+C Two-component system KO
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Two-Component System - Massilia violaceinigra
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C CR152_28055 phoR; phosphate regulon sensor histidine kinase PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C CR152_28060 DNA-binding response regulator K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C CR152_01020 two-component transcriptional regulator K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C CR152_18105 two-component sensor histidine kinase K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C CR152_18110 two-component system response regulator OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C CR152_04230 two-component system sensor histidine kinase CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C CR152_04225 two-component system response regulator CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C CR152_10585 hypothetical protein K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C CR152_20820 hypothetical protein K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C CR152_10580 two-component system response regulator BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
C CR152_20825 two-component system response regulator BaeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C CR152_10510 two-component system sensor histidine kinase KdbD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C CR152_10515 two-component system response regulator KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C CR152_20960 sensor histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C CR152_16605 sensor histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C CR152_16610 DNA-binding response regulator K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C CR152_31665 two-component sensor histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C CR152_01580 two-component sensor histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C CR152_15315 two-component sensor histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C CR152_15310 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CR152_31620 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CR152_25010 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CR152_03650 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CR152_10530 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CR152_10960 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CR152_04470 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CR152_20955 DNA-binding response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C CR152_22770 transcriptional regulator K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C CR152_04685 DNA-binding response regulator K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
C CR152_22775 two-component system response regulator NarL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C CR152_03970 sensor histidine kinase K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C CR152_14905 histidine kinase K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
C CR152_03960 DNA-binding response regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
C CR152_14900 DNA-binding response regulator K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
C CR152_08920 histidine kinase K07778 desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
C CR152_30310 histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C CR152_27155 sensor histidine kinase K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C CR152_04930 sensor histidine kinase K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C CR152_15405 hypothetical protein K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C CR152_27150 DNA-binding response regulator K02477 K02477; two-component system, LytTR family, response regulator
C CR152_04935 DNA-binding response regulator K02477 K02477; two-component system, LytTR family, response regulator
C CR152_17860 DNA-binding response regulator K02477 K02477; two-component system, LytTR family, response regulator
C CR152_15400 two-component system response regulator K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C CR152_08705 PAS domain-containing sensor histidine kinase K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C CR152_08710 ntrC; nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
C CR152_06870 PAS domain-containing sensor histidine kinase K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
C CR152_06875 two-component system response regulator K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C CR152_12360 two-component sensor histidine kinase K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C CR152_12365 sigma-54-dependent Fis family transcriptional regulator K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C CR152_13805 C4-dicarboxylate ABC transporter K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C CR152_01820 sensor histidine kinase K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C CR152_13800 Fis family transcriptional regulator K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C CR152_23120 hybrid sensor histidine kinase/response regulator K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C CR152_14090 two-component sensor histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C CR152_29520 PAS domain-containing sensor histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C CR152_29535 PAS domain-containing sensor histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C CR152_16265 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C CR152_18295 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C CR152_31505 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CR152_31495 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CR152_18290 response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CR152_18325 chemotaxis protein CheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CR152_18320 chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C CR152_06995 chemotaxis protein CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C CR152_20860 chemotaxis protein CheB K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C CR152_27620 chemotaxis protein CheB K13924 cheBR; two-component system, chemotaxis family, CheB/CheR fusion protein [EC:2.1.1.80 3.1.1.61]
C CR152_19830 chemotaxis protein CheV K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C CR152_12535 hybrid sensor histidine kinase/response regulator K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C CR152_12515 two-component system response regulator K02657 pilG; twitching motility two-component system response regulator PilG
C CR152_12520 response regulator K02658 pilH; twitching motility two-component system response regulator PilH
C CR152_29785 two-component system response regulator K02658 pilH; twitching motility two-component system response regulator PilH
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C CR152_30880 hybrid sensor histidine kinase/response regulator K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C CR152_15610 diguanylate cyclase response regulator K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C CR152_15705 diguanylate cyclase response regulator K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C CR152_30890 diguanylate cyclase response regulator K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C CR152_30885 chemotaxis response regulator protein-glutamate methylesterase K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
C CR152_17315 ATPase K11354 cph1; two-component system, chemotaxis family, sensor kinase Cph1 [EC:2.7.13.3]
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ACell cycle family
B PleC-PleD (cell fate control)
C CR152_28345 response regulator K11443 divK; two-component system, cell cycle response regulator DivK
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
C CR152_14445 two-component sensor histidine kinase K10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
C CR152_12855 PAS domain-containing sensor histidine kinase K11711 dctS; two-component system, LuxR family, sensor histidine kinase DctS [EC:2.7.13.3]
C CR152_12850 DNA-binding response regulator K11712 dctR; two-component system, LuxR family, response regulator DctR
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
C CR152_11225 two-component system response regulator K13815 rpfG; two-component system, response regulator RpfG
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C CR152_26355 hybrid sensor histidine kinase/response regulator K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C CR152_26835 hybrid sensor histidine kinase/response regulator K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C CR152_26855 hybrid sensor histidine kinase/response regulator K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C CR152_13735 hybrid sensor histidine kinase/response regulator K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
B PdtaS-PdtaR
C CR152_07435 response regulator K22010 pdtaR; two-component system, response regulator PdtaR
B NasS-NasT
C CR152_20270 response regulator K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C CR152_25690 diguanylate cyclase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C CR152_26530 hypothetical protein K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C CR152_20505 hybrid sensor and regulator K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C CR152_11705 hybrid sensor histidine kinase/response regulator K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C CR152_13545 hybrid sensor histidine kinase/response regulator K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C CR152_15040 hybrid sensor histidine kinase/response regulator K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023