| Date | ko/br no | Title | Status |
|---|
| 2013-4-22 | 08316 | Pharmaceutical additives | Newly added |
| 2013-3-11 | 02001 | Solute carrier family | Deleted; merged into 02000 |
| 2013-3-5 | 04090 | CD molecules | Title changed |
| 2013-1-30 | 08341 | Genomic biomarkers | Deleted; available as a table file |
| 2013-1-10 | 04516 | Cell adhesion molecules and their ligands | Title changed |
| 2013-1-10 | 04515 | Cell adhesion molecules (CAMs) | Deleted; merged into 04516 |
| 2012-10-1 | 00003 | KEGG reaction modules | Newly added |
| 2012-9-14 | 08341 | Genomic biomarkers | Newly added |
| 2012-3-14 | 08009 | Natural toxins | Newly added |
| 2011-12-5 | 01008 | Polyketide biosynthesis proteins | Newly added |
| 2011-9-12 | 03016 | Transfer RNA biogenesis | Newly added |
| 2011-8-22 | 02001 | Solute carrier family | Newly added |
| 2011-7-19 | 08401 | Infectious diseases | Extracted from 08402 |
| 2011-7-19 | 08402 | Diseases with known genetic factors | Title changed; split into two files |
| 2011-6-27 | 03021 | Transcription machinery | Newly added |
| 2011-5-30 | 08310 | Target-based classification of drugs | Newly added |
| 2011-5-24 | 08008 | Carcinogens | Newly added |
| 2011-5-2 | 03009 | Ribosome biogenesis | Newly added |
| 2011-4-4 | 08007 | Pesticides | Newly added |
| 2011-2-3 | 08331 | Animal drugs in Japan | Newly added |
| 2010-12-28 | 08322 | Medicinal herbs | Newly added |
| 2010-12-28 | 01007 | Amino acid related enzymes | Newly added |
| 2010-11-17 | 08006 | Endocrine disrupting compounds | Newly added; split from 08001 |
| 2010-11-17 | 08004 | Polyketides and nonribosomal peptides | Deleted |
| 2010-11-16 | 08308 | Antineoplastics | Newly added |
| 2010-10-25 | 01006 | Prenyltransferases | Newly added |
| 2010-8-30 | 04030 | G protein-coupled receptors | Extracted from 04000 |
| 2010-8-30 | 01020 | Enzyme-linked receptors | Extracted from 04000 |
| 2010-8-30 | 04040 | Cytokine receptors | Extracted from 04000 |
| 2010-8-30 | 03310 | Nuclear receptors | Extracted from 04000 |
| 2010-8-30 | 04040 | Ion channels | Extracted from 04000 |
| 2010-8-30 | 04000 | Receptors and channels | Deleted; split into five files |
| 2010-8-26 | 08101 | Enzyme ligands | Deleted |
| 2010-8-26 | 08102 | Transporter substrates | Deleted |
| 2010-8-26 | 08103 | Ion channel ligands | Deleted |
| 2010-8-26 | 08104 | GPCR ligands | Deleted |
| 2010-8-26 | 08105 | Cytochrome P450 substrates | Deleted |
| 2010-8-26 | 08106 | Nuclear receptor ligands | Deleted |
| 2010-8-22 | 08604 | Photosynthetic organisms | Title changed |
| 2010-8-5 | 08502 | Human cells | Newly added |
| 2010-8-5 | 08501 | Human organ systems | Newly added |
| 2010-7-29 | 08204 | Reaction class | Newly added; computationally generated |
| 2010-7-6 | 08321 | Essential oils | Newly added |
| 2010-4-14 | 03051 | Proteasome | Newly added |
| 2010-1-15 | 03041 | Spliceosome | Newly added |
| 2009-12-29 | 08401 | Pathogens and infectious diseases | Deleted |
| 2009-12-7 | 01005 | Lipopolysaccharide biosynthesis proteins | Newly added |
| 2009-10-13 | 02044 | Secretion system | Newly added |
| 2009-8-12 | 01004 | Lipid biosynthesis proteins | Newly added |
| 2009-5-26 | 08307 | Antiinfectives | Newly added |
| 2009-4-24 | 08604 | Photosynthetic bacteria | Newly added |
| 2009-3-9 | 03036 | Chromosome | Newly added |
| 2009-1-1 | 08306 | Phytochemicals used as drugs | Newly added |
| 2008-8-29 | 02042 | Bacterial toxins | Newly added |
| 2008-7-23 | 03400 | DNA repair and recombination proteins | Newly added |
| 2008-5-16 | 08304 | Traditional Chinese Medicine in Japan | Newly added |
| 2008-3-25 | 08403 | ICD-10 disease classification | Newly added |
| 2008-3-18 | 03032 | DNA replication proteins | Newly added |
| 2008-1-8 | 04121 | Ubiquitin system | Newly added |
| 2007-11-13 | 08302 | USP drug classification | Newly added |
| 2007-10-22 | 04812 | Cytoskeleton proteins | Newly added |
| 2007-9-21 | 08303 | Anatomical Therapeutic Chemical (ATC) classification | Newly added |
| 2007-7-23 | 04091 | Glycan binding proteins | Newly added |
| 2007-6-4 | 08005 | Bioactive peptides | Newly added |
| 2007-4-5 | 08004 | Polyketides and nonribosomal peptides | Newly added |
| 2007-3-14 | 01003 | Glycosyltransferases | Newly added |
| 2007-3-12 | 03110 | Chaperones and folding catalysts | Newly added |
| 2006-12-28 | 03000 | Transcription factors | Newly added |
| 2006-11-10 | 08102 | Transporter substrates | Newly added |
| 2006-10-2 | 01001 | Protein kinases | Newly added |
| 2006-10-1 | 08202 | IUBMB reaction hierarchy | Newly added; computationally generated |
| 2006-10-1 | 08201 | Enzymatic reactions | Newly added; computationally generated |
| 2006-9-30 | 08203 | Glycosyltransferase reactions | Newly added |
| 2006-9-29 | 01002 | Peptidases | Newly added |
| 2006-9-29 | 08106 | Nuclear receptor ligands | Newly added |
| 2006-9-28 | 00194 | Photosynthesis proteins | Newly added |
| 2006-9-5 | 08101 | Enzyme ligands | Newly added; computationally generated |
| 2006-8-21 | 08402 | Human diseases | Newly added |
| 2006-7-19 | 08104 | GPCR ligands | Newly added |
| 2006-7-11 | 04131 | SNAREs | Newly added |
| 2006-5-1 | 04000 | Receptors and channels | Newly added |
| 2006-5-1 | 02000 | Transporters | Newly added |