Species

KNApSAcK Entry

Organism name Musa paradisiaca Linn.
Genus Musa
Family Musaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Musa
Linked NCBI taxonomy ID 4640
Linked level genus

Family

Family in NCBI taxonomy Musaceae
ID 4637

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (1)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001429 External link 512 Serotonin
/ Enteramin
/ Enteramine
/ DS substance
/ Thrombotonin
/ Thrombocytin
/ 5-Hydroxytryptamine
CHEMBL39
CHEMBL1628597
D012701
78 / 35 / 22 32 / 40 No. 1910 No. 4

Human Protein / Gene in interactions

78 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001429 1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00001429 3 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme C00001429 1 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter C00001429 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001429 2 / 0
Q7Z2W7 Transient receptor potential cation channel subfamily M member 8 Unclassified protein C00001429 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001429 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001429 0 / 3
Q13639 5-hydroxytryptamine receptor 4 Serotonin receptor C00001429 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001429 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001429 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001429 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00001429 0 / 0
P49286 Melatonin receptor type 1B Melatonin receptor C00001429 0 / 1
P23415 Glycine receptor subunit alpha-1 GLR alpha C00001429 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00001429 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00001429 1 / 2
P28222 5-hydroxytryptamine receptor 1B Serotonin receptor C00001429 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00001429 0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00001429 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001429 0 / 1
P16662 UDP-glucuronosyltransferase 2B7 Enzyme C00001429 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00001429 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001429 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00001429 0 / 0
P05164 Myeloperoxidase Enzyme C00001429 1 / 2
P28566 5-hydroxytryptamine receptor 1E Serotonin receptor C00001429 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00001429 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00001429 1 / 2
Q92830 Histone acetyltransferase KAT2A Enzyme C00001429 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00001429 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001429 1 / 0
P46098 5-hydroxytryptamine receptor 3A NS C00001429 0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001429 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00001429 0 / 0
P14679 Tyrosinase Oxidoreductase C00001429 4 / 2
P31645 Sodium-dependent serotonin transporter Serotonin C00001429 2 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001429 0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha C00001429 0 / 0
P48039 Melatonin receptor type 1A Melatonin receptor C00001429 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001429 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00001429 0 / 1
P06133 UDP-glucuronosyltransferase 2B4 Enzyme C00001429 0 / 0
P22303 Acetylcholinesterase Hydrolase C00001429 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001429 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001429 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001429 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001429 0 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00001429 5 / 1
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00001429 0 / 0
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00001429 1 / 0
P28221 5-hydroxytryptamine receptor 1D Serotonin receptor C00001429 0 / 0
P30939 5-hydroxytryptamine receptor 1F Serotonin receptor C00001429 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00001429 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00001429 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001429 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001429 0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00001429 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00001429 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00001429 1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00001429 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00001429 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00001429 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00001429 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00001429 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00001429 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00001429 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00001429 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00001429 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00001429 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00001429 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00001429 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00001429 1 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein C00001429 0 / 0
Q8WXA8 5-hydroxytryptamine receptor 3C NS C00001429 0 / 0
Q70Z44 5-hydroxytryptamine receptor 3D NS C00001429 0 / 0
O95264 5-hydroxytryptamine receptor 3B NS C00001429 0 / 0
A5X5Y0 5-hydroxytryptamine receptor 3E NS C00001429 0 / 0

32 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
847 CAT catalase (EC:1.11.1.6) C00001429
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00001429
2597 GAPDH, G3PD, GAPD glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) C00001429
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00001429
3352 HTR1D, 5-HT1D, HT1DA, HTR1DA, HTRL, RDC4 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled C00001429
3356 HTR2A, 5-HT2A, HTR2 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled C00001429
3359 HTR3A, 5-HT-3, 5-HT3A, 5-HT3R, 5HT3R, HTR3 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic C00001429
9177 HTR3B, 5-HT3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic C00001429
3363 HTR7, 5-HT7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled C00001429
3593 IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2 interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) C00001429
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00001429
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00001429
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001429
3690 ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) C00001429
4128 MAOA, MAO-A monoamine oxidase A (EC:1.4.3.4) C00001429
4353 MPO myeloperoxidase (EC:1.11.2.2) C00001429
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001429
6570 SLC18A1, CGAT, VAT1, VMAT1 solute carrier family 18 (vesicular monoamine transporter), member 1 C00001429
6571 SLC18A2, SVAT, SVMT, VAT2, VMAT2 solute carrier family 18 (vesicular monoamine transporter), member 2 C00001429
85413 SLC22A16, CT2, FLIPT2, OAT6, OCT6, OKB1, dJ261K5.1 solute carrier family 22 (organic cation/carnitine transporter), member 16 C00001429
6530 SLC6A2, NAT1, NET, NET1, SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 2 C00001429
6531 SLC6A3, DAT, DAT1, PKDYS solute carrier family 6 (neurotransmitter transporter), member 3 C00001429
6532 SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT solute carrier family 6 (neurotransmitter transporter), member 4 C00001429
6814 STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C syntaxin binding protein 3 C00001429
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00001429
6818 SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) C00001429
134864 TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1 trace amine associated receptor 1 C00001429
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001429
7166 TPH1, TPRH, TRPH, TPH tryptophan hydroxylase 1 (EC:1.14.16.4) C00001429
8989 TRPA1, ANKTM1, FEPS transient receptor potential cation channel, subfamily A, member 1 C00001429
54578 UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17) C00001429
7498 XDH, XO, XOR xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) C00001429

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (35)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P14416
P31645
P47869
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#143500 Gilbert syndrome P22309
P22310
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#149400 Hyperekplexia, hereditary 1; hkpx1 P23415
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#254600 Myeloperoxidase deficiency; mpod P05164
#159900 Myoclonic dystonia P14416
#164230 Obsessive-compulsive disorder; ocd P31645
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#614674 Periodic fever, menstrual cycle-dependent P08908
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#190300 Tremor, hereditary essential, 1; etm1 P35462
#112100 Yt blood group antigen P22303

KEGG DISEASE (22)

KEGG name UniProt
H00783 Febrile seizures O14764 (related)
P18507 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00101 Other phagocyte defects P05164 (related)
H00003 Acute myeloid leukemia (AML) P05164 (marker)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00769 Hyperekplexia P23415 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00409 Type II diabetes mellitus P49286 (related)

Diseases related to CTD interactions

40 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000544 Alzheimer Disease C00001429
D000648 Amnesia, Retrograde C00001429
D001008 Anxiety Disorders C00001429
D001022 Aortic Valve Insufficiency C00001429
D001049 Apnea C00001429
D001281 Atrial Fibrillation C00001429
D001321 Autistic Disorder C00001429
D001919 Bradycardia C00001429
D002375 Catalepsy C00001429
D002389 Catatonia C00001429
D002659 Child Development Disorders, Pervasive C00001429
D021081 Chronobiology Disorders C00001429
D015140 Dementia, Vascular C00001429
D003967 Diarrhea C00001429
D004195 Disease Models, Animal C00001429
D004487 Edema C00001429
D005355 Fibrosis C00001429
D005483 Flushing C00001429
D006349 Heart Valve Diseases C00001429
D006930 Hyperalgesia C00001429
D006973 Hypertension C00001429
D006976 Hypertension, Pulmonary C00001429
D017379 Hypertrophy, Left Ventricular C00001429
D007022 Hypotension C00001429
D007249 Inflammation C00001429
D043183 Irritable Bowel Syndrome C00001429
D008944 Mitral Valve Insufficiency C00001429
D009135 Muscular Diseases C00001429
D009336 Necrosis C00001429
D009422 Nervous System Diseases C00001429
D010146 Pain C00001429
D011537 Pruritus C00001429
D012640 Seizures C00001429
D020230 Serotonin Syndrome C00001429
D013226 Status Epilepticus C00001429
D013276 Stomach Ulcer C00001429
D020521 Stroke C00001429
D013610 Tachycardia C00001429
D059246 Tachypnea C00001429
D014202 Tremor C00001429