Theobroma cacao

• Index
• Plant Species
• Metabolite list (17)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Theobroma cacao
Genus	Theobroma
Family	Malvaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Theobroma cacao
Linked NCBI taxonomy ID	3641
Linked level	species

Family

Family in NCBI taxonomy	Malvaceae
ID	3629

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (17)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00006652	Idaein / Cyanidin 3-galactoside / Cyanidin 3-O-galactoside / Cyanidin 3-O-beta-D-galactopyranoside	CHEMBL257839 CHEMBL1197952		1 / 0 / 1		No. 2	No. 15
C00006650	Cyanidin 3-arabinoside					No. 2	No. 15
C00009076	Procyanidin B5 / Epicatechin-(4beta-6)-epicatechin	CHEMBL506487 CHEMBL502984 CHEMBL451115				No. 16	No. 19
C00009077	Procyanidin B2 / Epicathechin-(4beta->8)-epicathechin	CHEMBL38714 CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914	C479580	20 / 7 / 8	10 / 0	No. 16	No. 19
C00009075	Procyanidin B1 / Epicatechin-(4beta->8)-catechin	CHEMBL38714 CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914	C479579	20 / 7 / 8		No. 16	No. 19
C00009275	Proanthocyanidin A7					No. 16	No. 19
C00002935	Procyanidin B4 / Catechin-(4alpha->8)-epicatechin	CHEMBL38714 CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914		20 / 7 / 8		No. 16	No. 19
C00009098	Procyanidin C1 / [Epicatechin-(4beta->8)]2-epicatechin	CHEMBL290632		13 / 5 / 6		No. 29	No. 19
C00000956	(-)-Epicatechin	CHEMBL80941 CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912		85 / 58 / 54		No. 52	No. 14
C00009107	Cinnamtannin A1					No. 113	No. 19
C00013256	Epicatechin 8-C-beta-D-galactoside					No. 261	No. 14
C00002724	Heriguard / Chlorogenic acid / 3-O-Caffeoylquinic acid	CHEMBL284616 CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319	D002726	30 / 19 / 22	37 / 9	No. 314	No. 6
C00009313	3-O-L-Arabinopyranosyl-ent-epicatechin-(2alpha->7,4alpha->8)-epicatechin					No. 341
C00009314	3-O-beta-D-Galactopyranosyl-ent-epicatechin-(2alpha->7,4alpha->8)-epicatechin					No. 341
C00001509	Theobromine	CHEMBL1114	D013805	13 / 9 / 7	2 / 1	No. 2266	No. 12
C00001915	Salsolinol / (-)-Salsolinol	CHEMBL416732 CHEMBL1193327 CHEMBL1195032		14 / 11 / 9		No. 2962	No. 4
C00001492	Caffeine	CHEMBL113	D002110	115 / 59 / 49	109 / 161	No. 3446	No. 12

Human Protein / Gene in interactions

202 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000956 C00001492 C00001509 C00001915 C00002724 C00002935 C00009075 C00009077	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000956 C00001492 C00001509 C00001915 C00002724 C00002935 C00009075 C00009077	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000956 C00001492 C00001509 C00001915 C00002724 C00002935 C00009075 C00009077	1 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000956 C00001492 C00001509 C00001915 C00002724 C00002935 C00009075 C00009077	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000956 C00001492 C00001509 C00001915 C00002724 C00002935 C00009075 C00009077	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000956 C00001915 C00002724 C00002935 C00009075 C00009077	3 / 3
P17252	Protein kinase C alpha type	Alpha	C00000956 C00001492 C00002935 C00009075 C00009077 C00009098	0 / 0
O94806	Serine/threonine-protein kinase D3	Pkd	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 0
Q02156	Protein kinase C epsilon type	Eta	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 0
Q04759	Protein kinase C theta type	Delta	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 1
Q05513	Protein kinase C zeta type	Iota	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 0
Q05655	Protein kinase C delta type	Delta	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000956 C00001492 C00001509 C00001915 C00002724	0 / 0
P24723	Protein kinase C eta type	Eta	C00000956 C00002935 C00009075 C00009077 C00009098	1 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 0
P05771	Protein kinase C beta type	Alpha	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 0
P41743	Protein kinase C iota type	Iota	C00000956 C00002935 C00009075 C00009077 C00009098	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00000956 C00002935 C00009075 C00009077 C00009098	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000956 C00002935 C00009075 C00009077	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000956 C00001915 C00002724	3 / 2
P28482	Mitogen-activated protein kinase 1	Erk	C00000956 C00001492 C00001509	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00002935 C00009075 C00009077	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000956 C00001915 C00002724	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000956 C00001915 C00002724	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001492 C00001509 C00002724	2 / 2
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000956 C00001492 C00002724	0 / 3
P23467	Receptor-type tyrosine-protein phosphatase beta	Receptor tyrosine-protein phosphatase	C00002935 C00009075 C00009077	0 / 0
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000956 C00001509	5 / 2
P35372	Mu-type opioid receptor	Opioid receptor	C00000956 C00001492	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000956 C00001492	0 / 0
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00000956 C00002724	3 / 0
P14780	Matrix metalloproteinase-9	M10A	C00001492 C00009098	2 / 2
P06239	Tyrosine-protein kinase Lck	Src	C00001492 C00002724	0 / 1
P04150	Glucocorticoid receptor	NR3C1	C00001492 C00002724	0 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000956 C00001509	0 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000956 C00006652	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00001492 C00001509	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000956 C00001492	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00000956 C00001492	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00001492 C00001915	0 / 0
O75496	Geminin	Unclassified protein	C00001492 C00002724	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00000956 C00002724	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00000956 C00001492	1 / 2
P41145	Kappa-type opioid receptor	Opioid receptor	C00000956 C00001492	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000956 C00001492	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00001492 C00001915	2 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000956 C00002724	1 / 1
P02768	Serum albumin	Secreted protein	C00000956 C00001492	0 / 0
P04156	Major prion protein	Surface antigen	C00001492	6 / 2
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00001492	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00001492	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00001492	1 / 0
P08183	Multidrug resistance protein 1	drug	C00001492	1 / 0
P49327	Fatty acid synthase	Transferase	C00000956	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00001492	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00001492	0 / 0
Q08828	Adenylate cyclase type 1	Enzyme	C00001492	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00001492	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00001492	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00000956	1 / 2
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00001492	1 / 8
P11388	DNA topoisomerase 2-alpha	Isomerase	C00000956	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000956	2 / 3
P25021	Histamine H2 receptor	Histamine receptor	C00001492	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001492	1 / 1
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00001492	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00001492	0 / 1
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00001492	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00001492	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00000956	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00001492	0 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00000956	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00001492	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00001492	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00001492	1 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00000956	0 / 0
P29275	Adenosine receptor A2b	Adenosine receptor	C00001492	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00000956	1 / 2
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00001492	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00001915	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00000956	0 / 0
P07998	Ribonuclease pancreatic	Enzyme	C00000956	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000956	2 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00001509	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00002724	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00001492	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00001492	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00001492	3 / 1
P30988	Calcitonin receptor	Calcitonin receptor	C00001492	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00001492	1 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000956	1 / 1
Q92731	Estrogen receptor beta	NR3A2	C00001492	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00001492	0 / 0
P15121	Aldose reductase	Enzyme	C00002724	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00001492	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00001492	0 / 0
P10145	Interleukin-8	Secreted protein	C00002724	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00001492	1 / 0
P00915	Carbonic anhydrase 1	Lyase	C00000956	0 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00001492	0 / 0
P08311	Cathepsin G	S1A	C00001492	0 / 0
P07711	Cathepsin L1	C1A	C00000956	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00001492	1 / 0
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00002724	1 / 2
P03956	Interstitial collagenase	M10A	C00001492	0 / 1
Q13535	Serine/threonine-protein kinase ATR	Atypical serine/threonine protein kinase PIKK subfamily	C00001492	2 / 2
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00001492	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00000956	1 / 1
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00000956	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00000956	3 / 1
O15245	Solute carrier family 22 member 1	Drug uniporter	C00001492	0 / 0
Q9NPD5	Solute carrier organic anion transporter family member 1B3	Electrochemical transporter	C00001492	1 / 0
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00001492	1 / 4
P00734	Prothrombin	S1A	C00000956	4 / 2
Q8N1Q1	Carbonic anhydrase 13	Lyase	C00000956	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00001492	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00001492	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00001492	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00001492	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00001492	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00001492	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00001492	0 / 0
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00002724	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00001492	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00001492	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00001492	0 / 0
P04745	Alpha-amylase 1	Enzyme	C00000956	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001509	0 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00000956	2 / 3
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00001492	1 / 0
P52209	6-phosphogluconate dehydrogenase, decarboxylating	Enzyme	C00000956	0 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00000956	0 / 1
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00001492	2 / 1
P56817	Beta-secretase 1	A1A	C00000956	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00001492	0 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00000956	0 / 1
P08253	72 kDa type IV collagenase	M10A	C00009098	1 / 3
P29466	Caspase-1	C14	C00001492	0 / 0
P51692	Signal transducer and activator of transcription 5B	Unclassified protein	C00002724	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000956	2 / 2
Q9Y2T3	Guanine deaminase	Enzyme	C00001492	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00001492	0 / 0
P00374	Dihydrofolate reductase	Oxidoreductase	C00000956	1 / 1
P03372	Estrogen receptor	NR3A1	C00001492	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00001492	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00001492	1 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001492	0 / 0
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00001492	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00000956	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00001492	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00001492	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00001492	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00001492	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00000956	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000956	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00000956	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000956	1 / 1
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00001492	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00001492	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00000956	0 / 0
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000956	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002724	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00001492	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000956	5 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00000956	4 / 3
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00002724	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002724	0 / 0
P10275	Androgen receptor	NR3C4	C00001492	3 / 4
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00001492	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00001492	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00001492	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00001492	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00001492	1 / 1
P07451	Carbonic anhydrase 3	Lyase	C00000956	0 / 0
P78527	DNA-dependent protein kinase catalytic subunit	Atypical serine/threonine protein kinase PIKK subfamily	C00001492	0 / 0
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00001492	0 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00001492	0 / 0
P22748	Carbonic anhydrase 4	Lyase	C00000956	1 / 1
P10415	Apoptosis regulator Bcl-2	Other cytosolic protein	C00000956	0 / 7
P33765	Adenosine receptor A3	Adenosine receptor	C00001492	0 / 0
P08246	Neutrophil elastase	S1A	C00001492	2 / 1
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000956	0 / 0
P42224	Signal transducer and activator of transcription 1-alpha/beta	Unclassified protein	C00002724	3 / 3
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00001492	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00001492	0 / 0
O00255	Menin	Unclassified protein	C00000956	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000956	1 / 2
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00002724	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00001915	1 / 1
O94956	Solute carrier organic anion transporter family member 2B1	Unclassified protein	C00001492	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000956	0 / 0
Q9Y6L6	Solute carrier organic anion transporter family member 1B1	Electrochemical transporter	C00001492	1 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000956	4 / 1
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00000956	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000956	3 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00001492	0 / 0
P11217	Glycogen phosphorylase, muscle form	Enzyme	C00001492	1 / 1
Q9NY46	Sodium channel protein type 3 subunit alpha	SCN alpha, NaV1.x	C00001492	0 / 0
Q99250	Sodium channel protein type 2 subunit alpha	SCN alpha, NaV1.x	C00001492	2 / 2
P35498	Sodium channel protein type 1 subunit alpha	SCN alpha, NaV1.x	C00001492	3 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002724	0 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00000956	0 / 0

148 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00001492 C00009077
581	BAX, BCL2L4	BCL2-associated X protein	C00001492 C00009077
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001492 C00009077
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00001492 C00009077
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00001492 C00009077
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00001492 C00009077
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001492 C00009077
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001492 C00009077
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00001492 C00001509
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00001492 C00001509
47	ACLY, ACL, ATPCL, CLATP	ATP citrate lyase (EC:2.3.3.8)	C00002724
22985	ACIN1, ACINUS, ACN, fSAP152	apoptotic chromatin condensation inducer 1	C00001492
2181	ACSL3, ACS3, FACL3, PRO2194	acyl-CoA synthetase long-chain family member 3 (EC:6.2.1.3)	C00001492
135	ADORA2A, A2aR, ADORA2, RDC8	adenosine A2a receptor	C00001492
136	ADORA2B, ADORA2	adenosine A2b receptor	C00001492
5832	ALDH18A1, ARCL3A, GSAS, P5CS, PYCS	aldehyde dehydrogenase 18 family, member A1 (EC:1.2.1.41 2.7.2.11)	C00001492
283	ANG, ALS9, HEL168, RNASE4, RNASE5	angiogenin, ribonuclease, RNase A family, 5 (EC:3.1.27.-)	C00001492
335	APOA1	apolipoprotein A-I	C00001492
336	APOA2, Apo-AII, ApoA-II, apoAII	apolipoprotein A-II	C00001492
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00001492
341	APOC1	apolipoprotein C-I	C00001492
344	APOC2, APO-CII, APOC-II	apolipoprotein C-II	C00001492
345	APOC3, APOCIII, HALP2	apolipoprotein C-III	C00001492
23204	ARL6IP1, AIP1, ARL6IP, ARMER	ADP-ribosylation factor-like 6 interacting protein 1	C00001492
440	ASNS, TS11	asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4)	C00001492
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00001492
9551	ATP5J2, ATP5JL	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 (EC:3.6.1.14)	C00001492
545	ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1	ataxia telangiectasia and Rad3 related (EC:2.7.11.1)	C00001492
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00001492
637	BID, FP497	BH3 interacting domain death agonist	C00001492
699	BUB1, BUB1A, BUB1L, hBUB1	BUB1 mitotic checkpoint serine/threonine kinase (EC:2.7.11.1)	C00001492
813	CALU	calumenin	C00001492
823	CAPN1, CANP, CANP1, CANPL1, muCANP, muCL	calpain 1, (mu/I) large subunit (EC:3.4.22.52)	C00001492
835	CASP2, CASP-2, ICH1, NEDD-2, NEDD2, PPP1R57	caspase 2, apoptosis-related cysteine peptidase (EC:3.4.22.55)	C00001492
891	CCNB1, CCNB	cyclin B1	C00001492
995	CDC25C, CDC25, PPP1R60	cell division cycle 25C (EC:3.1.3.48)	C00001492
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00001492
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00001492
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00001492
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00001492
1111	CHEK1, CHK1	checkpoint kinase 1 (EC:2.7.11.1)	C00001492
11200	CHEK2, CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1	checkpoint kinase 2 (EC:2.7.11.1)	C00001492
1508	CTSB, APPS, CPSB	cathepsin B (EC:3.4.22.1)	C00001492
1537	CYC1, MC3DN6, UQCR4	cytochrome c-1	C00001492
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00009077
1548	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	C00001492
1565	CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1	cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1)	C00001492
4240	MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47	milk fat globule-EGF factor 8 protein	C00009077
1580	CYP4B1, CYPIVB1, P-450HP	cytochrome P450, family 4, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00001492
1603	DAD1, OST2	defender against cell death 1 (EC:2.4.99.18)	C00001492
1638	DCT, TRP-2, TYRP2	dopachrome tautomerase (EC:5.3.3.12)	C00001492
1813	DRD2, D2DR, D2R	dopamine receptor D2	C00001492
10209	EIF1, A121, EIF-1, EIF1A, ISO1, SUI1	eukaryotic translation initiation factor 1	C00001492
1978	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	C00001492
2688	GH1, GH, GH-N, GHN, IGHD1B, hGH-N	growth hormone 1	C00001492
2745	GLRX, GRX, GRX1	glutaredoxin (thioltransferase) (EC:1.8.4.1)	C00001492
55830	GLT8D1, MSTP139	glycosyltransferase 8 domain containing 1	C00001492
2746	GLUD1, GDH, GDH1, GLUD	glutamate dehydrogenase 1 (EC:1.4.1.3)	C00001492
9446	GSTO1, GSTO_1-1, GSTTLp28, P28, SPG-R	glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2)	C00001492
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00001492
3291	HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3	hydroxysteroid (11-beta) dehydrogenase 2 (EC:1.1.1.146)	C00001492
3484	IGFBP1, AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1	insulin-like growth factor binding protein 1	C00001492
3630	INS, IDDM2, ILPR, IRDN, MODY10	insulin	C00001492
3708	ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29	inositol 1,4,5-trisphosphate receptor, type 1	C00001492
3939	LDHA, GSD11, LDH1, LDHM	lactate dehydrogenase A (EC:1.1.1.27)	C00001492
4257	MGST1, GST12, MGST, MGST-I	microsomal glutathione S-transferase 1 (EC:2.5.1.18)	C00001492
4277	MICB, PERB11.2	MHC class I polypeptide-related sequence B	C00001492
4495	MT1G, MT1, MT1K	metallothionein 1G	C00001492
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00001492
10	NAT2, AAC2, NAT-2, PNAT	N-acetyltransferase 2 (arylamine N-acetyltransferase) (EC:2.3.1.5)	C00001492
4942	OAT, GACR, HOGA, OATASE, OKT	ornithine aminotransferase (EC:2.6.1.13)	C00001492
5062	PAK2, PAK65, PAKgamma	p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1)	C00001492
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00001492
5354	PLP1, GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2	proteolipid protein 1	C00001492
5521	PPP2R2B, B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12	protein phosphatase 2, regulatory subunit B, beta (EC:3.1.3.16)	C00001492
27166	PRELID1, PRELI, PX19, SBBI12	PRELI domain containing 1	C00001492
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00001492
5621	PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30	prion protein	C00001492
10197	PSME3, Ki, PA28-gamma, PA28G, PA28gamma, REG-GAMMA	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)	C00001492
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00001492
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00001492
5972	REN, HNFJ2	renin (EC:3.4.23.15)	C00001492
6194	RPS6, S6	ribosomal protein S6	C00001492
6197	RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1)	C00001492
6198	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)	C00001492
23212	RRS1	RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)	C00001492
6261	RYR1, CCO, MHS, MHS1, RYDR, RYR, RYR-1, SKRR	ryanodine receptor 1 (skeletal)	C00001492
23256	SCFD1, C14orf163, RA410, SLY1, SLY1P, STXBP1L2	sec1 family domain containing 1	C00001492
6396	SEC13, D3S1231E, SEC13L1, SEC13R, npp-20	SEC13 homolog (S. cerevisiae)	C00001492
10484	SEC23A, CLSD	Sec23 homolog A (S. cerevisiae)	C00001492
5265	SERPINA1, A1A, A1AT, AAT, PI, PI1, PRO2275, alpha1AT	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	C00001492
866	SERPINA6, CBG	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	C00001492
6566	SLC16A1, HHF7, MCT, MCT1	solute carrier family 16 (monocarboxylate transporter), member 1	C00001492
54498	SMOX, C20orf16, PAO, PAO-1, PAOH1, SMO	spermine oxidase (EC:1.5.3.16)	C00001492
6713	SQLE	squalene epoxidase (EC:1.14.13.132)	C00001492
8878	SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B	sequestosome 1	C00001492
6426	SRSF1, ASF, SF2, SF2p33, SFRS1, SRp30a	serine/arginine-rich splicing factor 1	C00001492
6770	STAR, STARD1	steroidogenic acute regulatory protein	C00001492
55342	STRBP, ILF3L, SPNR, p74	spermatid perinuclear RNA binding protein	C00001492
7027	TFDP1, DP1, DRTF1, Dp-1	transcription factor Dp-1	C00001492
10548	TM9SF1, HMP70, MP70	transmembrane 9 superfamily member 1	C00001492
9911	TMCC2, HUCEP11	transmembrane and coiled-coil domain family 2	C00001492
27346	TMEM97, MAC30	transmembrane protein 97	C00001492
7292	TNFSF4, CD134L, CD252, GP34, OX-40L, OX4OL, TXGP1	tumor necrosis factor (ligand) superfamily, member 4	C00001492
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001492
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00001492
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00001492
7385	UQCRC2, MC3DN5, QCR2, UQCR2	ubiquinol-cytochrome c reductase core protein II (EC:1.10.2.2)	C00001492
7498	XDH, XO, XOR	xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2)	C00001492
10971	YWHAQ, 14-3-3, 1C5, HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	C00001492
7587	ZNF37A, KOX21, ZNF37	zinc finger protein 37A	C00001492
39	ACAT2	acetyl-CoA acetyltransferase 2 (EC:2.3.1.9)	C00001492
358	AQP1, AQP-CHIP, CHIP28, CO	aquaporin 1	C00002724
360	AQP3, AQP-3, GIL	aquaporin 3 (Gill blood group)	C00002724
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00002724
960	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1	CD44 molecule (Indian blood group)	C00002724
999	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO	cadherin 1, type 1, E-cadherin (epithelial)	C00002724
1277	COL1A1, OI4	collagen, type I, alpha 1	C00002724
4512	COX1, COI, MTCO1, MT-CO1	cytochrome c oxidase subunit I	C00002724
114757	CYGB, HGB, STAP	cytoglobin	C00002724
1830	DSG3, CDHF6, PVA	desmoglein 3	C00002724
1950	EGF, HOMG4, URG	epidermal growth factor	C00002724
2200	FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2	fibrillin 1	C00002724
2201	FBN2, CCA, DA9	fibrillin 2	C00002724
2246	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1	fibroblast growth factor 1 (acidic)	C00002724
2896	GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN	granulin	C00002724
3036	HAS1, HAS	hyaluronan synthase 1 (EC:2.4.1.212)	C00002724
3315	HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27	heat shock 27kDa protein 1	C00002724
3552	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1	interleukin 1, alpha	C00002724
3852	KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A	keratin 5	C00002724
4157	MC1R, CMM5, MSH-R, SHEP2	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	C00002724
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00002724
5241	PGR, NR3C3, PR	progesterone receptor	C00002724
8985	PLOD3, LH3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4)	C00002724
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00002724
5886	RAD23A, HHR23A, HR23A	RAD23 homolog A (S. cerevisiae)	C00002724
5914	RARA, NR1B1, RAR	retinoic acid receptor, alpha	C00002724
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00002724
6649	SOD3, EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	C00002724
6716	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22)	C00002724
7178	TPT1, HRF, TCTP, p02, p23	tumor protein, translationally-controlled 1	C00002724
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00002724
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00002724
7306	TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN	tyrosinase-related protein 1 (EC:1.14.18.-)	C00002724
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002724
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00002724
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002724
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002724

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Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions