Hyptis verticillata
Species
KNApSAcK Entry
| Organism name | Hyptis verticillata |
|---|---|
| Genus | Hyptis |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Hyptis verticillata |
|---|---|
| Linked NCBI taxonomy ID | 986250 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (44)
| Species | Activity |
|---|---|
| Hyptis verticillata Jacq. | Analgesic |
| Hyptis verticillata Jacq. | Antibacterial |
| Hyptis verticillata Jacq. | Anticancer |
| Hyptis verticillata Jacq. | Anticancer |
| Hyptis verticillata Jacq. | Antidote |
| Hyptis verticillata Jacq. | Antidote, hippomane |
| Hyptis verticillata Jacq. | Antifertility |
| Hyptis verticillata Jacq. | Antifertility |
| Hyptis verticillata Jacq. | Antileukemic |
| Hyptis verticillata Jacq. | Antileukemic |
| Hyptis verticillata Jacq. | Antiprostaglandin |
| Hyptis verticillata Jacq. | Antiprostaglandin |
| Hyptis verticillata Jacq. | Antisecretory |
| Hyptis verticillata Jacq. | Antisecretory |
| Hyptis verticillata Jacq. | Antiseptic |
| Hyptis verticillata Jacq. | Antiseptic |
| Hyptis verticillata Jacq. | Aphrodisiac |
| Hyptis verticillata Jacq. | Aphrodisiac |
| Hyptis verticillata Jacq. | Astringent |
| Hyptis verticillata Jacq. | Astringent |
| Hyptis verticillata Jacq. | Bactericide |
| Hyptis verticillata Jacq. | Bechic |
| Hyptis verticillata Jacq. | Candidicide |
| Hyptis verticillata Jacq. | Candidicide |
| Hyptis verticillata Jacq. | Carminative |
| Hyptis verticillata Jacq. | Cytotoxic |
| Hyptis verticillata Jacq. | Cytotoxic |
| Hyptis verticillata Jacq. | Depurative |
| Hyptis verticillata Jacq. | Emmenagogue |
| Hyptis verticillata Jacq. | Febrifuge |
| Hyptis verticillata Jacq. | Laxative |
| Hyptis verticillata Jacq. | Laxative |
| Hyptis verticillata Jacq. | Molluscacide |
| Hyptis verticillata Jacq. | Molluscicide |
| Hyptis verticillata Jacq. | Pectoral |
| Hyptis verticillata Jacq. | Pediculifuge |
| Hyptis verticillata Jacq. | Pediculifuge |
| Hyptis verticillata Jacq. | Secretagogue |
| Hyptis verticillata Jacq. | Secretagogue |
| Hyptis verticillata Jacq. | Sedative |
| Hyptis verticillata Jacq. | Stimulant |
| Hyptis verticillata Jacq. | Stomachic |
| Hyptis verticillata Jacq. | Tranquilizer |
| Hyptis verticillata Jacq. | Vermifuge |
Metabolite list (12)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002598
|
Yatein
/ (-)-Yatein / (-)-Deoxypodorhizone / Dihydroanhydropodorhizol |
CHEMBL345590
CHEMBL471067 CHEMBL2021357 |
C452802
|
2 / 1 / 1 | No. 223 | No. 21 |
|
|
|
C00007202
|
(-)-Podorhizol
|
CHEMBL512541
CHEMBL1629990 |
No. 223 | No. 21 |
|
|||
|
C00007210
|
Dehydropodophyllotoxin
/ Tetradehydropodophyllotoxin |
CHEMBL487214
|
No. 285 | No. 21 |
|
|||
|
C00000610
|
(-)-Podophyllotoxin
|
CHEMBL61
CHEMBL273648 CHEMBL21260 CHEMBL282256 CHEMBL283120 CHEMBL24706 CHEMBL310129 CHEMBL1330659 |
D011034
|
132 / 81 / 78 | 1 / 5 | No. 427 | No. 21 |
|
|
C00002594
|
4'-Demethyldeoxypodophyllotoxin
|
CHEMBL89905
CHEMBL141117 CHEMBL1707682 CHEMBL1969951 |
27 / 14 / 4 | No. 427 | No. 21 |
|
||
|
C00007208
|
beta-Peltatin
/ (-)-beta-Peltatin |
CHEMBL97543
CHEMBL443566 CHEMBL1435754 |
9 / 16 / 14 | No. 427 | No. 21 |
|
||
|
C00002595
|
4'-Demethylpodophyllotoxin
|
CHEMBL28941
CHEMBL31929 CHEMBL290640 CHEMBL172476 CHEMBL172001 CHEMBL1514122 CHEMBL1723729 |
6 / 4 / 2 | No. 427 | No. 21 |
|
||
|
C00021239
|
Squamulosone
|
No. 595 | No. 38 |
|
||||
|
C00036334
|
(1S,10S)-allo-Aromadendran-9-one
|
No. 1947 |
|
|||||
|
C00036333
|
(1S,10S)-9alpha-Hydroxy-allo-aromadendrane
|
No. 1947 |
|
|||||
|
C00036326
|
(1R,10R)-Aromadendran-9-one
|
No. 1947 |
|
|||||
|
C00036763
|
Aromadendra-1,9-diene
|
No. 3181 |
|
Human Protein / Gene in interactions
138 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000610 C00002595 C00002598 C00007208 | 0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000610 C00002594 C00002595 C00007208 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000610 C00002594 C00007208 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000610 C00002594 C00002595 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000610 C00002594 C00007208 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00000610 C00002594 C00007208 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000610 C00002594 C00007208 | 1 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00000610 C00002594 C00002595 | 0 / 0 |
| Q3ZCM7 | Tubulin beta-8 chain | Structural | C00000610 C00002594 | 0 / 0 |
| Q13509 | Tubulin beta-3 chain | Structural | C00000610 C00002594 | 2 / 1 |
| P68371 | Tubulin beta-4B chain | Structural | C00000610 C00002594 | 0 / 0 |
| Q71U36 | Tubulin alpha-1A chain | Structural | C00000610 C00002594 | 1 / 1 |
| P07437 | Tubulin beta chain | Structural | C00000610 C00002594 | 0 / 0 |
| Q06710 | Paired box protein Pax-8 | Unclassified protein | C00000610 C00007208 | 1 / 2 |
| P04350 | Tubulin beta-4A chain | Structural | C00000610 C00002594 | 2 / 0 |
| Q9H4B7 | Tubulin beta-1 chain | Structural | C00000610 C00002594 | 1 / 0 |
| P68366 | Tubulin alpha-4A chain | Structural | C00000610 C00002594 | 0 / 0 |
| Q13748 | Tubulin alpha-3C/D chain | Structural | C00000610 C00002594 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000610 C00007208 | 11 / 10 |
| P68363 | Tubulin alpha-1B chain | Unclassified protein | C00000610 C00002594 | 0 / 0 |
| Q13885 | Tubulin beta-2A chain | Structural | C00000610 C00002594 | 0 / 0 |
| Q6PEY2 | Tubulin alpha-3E chain | Unclassified protein | C00000610 C00002594 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000610 C00007208 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000610 C00002595 | 4 / 1 |
| Q9BQE3 | Tubulin alpha-1C chain | Unclassified protein | C00000610 C00002594 | 0 / 0 |
| Q9BUF5 | Tubulin beta-6 chain | Structural | C00000610 C00002594 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000610 C00002598 | 1 / 0 |
| Q9BVA1 | Tubulin beta-2B chain | Structural | C00000610 C00002594 | 1 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00000610 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00000610 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00000610 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000610 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000610 | 1 / 8 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00000610 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000610 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00000610 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000610 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00000610 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00000610 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00000610 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00000610 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00000610 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00000610 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000610 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00000610 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000610 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00000610 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00000610 | 1 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00000610 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00000610 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00000610 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00000610 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00000610 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000610 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000610 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00000610 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00000610 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00000610 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00000610 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00000610 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000610 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00000610 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002594 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000610 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00000610 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002594 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000610 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000610 | 0 / 0 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00000610 | 2 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000610 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00000610 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00000610 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00000610 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00000610 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00000610 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00000610 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00000610 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00000610 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00000610 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00000610 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00000610 | 1 / 1 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00000610 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000610 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00000610 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000610 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000610 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00000610 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000610 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000610 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00000610 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000610 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00000610 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00000610 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000610 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00000610 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00000610 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00000610 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00000610 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000610 | 1 / 1 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00000610 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00000610 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00000610 | 1 / 1 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000610 | 1 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002594 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000610 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000610 | 4 / 3 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 1 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00000610 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00000610 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00000610 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00000610 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000610 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00000610 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00000610 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000610 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000610 | 1 / 2 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000610 | 3 / 2 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002595 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000610 | 2 / 2 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00000610 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000610 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00000610 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00000610 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000610 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00000610 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00000610 | 2 / 1 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002594 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000610 | 2 / 2 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000610 | 0 / 3 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00000610 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002594 | 2 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000610 | 7 / 37 |
| P42345 | Serine/threonine-protein kinase mTOR | Enzyme | C00000610 | 0 / 0 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00000610 | 0 / 0 |
1 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau |
C00000610
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (85)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #614039 | Cortical dysplasia, complex, with other brain malformations 1; cdcbm1 |
Q13509
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #128101 | Dystonia 4, torsion, autosomal dominant; dyt4 |
P04350
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600638 | Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement; cfeom3a |
Q13509
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #218700 | Hypothyroidism, congenital, nongoitrous, 2; chng2 |
Q06710
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #612438 | Leukodystrophy, hypomyelinating, 6; hld6 |
P04350
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #611603 | Lissencephaly 3; lis3 |
Q71U36
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #613112 | Macrothrombocytopenia, autosomal dominant, tubb1-related |
Q9H4B7
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #610031 | Polymicrogyria, symmetric or asymmetric; pmgysa |
Q9BVA1
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (80)
| KEGG | name | UniProt |
|---|---|---|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P35354 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P14780 (related) P35354 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
Q06710 (related) |
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
Q06710 (related) |
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00838 | Congenital fibrosis of the extraocular muscles (CFEOM) |
Q13509
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00268 | Lissencephaly (LIS) |
Q71U36
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
5 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D002295 | Carcinoma, Transitional Cell |
C00000610
|
| D003218 | Condylomata Acuminata |
C00000610
|
| D010523 | Peripheral Nervous System Diseases |
C00000610
|
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
C00000610
|
| D012678 | Sensation Disorders |
C00000610
|