Species

KNApSAcK Entry

Organism name Acorus calanus L.
Genus Acorus
Family Acoraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Acorus
Linked NCBI taxonomy ID 4464
Linked level genus

Family

Family in NCBI taxonomy Acoraceae
ID 42228

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (56)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00023769 External link 512 Clionasterol
/ gamma-Sitosterol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00003111 External link 512 Cedr-8-ene
/ (-)-Cedrene
/ alpha-Cedrene
No. 149 No. 38
C00035811 External link 512 beta-Funebrene
/ (-)-beta-Funebrene
No. 149 No. 38
C00021720 External link 512 beta-Cedrene
/ (+)-beta-Cedrene
No. 149 No. 38
C00021722 External link 512 alpha-Funebrene
No. 149 No. 38
C00035802 External link 512 alpha-Neocallitropsene
/ (-)-alpha-Neocallitropsene
No. 151 No. 38
C00029672 External link 512 alpha-Selinene
/ (-)-alpha-Selinene
No. 151 No. 38
C00021580 External link 512 beta-Acoradiene
No. 151 No. 38
C00003186 External link 512 beta-Selinene
C087920
No. 151 No. 38
C00021983 External link 512 Khusiol
No. 161 No. 38
C00003112 External link 512 Cedrol
/ (+)-Cedrol
/ alpha-Cedrol
CHEMBL1592444
CHEMBL1974890
C078669
5 / 14 / 11 No. 161 No. 38
C00030479 External link 512 Hexadecanoic acid
/ n-Hexadecanoic acid
CHEMBL82293
D019308
16 / 8 / 8 35 / 1 No. 184 No. 68
C00034905 External link 512 tau-Cadinol
CHEMBL486795
C072576
No. 205 No. 38
C00020065 External link 512 alpha-Cadinol
/ (-)-alpha-Cadinol
CHEMBL486795
No. 205 No. 38
C00029671 External link 512 alpha-Muurolene
No. 283 No. 39
C00035828 External link 512 gamma-Amorphene
/ (+)-gamma-Amorphene
No. 283 No. 39
C00035903 External link 512 Z-Isoeugenol
CHEMBL193598
CHEMBL445206
CHEMBL2135887
93 / 36 / 31 No. 310 No. 6
C00003118 External link 512 Copaene
/ alpha-Copaene
/ (-)-alpha-Copaene
No. 333 No. 38
C00013572 External link 512 Torilenol
/ (1R,1aR,1bS,5R,5aR,6aR)-Decahydro-5a-methyl-2-methylene-1-(1-methylethyl)cycloprop[a]inden-5-ol
No. 333 No. 38
C00001224 External link 512 Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid
CHEMBL267476
29 / 31 / 28 No. 367 No. 68
C00029350 External link 512 Z-beta-Farnesene
/ (Z)-beta-Farnesene
/ beta-cis-Farnesene
/ cis-beta-Farnesene
No. 404 No. 38
C00011617 External link 512 AR-Curcumene
/ (R)-(-)-alpha-Curcumene
CHEMBL469717
No. 456 No. 38
C00000805 External link 512 alpha-Pinene
CHEMBL442565
C005451
3 / 3 / 2 0 / 1 No. 476 No. 35
C00000816 External link 512 beta-Pinene
CHEMBL501351
C010789
No. 476 No. 35
C00012483 External link 512 Betula pubescens
/ Caryophyllene oxide
/ trans-Caryophyllene oxide
/ beta-Caryophyllene epoxide
/ (-)-Epoxydihydrocaryophyllene
/ 6,7-Epoxy-3(15)-caryophyllene
/ (-)-beta-Caryophyllene epoxide
/ 4beta,5alpha-Epoxycaryophyllene
/ Caryophyllene 4beta,5alpha-epoxide
CHEMBL399036
CHEMBL508894
CHEMBL479134
CHEMBL1513806
CHEMBL1553274
3 / 1 / 3 No. 500
C00021239 External link 512 Squamulosone
No. 595 No. 38
C00035800 External link 512 9-Alloaromadendrene
/ allo-Aromadendr-9-ene
No. 640
C00012425 External link 512 Bicyclogermacren
/ Bicyclogermacrene
/ (+)-Bicyclogermacrene
CHEMBL509566
No. 699 No. 38
C00011719 External link 512 Germacrene A
/ (-)-Germacrene A
C471077
No. 701 No. 38
C00002715 External link 512 beta-Asarone
CHEMBL333306
CHEMBL477752
2 / 1 / 1 No. 723 No. 6
C00029339 External link 512 E-Nerolidol
/ (E)-Nerolidol
/ trans-Nerolidol
CHEMBL25424
CHEMBL508801
CHEMBL561014
CHEMBL1923157
3 / 3 / 1 No. 726 No. 38
C00000823 External link 512 Limonene
CHEMBL15799
CHEMBL449062
C008281
7 / 21 / 48 6 / 6 No. 848 No. 35
C00003047 External link 512 Linalool
/ (R)-linalool
/ (R)-(-)-3,7-Dimethyl-1,6-octadien-3-ol
CHEMBL25306
CHEMBL235672
C018584
6 / 8 / 2 35 / 4 No. 958 No. 34
C00029674 External link 512 alpha-Terpineol
CHEMBL447597
CHEMBL449810
C016775
3 / 16 / 11 No. 983 No. 35
C00029881 External link 512 Calarene
/ (+)-1(10)-Aristolene
No. 1097
C00031258 External link 512 Sabinene
/ 4(10)-Thujene
CHEMBL452687
C035127
No. 1343 No. 35
C00000184 External link 512 alpha-Thujene
No. 1343 No. 35
C00007453 External link 512 Cyclohexane
/ beta-Elemene
CHEMBL448502
CHEMBL479707
No. 1400
C00003147 External link 512 Humulene
/ alpha-Caryophyllene
/ (+/-)-alpha-Humulene
CHEMBL251280
C042686
No. 1421 No. 38
C00029351 External link 512 Z-beta-Ocimene
/ cis-beta-Ocimene
/ (Z)-beta-Ocimene
No. 1698 No. 34
C00030757 External link 512 Methyl linoleate
/ Methyl 9Z,12Z-octadecadienoate
C005575
No. 1785
C00011630 External link 512 beta-Curcumene
/ l-beta-Curcumene
/ (-)-beta-Curcumene
No. 1788 No. 38
C00000819 External link 512 (+)-Camphor
CHEMBL504760
CHEMBL1316134
D002164
99 / 56 / 51 5 / 3 No. 1921 No. 35
C00003040 External link 512 p-Cymene
CHEMBL442915
C007210
No. 2172 No. 35
C00029544 External link 512 4-Terpineol
/ Terpin-4-ol
/ Terpineol-4
/ Terpinen-4-ol
CHEMBL507795
C034019
1 / 3 / 0 No. 2215
C00000853 External link 512 Myrcene
CHEMBL455491
C008574
3 / 3 / 3 No. 2285 No. 34
C00007630 External link 512 beta-Sesquiphellandrene
CHEMBL469718
No. 2380 No. 38
C00003029 External link 512 Camphene
CHEMBL506889
CHEMBL510535
C019286
No. 2460 No. 35
C00003061 External link 512 gamma-Terpinene
/ 1-Methyl-4-(1-methylethyl)-1,4-cyclohexadiene
CHEMBL449693
C018669
No. 2468 No. 35
C00011714 External link 512 Preisocalamendiol
/ Preisocalamenediol
CHEMBL1814553
No. 2470
C00035842 External link 512 iso-Acorone
No. 3631
C00000861 External link 512 Terpinolene
CHEMBL454697
C027009
1 / 0 No. 3725
C00012007 External link 512 Isoshyobunone
/ iso-Shyobunone
/ (1S,4S)-2-Isopropylidene-1-vinyl-p-menthan-3-one
CHEMBL1814554
No. 3953
C00035825 External link 512 Dihydrocarveyl acetate
CHEMBL1730107
1 / 0 / 0 No. 3978 No. 35
C00021585 External link 512 Acoronene
CHEMBL1164941
CHEMBL1164357
No. 4300
C00035798 External link 512 Acorenone
/ (-)-Acorenone
CHEMBL1814555
No. 4300

Human Protein / Gene in interactions

144 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000819 C00001224 C00002715 C00012483 C00023769 C00035903 0 / 1
P03372 Estrogen receptor NR3A1 C00000819 C00001224 C00023769 C00030479 C00035903 1 / 1
P02545 Prelamin-A/C Unclassified protein C00000819 C00000823 C00001224 C00003112 C00029674 11 / 10
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000819 C00002715 C00023769 C00035903 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000805 C00000819 C00003112 C00035903 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00000819 C00000853 C00001224 C00030479 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001224 C00003047 C00003112 C00029339 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000819 C00012483 C00023769 C00035903 1 / 1
P04150 Glucocorticoid receptor NR3C1 C00000819 C00000853 C00030479 C00035903 0 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00000805 C00000853 C00001224 C00023769 3 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00000823 C00003047 C00003112 C00029339 3 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000819 C00012483 C00023769 C00035903 0 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000819 C00000823 C00035903 0 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000819 C00001224 C00035903 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001224 C00029339 C00030479 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000819 C00001224 C00003112 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00003047 C00029544 C00029674 3 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000819 C00023769 C00035903 0 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000819 C00035903 0 / 0
P17252 Protein kinase C alpha type Alpha C00000819 C00035903 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000819 C00035903 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000823 C00001224 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000819 C00035903 2 / 2
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001224 C00030479 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000819 C00035903 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00023769 C00030479 0 / 0
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000819 C00035903 0 / 0
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001224 C00030479 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000823 C00001224 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000819 C00035903 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000819 C00035903 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000819 C00035903 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000819 C00035903 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000819 C00035903 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000819 C00035903 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000819 C00035903 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000819 C00035903 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000819 C00035903 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000819 C00035903 1 / 1
P08183 Multidrug resistance protein 1 drug C00023769 C00030479 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000819 C00035903 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000819 C00035903 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000819 C00035903 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000819 C00035903 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000819 C00035903 1 / 8
P10275 Androgen receptor NR3C4 C00001224 C00030479 3 / 4
P14416 D(2) dopamine receptor Dopamine receptor C00000819 C00035903 2 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000819 C00035903 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000819 C00035903 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000819 C00035903 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000819 C00035903 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000819 C00035903 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000819 C00035903 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000819 C00035903 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000819 C00035903 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000819 C00035903 1 / 0
P08246 Neutrophil elastase S1A C00000819 C00035903 2 / 1
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000819 C00035903 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001224 C00035825 0 / 0
O75496 Geminin Unclassified protein C00001224 C00030479 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000819 C00035903 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000819 C00035903 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000819 C00035903 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000819 C00035903 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000819 C00035903 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000819 C00035903 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000819 C00035903 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000819 C00035903 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000819 C00035903 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000819 C00035903 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000819 C00035903 1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000823 C00035903 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00003047 C00029674 5 / 1
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000819 C00035903 0 / 0
P08311 Cathepsin G S1A C00000819 C00035903 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000819 C00035903 1 / 0
P03956 Interstitial collagenase M10A C00000819 C00035903 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000819 C00035903 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000819 C00035903 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003047 C00035903 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000819 C00035903 2 / 2
P21728 D(1A) dopamine receptor Dopamine receptor C00000819 C00035903 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000819 C00035903 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000819 C00035903 2 / 0
P29466 Caspase-1 C14 C00000819 C00035903 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001224 C00030479 2 / 2
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001224 C00030479 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000819 C00035903 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000819 C00035903 2 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000819 C00035903 0 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000819 C00035903 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000819 C00035903 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000819 C00035903 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000819 C00035903 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000819 C00035903 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000819 C00035903 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000819 C00035903 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000819 C00035903 1 / 1
P25105 Platelet-activating factor receptor PAF receptor C00000819 C00035903 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000819 C00035903 1 / 0
P06239 Tyrosine-protein kinase Lck Src C00000819 C00035903 0 / 1
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000819 C00035903 2 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000819 C00035903 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000819 C00035903 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000819 C00035903 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000819 C00035903 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000819 C00035903 0 / 0
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000805 C00000819 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000819 C00035903 0 / 0
P22303 Acetylcholinesterase Hydrolase C00000819 C00035903 1 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000819 C00035903 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001224 C00023769 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000819 C00035903 1 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00000819 0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00003047 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001224 2 / 2
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00000819 1 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001224 3 / 3
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein C00030479 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00001224 0 / 0
P13726 Tissue factor Membrane receptor C00001224 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001224 5 / 3
P14679 Tyrosinase Oxidoreductase C00023769 4 / 2
P00734 Prothrombin S1A C00023769 4 / 2
Q9UGP5 DNA polymerase lambda Enzyme C00001224 0 / 0
O14842 Free fatty acid receptor 1 Free fatty acid receptor C00001224 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00023769 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000819 4 / 3
P12104 Fatty acid-binding protein, intestinal Other cytosolic protein C00030479 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00030479 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00001224 0 / 0
P06746 DNA polymerase beta Enzyme C00023769 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00023769 2 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00035903 0 / 0
Q8NET8 Transient receptor potential cation channel subfamily V member 3 Unclassified protein C00000819 1 / 0
O60603 Toll-like receptor 2 Membrane receptor C00030479 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00000823 7 / 37
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00023769 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00023769 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001224 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00035903 0 / 0
P35610 Sterol O-acyltransferase 1 Enzyme C00001224 0 / 0
O00255 Menin Unclassified protein C00000819 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000819 1 / 2

75 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000861 C00003047 C00030479
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000823 C00030479
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00003047 C00030479
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000823 C00003047
4852 NPY, PYY4 neuropeptide Y C00000823 C00003047
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000823 C00003047
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00030479
3265 HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1 Harvey rat sarcoma viral oncogene homolog C00000823
1386 ATF2, CRE-BP1, CREB2, HB16, TREB7 activating transcription factor 2 (EC:2.3.1.48) C00003047
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00003047
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00003047
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00003047
1027 CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 cyclin-dependent kinase inhibitor 1B (p27, Kip1) C00003047
1028 CDKN1C, BWCR, BWS, KIP2, WBS, p57, p57Kip2 cyclin-dependent kinase inhibitor 1C (p57, Kip2) C00003047
1030 CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) C00003047
1447 CSN2, CASB casein beta C00003047
1509 CTSD, CLN10, CPSD cathepsin D (EC:3.4.23.5) C00003047
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000823
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00003047
2335 FN1, CIG, ED-B, FINC, FN, FNZ, GFND, GFND2, LETS, MSF fibronectin 1 C00003047
1647 GADD45A, DDIT1, GADD45 growth arrest and DNA-damage-inducible, alpha C00003047
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00003047
3156 HMGCR, LDLCQ3 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) C00003047
3297 HSF1, HSTF1 heat shock transcription factor 1 C00003047
3320 HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2 heat shock protein 90kDa alpha (cytosolic), class A member 1 C00003047
3308 HSPA4, APG-2, HS24/P52, HSPH2, RY, hsp70, hsp70RY heat shock 70kDa protein 4 C00003047
3316 HSPB2, HSP27, Hs.78846, LOH11CR1K, MKBP heat shock 27kDa protein 2 C00003047
3398 ID2, GIG8, ID2A, ID2H, bHLHb26 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein C00003047
3638 INSIG1, CL-6, CL6 insulin induced gene 1 C00003047
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00003047
8850 KAT2B, CAF, P, P/CAF, PCAF K(lysine) acetyltransferase 2B (EC:2.3.1.48) C00003047
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00003047
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00003047
4790 NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 C00003047
100124292 C00003047
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00003047
7471 WNT1, BMND16, INT1, OI15 wingless-type MMTV integration site family, member 1 C00003047
26118 WSB1, SWIP1, WSB-1 WD repeat and SOCS box containing 1 C00003047
1555 CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) C00000819
2554 GABRA1, ECA4, EJM, EJM5 gamma-aminobutyric acid (GABA) A receptor, alpha 1 C00000819
2561 GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 C00000819
2566 GABRG2, CAE2, ECA2, GEFSP3 gamma-aminobutyric acid (GABA) A receptor, gamma 2 C00000819
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000819
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00030479
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00030479
581 BAX, BCL2L4 BCL2-associated X protein C00030479
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00030479
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00030479
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00030479
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00030479
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00030479
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00030479
57817 HAMP, HEPC, HFE2B, LEAP1, PLTR hepcidin antimicrobial peptide C00030479
3481 IGF2, C11orf43, IGF-II, PP9974 insulin-like growth factor 2 (somatomedin A) C00030479
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00030479
1646 AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8 aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357) C00003047
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00030479
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00030479
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00030479
4493 MT1E, MT1, MTD metallothionein 1E C00030479
4494 MT1F, MT1 metallothionein 1F C00030479
4496 MT1H, MT-0, MT-1H, MT-IH, MT1 metallothionein 1H C00030479
4501 MT1X, MT-1l, MT1 metallothionein 1X C00030479
4502 MT2A, MT2 metallothionein 2A C00030479
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00030479
3651 PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 pancreatic and duodenal homeobox 1 C00030479
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00030479
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00030479
29893 PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP PSMC3 interacting protein C00030479
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00030479
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00030479
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00030479
23216 TBC1D1, TBC, TBC1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 C00030479
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00030479
7351 UCP2, BMIQ4, SLC25A8, UCPH uncoupling protein 2 (mitochondrial, proton carrier) C00030479

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (100)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#614594 Palmoplantar keratoderma, mutilating, with periorificial keratotic plaques Q8NET8
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (93)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00344 Leprosy O60603 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

14 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003877 Dermatitis, Contact C00000805
C00000823
D006937 Hypercholesterolemia C00003047
D008107 Liver Diseases C00000823
D008114 Liver Neoplasms, Experimental C00000823
D008569 Memory Disorders C00000823
D013276 Stomach Ulcer C00000823
D017453 Dermatitis, Irritant C00003047
D007674 Kidney Diseases C00000823
D007938 Leukemia C00003047
D009369 Neoplasms C00003047
D003371 Cough C00000819
D004487 Edema C00000819
D012640 Seizures C00000819
D003072 Cognition Disorders C00030479