KEGG image  Pharmacogenomic Biomarkers in FDA Drug Labels

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Companion diagnostics

Drug ATC KEGG Efficacy Biomarker
Busulfan L01AB01 D00248 Antineoplastics Philadelphia chromosome (BCR-ABL fusion gene) negative
Rituximab L01XC02 D02994 Antineoplastics CD20 positive
Trastuzumab L01XC03 D03257 Antineoplastics HER2 overexpression or gene amplification positive
Cetuximab L01XC06 D03455 Antineoplastics EGFR expression positive
KRAS exon 2 codon 12/13 mutation negative
Panitumumab L01XC08 D05350 Antineoplastics EGFR expression positive
KRAS exon 2 codon 12/13 mutation negative
Ofatumumab L01XC10 D09314 Antineoplastics CD20 positive
Brentuximab vedotin L01XC12 D09587 Antineoplastics CD30 positive
Pertuzumab L01XC13 D05446 Antineoplastics HER2 overexpression positive
Trastuzumab emtansine L01XC14 D09980 Antineoplastics HER2 overexpression or gene amplification positive
Obinutuzumab L01XC15 D09321 Antineoplastics CD20 positive
Dinutuximab L01XC16 D10559 Antineoplastics MYCN amplification positive
Nivolumab L01XC17 D10316 Antineoplastics BRAF V600 mutation positive
PD-L1 protein expression positive
Pembrolizumab L01XC18 D10574 Antineoplastics BRAF V600 mutation positive
PD-L1 protein expression positive
Blinatumomab L01XC19 D09325 Antineoplastics Philadelphia chromosome (BCR-ABL fusion gene) negative
Imatinib L01XE01 D01441 Antineoplastics Philadelphia chromosome (BCR-ABL fusion gene) positive
FIP1L1-PDGFRA fusion gene positive
KIT mutation D816V negative
PDGFR rearrangement positive
Gefitinib L01XE02 D01977 Antineoplastics EGFR exon 19 deletion or exon 21 L858R mutation positive
Erlotinib L01XE03 D04023 Antineoplastics EGFR expression positive
EGFR exon 19 deletion or exon 21 L858R mutation positive
Dasatinib L01XE06 D06414 Antineoplastics Philadelphia chromosome positive, BCR-ABL T315I mutation positive
Lapatinib L01XE07 D04024 Antineoplastics HER2 overexpression positive
HLA-DQA1*0201 or HLA-DRB1*0701 allele carrier
Nilotinib L01XE08 D06413 Antineoplastics Philadelphia chromosome (BCR-ABL fusion gene) positive
UGT1A1*28 allele homozygotes
Everolimus L01XE10
L04AA18
D02714 Antineoplastics HER2 overexpression negative
ESR1 positive
Afatinib L01XE13 D09733 Antineoplastics EGFR exon 19 deletion or exon 21 L858R mutation positive
Bosutinib L01XE14 D09728 Antineoplastics Philadelphia chromosome (BCR-ABL fusion gene) positive
Vemurafenib L01XE15 D09996 Antineoplastics BRAF V600E mutation positive
NRAS mutation positive
Crizotinib L01XE16 D09731 Antineoplastics EML4-ALK gene rearrangement positive
Dabrafenib L01XE23 D10104 Antineoplastics BRAF V600E mutation positive
G6PD deficient
Ponatinib L01XE24 D09951 Antineoplastics Philadelphia chromosome positive, BCR-ABL T315I mutation positive
Trametinib L01XE25 D10176 Antineoplastics BRAF V600E/K mutation positive
Cabozantinib L01XE26 D10095 Antineoplastics RET mutation positive
Ibrutinib L01XE27 D10223 Antineoplastics Chromosome 17p deletion positive
Ceritinib L01XE28 D10551 Antineoplastics ALK gene rearrangement positive
Palbociclib L01XE33 D10372 Antineoplastics ESR1 positive
HER2 overexpression negative
Osimertinib L01XE35 D10766 Antineoplastics EGFR T790M mutation positive
Alectinib L01XE36 D10450 Antineoplastics ALK gene rearrangement positive
Cobimetinib L01XE38 D10615 Antineoplastics BRAF V600E/K mutation positive
Tretinoin L01XX14 D00094 Antineoplastics PML-RARA translocation positive
Arsenic trioxide L01XX27 D02106 Antineoplastics PML-RARA translocation positive
Denileukin diftitox L01XX29 D03682 Antineoplastics CD25 positive
Omacetaxine L01XX40 D08956 Antineoplastics Philadelphia chromosome (BCR-ABL fusion gene) negative
Olaparib L01XX46 D09730 Antineoplastics BRCA1,2 mutation positive
Belinostat L01XX49 D08870 Antineoplastics UGT1A1*28 allele homozygotes
Venetoclax L01XX52 D10679 Antineoplastics Chromosome 17p deletion positive
Tamoxifen L02BA01 D00966 Antineoplastics ESR1, PGR positive
Factor V Leiden negative
Prothrombin mutation negative
Fulvestrant L02BA03 D01161 Antineoplastics ESR1, PGR positive
Anastrozole L02BG03 D00960 Antineoplastics ESR1, PGR positive
Letrozole L02BG04 D00964 Antineoplastics ESR1, PGR positive
Exemestane L02BG06 D00963 Antineoplastics ESR1, PGR positive
Tositumomab V10XA53 D08622 Antineoplastics CD20 positive
Ibritumomab tiuxetan V10XX02 D04489 Antineoplastics CD20 positive

Polymorphisms and germline mutations

Drug ATC KEGG Efficacy Biomarker
Omeprazole A02BC01 D00455
D05259
Gastrointestinal agents; Proton pump inhibitors CYP2C19 poor metabolizer
Pantoprazole A02BC02 D02593 Gastrointestinal agents; Proton pump inhibitors CYP2C19 poor metabolizer
Lansoprazole A02BC03 D00355 Gastrointestinal agents; Proton pump inhibitors CYP2C19 intermediate or poor metabolizer
Rabeprazole A02BC04 D00724 Gastrointestinal agents; Proton pump inhibitors CYP2C19 poor metabolizer
Esomeprazole A02BC05 D01984
D04056
D10120
Gastrointestinal agents; Proton pump inhibitors CYP2C19 poor metabolizer
Dexlansoprazole A02BC06 D08903 Gastrointestinal agents; Proton pump inhibitors CYP2C19 poor metabolizer
Metoclopramide A03FA01 D05008 Antiemetics CYB5R1-4 deficient
G6PD deficient
Palonosetron A04AA05 D05343 Anti-emetic, 5-HT3 receptor antagonist CYP2D6 poor metabolizer
Cholic acid A05AA03 D10699 Choleretic AKR1D1,HSD3B7,CYP27A1,AMACR,CYP7A1 deficient
PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid Osmotic laxatives G6PD deficient
Glibenclamide (Glyburide) A10BB01 D00336 Antidiabetic agents G6PD deficient
Chlorpropamide A10BB02 D00271 Antidiabetic agents G6PD deficient
Glipizide A10BB07 D00335 Antidiabetic agents G6PD deficient
Glimepiride A10BB12 D00593 Antidiabetic agents G6PD deficient
Carglumic acid A16AA05 D07130 Antihyperammonemic NAGS deficient
Velaglucerase alfa A16AB10 D09029 Gaucher disease treatment GBA deficient
Elosulfase A16AB12 D10333 mucopolysaccharidosis IV treatment GALNS deficient
Sodium phenylbutyrate A16AX03 D05868 Antihyperammonemic CPS,OTC,NAGS /ASS,ASL /ARG deficient
Eliglustat A16AX10 D09893 Gaucher disease treatment CYP2D6 ultrarapid, intermediate or poor metabolizer
Sodium phenylacetate
and sodium benzoate
D10205 Antihyperammonemic CPS,OTC,NAGS /ASS,ASL /ARG deficient
Warfarin B01AA03 D00564 Antithrombotic agents VKORC1 rs9923231 allele carrier
CYP2C9 intermediate or poor metabolizer
PROS deficient
PROC deficient
Clopidogrel B01AC04 D00769 Antithrombotic agents CYP2C19 intermediate or poor metabolizers
Prasugrel B01AC22 D05597 Antithrombotic agents CYP2C19 poor metabolizer
CYP2C9 variant allele carrier
CYP3A5 variant allele carrier
CYP2B6 variant allele carrier
Ticagrelor B01AC24 D09017 Antithrombotic agents CYP2C19 poor metabolizer
Eltrombopag B02BX05 D03978 Antihemorrhagics Factor V Leiden carrier
SERPINC1 deficient
Quinidine C01BA01 D00642
D02272
Cardiovascular agents; Antiarrhythmics CYP2D6 poor metabolizer
Propafenone C01BC03 D00640 Cardiovascular agents; Antiarrhythmics CYP2D6 poor metabolizer
Hydralazine and isosorbide D10209 Cardiovascular agents; Vasodilators NAT1,2 slow acetylator
Propranolol C07AA05 D00483 Cardiovascular agents; Beta blocking agents CYP2D6 poor metabolizer
Metoprolol C07AB02 D00601
D00635
Cardiovascular agents; Beta blocking agents CYP2D6 poor metabolizer
Carvedilol C07AG02 D00255
D03415
Cardiovascular agents; Beta blocking agents CYP2D6 poor metabolizer
Pravastatin C10AA03 D00893 Cardiovascular agents; HMG-CoA reductase inhibitors LDLR mutation heterozygotes and homozygotes
Atorvastatin C10AA05 D00887
D02258
Cardiovascular agents; HMG-CoA reductase inhibitors LDLR deficient
Rosuvastatin C10AA07 D01915 Cardiovascular agents; HMG-CoA reductase inhibitors LDLR deficient
Mipomersen C10AX11 D08946 Antisense ApoB-100 mRNA LDLR mutation heterozygotes and homozygotes
Lomitapide C10AX12 D09638 MTTP inhibitor LDLR mutation homozygotes
Evolocumab C10AX13 D10557 Antihyperlipidemic LDLR mutation heterozygotes and homozygotes
Alirocumab C10AX14 D10335 Antihyperlipidemic LDLR mutation heterozygotes
Terbinafine D01AE15
D01BA02
D02219 Antifungals CYP2D6 poor metabolizer
Mafenide D06BA03 D01166 Antiinfectives G6PD deficient
Dapsone D10AX05
J04BA02
D00592 Antimycobacterials G6PD deficient
Drospirenone and ethinylestradiol G03AA12 D09741 Hormonal agents CYP2C19 intermediate metabolizer
Tolterodine G04BD07 D01148 Genitourinary agents CYP2D6 poor metabolizer
Fesoterodine G04BD11 D08923 Genitourinary agents CYP2D6 poor metabolizer
Parathyroid hormone H05AA03 D05364 Antihypocalcemia CASR positive
Sulfamethoxazole and trimethoprim J01EE01 D00285 Antibacterials G6PD deficient
Nalidixic acid J01MB02 D00183 Antibacterials G6PD deficient
Nitrofurantoin J01XE01 D00439 Antibacterials G6PD deficient
Voriconazole J02AC03 D00578 Antifungals CYP2C19 intermediate or poor metabolizer
Rifampin, isoniazid, and pyrazinamide D10210 Antiinfective NAT1,2 slow acetylator
Telaprevir J05AE11 D09012 Antivirals IL28B SNP rs12979860
Boceprevir J05AE12 D08876 Antivirals IL28B SNP rs12979860
Simeprevir J05AE14 D10469 Antivirals IL28B SNP rs12979860
Sofosbuvir J05AX15 D10366 Antivirals IL28B SNP rs12979860
Abacavir J05AF06 D00891 Antivirals HLA-B polymorphism *5701
Dolutegravir J05AX12 D10113 Antivirals UGT1A1 poor metabolizer
Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir J05AX66 D10582 Antivirals IL28B SNP rs12979860
Mercaptopurine L01BB02 D00161 Antineoplastics TPMT polymorphism
Thioguanine L01BB03 D06109 Antineoplastics TPMT polymorphism
Fluorouracil L01BC02 D00584 Antineoplastics DPD deficient
Capecitabine L01BC06 D01223 Antineoplastics DPD deficient
Cisplatin L01XA01 D00275 Antineoplastics TPMT polymorphism
Lapatinib L01XE07 D04024 Antineoplastics HLA-DQA1 polymorphism *0201
HLA-DRB1 polymorphism *0701
Pazopanib L01XE11 D05380 Antineoplastics UGT1A1*28 allele homozygotes
Irinotecan L01XX19 D01061 Antineoplastics UGT1A1*28 allele carrier
Peginterferon alfa-2b L03AB10 D02748 Immunomodulator IL28B SNP rs12979860
Mycophenolic acid L04AA06 D00752
D05095
D05096
Immunomodulator HGPRT deficient
Belimumab L04AA26 D03068 Immunomodulator ANA positive
Azathioprine L04AX01 D00238 Immunomodulator TPMT polymorphism
Lenalidomide L04AX04 D04687 Antineoplastics Chromosome 5q deletion
Celecoxib L01XX33
M01AH01
D00567 Antiinflammatory (NSAID) CYP2C9 polymorphism
Flurbiprofen M01AE09
M02AA19
R02AX01
S01BC04
D00330
D02290
Antiinflammatory (NSAID) CYP2C9 polymorphism
Carisoprodol M03BA02 D00768 Muscle relaxants CYP2C19 polymorphism
Lesinurad M04AB05 D09921 Antigout agents CYP2C9 poor metabolizer
Pegloticase M04AX02 D09316 Antigout agents G6PD deficient
Sevoflurane N01AB08 D00547 Anesthetic RYR1 positive
Prilocaine and lidocaine N01BB52
N01BB54
D02740 Anesthetics CYBR1-4 deficient
G6PD deficient
Tramadol N02AX02 D01355 Analgesics CYP2D6 poor metabolizer
Tramadol and acetaminophen N02AX52 D09999 Analgesics CYP2D6 poor metabolizer
Phenytoin N03AB02 D00512
D02103
Antiepileptics HLA-B polymorphism *1502
Carbamazepine N03AF01 D00252 Antiepileptics HLA-B polymorphism *1502
HLA-A polymorphism *3101
Valproic acid N03AG01 D00399
D00304
D00710
Antiepileptics POLG deficient
CPS,OTC,NAGS /ASS,ASL /ARG deficiency
Lacosamide N03AX18 D07299 Antiepileptics CYP2C19 poor metabolizer
Perphenazine N05AB03 D00503 Antipsychotics CYP2D6 poor metabolizer
Thioridazine N05AC02 D00798 Antipsychotics CYP2D6 poor metabolizer
Pimozide N05AG02 D00560 Antipsychotics CYP2D6 poor metabolizer
Clozapine N05AH02 D00283 Antipsychotics CYP2D6 poor metabolizer
Risperidone N05AX08 D00426 Antipsychotics CYP2D6 poor metabolizer
Aripiprazole N05AX12 D01164
D10364
Antipsychotics CYP2D6 poor metabolizer
Brexpiprazole N05AX13 D10309 Antipsychotics CYP2D6 poor metabolizer
Iloperidone N05AX14 D02666 Antipsychotics CYP2D6 poor metabolizer
Diazepam N05BA01 D00293 Anxiolytics CYP2C19 polymorphism
Clobazam N05BA09 D01253 Anxiolytics CYP2C19 polymorphism
Desipramine N06AA01 D00812 Antidepressants CYP2D6 poor metabolizer
Imipramine N06AA02 D00815 Antidepressants CYP2D6 poor metabolizer
Clomipramine N06AA04 D00811 Antidepressants CYP2D6 poor metabolizer
Amitriptyline N06AA09 D00809 Antidepressants CYP2D6 poor metabolizer
Trimipramine N06AA06 D02408 Antidepressants CYP2D6 poor metabolizer
Nortriptyline N06AA10 D00816 Antidepressants CYP2D6 poor metabolizer
Protriptyline N06AA11 D00484 Antidepressants CYP2D6 poor metabolizer
Doxepin N06AA12 D00814 Antidepressants CYP2C19 poor metabolizer
CYP2D6 polymorphism
Fluoxetine N06AB03 D00823 Antidepressants (SSRI) CYP2D6 poor metabolizer
Citalopram N06AB04 D00822 Antidepressants (SSRI) CYP2C19 poor metabolizer
CYP2D6 polymorphism
Paroxetine N06AB05 D02260
D05374
D05375
Antidepressants (SSRI) CYP2D6 poor metabolizer
Fluvoxamine N06AB08 D00824 Antidepressants (SSRI) CYP2D6 poor metabolizer
Escitalopram N06AB10 D02567 Antidepressants (SSRI) CYP2C19 poor metabolizer
CYP2D6 poor metabolizer
Nefazodone N06AX06 D00819 Antidepressants CYP2D6 poor metabolizer
Venlafaxine N06AX16 D00821 Antidepressants CYP2D6 poor metabolizer
Vortioxetine N06AX26 D10185 Antidepressants CYP2D6 poor metabolizer
Chlordiazepoxide and amitriptyline N06CA01 D10207 Antidepressants CYP2D6 poor metabolizer
Modafinil N06BA07 D01832 Antipsychotics CYP2D6 poor metabolizer
Atomoxetine N06BA09 D02574 Antipsychotics CYP2D6 poor metabolizer
Galantamine N06DA04 D02173 Antidementia CYP2D6 poor metabolizer
Cevimeline N07AX03 D00661 Sjögren's syndrome dry-mouth treatment CYP2D6 poor metabolizer
Tetrabenazine N07XX06 D08575 Huntington's disease chorea treatment CYP2D6 poor metabolizer
Dextromethorphan and quinidine N07XX59 D10208 Pseudobulbar affect (PBA) treatment CYP2D6 poor metabolizer
Chloroquine P01BA01 D02125 Antiparasitics G6PD deficient
Primaquine P01BA03 D02126 Antiparasitics G6PD deficient
Quinine sulfate P01BC01 D02262 Antiparasitics G6PD deficient
CYP2D6 poor metabolizer
Indacaterol R03AC18 D09319 Chronic obstructive pulmonary disease (COPD) treatment UGT1A1 polymorphism *28
Arformoterol D02981 Chronic obstructive pulmonary disease (COPD) treatment UGT1A1 poor metabolizer
CYP2D6 intermediate or poor metabolizer
Codeine R05DA04 D03580 Analgesics CYP2D6 poor metabolizer
Ivacaftor R07AX02 D09916 Cystic fibrosis treatment CFTR mutation (G551D)
Lumacaftor and ivacaftor R07AX30 D10685 Cystic fibrosis treatment CFTR mutation (F508del)
Sodium nitrite V03AB08 D05865 Antidotes G6PD deficient
Methylene blue V03AB17 D02312 Antidotes G6PD deficient
Succimer D00572 Electrolytes G6PD deficient
Rasburicase V03AF07 D05704 Antihyperuricemics G6PD deficient
CYB5R1-4 deficiency

Pathogen genes

Drug ATC KEGG Efficacy Biomarker
Maraviroc J05AX09 D06670 Antivirals CCR5-tropic HIV-1

According to the Pharmacogenomic biomarkers in drug labels

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Last updated: March 13, 2017