KEGG   Homo sapiens (human): 7157Help
Entry
7157              CDS       T01001                                 

Gene name
TP53, BCC7, LFS1, P53, TRP53
Definition
tumor protein p53
Orthology
K04451  
tumor protein p53
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Wnt signaling pathway
Neurotrophin signaling pathway
Thyroid hormone signaling pathway
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Hepatitis C
Hepatitis B
Measles
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Basal cell carcinoma
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Disease
H00004  
Chronic myeloid leukemia (CML)
H00005  
Chronic lymphocytic leukemia (CLL)
H00006  
Hairy-cell leukemia
H00008  
Burkitt lymphoma
H00009  
Adult T-cell leukemia
H00010  
Multiple myeloma
H00013  
Small cell lung cancer
H00014  
Non-small cell lung cancer
H00015  
Malignant pleural mesothelioma
H00016  
Oral cancer
H00017  
Esophageal cancer
H00018  
Gastric cancer
H00019  
Pancreatic cancer
H00020  
Colorectal cancer
H00022  
Bladder cancer
H00025  
Penile cancer
H00026  
Endometrial Cancer
H00027  
Ovarian cancer
H00028  
Choriocarcinoma
H00029  
Vulvar cancer
H00031  
Breast cancer
H00032  
Thyroid cancer
H00033  
Adrenal carcinoma
H00036  
Osteosarcoma
H00038  
Malignant melanoma
H00039  
Basal cell carcinoma
H00040  
Squamous cell carcinoma
H00041  
Kaposi's sarcoma
H00042  
Glioma
H00044  
Cancer of the anal canal
H00046  
Cholangiocarcinoma
H00047  
Gallbladder cancer
H00048  
Hepatocellular carcinoma
H00055  
Laryngeal cancer
H00881  
Li-Fraumeni syndrome
H01007  
Choroid plexus papilloma
Drug target
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    7157 (TP53)
   04310 Wnt signaling pathway
    7157 (TP53)
   04151 PI3K-Akt signaling pathway
    7157 (TP53)
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    7157 (TP53)
   04210 Apoptosis
    7157 (TP53)
   04115 p53 signaling pathway
    7157 (TP53)
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    7157 (TP53)
  Nervous system
   04722 Neurotrophin signaling pathway
    7157 (TP53)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    7157 (TP53)
   05230 Central carbon metabolism in cancer
    7157 (TP53)
   05202 Transcriptional misregulation in cancers
    7157 (TP53)
   05206 MicroRNAs in cancer
    7157 (TP53)
   05205 Proteoglycans in cancer
    7157 (TP53)
   05203 Viral carcinogenesis
    7157 (TP53)
   05210 Colorectal cancer
    7157 (TP53)
   05212 Pancreatic cancer
    7157 (TP53)
   05214 Glioma
    7157 (TP53)
   05216 Thyroid cancer
    7157 (TP53)
   05220 Chronic myeloid leukemia
    7157 (TP53)
   05217 Basal cell carcinoma
    7157 (TP53)
   05218 Melanoma
    7157 (TP53)
   05219 Bladder cancer
    7157 (TP53)
   05215 Prostate cancer
    7157 (TP53)
   05213 Endometrial cancer
    7157 (TP53)
   05222 Small cell lung cancer
    7157 (TP53)
   05223 Non-small cell lung cancer
    7157 (TP53)
  Neurodegenerative diseases
   05014 Amyotrophic lateral sclerosis (ALS)
    7157 (TP53)
   05016 Huntington's disease
    7157 (TP53)
  Infectious diseases
   05166 HTLV-I infection
    7157 (TP53)
   05162 Measles
    7157 (TP53)
   05161 Hepatitis B
    7157 (TP53)
   05160 Hepatitis C
    7157 (TP53)
   05168 Herpes simplex infection
    7157 (TP53)
   05169 Epstein-Barr virus infection
    7157 (TP53)
Transcription factors [BR:hsa03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   p53
    7157 (TP53)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
Structure
PDB: 

Jmol
Position
17p13.1
AA seq 393 aa AA seqDB search
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atggaggagccgcagtcagatcctagcgtcgagccccctctgagtcaggaaacattttca
gacctatggaaactacttcctgaaaacaacgttctgtcccccttgccgtcccaagcaatg
gatgatttgatgctgtccccggacgatattgaacaatggttcactgaagacccaggtcca
gatgaagctcccagaatgccagaggctgctccccccgtggcccctgcaccagcagctcct
acaccggcggcccctgcaccagccccctcctggcccctgtcatcttctgtcccttcccag
aaaacctaccagggcagctacggtttccgtctgggcttcttgcattctgggacagccaag
tctgtgacttgcacgtactcccctgccctcaacaagatgttttgccaactggccaagacc
tgccctgtgcagctgtgggttgattccacacccccgcccggcacccgcgtccgcgccatg
gccatctacaagcagtcacagcacatgacggaggttgtgaggcgctgcccccaccatgag
cgctgctcagatagcgatggtctggcccctcctcagcatcttatccgagtggaaggaaat
ttgcgtgtggagtatttggatgacagaaacacttttcgacatagtgtggtggtgccctat
gagccgcctgaggttggctctgactgtaccaccatccactacaactacatgtgtaacagt
tcctgcatgggcggcatgaaccggaggcccatcctcaccatcatcacactggaagactcc
agtggtaatctactgggacggaacagctttgaggtgcgtgtttgtgcctgtcctgggaga
gaccggcgcacagaggaagagaatctccgcaagaaaggggagcctcaccacgagctgccc
ccagggagcactaagcgagcactgcccaacaacaccagctcctctccccagccaaagaag
aaaccactggatggagaatatttcacccttcagatccgtgggcgtgagcgcttcgagatg
ttccgagagctgaatgaggccttggaactcaaggatgcccaggctgggaaggagccaggg
gggagcagggctcactccagccacctgaagtccaaaaagggtcagtctacctcccgccat
aaaaaactcatgttcaagacagaagggcctgactcagactga

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