| Date | ko/br no | Title | Status |
| 2017-6-15 | 06110 | Sequence data for CYP nomenclature | Title changed |
| 2017-4-3 | 01011 | Peptidoglycan biosynthesis and degradation proteins | Newly added |
| 2017-1-5 | 08457 | Antimicrobial resistance: others | Newly added table file |
| 2017-1-1 | 06110 | Cytochrome P450 | Newly added table file |
| 2016-12-5 | 08329 | New drug approvals in Europe | Newly added table file |
| 2016-12-5 | 08328 | New drug approvals in the USA, Europe and Japan | Newly added table file |
| 2016-11-15 | 08370 | Dermatological agents | Newly added table file |
| 2016-11-15 | 08317 | Topical steroids | Replaced by 08370 |
| 2016-9-1 | 04131 | Membrane trafficking | Title changed |
| 2016-7-1 | 08620 | KEGG viruses in the NCBI taxonomy | Newly added |
| 2016-3-30 | 08355 | Orphan drugs in the USA | Newly added table file |
| 2016-3-30 | 08354 | Orphan drugs in Japan (Japanese only) | Newly added table file |
| 2016-3-22 | 08371 | Gastrointestinal agents | Newly added table file |
| 2016-3-8 | 00537 | Glycosylphosphatidylinositol (GPI)-anchored proteins | Newly added |
| 2016-3-4 | 01504 | Antimicrobial resistance genes | Newly added |
| 2016-1-15 | 08307 | Antiinfectives | Changed back from table to htext file |
| 2015-10-20 | 08372 | Respiratory agents | Newly added table file |
| 2015-10-16 | 08373 | Endocrine and hormonal agents | Newly added table file |
| 2015-10-12 | 08350 | Antibacterials | Newly added table file |
| 2015-10-9 | 08353 | Antiparasitics | Newly added table file |
| 2015-10-1 | 08454 | Antimicrobial resistance: aminoglycoside resistance genes | Newly added table file |
| 2015-10-1 | 08456 | Antimicrobial resistance: tetracycline resistance genes | Newly added table file |
| 2015-10-1 | 08455 | Antimicrobial resistance: macrolide resistance genes | Newly added table file |
| 2015-9-16 | 08366 | Antirheumatic and antigout drugs | Newly added table file |
| 2015-8-6 | 08367 | Neurological agents | Newly added table file |
| 2015-7-23 | 08369 | Anesthetics and analgesics | Newly added table file |
| 2015-6-19 | 08368 | Osteoporosis drugs | Newly added table file |
| 2015-6-11 | 08364 | Cardiovascular agents | Newly added table file |
| 2015-6-10 | 08365 | Hypolipidemic agents | Newly added table file |
| 2015-6-9 | 08351 | Antivirals | Newly added table file |
| 2015-6-9 | 08352 | Antifungals | Newly added table file |
| 2015-6-8 | 08431 | Carbohydrates in viral and bacterial infections | Newly added table file |
| 2015-5-1 | 02048 | Prokaryotic defense system | Newly added |
| 2015-4-28 | 08412 | Specified intractable diseases in Japan (Japanese only) | Newly added table file |
| 2015-4-22 | 06001 | Enzymes of 2-oxocarboxylic acid metabolism | Included in BRITE as table file |
| 2015-4-22 | 06002 | Dioxygenases | Included in BRITE as table file |
| 2015-4-22 | 06010 | Ribosomal proteins | Included in BRITE as table file |
| 2015-4-22 | 06011 | RNA polymerases | Included in BRITE as table file |
| 2015-4-22 | 06020 | Photosynthetic and chemosynthetic capacities | Included in BRITE as table file |
| 2015-4-22 | 06021 | Signaling modules | Included in BRITE as table file |
| 2015-4-21 | 08363 | Psychiatric agents | Newly added table file |
| 2015-4-21 | 08362 | Anti-allergic agents | Newly added table file |
| 2015-4-1 | 08451 | Antibiotic resistance: KEGG signatures | Newly added table file |
| 2015-4-1 | 08452 | Antibiotic resistance: KEGG organisms | Newly added table file |
| 2015-4-1 | 08453 | Antibiotic resistance: beta-Lactamases | Newly added table file |
| 2015-3-30 | 08361 | Antidiabetics | Newly added table file |
| 2015-3-26 | 08340 | Antineoplastics | New table file number; changed from 08308 |
| 2015-3-9 | 08307 | Antiinfectives | Converted from htext to table file |
| 2015-3-6 | 00536 | Glycosaminoglycan binding proteins | Title changed |
| 2015-3-5 | 08308 | Antineoplastics | Converted from htext to table file |
| 2015-3-2 | 08317 | Topical steroids | Converted from htext to table file; Title changed |
| 2015-3-2 | 08411 | Infectious diseases by law in Japan (Japanese only) | Converted from htext to table file |
| 2015-2-16 | 08319 | New Drug Approvals in the U.S.A. | Newly added table file |
| 2015-2-16 | 08318 | New Drug Approvals in Japan (Japanese only) | Newly added table file |
| 2014-12-8 | 03019 | Messenger RNA biogenesis | Newly added |
| 2014-11-12 | 08442 | Tumor markers | Newly added table file |
| 2014-9-12 | 08441 | Cancer-accociated carbohydrates | Newly added table file |
| 2014-7-9 | 08323 | Major components of natural products | Computationally generated from 08305, 08321, 08322 |
| 2014-5-30 | 08611 | KEGG prokaryotes in the NCBI taxonomy | Computationally generated from 08601 |
| 2014-5-29 | 08610 | KEGG organisms in the NCBI taxonomy | Computationally generated from 08601 |
| 2014-3-6 | 01009 | Protein phosphatases and associated proteins | Newly added |
| 2014-2-12 | 03029 | Mitochondrial biogenesis | Newly added |
| 2013-11-26 | 08309 | Cytochrome P450 interactions | Newly added |
| 2013-9-27 | 08010 | Target-based classification of compounds | Newly added |
| 2013-9-27 | 04091 | Lectins | Title changed |
| 2013-7-26 | 08317 | Topical steroids potency in Japan | Newly added |
| 2013-7-22 | 04147 | Exosome | Newly added |
| 2013-6-14 | 08605 | Plant pathogens | Newly added |
| 2013-6-14 | 03100 | Non-coding RNAs | Newly added |
| 2013-4-22 | 08316 | Pharmaceutical additives | Newly added |
| 2013-3-15 | 00536 | Heparan sulfate/heparin binding proteins | Newly added |
| 2013-3-11 | 02001 | Solute carrier family | Deleted; merged into 02000 |
| 2013-3-5 | 04090 | CD molecules | Title changed |
| 2013-1-30 | 08341 | Genomic biomarkers | Converted from htext to table file |
| 2013-1-10 | 04516 | Cell adhesion molecules and their ligands | Title changed |
| 2013-1-10 | 04515 | Cell adhesion molecules (CAMs) | Deleted; merged into 04516 |
| 2012-10-1 | 00003 | KEGG reaction modules | Newly added |
| 2012-9-14 | 08341 | Genomic biomarkers | Newly added |
| 2012-3-14 | 08009 | Natural toxins | Newly added |
| 2011-12-5 | 01008 | Polyketide biosynthesis proteins | Newly added |
| 2011-9-12 | 03016 | Transfer RNA biogenesis | Newly added |
| 2011-8-22 | 02001 | Solute carrier family | Newly added |
| 2011-7-19 | 08401 | Infectious diseases | Extracted from 08402 |
| 2011-7-19 | 08402 | Diseases with known genetic factors | Title changed; split into two files |
| 2011-6-27 | 03021 | Transcription machinery | Newly added |
| 2011-5-30 | 08310 | Target-based classification of drugs | Newly added |
| 2011-5-24 | 08008 | Carcinogens | Newly added |
| 2011-5-2 | 03009 | Ribosome biogenesis | Newly added |
| 2011-4-4 | 08007 | Pesticides | Newly added |
| 2011-2-3 | 08331 | Animal drugs in Japan | Newly added |
| 2010-12-28 | 08322 | Medicinal herbs | Newly added |
| 2010-12-28 | 01007 | Amino acid related enzymes | Newly added |
| 2010-11-17 | 08006 | Endocrine disrupting compounds | Newly added; split from 08001 |
| 2010-11-17 | 08004 | Polyketides and nonribosomal peptides | Deleted |
| 2010-11-16 | 08308 | Antineoplastics | Newly added |
| 2010-10-25 | 01006 | Prenyltransferases | Newly added |
| 2010-8-30 | 04030 | G protein-coupled receptors | Extracted from 04000 |
| 2010-8-30 | 01020 | Enzyme-linked receptors | Extracted from 04000 |
| 2010-8-30 | 04040 | Cytokine receptors | Extracted from 04000 |
| 2010-8-30 | 03310 | Nuclear receptors | Extracted from 04000 |
| 2010-8-30 | 04040 | Ion channels | Extracted from 04000 |
| 2010-8-30 | 04000 | Receptors and channels | Deleted; split into five files |
| 2010-8-26 | 08101 | Enzyme ligands | Deleted |
| 2010-8-26 | 08102 | Transporter substrates | Deleted |
| 2010-8-26 | 08103 | Ion channel ligands | Deleted |
| 2010-8-26 | 08104 | GPCR ligands | Deleted |
| 2010-8-26 | 08105 | Cytochrome P450 substrates | Deleted |
| 2010-8-26 | 08106 | Nuclear receptor ligands | Deleted |
| 2010-8-22 | 08604 | Photosynthetic organisms | Title changed |
| 2010-8-5 | 08502 | Human cells | Newly added |
| 2010-8-5 | 08501 | Human organ systems | Newly added |
| 2010-7-29 | 08204 | Reaction class | Newly added; computationally generated |
| 2010-7-6 | 08321 | Essential oils | Newly added |
| 2010-4-14 | 03051 | Proteasome | Newly added |
| 2010-1-15 | 03041 | Spliceosome | Newly added |
| 2009-12-29 | 08401 | Pathogens and infectious diseases | Deleted |
| 2009-12-7 | 01005 | Lipopolysaccharide biosynthesis proteins | Newly added |
| 2009-10-13 | 02044 | Secretion system | Newly added |
| 2009-8-12 | 01004 | Lipid biosynthesis proteins | Newly added |
| 2009-5-26 | 08307 | Antiinfectives | Newly added |
| 2009-4-24 | 08604 | Photosynthetic bacteria | Newly added |
| 2009-3-9 | 03036 | Chromosome | Newly added |
| 2009-1-1 | 08306 | Phytochemicals used as drugs | Newly added |
| 2008-8-29 | 02042 | Bacterial toxins | Newly added |
| 2008-7-23 | 03400 | DNA repair and recombination proteins | Newly added |
| 2008-5-16 | 08304 | Traditional Chinese Medicine in Japan | Newly added |
| 2008-3-25 | 08403 | ICD-10 disease classification | Newly added |
| 2008-3-18 | 03032 | DNA replication proteins | Newly added |
| 2008-1-8 | 04121 | Ubiquitin system | Newly added |
| 2007-11-13 | 08302 | USP drug classification | Newly added |
| 2007-10-22 | 04812 | Cytoskeleton proteins | Newly added |
| 2007-9-21 | 08303 | Anatomical Therapeutic Chemical (ATC) classification | Newly added |
| 2007-7-23 | 04091 | Glycan binding proteins | Newly added |
| 2007-6-4 | 08005 | Bioactive peptides | Newly added |
| 2007-4-5 | 08004 | Polyketides and nonribosomal peptides | Newly added |
| 2007-3-14 | 01003 | Glycosyltransferases | Newly added |
| 2007-3-12 | 03110 | Chaperones and folding catalysts | Newly added |
| 2006-12-28 | 03000 | Transcription factors | Newly added |
| 2006-11-10 | 08102 | Transporter substrates | Newly added |
| 2006-10-2 | 01001 | Protein kinases | Newly added |
| 2006-10-1 | 08202 | IUBMB reaction hierarchy | Newly added; computationally generated |
| 2006-10-1 | 08201 | Enzymatic reactions | Newly added; computationally generated |
| 2006-9-30 | 08203 | Glycosyltransferase reactions | Newly added |
| 2006-9-29 | 01002 | Peptidases | Newly added |
| 2006-9-29 | 08106 | Nuclear receptor ligands | Newly added |
| 2006-9-28 | 00194 | Photosynthesis proteins | Newly added |
| 2006-9-5 | 08101 | Enzyme ligands | Newly added; computationally generated |
| 2006-8-21 | 08402 | Human diseases | Newly added |
| 2006-7-19 | 08104 | GPCR ligands | Newly added |
| 2006-7-11 | 04131 | SNAREs | Newly added |
| 2006-5-1 | 04000 | Receptors and channels | Newly added |
| 2006-5-1 | 02000 | Transporters | Newly added |