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KEGG DRUG

Drugs viewed as perturbants to the molecular system
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KEGG2 PATHWAY BRITE MODULE DISEASE DRUG ENVIRON MEDICUS
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KEGG DRUG Database

KEGG DRUG is a comprehensive drug information resource for approved drugs in Japan, USA, and Europe unified based on the chemical structures and/or the chemical components, and associated with target, metabolizing enzyme, and other molecular interaction network information. All the marketed drugs in Japan, not only the prescription drugs but also the OTC drugs, are fully represented in KEGG DRUG and integrated with the package insert information (labels information). These include crude drugs and TCM (Tradictional Chinese Medicine) drugs.

Each KEGG DRUG entry is identified by the D number distinguishing the chemical structure of chemicals or the chemical component of mixtures. It is associated with the following information (see, for example, D01441 or Gleevec for the treatment of chronic myeloid leukemia).
  • Generic names (associated with chemical structures, see details below)
  • Representative trade names
  • Links to FDA approved drug labels information in DailyMed
  • Chemical structure, chemical component, peptide/polyketide sequence
  • Text description of activity and efficacy
  • Therapeutic category, ATC code, and other comments
  • Target molecules in the context of KEGG pathway maps
  • Drug metabolizing enzymes and transporters
  • Other interacting molecules including genomic biomarkers, CYP inducers/inhibitors, etc.
  • Adverse drug-drug interaction data (collected from the Japanese package inserts)
  • History of drug development represented as a KEGG DRUG structure map
  • Drug classification information in BRITE hierarchy
  • Links to outside databases

Drug Interaction Database

The KEGG drug interaction database contains known adverse drug-drug interactions associated with contraindications (CI) and precautions (P) extracted from the package inserts (drug labels) of all prescription drugs in Japan. The database currently contains over 200,000 interactions (D number pairs) involving more than 4,000 drugs (D number entries) together with annotation about CYP enzymes, overlapping targets, etc. (see reference)

Enter a set of D numbers to check if any interacting pair exists


Drug Classification

For representation of efficacy and therapeutic use, different drug classification systems are maintained as part of the KEGG BRITE functional hierarchies. The first group is based on the established classification systems to which KEGG DRUG entries are manually assigned. The classification may be examined with additional information on targets and metabolizing enzymes as well as marketed products linked to DailyMed, shown in a separate column or an additional hierarchy level.
The second group consists of additional classification systems developed by KEGG.
Category Classification Remark
Prescription drug Target-based classification
Antiinfectives
Antineoplastics
Crude drug
(Japan)
TCM drugs in Japan See also: KEGG ENVIRON
Crude drugs in Japan
Furthermore, the following information is provided.
Labels information (in Japanese) of all marketed drugs in Japan is provided through the Japanese version of KEGG DRUG.

KEGG DRUG Structure Maps

Many marketed drugs have been developed from lead compounds or existing drugs by introducing chemical structure transformations retaining the core chemical structures. KEGG DRUG structure maps graphically illustrate, in a manner similar to KEGG pathway maps, our knowledge on such drug development. They are in the Drug Development category of the KEGG PATHWAY database.

Generic Names and Trade Names

The chemical structure of a drug is identified by the standardized generic name, but the names can be different in different countries or organizations. The same structure may be called differently and the same name may mean different structures. To accomodate such differences the generic names are associated with the following codes in parentheses.
  • JAN - Japanese Approved Name
  • USAN - United States Adopted Name
  • NF - National Formulary drug name
  • INN - International Nonproprietary Name
  • BAN - British Approved Name
  • DCF - Dénomination commune française
Specifically, for the drugs in Japan and USA whether they are listed in the pharmacopoeia is denoted by: which also imply the JAN and USAN names, respectively. Furthermore, the drugs in Japan include:
  • non-JP - Japanese standards for non-Pharmacopoeial crude drugs
for additional crude drugs.

Selected trade names (TNs) are also given in each KEGG DRUG entry. More names may be found from the outside link to DailyMed, which provides FDA approved labels information of marketed drugs.

Last updated: April 1, 2014
KEGG GenomeNet Kanehisa Laboratories