SYN, p59-FYN | FYN oncogene related to SRC, FGR, YES (EC:2.7.10.2) |
C00007366
|
| 2879 | GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx | glutathione peroxidase 4 (EC:1.11.1.12) |
C00007366
|
| 3048 | HBG2, TNCY | hemoglobin, gamma G |
C00007366
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00007366
|
| 3240 | HP, BP, HP2ALPHA2, HPA1S | haptoglobin |
C00007366
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00007366
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00007366
|
| 3932 | LCK, LSK, YT16, p56lck, pp58lck | lymphocyte-specific protein tyrosine kinase (EC:2.7.10.2) |
C00007366
|
| 4067 | LYN, JTK8, p53Lyn, p56Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) |
C00007366
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00007366
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00007366
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00007366
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00007366
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00007366
|
| 4155 | MBP | myelin basic protein |
C00007366
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00007366
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00007366
|
| 11315 | PARK7, DJ-1, DJ1 | parkinson protein 7 |
C00007366
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00035077
|
| 5230 | PGK1, MIG10, PGKA | phosphoglycerate kinase 1 (EC:2.7.2.3) |
C00007366
|
| 5340 | PLG | plasminogen (EC:3.4.21.7) |
C00007366
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00007366
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00007366
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00007366
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00007366
|
| 6401 | SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 | selectin E |
C00007366
|
| 4089 | SMAD4, DPC4, JIP, MADH4, MYHRS | SMAD family member 4 |
C00007366
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00007366
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00007366
|
| 7015 | TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT | telomerase reverse transcriptase (EC:2.7.7.49) |
C00007366
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00007366
|
| 8795 | TNFRSF10B, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9 | tumor necrosis factor receptor superfamily, member 10b |
C00007366
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00007366
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00007366
|
| 7494 | XBP1, TREB5, XBP-1, XBP2 | X-box binding protein 1 |
C00007366
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (57)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (52)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
Diseases related to CTD interactions
55 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D015746 | Abdominal Pain |
C00007366
|
| D058186 | Acute Kidney Injury |
C00007366
|
| D000755 | Anemia, Sickle Cell |
C00007366
|
| D001247 | Asthenia |
C00007366
|
| C535393 | Ataxia with vitamin E deficiency |
C00007366
|
| D001284 | Atrophy |
C00007366
|
| D001836 | Body Weight Changes |
C00007366
|
| D001930 | Brain Injuries |
C00007366
|
| D002279 | Carcinoma 256, Walker |
C00007366
|
| D002318 | Cardiovascular Diseases |
C00007366
|
| D002471 | Cell Transformation, Neoplastic |
C00007366
|
| D002493 | Central Nervous System Diseases |
C00007366
|
| D003072 | Cognition Disorders |
C00007366
|
| D003556 | Cystitis |
C00007366
|
| D003924 | Diabetes Mellitus, Type 2 |
C00007366
|
| D056486 | Drug-Induced Liver Injury |
C00007366
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00007366
|
| D005334 | Fever |
C00007366
|
| D005355 | Fibrosis |
C00007366
|
| D005767 | Gastrointestinal Diseases |
C00007366
|
| D005923 | Glomerulosclerosis, Focal Segmental |
C00007366
|
| D006261 | Headache |
C00007366
|
| D006461 | Hemolysis |
C00007366
|
| D006949 | Hyperlipidemias |
C00007366
|
| D006965 | Hyperplasia |
C00007366
|
| D006973 | Hypertension |
C00007366
|
| D007511 | Ischemia |
C00007366
|
| D007674 | Kidney Diseases |
C00007366
|
| D008113 | Liver Neoplasms |
C00007366
|
| D008175 | Lung Neoplasms |
C00007366
|
| D008569 | Memory Disorders |
C00007366
|
| D009135 | Muscular Diseases |
C00007366
|
| D009203 | Myocardial Infarction |
C00007366
|
| D009325 | Nausea |
C00007366
|
| D009336 | Necrosis |
C00007366
|
| D009362 | Neoplasm Metastasis |
C00007366
|
| D009410 | Nerve Degeneration |
C00007366
|
| D009422 | Nervous System Diseases |
C00007366
|
| D009436 | Neural Tube Defects |
C00007366
|
| D010014 | Osteolysis |
C00007366
|
| D010049 | Ovarian Diseases |
C00007366
|
| D010146 | Pain |
C00007366
|
| D011041 | Poisoning |
C00007366
|
| D011230 | Precancerous Conditions |
C00007366
|
| D011507 | Proteinuria |
C00007366
|
| D011561 | Pseudoxanthoma Elasticum |
C00007366
|
| D011657 | Pulmonary Eosinophilia |
C00007366
|
| D011832 | Radiation Injuries |
C00007366
|
| D051437 | Renal Insufficiency |
C00007366
|
| D015427 | Reperfusion Injury |
C00007366
|
| D012174 | Retinitis Pigmentosa |
C00007366
|
| D012640 | Seizures |
C00007366
|
| D014029 | Tobacco Use Disorder |
C00007366
|
| D014591 | Uterine Diseases |
C00007366
|
| D014717 | Vertigo |
C00007366
|