Functional Hierarchies
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KEGG BRITE is a collection of hierarchical classifications (see new hierarchies and last updates) representing our knowledge on various aspects of biological systems.
In contrast to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships.
The hierarchies, especially those with additional tab-delimited fields, can better be examined with a desktop application called KegHier, which works on Mac, Windows, and Linux platforms.
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Brite Mapping
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KEGG BRITE mapping is the process to map molecular datasets, especially large-scale datasets in genomics, transcriptomics, proteomics, and metabolomics, to the BRITE functional hierarchies for biological interpretation of higher-level systemic functions.
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Binary Relationships
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A binary relation file is a tab-delimited two-column file.
It is used to add an attribute (column) to a BRITE hierarchy, to link between different BRITE hierarchies, and to link to/from outside databases.
A BRITE hierarchical text file and a binary relation file are combined by the common key, such as the K number for KO or the D number for drugs, in a way similar to the join operation in the relational database.
The following preliminary interface displays the result of join, with an option to display all the data (outer join) or to limit to those that are matched (inner join) in the hierarchical text file.
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 Binary relation files linking to/from KO
Disease
EC number
Reaction
GO
COG
TC
CAZy
 Binary relation files linking to/from Drug
Target
Enzyme
Transporter
Map number
Codes and Abbreviations
Last updated: July 29, 2010
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Pathways and Ontologies