Species

KNApSAcK Entry

Organism name Peucedanum paniculatum L.
Genus Peucedanum
Family Apiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Peucedanum
Linked NCBI taxonomy ID 49562
Linked level genus

Family

Family in NCBI taxonomy Apiaceae
ID 4037

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (38)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003186 External link 512 beta-Selinene
C087920
No. 151 No. 38
C00029672 External link 512 alpha-Selinene
/ (-)-alpha-Selinene
No. 151 No. 38
C00021213 External link 512 Globulol
/ (-)-Globulol
CHEMBL2171207
1 / 2 / 3 No. 197 No. 38
C00020065 External link 512 alpha-Cadinol
/ (-)-alpha-Cadinol
CHEMBL486795
No. 205 No. 38
C00020154 External link 512 T-Muurolol
/ epi-alpha-Muurolol
CHEMBL486795
No. 205 No. 38
C00029421 External link 512 epi-Cubenol
/ 1-epi-Cubenol
/ (+)-ent-Epicubenol
No. 205 No. 38
C00020130 External link 512 gamma-Muurolene
/ 1beta-Cadina-4,10(15)-diene
No. 283 No. 39
C00003118 External link 512 Copaene
/ alpha-Copaene
/ (-)-alpha-Copaene
No. 333 No. 38
C00021884 External link 512 beta-Bourbonene
/ (E)-beta-Bourbonene
No. 333 No. 38
C00035496 External link 512 4,5-epi-Cryptomeridiol
CHEMBL465860
CHEMBL1288770
No. 351
C00012815 External link 512 Neointermedeol
/ neo-Intermedeol
/ (-)-Neointermedeol
/ [1S-(1alpha,4aalpha,7alpha,8abeta)]-Decahydro-1,4a-dimethyl-7-(1-methylethenyl)-1-naphthalenol
CHEMBL481844
CHEMBL505457
No. 398 No. 38
C00012813 External link 512 Kongol
/ Selin-11-en-4alpha-ol
/ 5alpha,7alphaH-Eudesm-11(13)en-4alpha-ol
/ [1R-(1alpha,4abeta,7beta,8aalpha)]-decahydro-1,4a-dimethyl-7-(1-methylethenyl)-1-naphthalenol
CHEMBL481844
CHEMBL505457
No. 398 No. 38
C00003110 External link 512 Caryophyllene
/ (E)-Caryophyllene
/ beta-Caryophyllene
/ (-)-(E)-Caryophyllene
/ (E)-beta-Caryophyllene
CHEMBL445740
CHEMBL448700
2 / 3 / 7 No. 478 No. 38
C00032309 External link 512 Tetradecanol
/ 1-Tetradecanol
CHEMBL24022
C020940
1 / 0 / 0 No. 599
C00012425 External link 512 Bicyclogermacren
/ Bicyclogermacrene
/ (+)-Bicyclogermacrene
CHEMBL509566
No. 699 No. 38
C00000823 External link 512 Limonene
CHEMBL15799
CHEMBL449062
C008281
7 / 21 / 48 6 / 6 No. 848 No. 35
C00030100 External link 512 Decanol
/ 1-Decanol
/ n-Decanol
CHEMBL25363
C029383
1 / 0 / 0 1 / 0 No. 877
C00031258 External link 512 Sabinene
/ 4(10)-Thujene
CHEMBL452687
C035127
No. 1343 No. 35
C00007453 External link 512 Cyclohexane
/ beta-Elemene
CHEMBL448502
CHEMBL479707
No. 1400
C00003147 External link 512 Humulene
/ alpha-Caryophyllene
/ (+/-)-alpha-Humulene
CHEMBL251280
C042686
No. 1421 No. 38
C00007636 External link 512 delta-Cadinene
CHEMBL445759
No. 1524 No. 39
C00000149 External link 512 Spathulenol
CHEMBL518542
CHEMBL1774433
C013258
No. 1603
C00029351 External link 512 Z-beta-Ocimene
/ cis-beta-Ocimene
/ (Z)-beta-Ocimene
No. 1698 No. 34
C00029335 External link 512 beta-Ocimene
/ E-beta-Ocimene
/ (E)-beta-Ocimene
C443996
No. 1698 No. 34
C00012708 External link 512 Selina-3,7(11)-diene
No. 2008
C00029544 External link 512 4-Terpineol
/ Terpin-4-ol
/ Terpineol-4
/ Terpinen-4-ol
CHEMBL507795
C034019
1 / 3 / 0 No. 2215
C00000853 External link 512 Myrcene
CHEMBL455491
C008574
3 / 3 / 3 No. 2285 No. 34
C00035538 External link 512 beta-Isocyclolavandulyl acetate
No. 2490
C00035540 External link 512 beta-Isocyclolavandulyl isovalerate
No. 2490
C00035541 External link 512 beta-Isocyclolavandulyl propionate
No. 2490
C00035539 External link 512 beta-Isocyclolavandulyl isobutyrate
No. 2490
C00011720 External link 512 Germacrene D
/ (-)-Germacrene D
CHEMBL105432
CHEMBL1836650
No. 2639 No. 38
C00035674 External link 512 Lavandulyl acetate
/ (-)-Lavandulyl acetate
No. 3562
C00035675 External link 512 Lavandulyl isobutyrate
No. 3562
C00000861 External link 512 Terpinolene
CHEMBL454697
C027009
1 / 0 No. 3725
C00010998 External link 512 beta-Cyclolavandulal
/ 2,4,4-Trimethyl-1-cyclohexene-1-carboxyaldehyde
No. 4106 No. 38
C00035537 External link 512 beta-Isocyclolavandulol
No. 6887
C00034575 External link 512 Lavandulol
No. 7188

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q96RI1 Bile acid receptor NR1H4 C00000853 C00030100 C00032309 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000823 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000823 0 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000823 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000823 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000853 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00000823 3 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00000823 7 / 37
P04150 Glucocorticoid receptor NR3C1 C00000853 0 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00029544 3 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00021213 2 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000823 0 / 0
O00255 Menin Unclassified protein C00003110 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003110 1 / 2

8 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000823
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000823
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000823
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00000823
4852 NPY, PYY4 neuropeptide Y C00000823
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000823
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000861
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00030100

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (32)

OMIM preferred title UniProt
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22310
#606785 Crigler-najjar syndrome, type ii P22310
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#143500 Gilbert syndrome P22310
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P08581
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#260500 Papilloma of choroid plexus; cpp P04637
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (57)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P04637 (related)
P08581 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P08581 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
P08581 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

6 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003877 Dermatitis, Contact C00000823
D007674 Kidney Diseases C00000823
D008107 Liver Diseases C00000823
D008114 Liver Neoplasms, Experimental C00000823
D008569 Memory Disorders C00000823
D013276 Stomach Ulcer C00000823