KEGG image  Pharmacogenomic Biomarkers in FDA Drug Labels

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Companion diagnostics

Drug KEGG ATC Efficacy Biomarker Network Variant
Busulfan D00248 L01AB01 Antineoplastic,
Alkylating agent
Philadelphia chromosome (BCR-ABL fusion gene) negative
Rituximab D02994 L01XC02 Antineoplastic,
Monoclonal antibody
CD20 positive
Trastuzumab D03257 L01XC03 HER2 overexpression/amplification N10009 2064v1
2064v3
Cetuximab D03455 L01XC06 EGFR expression, KRAS wild type
Panitumumab D05350 L01XC08 EGFR expression, KRAS wild type
Ofatumumab D09314 L01XC10 CD20 positive
Brentuximab vedotin D09587 L01XC12 CD30 positive
Pertuzumab D05446 L01XC13 HER2 overexpression N10009 2064v1
Trastuzumab emtansine D09980 L01XC14 HER2 overexpression/amplification N10009 2064v1
2064v3
Obinutuzumab D09321 L01XC15 CD20 positive
Dinutuximab D10559 L01XC16 MYCN amplification
Nivolumab D10316 L01XC17 PDL1 positive
Pembrolizumab D10574 L01XC18 PDL1 positive
Blinatumomab D09325 L01XC19 Philadelphia chromosome negative
Durvalumab D10808 L01XC28 PDL1 positive
Avelumab D10817 (L01XC31) PDL1 positive
Atezolizumab D10773 (L01XC32) PDL1 positive
Tositumomab D08622 V10XA53 CD20 positive
Ibritumomab tiuxetan D04489 V10XX02 CD20 positive
Imatinib D01441 L01XE01 Antineoplastic,
Kinase inhibitor
Philadelphia chromosome (BCR-ABL fusion gene)
FIP1L1-PDGFRA fusion gene
KIT mutation D816V negative
PDGFR rearrangement
N10001 25v1
Gefitinib D01977 L01XE02 EGFR exon 19 deletion or exon 21 L858R mutation N10005 1956v2
Erlotinib D04023 L01XE03 EGFR exon 19 deletion or exon 21 L858R mutation N10005 1956v2
Dasatinib D06414 L01XE06 Philadelphia chromosome, BCR-ABL T315I mutation N10002 25v2
Lapatinib D04024 L01XE07 HER2 overexpression
HLA-DQA1*0201 or HLA-DRB1*0701 allele carrier
N10009 2064v1
Nilotinib D06413 L01XE08 Philadelphia chromosome (BCR-ABL fusion gene)
UGT1A1*28 allele homozygotes
N10002 25v2
54658v1
Everolimus D02714 L01XE10
L04AA18
HER2 overexpression negative
ESR1 positive
Afatinib D09733 L01XE13 EGFR exon 19 deletion or exon 21 L858R mutation N10005 1956v2
Bosutinib D09728 L01XE14 Philadelphia chromosome (BCR-ABL fusion gene) N10002 25v2
Vemurafenib D09996 L01XE15 BRAF V600E mutation
NRAS mutation
N10007 673v1
Crizotinib D09731 L01XE16 EML4-ALK fusion gene
ROS1 fusion gene
N10003 238v1
6098v1
Dabrafenib D10104 L01XE23 BRAF V600E mutation
G6PD deficient
N10007 673v1
Ponatinib D09951 L01XE24 Philadelphia chromosome, BCR-ABL T315I mutation N10002 25v2
Trametinib D10176 L01XE25 BRAF V600E/K mutation N10008 673v1
Cabozantinib D10095 L01XE26 RET mutation
Ibrutinib D10223 L01XE27 Chromosome 17p deletion
Ceritinib D10551 L01XE28 ALK gene rearrangement N10004 238v2
Palbociclib D10372 L01XE33 ESR1 positive
HER2 overexpression negative
Osimertinib D10766 L01XE35 EGFR T790M mutation N10006 1956v3
Alectinib D10450 L01XE36 ALK gene rearrangement N10004 238v2
Cobimetinib D10615 L01XE38 BRAF V600E/K mutation N10008
Midostaurin D05029 L01XE39 FLT3 mutation
Ribociclib D10883 L01XE42 HER2 negative
ESR1, PGR positive
Brigatinib D10866 L01XE43 ALK gene rearrangement N10004 238v2
Neratinib D10898 (L01XE45) HER2 overexpression/amplification N10009 2064v1
2064v3
Tretinoin D00094 L01XX14 Antineoplastic,
RAR agonist
PML-RARA translocation 5371v1
Arsenic trioxide D02106 L01XX27 Antineoplastic PML-RARA translocation 5371v1
Denileukin diftitox D03682 L01XX29 Antineoplastic CD25 positive
Omacetaxine D08956 L01XX40 Antineoplastic, Protein
synthesis inhibitor
Philadelphia chromosome negative
Venetoclax D10679 L01XX52 Antineoplastic,
BCL2 inhibitor
Chromosome 17p deletion
Olaparib D09730 L01XX46 Antineoplastic,
PARP inhibitor
BRCA1,2 mutation
Niraparib D10140 L01XX54 BRCA1,2 mutation or wild type
Rucaparib D10079 L01XX55
Enasidenib D11044 (L01XX59) Antineoplastic,
IDH2 inhibitor
IDH2 mutation 3418v1
Tamoxifen D00966 L02BA01 Antineoplastic,
ESR antagonist
ESR1, PGR positive
Factor V Leiden negative
Prothrombin mutation negative
Fulvestrant D01161 L02BA03 ESR1, PGR positive
Anastrozole D00960 L02BG03 Antineoplastic, Estrogen
biosynthesis inhibitor
ESR1, PGR positive
Letrozole D00964 L02BG04 ESR1, PGR positive
Exemestane D00963 L02BG06 ESR1, PGR positive
Ivacaftor D09916 R07AX02 Cystic fibrosis treatment CFTR mutation (G551D, etc.)
Lumacaftor and ivacaftor D10685 R07AX30 CFTR mutation (F508del)

Polymorphisms and germline mutations

Drug KEGG ATC Efficacy Biomarker Variant
Omeprazole D00455
D05259
A02BC01 Anti-ulcerative,
Proton pump inhibitor
CYP2C19 poor metabolizer 1557v1
Pantoprazole D02593 A02BC02 CYP2C19 poor metabolizer 1557v1
Lansoprazole D00355 A02BC03 CYP2C19 intermediate or poor metabolizer 1557v1
Rabeprazole D00724 A02BC04 CYP2C19 poor metabolizer 1557v1
Esomeprazole D01984
D04056
D10120
A02BC05 CYP2C19 poor metabolizer 1557v1
Dexlansoprazole D08903 A02BC06 CYP2C19 poor metabolizer 1557v1
Metoclopramide D05008 A03FA01 Anti-emetic,
D2 receptor antagonist
CYB5R1-4 deficient
G6PD deficient
Palonosetron D05343 A04AA05 Anti-emetic,
5-HT3 receptor antagonist
CYP2D6 poor metabolizer 1565v1
Dronabinol D00306 A04AD10 Anti-emetic,
Cannabinoid receptor agonist
CYP2C9 poor metabolizer 1559v1
Cholic acid D10699 A05AA03 Choleretic AKR1D1,HSD3B7,CYP27A1,AMACR,CYP7A1 deficient
PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid Osmotic laxatives G6PD deficient
Glibenclamide (Glyburide) D00336 A10BB01 Antidiabetic,
Sulfonylurea receptor agonist
G6PD deficient
Chlorpropamide D00271 A10BB02 G6PD deficient
Glipizide D00335 A10BB07 G6PD deficient
Glimepiride D00593 A10BB12 G6PD deficient
Carglumic acid D07130 A16AA05 Antihyperammonemic NAGS deficient
Velaglucerase alfa D09029 A16AB10 Enzyme replenisher,
Gaucher disease treatment
GBA deficient
Elosulfase D10333 A16AB12 Enzyme replenisher,
Mucopolysaccharidosis treatment
GALNS deficient
Cerliponase alfa D10813 A16AB17 Enzyme replenisher,
CLN2 disease treatment
Sodium phenylbutyrate D05868 A16AX03 Antihyperammonemic CPS,OTC,NAGS /ASS,ASL /ARG deficient
Sodium phenylacetate and sodium benzoate D10205 Antihyperammonemic CPS,OTC,NAGS /ASS,ASL /ARG deficient
Eliglustat D09893 A16AX10 Gaucher disease treatment CYP2D6 ultrarapid, intermediate or poor metabolizer
Warfarin D00564 B01AA03 Antithrombotic agent VKORC1 rs9923231 allele carrier
CYP2C9 intermediate or poor metabolizer
PROS deficient
PROC deficient
79001v1
1559v1
Clopidogrel D00769 B01AC04 Antithrombotic agent CYP2C19 intermediate or poor metabolizers 1557v1
Prasugrel D05597 B01AC22 Antithrombotic agent CYP2C19 poor metabolizer
CYP2C9 variant allele carrier
CYP3A5 variant allele carrier
CYP2B6 variant allele carrier
1557v1
1559v1
1577v1
Ticagrelor D09017 B01AC24 Antithrombotic agent CYP2C19 poor metabolizer 1557v1
Eltrombopag D03978 B02BX05 Antihemorrhagic Factor V Leiden carrier
SERPINC1 deficient
Quinidine D00642
D02272
C01BA01 Antiarrhythmic,
Sodium channel blocker
CYP2D6 poor metabolizer 1565v1
Propafenone D00640 C01BC03 CYP2D6 poor metabolizer 1565v1
Hydralazine and isosorbide D10209 Vasodilator NAT1,2 slow acetylator 9v1
10v1
Propranolol D00483 C07AA05 Antiarrhythmic,
Beta blocking agent
CYP2D6 poor metabolizer 1565v1
Metoprolol D00601
D00635
C07AB02 CYP2D6 poor metabolizer 1565v1
Carvedilol D00255
D03415
C07AG02 CYP2D6 poor metabolizer 1565v1
Pravastatin D00893 C10AA03 Antihyperlipidemic,
HMG-CoA reductase inhibitor
LDLR mutation heterozygotes and homozygotes
Atorvastatin D00887
D02258
C10AA05 LDLR deficient
Rosuvastatin D01915 C10AA07 LDLR deficient
Mipomersen D08946 C10AX11 Antihyperlipidemic,
Antisense ApoB-100 mRNA
LDLR mutation heterozygotes and homozygotes
Lomitapide D09638 C10AX12 Antihyperlipidemic,
MTTP inhibitor
LDLR mutation homozygotes
Evolocumab D10557 C10AX13 Antihyperlipidemic,
Monoclonal antibody
LDLR mutation heterozygotes and homozygotes
Alirocumab D10335 C10AX14 LDLR mutation heterozygotes
Terbinafine D02219 D01AE15
D01BA02
Antifungal CYP2D6 poor metabolizer 1565v1
Mafenide D01166 D06BA03 Antiinfectives G6PD deficient
Dapsone D00592 D10AX05
J04BA02
Antimycobacterials G6PD deficient
Drospirenone and ethinylestradiol D09741 G03AA12 Hormonal agent CYP2C19 intermediate metabolizer 1557v1
Tolterodine D01148 G04BD07 Overactive bladder agent CYP2D6 poor metabolizer 1565v1
Darifenacin D01699 G04BD10 Overactive bladder agent CYP2D6 poor metabolizer 1565v1
Fesoterodine D08923 G04BD11 Overactive bladder agent CYP2D6 poor metabolizer 1565v1
Parathyroid hormone D05364 H05AA03 Antihypocalcemia CASR positive
Sulfamethoxazole and trimethoprim D00285 J01EE01 Antibacterials G6PD deficient
Nalidixic acid D00183 J01MB02 Antibacterials G6PD deficient
Nitrofurantoin D00439 J01XE01 Antibacterials G6PD deficient
Voriconazole D00578 J02AC03 Antifungals CYP2C19 intermediate or poor metabolizer 1557v1
Rifampin, isoniazid, and pyrazinamide D10210 Antiinfective NAT1,2 slow acetylator 9v1
10v1
Telaprevir D09012 J05AE11 Antiviral,
Protease inhibitor
IL28B SNP rs12979860
Boceprevir D08876 J05AE12 IL28B SNP rs12979860
Simeprevir D10469 J05AE14 IL28B SNP rs12979860
Efavirenz D00896 J05AG03 Antiviral,
Reverse transcriptase inhibitor
CYP2B6
Abacavir D00891 J05AF06 Antiviral HLA-B*5701
Daclatasvir D10105 J05AP07 Antiviral IL28B SNP rs12979860
Elbasvir and Grazoprevir D10778 J05AP54 Antiviral IL28B allele carrier
Dolutegravir D10113 J05AX12 Antiviral UGT1A1 poor metabolizer 54658v1
Sofosbuvir D10366 J05AX15 Antiviral IL28B SNP rs12979860
Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir D10582 J05AX66 Antiviral IL28B SNP rs12979860
Mercaptopurine D00161 L01BB02 Antineoplastic TPMT polymorphism 7172v1
Thioguanine D06109 L01BB03 Antineoplastic TPMT polymorphism 7172v1
Fluorouracil D00584 L01BC02 Antineoplastic DPD deficient
Capecitabine D01223 L01BC06 Antineoplastic DPD deficient
Cisplatin D00275 L01XA01 Antineoplastic TPMT polymorphism 7172v1
Lapatinib D04024 L01XE07 Antineoplastic HLA-DQA1*0201
HLA-DRB1*0701
Nilotinib D06413 L01XE08 Antineoplastic UGT1A1 poor metabolizer 54658v1
Pazopanib D05380 L01XE11 Antineoplastic UGT1A1 poor metabolizer 54658v1
Irinotecan D01061 L01XX19 Antineoplastic UGT1A1 poor metabolizer 54658v1
Belinostat D08870 L01XX49 Antineoplastic UGT1A1 poor metabolizer 54658v1
Peginterferon alfa-2b D02748 L03AB10 Immunomodulator IL28B SNP rs12979860
Mycophenolic acid D00752
D05095
D05096
L04AA06 Immunomodulator HGPRT deficient
Belimumab D03068 L04AA26 Immunomodulator ANA positive
Azathioprine D00238 L04AX01 Immunomodulator TPMT polymorphism 7172v1
Lenalidomide D04687 L04AX04 Antineoplastic Chromosome 5q deletion
Celecoxib D00567 L01XX33
M01AH01
Antiinflammatory (NSAID) CYP2C9 polymorphism 1559v1
Flurbiprofen D00330
D02290
M01AE09
M02AA19
R02AX01
S01BC04
Antiinflammatory (NSAID) CYP2C9 polymorphism 1559v1
Carisoprodol D00768 M03BA02 Muscle relaxants CYP2C19 polymorphism 1557v1
Lesinurad D09921 M04AB05 Antigout agent CYP2C9 poor metabolizer 1559v1
Pegloticase D09316 M04AX02 Antigout agent G6PD deficient
Sevoflurane D00547 N01AB08 Anesthetic RYR1 positive
Prilocaine and lidocaine D02740 N01BB52
N01BB54
Anesthetic CYBR1-4 deficient
G6PD deficient
Tramadol D01355 N02AX02 Analgesic CYP2D6 poor metabolizer 1565v1
Tramadol and acetaminophen D09999 N02AX52 Analgesic CYP2D6 poor metabolizer 1565v1
Phenytoin D00512
D02103
N03AB02 Antiepileptic HLA-B*1502
Carbamazepine D00252 N03AF01 Antiepileptic HLA-B*1502
HLA-A*3101
Valproic acid D00399
D00304
D00710
N03AG01 Antiepileptic POLG deficient
CPS,OTC,NAGS /ASS,ASL /ARG deficiency
Lacosamide D07299 N03AX18 Antiepileptic CYP2C19 poor metabolizer 1557v1
Brivaracetam D08879 N03AX23 Antiepileptic CYP2C19 poor metabolizer 1557v1
Perphenazine D00503 N05AB03 Antipsychotic CYP2D6 poor metabolizer 1565v1
Thioridazine D00798 N05AC02 Antipsychotic CYP2D6 poor metabolizer 1565v1
Pimozide D00560 N05AG02 Antipsychotic CYP2D6 poor metabolizer 1565v1
Clozapine D00283 N05AH02 Antipsychotic CYP2D6 poor metabolizer 1565v1
Risperidone D00426 N05AX08 Antipsychotic CYP2D6 poor metabolizer 1565v1
Aripiprazole D01164
D10364
N05AX12 Antipsychotic CYP2D6 poor metabolizer 1565v1
Brexpiprazole D10309 N05AX13 Antipsychotic CYP2D6 poor metabolizer 1565v1
Iloperidone D02666 N05AX14 Antipsychotic CYP2D6 poor metabolizer 1565v1
Diazepam D00293 N05BA01 Anxiolytic CYP2C19 polymorphism 1557v1
Clobazam D01253 N05BA09 Anxiolytic CYP2C19 polymorphism 1557v1
Desipramine D00812 N06AA01 Antidepressant CYP2D6 poor metabolizer 1565v1
Imipramine D00815 N06AA02 Antidepressant CYP2D6 poor metabolizer 1565v1
Clomipramine D00811 N06AA04 Antidepressant CYP2D6 poor metabolizer 1565v1
Amitriptyline D00809 N06AA09 Antidepressant CYP2D6 poor metabolizer 1565v1
Trimipramine D02408 N06AA06 Antidepressant CYP2D6 poor metabolizer 1565v1
Nortriptyline D00816 N06AA10 Antidepressant CYP2D6 poor metabolizer 1565v1
Protriptyline D00484 N06AA11 Antidepressant CYP2D6 poor metabolizer 1565v1
Doxepin D00814 N06AA12 Antidepressant CYP2C19 poor metabolizer
CYP2D6 polymorphism
1557v1
1565v1
Fluoxetine D00823 N06AB03 Antidepressant (SSRI) CYP2D6 poor metabolizer 1565v1
Citalopram D00822 N06AB04 Antidepressant (SSRI) CYP2C19 poor metabolizer
CYP2D6 polymorphism
1557v1
1565v1
Paroxetine D02260
D05374
D05375
N06AB05 Antidepressant (SSRI) CYP2D6 poor metabolizer 1565v1
Fluvoxamine D00824 N06AB08 Antidepressant (SSRI) CYP2D6 poor metabolizer 1565v1
Escitalopram D02567 N06AB10 Antidepressant (SSRI) CYP2C19 poor metabolizer
CYP2D6 poor metabolizer
1557v1
1565v1
Nefazodone D00819 N06AX06 Antidepressant CYP2D6 poor metabolizer 1565v1
Venlafaxine D00821 N06AX16 Antidepressant CYP2D6 poor metabolizer 1565v1
Duloxetine D01179 N06AX21 Antidepressant CYP2D6 poor metabolizer 1565v1
Vortioxetine D10185 N06AX26 Antidepressant CYP2D6 poor metabolizer 1565v1
Chlordiazepoxide and amitriptyline D10207 N06CA01 Antidepressant CYP2D6 poor metabolizer 1565v1
Modafinil D01832 N06BA07 Antipsychotic CYP2D6 poor metabolizer 1565v1
Atomoxetine D02574 N06BA09 Antipsychotic CYP2D6 poor metabolizer 1565v1
Galantamine D02173 N06DA04 Antidementia CYP2D6 poor metabolizer 1565v1
Cevimeline D00661 N07AX03 Sjögren's syndrome dry-mouth treatment CYP2D6 poor metabolizer 1565v1
Tetrabenazine D08575 N07XX06 Huntington's disease chorea treatment CYP2D6 poor metabolizer 1565v1
Dextromethorphan and quinidine D10208 N07XX59 Pseudobulbar affect (PBA) treatment CYP2D6 poor metabolizer 1565v1
Chloroquine D02125 P01BA01 Antiparasitic G6PD deficient
Primaquine D02126 P01BA03 Antiparasitic G6PD deficient
Quinine sulfate D02262 P01BC01 Antiparasitic G6PD deficient
CYP2D6 poor metabolizer

1565v1
Indacaterol D09319 R03AC18 COPD treatment UGT1A1 poor metabolizer 54658v1
Arformoterol D02981 COPD treatment UGT1A1 poor metabolizer
CYP2D6 intermediate or poor metabolizer
54658v1
1565v1
Codeine D03580 R05DA04 Analgesic CYP2D6 poor metabolizer 1565v1
Sodium nitrite D05865 V03AB08 Antidote G6PD deficient
Methylene blue D02312 V03AB17 Antidote G6PD deficient
Succimer D00572 Antidote G6PD deficient
Rasburicase D05704 V03AF07 Antihyperuricemic G6PD deficient
CYB5R1-4 deficiency

Pathogen genes

Drug KEGG ATC Efficacy Biomarker
Maraviroc D06670 J05AX09 Antiviral CCR5-tropic HIV-1

According to the Pharmacogenomic biomarkers in drug labels

[ DRUG | MEDICUS | BRITE | KEGG ]
Last updated: March 23, 2018